scholarly journals Comparative Analysis of C-Reactive Protein Levels in the Saliva and Serum of Dogs with Various Diseases

Animals ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1042
Author(s):  
Yoo-Ra Cho ◽  
Ye-In Oh ◽  
Gun-Ho Song ◽  
Young Jun Kim ◽  
Kyoung-Won Seo
Keyword(s):  
Comparative Analysis ◽  
C Reactive Protein ◽  
Positive Correlation ◽  
Protein Levels ◽  
Reactive Protein ◽  
Inflammatory Status ◽  
Inflammatory State ◽  
The Difference ◽  
Serum Crp ◽  
Inflammation Group

We performed this study to characterize the difference between the inflammatory and non-inflammatory status in diseased dogs by measuring salivary C-reactive protein (CRP) levels. In addition, we assessed whether a correlation exists between CRP levels in saliva and those in serum. CRP levels were measured in 32 client-owned dogs, which were then divided into inflammation and non-inflammation groups based on the serum CRP level. The salivary CRP level was higher in the inflammation group than in the non-inflammation group (p < 0.05). Furthermore, there was a positive correlation between the salivary and serum CRP levels (R = 0.866, p < 0.001). These data suggest that canine salivary CRP measurements can effectively and non-invasively detect an inflammatory state in dogs.

scholarly journals Periodontitis Predicts Elevated C-reactive Protein Levels in Chronic Kidney Disease

2011 ◽  
Vol 90 (12) ◽  
pp. 1411-1415 ◽  
Author(s):  
E. Ioannidou ◽  
H. Swede ◽  
A. Dongari-Bagtzoglou
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Case Definition ◽  
Cutoff Point ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Inflammatory Status ◽  
Periodontal Infection ◽  
Serum Crp

Based on the existing evidence supporting a state of chronic inflammation in chronic kidney disease (CKD), we hypothesized that periodontal infection may affect the systemic inflammatory status of a nationally representative CKD population as measured by serum C-reactive protein (CRP). We examined this hypothesis using the National Health and Nutrition Examination Survey 1988-1994 (NHANES III) dataset including 2303 individuals. We followed the American Academy of Periodontology (AAP)/Centers for Disease Control and Prevention (CDC) case definition for periodontitis. We used a cutoff point of 30% sites with (PD) ≥ 5 mm and (CAL) ≥ 4 mm to define generalized periodontitis cases. We estimated glomerular filtration rate based on cystatin C levels using the relevant equation. Urinary albumin-to-creatinine ratio was calculated in milligrams per gram with a cutoff point of 30 mg/g. CKD was defined based on eGFR < 60 mL/min/1.73m2 and albuminuria ≥ 30 mg/g. Periodontitis was found in 427 (12.3%) individuals. Of individuals with periodontitis, 41.8% had serum CRP higher than 0.3 mg/dL compared with 27.1% of non-periodontitis and 53.1% of edentulous individuals (p = 0.001 for all comparisons). When the extent of periodontitis was used as one of the independent variables, the parsimonious model showed a strong independent association between extent of periodontitis and serum CRP levels (OR = 2.0, CI95% = 1.2-3.6).

Abstract P096: Maternal Serum C-Reactive Protein Levels During Pregnancy and Risk for High C-Reactive Protein 7-13 Years Later

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Bonny Rockette-Wagner ◽  
Claudia Holzman ◽  
Bertha L Bullen ◽  
Andrew D Althouse ◽  
Janet M Catov
Keyword(s):  
Relative Risk ◽  
Weight Change ◽  
Elevated Serum ◽  
Maternal Serum ◽  
Health Study ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Inflammatory Status

Introduction: Elevated serum C-reactive protein (CRP) can be a marker of disease activity involving inflammation, such as pregnancy complications and cardiovascular disease (CVD). Systemically high levels of CRP in women, including during pregnancy, may indicate higher risk for CVD. It is unknown if CRP measured during the pro-inflammatory state of pregnancy correlates with concentrations assessed 7-13 years after delivery. Hypothesis: Concentrations of CRP assessed during pregnancy will be related to CRP measured several years after pregnancy, independent of weight gain. Methods: We studied the first 252 women enrolled in the follow-up of the Pregnancy Outcomes and Community Health Study (POUCHmoms 2011-2013) with complete CRP data for the pregnancy (mean gestational age: 22.36 [2.22] weeks) and POUCHmoms visits (mean follow-up: 10.76 [1.38] years). The relative risk for high hsCRP (≥ 3.39 μg/ml) at the follow-up visit, related to quartiles of CRP during pregnancy, was examined using stepwise regression models. Results: Median (IQR) levels of pregnancy CRP and hsCRP at the follow-up visit were 5.68 [3.08, 9.76] and 3.39 [0.69, 9.73] μg/ml, respectively. Although absolute values of hsCRP at follow-up were generally lower than pregnancy CRP, 56% of women in the top and bottom quartiles of pregnancy CRP (71 of 126) were in the same quartile for hsCRP at follow-up (figure). The relative risk of having high hsCRP (≥ 3.39 μg/ml) at follow-up ranged from 2.7-5.2 for the 2 nd - 4 th quartiles of pregnancy CRP (vs. the 1st quartile). Controlling for pre-pregnancy BMI and follow-up weight change, the relative risk of having high hsCRP at follow-up was significantly higher for the 2 nd (1.15 [1.02-1.30]),3 rd (1.19 [1.05-1.35), and 4 th (1.22 [1.05-1.41]) quartiles of pregnancy CRP. Conclusions: Pregnancy CRP levels are related to hsCRP levels several years later in this cohort of women, even after adjusting for pre-pregnancy BMI and follow-up weight change. CRP assessed in pregnancy may reflect inflammatory status later in life.

scholarly journals Serum C-reactive protein levels predict neurological outcome after aneurysmal subarachnoid hemorrhage

2012 ◽  
Vol 70 (3) ◽  
pp. 202-205 ◽  
Author(s):  
Flávio Ramalho Romero ◽  
Eduardo de Freitas Bertolini ◽  
Eberval G. Figueiredo ◽  
Manoel Jacobsen Teixeira
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
C Reactive Protein ◽  
Clinical Prognosis ◽  
Protein Levels ◽  
Reactive Protein ◽  
Fisher Grade ◽  
Serial Serum ◽  
Gcs Score ◽  
Serum Crp

OBJECTIVES: Our aim was to evaluate the relationship between serum C-reactive protein (CRP) levels and the neurological prognosis and development of vasospasm in patients with aneurysmal subarachnoid hemorrhage (aSAH). METHODS: Eighty-two adult patients with aSAH diagnoses were prospectively evaluated. Glasgow Coma Scale (GCS) score, Hunt and Hess grade, Fisher grade, cranial CT scans, digital subtraction angiography studies and daily neurological examinations were recorded. Serial serum CRP measurements were obtained daily between admission and the tenth day. Glasgow Outcome Scale (GOS) and the modified Rankin Scale (mRS) were used to assess the prognosis. RESULTS: Serum CRP levels were related to severity of aSAH. Patients with lower GCS scores and higher Hunt and Hess and Fisher grades presented statistically significant higher serum CRP levels. Patients with higher serum CRP levels had a less favorable prognosis. CONCLUSIONS: Increased serum CRP levels were strongly associated with worse clinical prognosis in this study.

scholarly journals Adiponectin Expression Is Modulated by Long-Term Physical Activity in Adult Patients Affected by Cystic Fibrosis

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Rita Polito ◽  
Ersilia Nigro ◽  
Ausilia Elce ◽  
Maria Ludovica Monaco ◽  
Paola Iacotucci ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cystic Fibrosis ◽  
Forced Expiratory Volume ◽  
Total Serum ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Inflammatory Status ◽  
Inflammatory Processes

Cystic fibrosis (CF) is a genetic disease characterized by progressive decline of lung function and chronic airway inflammation. Adipose tissue, through adiponectin and leptin, exerts several effects on energy metabolism and inflammatory processes. This study evaluated the levels of adiponectin and leptin in adult healthy subjects, in patients with CF and their correlation with long-term physical activity. CF patients were divided into two groups (sedentary versus active) based on their regular physical activity over 3 years. Anthropometric and serum biochemical profiles of CF patients and controls were evaluated and compared. Total serum adiponectin and leptin levels were measured by ELISA; adiponectin oligomeric profiles were analysed by western blot. Adiponectin levels were significantly higher while leptin levels were lower in patients with CF than in healthy controls. Furthermore, adiponectin was significantly lower in active compared to sedentary CF (p=0.047), while leptin was slightly increased in active compared to sedentary CF. In addition, C-reactive protein levels were significantly lower in active than in sedentary CF patients (p=0.048). Interestingly, only in the active group adiponectin levels were inversely correlated with forced expiratory volume (FEV) 1% decrease/year and FEV1% decrease. Moreover, adiponectin levels negatively correlated with lipid profiles. Our findings indicated that regular, long-term physical activity in CF improves respiratory function, metabolism, and inflammation status. These improvements in patients’ conditions are associated with immunometabolic processes involving adiponectin, leptin, and C-reactive protein. Therefore, we propose that both adipokines may be a useful biomarker in the evaluation of metabolic and inflammatory status in patients with CF.

scholarly journals Porphyromonas gingivalis in dental plaque and serum C-reactive protein levels in pregnancy

2010 ◽  
Vol 4 (06) ◽  
pp. 362-366 ◽  
Author(s):  
Nada M. Souccar ◽  
Marita Chakhtoura ◽  
Joseph G. Ghafari ◽  
Alexander Michael Abdelnoor
Keyword(s):  
Pregnant Women ◽  
Porphyromonas Gingivalis ◽  
Preterm Labour ◽  
Systemic Infection ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Vaginal Swabs ◽  
Serum Crp ◽  
In Pregnancy

Background: The periodontopathogen Porphyromonas gingivalis (Pg) has been reported as a risk factor for preterm labour. Its pathogenesis and role in pregnancy have not been investigated in Lebanon. Elevated C-reactive protein (CRP) levels in pregnant women with periodontitis also appear to mediate preterm labour. Methodology: The study included 20 pregnant women with periodontitis and 20 with normal periodontium. PCR was done for Pg detection in oral plaque and vaginal samples. Serum CRP levels were determined by ELISA. Results: Pg was detected in the oral plaque of 13 of 20 pregnant subjects with clinical periodontitis (patients) and 2 of 20 controls with a healthy periodontium. Vaginal swabs were all Pg-negative, ruling out systemic infection. Serum CRP levels were elevated in 12 of 20 patients and 8 of 20 controls. None of the participants experienced preterm labour. Conclusions: This is the first report that implicates Pg in Lebanese periodontitis patients. Preliminary results do not indicate a relationship among Pg, periodontitis, CRP levels and preterm labour.

scholarly journals Interleukin-6 and highly sensitive C-reactive protein in obese adolescents

2012 ◽  
Vol 52 (4) ◽  
pp. 219
Author(s):  
Michael Kasenda ◽  
Suryadi Tantura ◽  
Sarah Warouw
Keyword(s):  
Interleukin 6 ◽  
Cross Sectional Study ◽  
Low Grade ◽  
C Reactive Protein ◽  
Tissue Mass ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Positive Correlation ◽  
Reactive Protein ◽  
Inflammatory State

Background Childhood obesity is a major health concern.Obesity is due to an expansion of adipose tissue mass. This tissueproduces pro􀁞inflarmnatory cytokines, such as interleukin􀁞6 (IL--6).IL􀁞6 is considered to be the chief stimulator of the production ofhighly sensitive C􀁞reactive protein (hsCRP) in the liver. Bothmolecules are responsible for the chronic low􀁞grade inflammatorystate in obese individuals.Objective To assess a correlation between IL􀁞6 and hsCRP inobese adolescents.Methods This cross􀁞sectional study was conducted from Marchto June 2011 in Manado. Subjects were obese and normal bodymass index (BMI) teens aged 13􀁞18 years. Serum glutamicoxaloacetic transaminase (SOOT) and serum glutamic pyruvictransaminase (SOPT) levels were measured to rule out liverimpairment. IL􀁞6 and hsCRP levels were also measured. Data wasanalyzed by Pearson's correlation and linear regression to test forcorrelation between IL--6 and hsCRP levels.Results There was a strongly positive correlation between IL􀁞6and hsCRP levels in obese adolescents (r=0.79 with P<O.OOl).IL--6 and hsCRP levels were not significantly associated in subjectswith normal BMI.Conclusions There was a strongly positive correlation betweenIL--6 and hsCRP levels in obese adolescents, suggestive of anongoing, chronic, low􀁞grade inflammatory state. [PaediatrIndanes.2012;52:219-22].

scholarly journals Essential amino acid supplementation is associated with reduced serum C-reactive protein levels and improved circulating lymphocytes in post-acute inflamed elderly patients

2021 ◽  
Vol 35 ◽  
pp. 205873842110368
Author(s):  
Roberto Aquilani ◽  
Ginetto C Zuccarelli ◽  
Roberto Maestri ◽  
Mirella Boselli ◽  
Maurizia Dossena ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Systemic Inflammation ◽  
Adaptive Immune System ◽  
Essential Amino Acids ◽  
Amino Acid Supplementation ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Circulating Lymphocytes ◽  
Inflammatory State

Background Persistent systemic inflammation leads to multidistrectual body dysfunctions. Attenuation of inflammation may improve patients’ functional and life prognoses. We hypothesized that essential amino acids (EAAs) given to elderly patients in rehabilitation after acute diseases may be associated with a reduced inflammatory state. Therefore, this retrospective study investigated whether the supplementation of EAAs – modulators of immune competence – was associated with a reduced inflammation rate in elderly patients. Methods The medical records of 282 patients admitted to the rehabilitation (rehab) institute after acute index events (surgery or medical diseases) (age: 81.18 ± 8.58 years; females: 67.9%) were analyzed. Results 46 patients (16.3% of the entire population) had received EAA supplements (S), whereas the remaining 236 patients had not (N-S). Systemic inflammation (I) (serum C-reactive protein (CRP) > 0.5 mg/dL) was present in 67.4% of the I-S group and 57.2% of the I-N-S group. During rehab, the I-S group (but not the I-N-S group) showed a reduction in CRP levels ( p = 0.03) and an increase in circulating lymphocytes ( p = 0.035), immune cells of the adaptive immune system. C-reactive protein levels remained virtually unchanged in non-inflamed patients who received supplements but increased in non-inflamed patients who did not receive supplements ( p = 0.05). Stratified for developed infections, CRP levels reduced in S patients ( p = 0.008) but did not in N-S patients. Conclusion EAA supplementation was associated with reduced inflammation in both inflamed and infected patients. In addition, EAA supplementation was associated with increased circulating lymphocytes in inflamed patients.

scholarly journals Evaluation of Serum Levels of Procalcitonin and C-Reactive Protein as Prognostic Indicators in Burns

2021 ◽  
Author(s):  
Aparna Sinha ◽  
Mukesh Kumar Sharma ◽  
Komal Tripathi ◽  
Nandini Duggal ◽  
Vinay Kumar Tiwari
Keyword(s):  
Poor Prognosis ◽  
Serum Levels ◽  
Prognostic Indicators ◽  
Burn Patients ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Serum Crp ◽  
Time Of Admission ◽  
Increasing Trends

Abstract Background Burn is a leading cause of fatality in a developing country. C-reactive protein levels (CRP) and procalcitonin (PCT) can be prognostic indicators for the burn patients' mortality. Aim To assess serial levels of serum PCT and serum CRP as prognostic indicators in burns. Patient and Methods In patients admitted with burns, alternate-day serum PCT and CRP were measured from the time of admission until the time of discharge or until survival. The change in trends of CRP and PCT serum levels were studied, and it was then correlated with mortality among these burn patients. Results The first-day value of serum PCT > 1772 pg/mL and serum CRP > 71 mg/mL or any value of serum PCT > 2163 pg/mL and of serum CRP > 90 mg/L indicate a poor prognosis in burns. Conclusions The day-1 values of PCT and CRP were significantly higher in nonsurvivors than survivors in burns. The increasing trends of serum PCT and CRP levels are independent predictors of mortality in burns requiring prompt intervention. Rising PCT and CRP level denote poor prognosis in burns with an increased likelihood of death by 4.5 and 23.6 times, respectively.

scholarly journals Evaluation of C-reactive Protein Levels in the Saliva of Covid Recovered Patients

2021 ◽  
pp. 344-351
Author(s):  
Soorya Ganesh ◽  
Palati Sinduja ◽  
. Priyadharshini ◽  
V. Meghashree
Keyword(s):  
Point Of Care ◽  
Complete Recovery ◽  
Acute Phase Reactant ◽  
Healthy Controls ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Non Invasive ◽  
The Difference ◽  
Set Up

Introduction: The acute phase reactant synthesized by the liver. CRP is an annular (ring- shaped) metameric protein set up in plasma, whose circulating immersion rise in response to inflammation. The idea of the study is to estimate the C-reactive protein situations in the salivary samples of COVID- 19 recovered cases and healthy controls. Materials and Methods: An experimental study on salivary samples of COVID recovered cases. The study was non-invasive and easy to perform without important vexation to cases. The samples were acquired from cases who came to the clinics of Saveetha Dental College and Hospitals. An aggregate of 20 saliva samples was collected from recruited cases 10 of whom were healthy controls and 10 were collected from cases who had made complete recovery from COVID infection. Results: C-reactive protein (CRP) could be generally used as a biomarker of systemic inflammation, routinely measured in serum blood samples. Still salivary samples offer a non-invasive and simply accessible preference which might upgrade point of care (POC) testing for inflammation. This study illustrates the group of healthy controls and COVID recovered cases. Conclusion: Within the limitations of our study, we were capable to interpret the difference of CRP levels between COVID recovered cases and healthy individualities.

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