Response-Disequilibrium Therapy: Clinical Case Studies

2019 ◽  
Vol 7 (5) ◽  
pp. 982-999 ◽  
Author(s):  
Richard M. McFall ◽  
James Allison ◽  
Richard J. Viken ◽  
William Timberlake

Basic learning theorists developed the response-disequilibrium model to resolve the long-standing psychological puzzle of how to specify in advance the circumstances that will yield reinforcement effects. The model explains the behavioral changes in reinforcement effects as predictable adaptations to external constraints on the free-baseline levels of those behaviors. Here we introduce response-disequilibrium therapy (RDx), a clinical intervention based on this model. We present a series of clinical case studies using RDx to treat obsessive-compulsive disorders, report highly favorable results in comparison with the standard therapy, and discuss the implications.

2020 ◽  
Vol 23 (9) ◽  
pp. 225-227
Author(s):  
Dante Ferrara

The paper describes the clinical case of a ten-year-old boy with Tourette’s syndrome, initially classified as PANDAS. The persistence, the complexity of the symptoms and the comorbidity with obsessive-compulsive disorders (OCD) have framed the case as Tourette syndrome and OCD. Treatment with cognitive behavioural therapy and aripiprazole gave a good clinical response, with partial regression of the symptoms. In the light of clinical improvement, a good prognosis is expected in the long term.


2019 ◽  
Author(s):  
German I. Todorov ◽  
Karthikeyan Mayilvahanan ◽  
David Ashurov ◽  
Catarina Cunha

Autism Spectrum Disorder (ASD) is a pervasive developmental disorder, that is raising at a concerning rate. However, underlying mechanisms are still to be discovered. Obsessions and compulsions are the most debilitating aspect of these disorders (OCD), and they are the treatment priority for patients. SAPAP3 knock out mice present a reliable mouse model for repetitive compulsive behavior and are mechanistically closely related to the ASD mouse model Shank3 on a molecular level and AMPA receptor net effect. The phenotype of SAPAP3 knock out mice is obsessive grooming that leads to self-inflicted lesions by 4 months of age. Recent studies have accumulated evidence, that epigenetic mechanisms are important effectors in psychiatric conditions such as ASD and OCD. Methylation is the most studied mechanism, that recently lead to drug developments for more precise cancer treatments. We injected SAPAP3 mice with an epigenetic demethylation drug RG108 during pregnancy and delayed the onset of the phenotype in the offspring by 4 months. This result gives us clues about possible mechanism involved in OCD and ASD. Additionally, it shows that modulation of methylation mechanisms during development might be explored as a preventative treatment in the cases of high inherited risk of certain mental health conditions.


2013 ◽  
Vol 12 (2) ◽  
pp. 75-75

The case studies below are referred to in the articles “Pulmonary Hypertension in Patients with Chronic Kidney Disease: Noninvasive Strategies for Patient Phenotyping and Risk Assessment” by Amresh Raina, MD, and “Hemodynamic Evaluation of Pulmonary Hypertension in Chronic Kidney Disease” by Ryan Tedford, MD, and Paul Forfia, MD, on the following pages.


2016 ◽  
Vol 4 (2) ◽  
pp. 103-111
Author(s):  
María Yoldi-Negrete ◽  
Mónica Flores-Ramos ◽  
Alejandra Montserrat Rodríguez-Ramírez ◽  
Carvajal-Lohr Armando ◽  
Jorge Ávila-Solorio ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document