The Paramedian Forehead Flap: A Retrospective Clinical Model for Understanding the Connection Between Supraorbital and Supratrochlear Nerve Pathology and Headaches

2021 ◽  
pp. 229255032110072
Author(s):  
Eva B. Niklinska ◽  
Juan M. Colazo ◽  
James Randall Patrinely ◽  
Brian C. Drolet ◽  
Salam A. Kassis
Keyword(s):  
Scar Tissue ◽  
Tissue Formation ◽  
Forehead Flap ◽  
Clinical Model ◽  
Post Surgery ◽  
Patient Reported ◽  
Paramedian Forehead Flap ◽  
Before And After ◽  
History Of ◽  
Scar Tissue Formation

Background: In the later stages of a paramedian forehead flap (PMFF) surgery, the supratrochlear (STN) and branches of the supraorbital nerve (SON) are transected during flap inset above the supraorbital rim. This can lead to either a nerve release if the compression point was previously distal to the transection point or a new nerve compression through neuroma or scar tissue formation. We inferred that PMFF could be a model for understanding the correlation between STN/SON pathology and migraines headaches (MH). We hypothesized that patients undergoing PMFF would experience either a change in severity or an onset of a new headache (HA) or MH. Methods: One hundred ninety-nine patients who underwent a PMFF at a tertiary medical centre were identified and contacted by phone. Patients were asked about the presence of MH or HA before and after the procedure. If a patient reported a perioperative history of MH/HA, their pre- and postoperative MH/HA characteristics were recorded. Results: Of the 199 patients contacted, 74 reported no perioperative HA/MH history and 14 reported a perioperative history of HA/MH. Of these 14 patients, 5 had stable HA/MH pre- and post-surgery, and 9 reported a change in HA/MH post-surgery. In this subset of 9 patients, 3 reported change in HA/MH quality post-surgery, 1 reported HA/MH resolution post-surgery, and 5 reported new onset HA/MH post-surgery. Conclusion: Sixty-four percent of patients with perioperative HA/MH experienced a change in headache quality following surgery. These results suggest a potential connection between SON and STN pathology and HA/MH pathophysiology; further work is warranted.

scholarly journals Experimental Methods to Simulate and Evaluate Postsurgical Peripheral Nerve Scarring

2021 ◽  
Vol 10 (8) ◽  
pp. 1613
Author(s):  
Alessandro Crosio ◽  
Giulia Ronchi ◽  
Benedetta Elena Fornasari ◽  
Simonetta Odella ◽  
Stefania Raimondo ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Peripheral Nerves ◽  
Experimental Methods ◽  
Scar Tissue ◽  
Experimental Models ◽  
Tissue Formation ◽  
Surgical Interventions ◽  
Pubmed Database ◽  
Different Types ◽  
Scar Tissue Formation

As a consequence of trauma or surgical interventions on peripheral nerves, scar tissue can form, interfering with the capacity of the nerve to regenerate properly. Scar tissue may also lead to traction neuropathies, with functional dysfunction and pain for the patient. The search for effective antiadhesion products to prevent scar tissue formation has, therefore, become an important clinical challenge. In this review, we perform extensive research on the PubMed database, retrieving experimental papers on the prevention of peripheral nerve scarring. Different parameters have been considered and discussed, including the animal and nerve models used and the experimental methods employed to simulate and evaluate scar formation. An overview of the different types of antiadhesion devices and strategies investigated in experimental models is also provided. To successfully evaluate the efficacy of new antiscarring agents, it is necessary to have reliable animal models mimicking the complications of peripheral nerve scarring and also standard and quantitative parameters to evaluate perineural scars. So far, there are no standardized methods used in experimental research, and it is, therefore, difficult to compare the results of the different antiadhesion devices.

scholarly journals VEGF Receptor-2 Activation Mediated by VEGF-E Limits Scar Tissue Formation Following Cutaneous Injury

2018 ◽  
Vol 7 (8) ◽  
pp. 283-297 ◽  
Author(s):  
Lyn M. Wise ◽  
Gabriella S. Stuart ◽  
Nicola C. Real ◽  
Stephen B. Fleming ◽  
Andrew A. Mercer
Keyword(s):  
Scar Tissue ◽  
Vegf Receptor ◽  
Tissue Formation ◽  
Cutaneous Injury ◽  
Scar Tissue Formation

The effects of mitomycin C and 5-fluorouracil/triamcinolone on fibrosis/scar tissue formation secondary to subglottic trauma (experimental study)

2005 ◽  
Vol 26 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Hakan Cincik ◽  
Atila Gungor ◽  
Adem Cakmak ◽  
Atilla Omeroglu ◽  
Ethem Poyrazoglu ◽  
...  
Keyword(s):  
Experimental Study ◽  
Mitomycin C ◽  
Scar Tissue ◽  
Tissue Formation ◽  
Scar Tissue Formation

Identifying wound infections for veterinary nurses

2020 ◽  
Vol 11 (10) ◽  
pp. 447-451
Author(s):  
Amanda Curtis
Keyword(s):  
Healing Process ◽  
Scar Tissue ◽  
Care Practice ◽  
Wound Infections ◽  
Tissue Formation ◽  
Deep Tissue ◽  
The Difference ◽  
Bite Wounds ◽  
Major Factors ◽  
Scar Tissue Formation

Heavily contaminated wounds are a common occurrence in both referral and primary care practice, with traumatic and bite wounds being among the most typical aetiologies seen. Each type of wound can be affected by numerous factors that can inhibit the healing process, one of these major factors is infection. Wound infections and the formation of biofilms can present veterinary nurses with a variety of challenges, which is why it is important that we understand the difference between normal inflammatory signs and the signs of infection. The early identification of infection and biofilms within a wound can influence healing times, scar tissue formation and length of healing. This article aims to highlight the difference between inflammation and infection, the different levels of contamination within a wound, and ways to decipher between superficial and deep tissue infections.

NEW TECHNOLOGICAL APPROACH TO STUDY ROTATOR CUFF PATHOLOGY

2012 ◽  
Vol 15 (01) ◽  
pp. 1250010 ◽  
Author(s):  
Christopher Vercollone ◽  
Christopher Rashidifard ◽  
Shiyi Zan ◽  
Scott D. Martin ◽  
Mark E. Brezinski
Keyword(s):  
Rotator Cuff ◽  
Imaging Modality ◽  
Supraspinatus Tendon ◽  
Scar Tissue ◽  
Tissue Formation ◽  
Structural Abnormalities ◽  
Male Wistar Rats ◽  
Picrosirius Red ◽  
Cuff Repair ◽  
Scar Tissue Formation

Rotator cuff repair (RCR) is a crucial surgical procedure, but has unacceptable mechanical failure rates between 25–60%. Examining supplemental synergistic interventions, such as biological augmentations (ex: growth factors) to improve fibrocartilage formation rather than scar tissue formation, would make tears more amenable to surgical repair. Due to the large number of agents and application methods (and times), improved techniques are needed for assessing RCR in animals. In particular, high-resolution real-time imaging is needed to guide tissue engineering in animal models. Optical coherence tomography (OCT) is well suited for this role, with resolutions 25 × greater than any clinical imaging modality and an ability to identify organized collagen with polarization sensitive techniques. For example, it can determine severe collagen depletion in visually normal tendons. The images here show the first OCT and PS-OCT of the rotator cuff in male Wistar rats. The structure of the supraspinatus tendon, enthesis, and humerus are well defined. For histological comparison, this sample was stained with both Masson's Trichrome, to expose any structural abnormalities, and Picrosirius Red, to determine collagen content using a polarization filter. OCT studies offer the potential of understanding RCR failure mechanisms and potential tissue altering agents, substantially impacting outcomes.

scholarly journals Pharmaceutical Modulation of Scar Tissue Formation after Cleft Palate Surgery.

2005 ◽  
Vol 14 (2) ◽  
pp. 271-272
Author(s):  
Hitoshi Kawanabe ◽  
Yuichirou Hata ◽  
wookjin Choi ◽  
Hiroyuki Ishikawa ◽  
Kunihisa Taniguchi
Keyword(s):  
Cleft Palate ◽  
Scar Tissue ◽  
Tissue Formation ◽  
Scar Tissue Formation
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