Bone Contusion on the Medial Compartment is a Predictive Factor for more Associated Injuries After ACL Rupture

Objectives: Determine the frequency of bone contusion and associated injuries, observed in patients with anterior cruciate ligament (ACL) rupture. Methods: Seventy two patients with an ACL rupture were enrolled in our prospective study. Magnetic resonance images (MRI) and arthroscopic findings of all patients were examined in order to detect bone contusions and associated injuries, such as meniscal lesions and medial collateral ligament (MCL) injury. ACL rupture and meniscal lesions were also verified with knee arthroscopy. Correlation between bone contusions and meniscal lesions or MCL injury was performed. Statistical packet STATA 8.0 was used for data analysis and significance was set at p<0.05. Results: Fifty eight (80.5%) patients presented with associated bone contusions observed on magnetic resonance imaging. Lateral aspect of the tibia plateau (71%) and lateral femoral condyle (69%) were the most common sites with contusions. Medial compartment was associated with contusions of medial aspect of the tibia plateau and medial femoral condyle in 25% and 22% of patients respectively. The frequency of lateral meniscus (p = 0.022), medial meniscus (p = 0.036) and MCL (p = 0.05) injuries, significantly increased in patients with bone contusions of medial and lateral compartments compared to those with bone contusions on lateral only compartment or without bone contusions. Conclusion: Bone contusion on the medial compartment is a predictive factor for more associated injuries, seen after ACL rupture and it suggest a higher energy trauma.

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Prevalence of Asymptomatic Intra-articular Changes of the Knee in Adult Professional Soccer Players

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967119885370 ◽

2019 ◽

Vol 7 (11) ◽

pp. 232596711988537 ◽

Cited By ~ 2

Author(s):

Eduard Nikolayevich Bezuglov ◽

Anastasiya Vladimirovna Lyubushkina ◽

Vladimir Yurevich Khaitin ◽

Alisa Viktorovna Tokareva ◽

Evgeny Nikolayevich Goncharov ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Femoral Condyle ◽

Lateral Meniscus ◽

Soccer Players ◽

Knee Joints ◽

Resonance Imaging ◽

Cartilage Lesions ◽

Professional Soccer ◽

Meniscal Lesions

Background: Currently, there are few data on the association between participation in soccer and the condition of the knee joints in adult professional players. Hypothesis: A high percentage of professional soccer players will have asymptomatic intra-articular changes of the knee. Study Design: Cross-sectional study; Level of evidence, 3. Methods: The condition of the intra-articular structures (osteophytes, cartilage, and menisci) in 94 knee joints of 47 adult professional soccer players (mean ± SD age, 25.7 ± 4.6 years; body mass index, 22.8 ± 1.4 kg/m2) was analyzed. A 1.5-T magnetic resonance imaging scanner was used to perform the imaging, and the anonymized data were analyzed by 2 experienced radiologists. Results: Cartilage of both knee joints was affected in 97.9% of soccer players. Meniscal lesions were detected in 97.8% of joints, affecting both joints in 93.6% of athletes. Grade 2 cartilage lesions were the most prevalent (36%-60% depending on the lesion site), and grade 4 lesions were detected in 12.7% of joints. The medial femoral condyle and medial tibial plateau were most frequently affected by cartilage lesions (85.1%). Among meniscal lesions, grade 2 lesions were the most prevalent, being detected in 71% of the cases. Grade 3 lesions were detected in 13.8% of the joints. The posterior horn of the lateral meniscus was the most common site of meniscal lesions (affected in 95.7% of the joints). Osteophytes were detected in 4.2% of joints. Conclusion: The prevalence of asymptomatic cartilage and meniscal lesions in the knees of adult professional soccer players is extremely high and is not associated with the reduction of sports involvement. This research should promote the correct interpretation of magnetic resonance imaging data obtained from soccer players with acute trauma and the reduction of the number of unwarranted surgical procedures.

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Relationship between abnormalities detected by magnetic resonance imaging and knee symptoms in early knee osteoarthritis

Scientific Reports ◽

10.1038/s41598-021-94382-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Seiya Ota ◽

Eiji Sasaki ◽

Shizuka Sasaki ◽

Daisuke Chiba ◽

Yuka Kimura ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Knee Osteoarthritis ◽

Cartilage Damage ◽

Resonance Imaging ◽

Mri Findings ◽

Radiographic Evidence ◽

Cross Sectional ◽

Meniscal Lesions ◽

Magnetic Resonance Imaging Mri

AbstractWe investigated the prevalence of magnetic resonance imaging (MRI) findings and their relationship with knee symptoms in women without radiographic evidence of knee osteoarthritis (KOA). This cross-sectional cohort study included 359 Japanese women without radiographic evidence of KOA (Kellgren‒Lawrence grade < 2). All participants underwent T2-weighted fat-suppressed MRI of their knees. Structural abnormalities (cartilage damage, bone marrow lesions [BMLs], subchondral cysts, bone attrition, osteophytes, meniscal lesions, and synovitis) were scored according to the whole-organ MRI score method. Knee symptoms were evaluated using the Knee Injury and Osteoarthritis Outcome Score. Participants were divided into early and non-KOA groups based on early KOA classification criteria. Logistic regression analysis was performed to evaluate the relationship between MRI abnormalities and knee symptoms. Cartilage damage was the most common abnormality (43.5%). The prevalences of cartilage damage, BMLs, subchondral cysts, bone attrition, meniscal lesions, and synovitis were higher in patients with early KOA than in those without. Synovitis (odds ratio [OR] 2.254, P = 0.002) and meniscal lesions (OR 1.479, P = 0.031) were positively associated with the presence of early KOA. Synovitis was most strongly associated with knee pain and might be a therapeutic target in patients with early KOA.

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Bone Contusions After Acute Noncontact Anterior Cruciate Ligament Injury Are Associated With Knee Joint Laxity, Concomitant Meniscal Lesions, and Anterolateral Ligament Abnormality

Arthroscopy The Journal of Arthroscopic and Related Surgery ◽

10.1016/j.arthro.2016.03.015 ◽

2016 ◽

Vol 32 (11) ◽

pp. 2331-2341 ◽

Cited By ~ 40

Author(s):

Guan-yang Song ◽

Hui Zhang ◽

Qian-qian Wang ◽

Jin Zhang ◽

Yue Li ◽

...

Keyword(s):

Anterior Cruciate Ligament ◽

Knee Joint ◽

Anterior Cruciate Ligament Injury ◽

Cruciate Ligament ◽

Anterolateral Ligament ◽

Ligament Injury ◽

Meniscal Lesions ◽

Knee Joint Laxity ◽

Anterior Cruciate ◽

Bone Contusions

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An In Vitro Osteotomy Method to Expose the Medial Compartment of the Human Knee

Journal of Biomechanical Engineering ◽

10.1115/1.2798282 ◽

1997 ◽

Vol 119 (4) ◽

pp. 379-385 ◽

Cited By ~ 30

Author(s):

T. A. Martens ◽

M. L. Hull ◽

S. M. Howell

Keyword(s):

Contact Pressure ◽

Pressure Measurement ◽

Femoral Condyle ◽

Compressive Load ◽

Medial Femoral Condyle ◽

Medial Compartment ◽

New Method ◽

Load Bearing ◽

Coronary Ligament

This study was conducted to validate a new in vitro method to expose the medial compartment of the knee to be used in subsequent studies aimed at examining the load bearing capabilities of medial meniscal allografts. The new method involves an osteotomy and reattachment of the medial femoral condyle. The primary hypothesis was that the new method does not alter tibio-femoral contact pressure and area. To validate this method, the baseline contact pressure of the intact medial compartment was measured using a new nondestructive procedure for inserting pressure measurement film into the intact medial hemijoint. A secondary and related hypothesis was that incising the coronary ligament, a destructive method used by previous investigators to position pressure measurement film, alters the normal tibio-femoral contact pressure. To test these hypotheses, Fuji Prescale pressure-sensitive film was used to measure both tibio-femoral contact pressure and area within the medial compartment of the (1) intact knee, (2) the knee after osteotomizing and reattaching the medial femoral condyle, and (3) the osteotomized knee with an incised coronary ligament, using seven cadaver specimens. Measurements were taken at a compressive load of approximately two times body weight with the knee in 0, 15, 30, 45 deg of flexion. No significant differences between the intact and osteotomized knee were detected. Likewise, no significant differences were observed between the osteotomized knee and the osteotomized knee with an incised coronary ligament. These results confirm the utility of the new method in exposing the medial compartment for manipulation and placement of medial meniscal allografts in future studies examining the load-bearing characteristics of meniscal allografts.

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One Screening Magnetic Resonance Imaging Sequence in Evaluation of Chondral and Meniscal Lesions of the Knee - A Pilot Study

The Open Orthopaedics Journal ◽

10.2174/1874325000802010019 ◽

2007 ◽

Vol 2 (1) ◽

pp. 19-22 ◽

Cited By ~ 1

Author(s):

Paavo-Ilari Kuikka ◽

Ole M. Bostman ◽

Martti J. Kiuru ◽

Sari T. Salminen ◽

Sakari Mikkola ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Pilot Study ◽

Magnetic Resonance ◽

Resonance Imaging ◽

Magnetic Resonance Imaging Sequence ◽

Imaging Sequence ◽

Meniscal Lesions

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First-in-Human Pilot Study of Implantation of a Scaffold-Free Tissue-Engineered Construct Generated From Autologous Synovial Mesenchymal Stem Cells for Repair of Knee Chondral Lesions

The American Journal of Sports Medicine ◽

10.1177/0363546518781825 ◽

2018 ◽

Vol 46 (10) ◽

pp. 2384-2393 ◽

Cited By ~ 20

Author(s):

Kazunori Shimomura ◽

Yukihiko Yasui ◽

Kota Koizumi ◽

Ryota Chijimatsu ◽

David A. Hart ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Magnetic Resonance ◽

Cartilage Repair ◽

Femoral Condyle ◽

Chondral Lesions ◽

Repair Tissue ◽

Biopsy Specimens ◽

Implantation Procedure

Background: Articular cartilage has limited healing capacity, owing in part to poor vascularity and innervation. Once injured, it cannot be repaired, typically leading to high risk for developing osteoarthritis. Thus, cell-based and/or tissue-engineered approaches have been investigated; however, no approach has yet achieved safety and regenerative repair capacity via a simple implantation procedure. Purpose: To assess the safety and efficacy of using a scaffold-free tissue-engineered construct (TEC) derived from autologous synovial membrane mesenchymal stem cells (MSCs) for effective cartilage repair. Study Design: Case series; Level of evidence, 4. Methods: Five patients with symptomatic knee chondral lesions (1.5-3.0 cm2) on the medial femoral condyle, lateral femoral condyle, or femoral groove were included. Synovial MSCs were isolated from arthroscopic biopsy specimens and cultured to develop a TEC that matched the lesion size. The TECs were then implanted into chondral defects without fixation and assessed up to 24 months postoperatively. The primary outcome was the safety of the procedure. Secondary outcomes were self-assessed clinical scores, arthroscopy, tissue biopsy, and magnetic resonance image–based estimation of morphologic and compositional quality of the repair tissue. Results: No adverse events were recorded, and self-assessed clinical scores for pain, symptoms, activities of daily living, sports activity, and quality of life were significantly improved at 24 months after surgery. Secure defect filling was confirmed by second-look arthroscopy and magnetic resonance imaging in all cases. Histology of biopsy specimens indicated repair tissue approaching the composition and structure of hyaline cartilage. Conclusion: Autologous scaffold-free TEC derived from synovial MSCs may be used for regenerative cartilage repair via a sutureless and simple implantation procedure. Registration: 000008266 (UMIN Clinical Trials Registry number).

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Risedronate Effects on the In Vivo Bioactive Glass Behavior: Nuclear Magnetic Resonance and Histopathological Studies

BioMed Research International ◽

10.1155/2019/2175731 ◽

2019 ◽

Vol 2019 ◽

pp. 1-16

Author(s):

Siwar Mosbahi ◽

Hassane Oudadesse ◽

Claire Roiland ◽

Bertrand Lefeuvre ◽

Lotfi Slimani ◽

...

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Bioactive Glass ◽

Volume Fraction ◽

Chemical Reactivity ◽

Femoral Condyle ◽

Mineral Density ◽

Nuclear Magnetic

The present study aimed to enhance the anti-osteoporotic performance of bioactive glass (46S6) through its association with bisphosphonate such as risedronate with amounts of 8, 12, and 20%. Obtained composites have been called 46S6-8RIS, 46S6-12RIS, and 46S6-20RIS, respectively. In vitro and in vivo explorations have been carried out. Bioactive glass and risedronate association has been performed by adsorption process. Structure analyses have been carried out to evaluate and to understand their chemical interactions. Solid Nuclear Magnetic Resonance (NMR) has been employed to study the structural properties of obtained biocomposite. The spectra deconvolution showed the appearance of a species (Q4) in the biocomposites 46S6-8RIS, 46S6-12RIS, and 46S6-20RIS indicating their successful chemical association. In vitro experiments showed the enhancement of the chemical reactivity of the composites 46S6-xRIS compared to the pure bioactive glass. In fact, the silicon liberation after 30 days of immersion was 50 ppm for pure bioactive glass 46S6, and 41, 64, and 62 from 46S6-8RIS, 46S6-12RIS, and 46S6-20RIS, respectively. Based on the in vitro results, 46S6-8RIS was implanted in the femoral condyle of an ovariectomized rat and compared with implanted pure glass in the goal to highlight its anti-osteoporotic performance. After 60 days, implanted group with 46S6-8RIS showed the increase in bone mineral density (BMD with 10%) and bone volume fraction (BV/TV with 80%) and the decrease in trabecular separation (Tb/Sp with 74%) when compared to that of 46S6 group. These results are confirmed by the histopathological analyses, which showed the bone trabeculae reconnection after the 46S6-8RIS implantation. Chemical analyses showed the reduction in silicon (Si) and sodium (Na) ion concentrations, and the rise in calcium (Ca) and phosphorus (P) ion levels, which was explained by the dissolution of biocomposite matrix and the deposition of hydroxyapatite layer. Histomorphometric results highlighted the risedronate effect on the antiosteoporotic phenomenon. Obtained results showed good behavior with only 8% of introduced risedronate in the glass matrix.

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