scholarly journals Essential amino acid supplementation is associated with reduced serum C-reactive protein levels and improved circulating lymphocytes in post-acute inflamed elderly patients

2021 ◽  
Vol 35 ◽  
pp. 205873842110368
Author(s):  
Roberto Aquilani ◽  
Ginetto C Zuccarelli ◽  
Roberto Maestri ◽  
Mirella Boselli ◽  
Maurizia Dossena ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Systemic Inflammation ◽  
Adaptive Immune System ◽  
Essential Amino Acids ◽  
Amino Acid Supplementation ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Circulating Lymphocytes ◽  
Inflammatory State

Background Persistent systemic inflammation leads to multidistrectual body dysfunctions. Attenuation of inflammation may improve patients’ functional and life prognoses. We hypothesized that essential amino acids (EAAs) given to elderly patients in rehabilitation after acute diseases may be associated with a reduced inflammatory state. Therefore, this retrospective study investigated whether the supplementation of EAAs – modulators of immune competence – was associated with a reduced inflammation rate in elderly patients. Methods The medical records of 282 patients admitted to the rehabilitation (rehab) institute after acute index events (surgery or medical diseases) (age: 81.18 ± 8.58 years; females: 67.9%) were analyzed. Results 46 patients (16.3% of the entire population) had received EAA supplements (S), whereas the remaining 236 patients had not (N-S). Systemic inflammation (I) (serum C-reactive protein (CRP) > 0.5 mg/dL) was present in 67.4% of the I-S group and 57.2% of the I-N-S group. During rehab, the I-S group (but not the I-N-S group) showed a reduction in CRP levels ( p = 0.03) and an increase in circulating lymphocytes ( p = 0.035), immune cells of the adaptive immune system. C-reactive protein levels remained virtually unchanged in non-inflamed patients who received supplements but increased in non-inflamed patients who did not receive supplements ( p = 0.05). Stratified for developed infections, CRP levels reduced in S patients ( p = 0.008) but did not in N-S patients. Conclusion EAA supplementation was associated with reduced inflammation in both inflamed and infected patients. In addition, EAA supplementation was associated with increased circulating lymphocytes in inflamed patients.

scholarly journals Comparative Analysis of C-Reactive Protein Levels in the Saliva and Serum of Dogs with Various Diseases

Animals ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1042
Author(s):  
Yoo-Ra Cho ◽  
Ye-In Oh ◽  
Gun-Ho Song ◽  
Young Jun Kim ◽  
Kyoung-Won Seo
Keyword(s):  
Comparative Analysis ◽  
C Reactive Protein ◽  
Positive Correlation ◽  
Protein Levels ◽  
Reactive Protein ◽  
Inflammatory Status ◽  
Inflammatory State ◽  
The Difference ◽  
Serum Crp ◽  
Inflammation Group

We performed this study to characterize the difference between the inflammatory and non-inflammatory status in diseased dogs by measuring salivary C-reactive protein (CRP) levels. In addition, we assessed whether a correlation exists between CRP levels in saliva and those in serum. CRP levels were measured in 32 client-owned dogs, which were then divided into inflammation and non-inflammation groups based on the serum CRP level. The salivary CRP level was higher in the inflammation group than in the non-inflammation group (p < 0.05). Furthermore, there was a positive correlation between the salivary and serum CRP levels (R = 0.866, p < 0.001). These data suggest that canine salivary CRP measurements can effectively and non-invasively detect an inflammatory state in dogs.

scholarly journals Waist Circumference Adds to the Variance in Plasma C-Reactive Protein Levels in Elderly Patients with Metabolic Syndrome

Gerontology ◽  
2007 ◽  
Vol 53 (6) ◽  
pp. 329-339 ◽  
Author(s):  
A.M. Dupuy ◽  
I. Jaussent ◽  
A. Lacroux ◽  
R. Durant ◽  
J.P. Cristol ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Elderly Patients ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals C-reactive Protein and Hepcidin in Non-Dialysis Chronic Kidney Disease

2020 ◽  
Vol 8 (3) ◽  
pp. 161
Author(s):  
Edward Muliawan Putera ◽  
Widodo Widodo ◽  
Nunuk Mardiana
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
P Value ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Cross Sectional ◽  
Protein Levels ◽  
Reactive Protein ◽  
Inflammatory State

Complications such as anemia and its clinical consequences arise as chronic kidney diseases progress,. One renal anemia pathophysiology is a disruption of iron metabolism, regulated by the main iron exporter hormone, hepcidin. Chronic kidney disease patients were constantly in an inflammatory state, represented by an increased in C-reactive protein. This inflammatory state would facilitate the liver to secrete hepcidin, which would subsequently follow a decrease of iron circulation, thus resulting in functional iron deficiency. Both acute phase reactants which used thoroughly as markers in tropical and infectious diseases, had their own roles in chronic kidney disease. The correlation of c-reactive protein and hepcidin in chronic kidney disease patients was still controversial. To analyse the relationship between c-reactive protein and hepcidin in non-dialysis chronic kidney disease patients. We conducted an observational cross-sectional study with 40 non-dialysis chronic kidney disease patients who met the inclusion and exclusion criteria. Patients were enrolled with consecutive sampling and were examined for serum c-reactive protein and hepcidin levels.A total of forty subjects (67.5% male with mean age of 50.23 ± 1.04 years) were eligible for enrolment in this study. The most comorbid factor was hypertension (62.5%). The common stage for chronic kidney disease was stage 3 (40%). The mean hemoglobin value was 10.74 ± 0.36 g/dL, mean blood urea nitrogen was 39.98 ± 29.59 mg/dL, and serum creatinine of 4.12 ± 3.39 mg/dL. Mean serum c-reactive protein levels were 3.52 ± 5.13 mg/l. Mean hepcidin level were 94,03 ± 95,39 ng/ml. Serum C-reactive protein levels correlated positively (r=0.487) and significantly (p-value=0.001) with serum hepcidin value. C-reactive protein and hepcidin was significantly correlated in non-dialysis chronic kidney disease patients. 

Ethnic differences in systemic inflammation: An investigation of C-reactive protein levels among Moroccan, Turkish and Dutch groups in the Netherlands

2011 ◽  
Vol 218 (2) ◽  
pp. 511-516 ◽  
Author(s):  
Joanne K. Ujcic-Voortman ◽  
Caroline A. Baan ◽  
Arnoud P. Verhoeff ◽  
Anneke Krol ◽  
Jacob C. Seidell
Keyword(s):  
The Netherlands ◽  
Ethnic Differences ◽  
Systemic Inflammation ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals Increased YKL-40 but Not C-Reactive Protein Levels in Patients with Alzheimer’s Disease

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1094
Author(s):  
Víctor Antonio Blanco-Palmero ◽  
Marcos Rubio-Fernández ◽  
Desireé Antequera ◽  
Alberto Villarejo-Galende ◽  
José Antonio Molina ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Elderly Patients ◽  
Orbitofrontal Cortex ◽  
Protein Unfolding ◽  
Testable Hypothesis ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

Neuroinflammation is a common feature in Alzheimer’s (AD) and Parkinson’s (PD) disease. In the last few decades, a testable hypothesis was proposed that protein-unfolding events might occur due to neuroinflammatory cascades involving alterations in the crosstalk between glial cells and neurons. Here, we tried to clarify the pattern of two of the most promising biomarkers of neuroinflammation in cerebrospinal fluid (CSF) in AD and PD. This study included cognitively unimpaired elderly patients, patients with mild cognitive impairment, patients with AD dementia, and patients with PD. CSF samples were analyzed for YKL-40 and C-reactive protein (CRP). We found that CSF YKL-40 levels were significantly increased only in dementia stages of AD. Additionally, increased YKL-40 levels were found in the cerebral orbitofrontal cortex from AD patients in agreement with augmented astrogliosis. Our study confirms that these biomarkers of neuroinflammation are differently detected in CSF from AD and PD patients.

Positive correlation between neovascularization degree of carotid atherosclerosis determined by contrast-enhanced ultrasound and level of serum C-reactive protein

VASA ◽  
2015 ◽  
Vol 44 (3) ◽  
pp. 0187-0194 ◽  
Author(s):  
Xiaoni Chang ◽  
Jun Feng ◽  
Litao Ruan ◽  
Jing Shang ◽  
Yanqiu Yang ◽  
...  
Keyword(s):  
Contrast Enhancement ◽  
Rank Correlation ◽  
Artery Stenosis ◽  
Contrast Enhanced Ultrasound ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Contrast Enhanced ◽  
Grade 3 ◽  
Axis View

Background: Neovascularization is one of the most important risk factors for unstable plaque. This study was designed to correlate plaque thickness, artery stenosis and levels of serum C-reactive protein with the degree of intraplaque enhancement determined by contrast-enhanced ultrasound. Patients and methods: Contrast-enhanced ultrasound was performed on 72 carotid atherosclerotic plaques in 48 patients. Contrast enhancement within the plaque was categorized as grade 1, 2 or 3. Maximum plaque thickness was measured in short-axis view. Carotid artery stenosis was categorized as mild, moderate or severe. Results: Plaque contrast enhancement was not associated with the degree of artery stenosis or with plaque thickness. Serum C-reactive protein levels were positively correlated with the number of new vessels in the plaque. C-reactive protein levels increased in the three groups(Grade 1: 3.72±1.79mg/L; Grade 2: 7.88±4.24 mg/L; Grade 3: 11.02±3.52 mg/L), with significant differences among them (F=10.14, P<0.01), and significant differences between each two groups (P<0.05). Spearman’s rank correlation analysis showed that serum C-reactive protein levels were positively correlated with the degree of carotid plaque enhancement (Rs =0.69, P<0.01). Conclusions: The combination of C-reactive protein levels and intraplaque neovascularization detected by contrast-enhanced ultrasound may allow more accurate evaluation of plaque stability.

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