High-Grade Patellar Chondral Defects: Promising Results From Management With Osteochondral Autografts

Background: Patellar chondral defects represent up to 34.6% of defects found during routine arthroscopy. Surgical management has evolved during the past 20 years in an effort to develop techniques to replace hyaline cartilage. Currently, the only technique that achieves this is osteochondral autologous transfer (OAT). Although good and excellent results have often been reported at midterm and long-term follow-up for femoral lesions, little is known about isolated patellar defects. Purpose: To assess clinical and imaging results of patients treated with OAT for high-grade patellar defects. Study Design: Case series; Level of evidence, 4. Methods: This was a retrospective study on all patients who received OAT for high-grade symptomatic patellar chondral defects between 2010 and 2018 at our institution. The study included patients younger than 40 years of age with anterior knee pain and a grade 4 International Cartilage Repair Society patellar chondral defect between 1 and 2.5 cm2. Patients with surgery in other knee compartments, concomitant anterior cruciate ligament ruptures, infection, rheumatoid arthritis, and degenerative lesions were excluded. Six months postoperatively, all patients underwent magnetic resonance imaging (MRI) to allow assessment of graft integrity via the MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) score to evaluate morphologic features and integration. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Kujala scores were used to assess functional outcomes at final follow-up. Results: A total of 26 patients who received a patellar OAT were included. Most patients were male (88.4%), and the mean ± SD age was 28.5 ± 9.7 years. Patellar chondral defects had a median size of 180 mm2 (range, 64-250 mm2), and patients received a median of 1 autograft (range, 1-3). Functional outcomes assessed at a minimum of 1 year after surgery showed a mean Kujala score of 90.42 ± 6.7 and a mean WOMAC score of 95 ± 3.6. MRI revealed a median MOCART score of 75 points (range, 20-90 points). Conclusion: To our knowledge, this is the largest series to date regarding isolated patellar OAT. At midterm follow-up, most patients reported good and excellent results regarding symptoms and activity levels. Most autografts showed good osseous integration and excellent filling of the chondral surface, as evidenced on MRI. OAT is a good alternative to treat high-grade patellar chondral defects, especially among young patients.

Download Full-text

All-Arthroscopic Autologous Matrix-Induced Chondrogenesis-Aided Repair of a Patellar Cartilage Defect Using Dry Arthroscopy and a Retraction System

The Journal of Knee Surgery ◽

10.1055/s-0037-1599246 ◽

2017 ◽

Vol 30 (09) ◽

pp. 925-929 ◽

Cited By ~ 8

Author(s):

Mariusz Puszkarz ◽

Lidia Kosmalska ◽

Martin Wiewiorski ◽

Boguslaw Sadlik

Keyword(s):

Magnetic Resonance ◽

Cartilage Repair ◽

Case Series ◽

Collagen Matrix ◽

International Knee Documentation Committee ◽

Level Of Evidence ◽

Patellar Cartilage ◽

Radiological Data ◽

Implantation Techniques

AbstractThe technique of all-arthroscopic autologous matrix-induced chondrogenesis (AMIC)-aided repair of patellar cartilage lesions using a retraction system and dry arthroscopy has been recently described. We report the first clinical and radiological data at a short-term follow-up. Twelve patients underwent AMIC-aided cartilage repair for a patellar lesion. All steps of the procedure were performed arthroscopically, which include the use of an intra-articularly placed retraction plate for distraction of the patellofemoral joint and evacuation of saline solution for collagen matrix insertion and fixation. Clinical assessment performed before surgery and at a mean follow-up time of 38 months (range: 24–70) included the following scores: Knee Injury and Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee (IKDC), and visual analog scale (VAS). Magnetic resonance imaging was performed at the follow-up examination, including the magnetic resonance observation of cartilage repair tissue (MOCART) score. The mean KOOS and IKDC scores increased significantly (p < 0.01) from 50.3 and 37.4 points preoperatively to 90.1 and 79.4 postoperatively. The VAS score decreased from 7.8 to 2.3 points. Mean MOCART score at follow-up was 58.3 points. Cartilage repair of patellar lesions aided by a retraction system in a dry arthroscopy setup is a promising approach. Further studies are needed to evaluate this procedure and compare it to existing matrix implantation techniques. The level of evidence for the study is 4 (case series).

Download Full-text

Safety and Performance of Titanium Suture Anchors Used in Knee Ligament Repair Procedures

Medicina ◽

10.3390/medicina57030287 ◽

2021 ◽

Vol 57 (3) ◽

pp. 287

Author(s):

Antonio Maestro ◽

Iván Pipa ◽

Nicolás Rodríguez ◽

Carmen Toyos ◽

Marcelino Torrontegui-Duarte ◽

...

Keyword(s):

Ligament Reconstruction ◽

Cruciate Ligament ◽

Young Patients ◽

Case Series ◽

Invasive Technique ◽

Ligament Repair ◽

Knee Ligament ◽

And Performance

Injuries to the knee ligaments can be particularly disabling in young patients, given the risk of long-term disability if adequate fixation is not achieved during initial repair. The TWINFIX™ titanium (Ti) suture anchor with ULTRABRAID™ Suture (Smith and Nephew, London, UK) was designed to secure tendon and ligament reconstructions with increased boney ingrowth at the anchor site with minimal invasive technique. This retrospective analysis looked at 33 patients (41 implants) operated with this device between 2015 and 2019 at a single institution. The average age of patients was 33.18 years (standard deviation [SD], 15.26), with an average body mass index of 24.88 (SD, 3.49). The indications were lateral extra-articular tenodesis during anterior cruciate ligament reconstruction, medial patellofemoral ligament reconstruction, quadriceps or patellar tendon repair and medial collateral ligament repair. After an average follow up of 24.3 + 6.53 months, there was no reports of clinical failure or radiographic evidence of implant failure or loosening. One patient experienced a complication unrelated to the study device, requiring manipulation under anesthesia with resolution of symptoms. This case series supports the safety and performance of this implants for the knee procedures in which its use is indicated. Additional follow-up will be required to determine whether these effects are sustained at medium- and long-term durations.

Download Full-text

Ultrasound and Functional Assessment of Transtendinous Repairs of Partial-Thickness Articular-Sided Rotator Cuff Tears

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967117697375 ◽

2017 ◽

Vol 5 (3) ◽

pp. 232596711769737 ◽

Cited By ~ 4

Author(s):

Roger V. Ostrander ◽

Jeffrey M. Klauser ◽

Sanjay Menon ◽

Joshua G. Hackel

Keyword(s):

Los Angeles ◽

Rotator Cuff ◽

Functional Outcomes ◽

Case Series ◽

Rotator Cuff Tears ◽

High Grade ◽

Partial Thickness ◽

Ultrasound Evaluation ◽

Functional Scores

Background: Partial-thickness articular-sided rotator cuff tears are a frequent source of shoulder pain. Despite conservative measures, some patients continue to be symptomatic and require surgical management. However, there is some controversy as to which surgical approach results in the best outcomes for grade 3 tears. Hypothesis/Purpose: The purpose of this study was to evaluate repair integrity and the clinical results of patients treated with transtendinous repair of high-grade partial-thickness articular-sided rotator cuff tears. Our hypothesis was that transtendinous repairs would result in reliable healing and acceptable functional outcomes. Study Design: Case series; Level of evidence, 4. Methods: Twenty patients with a minimum follow-up of 2 years were included in the study. All patients underwent arthroscopic repair of high-grade partial-thickness rotator cuff tears utilizing a transtendinous technique by a single surgeon. At latest follow-up, the repair integrity was evaluated using ultrasound imaging, and functional scores were calculated. Results: Ultrasound evaluation demonstrated that 18 of 20 patients had complete healing with a normal-appearing rotator cuff. Two patients had a minor residual partial tear. Sixteen of 20 patients had no pain on visual analog scale. Four patients complained of mild intermittent residual pain. All patients were rated as “excellent” by both the University of California at Los Angeles Shoulder Score and the Simple Shoulder Test. Conclusion: The transtendon technique for the repair of articular-sided high-grade partial rotator cuff tears results in reliable tendon healing and excellent functional outcomes.

Download Full-text

Good Short-Term Clinical Outcomes and Low Rates of Return to Sports after Repeat Revision ACL Reconstruction

The Journal of Knee Surgery ◽

10.1055/s-0041-1723765 ◽

2021 ◽

Author(s):

Tomás D. Gorodischer ◽

Juan Pablo Zicaro ◽

Carlos Yacuzzi ◽

Matías Costa Paz

Keyword(s):

Functional Outcomes ◽

Cruciate Ligament ◽

Case Series ◽

Cartilage Regeneration ◽

Tibial Slope ◽

Cartilage Injury ◽

Return To Sports ◽

Kt 1000 ◽

Anatomical Parameters

AbstractRepeat revision anterior cruciate ligament reconstruction (ACL-R) is a rare, demanding procedure and, as such, has not been well studied. Most of the available literature shows improved functional outcomes compared with preoperative state but inferior results when compared with primary ACL-R, particularly regarding return to preinjury level of sports. The purpose of this study was to assess functional outcomes in patients who had undergone repeat revision ACL-R. The secondary aims were to register return to sports, associated meniscal and/or chondral lesions, and evaluate radiological anatomical parameters. Nine patients between 2011 and 2017 were evaluated, who had a minimum follow-up of 2 years. Median age at repeat ACL-R was 32 years (interquartile range [IQR], 30–34 years) and the median follow-up was 27 months (IQR, 24–39 months). Data collected prior to surgery and at last follow-up included patient demographics, operative findings, physical examination findings including pivot shift and KT-1000 arthrometer measurement; Lysholm and International Knee Documentation Committee (IKDC) subjective scores; and return to sports and level using the Tegner score. Knee Injury and Osteoarthritis Outcome Score (KOOS) subjective score and radiographic anatomical parameters were recorded at last follow-up. Mean IKDC and Lysholm score improvement was 25 points (confidence interval [CI] 12–37) and 25 points (CI 11–39), respectively (p < 0.001). The median postoperative KOOS score was pain: 93 (IQR, 64–96); symptoms: 94 (IQR, 83–97); activities of daily life: 96 (IQR, 90–100); sports: 75 (IQR, 50–90); and quality of life: 50 (IQR, 43–81). Postoperative median side-to-side KT-1000 arthrometer difference was 2 mm (IQR, 1–8 mm). The median radiographic posterior tibial slope was 10 degrees (IQR, 9–10). One patient was considered a failure at 16 months postoperative. Only 44% (four out of nine) patients were able to return to their sports. None of these patients had a cartilage injury, while three out of five patients who did not return to their sports had International Cartilage Regeneration & Joint Preservation Society grade III or IV cartilage injury. Patients should be counseled on the challenging outcomes of repeat revision ACL-R. This is Level IV, therapeutic case series.

Download Full-text

Treatment of Knee Osteochondritis Dissecans With a Cell-Free Biomimetic Osteochondral Scaffold: Clinical and Imaging Findings at Midterm Follow-up

The American Journal of Sports Medicine ◽

10.1177/0363546517737763 ◽

2017 ◽

Vol 46 (2) ◽

pp. 314-321 ◽

Cited By ~ 23

Author(s):

Francesco Perdisa ◽

Elizaveta Kon ◽

Andrea Sessa ◽

Luca Andriolo ◽

Maurizio Busacca ◽

...

Keyword(s):

Magnetic Resonance ◽

Cartilage Repair ◽

Subchondral Bone ◽

Osteochondritis Dissecans ◽

Osteochondral Scaffold ◽

Imaging Results ◽

The Mean ◽

Tegner Score ◽

Over Time

Background: Osteochondritis dissecans (OCD) is a developmental condition of subchondral bone that may result in secondary separation and instability of the overlying articular cartilage, which in turn may lead to degeneration of the overall joint and early osteoarthritis. Biphasic scaffolds have been developed to address defects of the entire osteochondral unit by reproducing the different biological and functional requirements and guiding the growth of both bone and cartilage. Purpose: To evaluate midterm clinical and imaging results after cell-free osteochondral scaffold implantation for the treatment of knee OCD. Study Design: Case series; Level of evidence, 4. Methods: Twenty-seven patients (8 women, 19 men; mean age, 25.5 ± 7.7 years) were treated for knee OCD, with International Cartilage Repair Society (ICRS) grade 3 to 4 lesions with a mean size of 3.4 ± 2.2 cm2 (range, 1.5-12 cm2), and prospectively evaluated for up to 5 years using the ICRS classification system and the Tegner score. Eighteen patients underwent magnetic resonance imaging (MRI) at 24 and 60 months of follow-up, and the graft was evaluated using the magnetic resonance observation of cartilage repair tissue (MOCART) score for the cartilage layer, while a specific score was used for subchondral bone. Results: All patients significantly improved their clinical scores at each follow-up until their final evaluation. The mean International Knee Documentation Committee (IKDC) subjective score improved from 48.4 ± 17.8 to 82.2 ± 12.2 at 2 years ( P < .0005), and it then remained stable for up to 5 years postoperatively (90.1 ± 12.0). The mean Tegner score increased from 2.4 ± 1.7 preoperatively to 4.4 ± 1.6 at 2 years ( P = .001), with a further increase up to 5.0 ± 1.7 at 5 years of follow-up ( P < .0005 vs preoperatively), reaching almost the preinjury level (5.7 ± 2.2). The MOCART score showed stable results between 24 and 60 months, whereas the subchondral bone status significantly improved over time. No correlation was found between MRI findings and clinical outcomes. Conclusion: This 1-step cell-free scaffold implantation procedure showed good and stable results for up to 60 months of follow-up for the treatment of knee OCD. MRI showed abnormalities, in particular at the subchondral bone level, but there was an overall improvement of features over time. No correlation was found between imaging and clinical findings.

Download Full-text

MENISCAL REPAIR RESULTS COMPARING MRI, ARTHRO-MRI, AND ARTHRO-CT

Acta Ortopédica Brasileira ◽

10.1590/1413-785220182603184536 ◽

2018 ◽

Vol 26 (3) ◽

pp. 166-169

Author(s):

ADRIANO MARQUES DE ALMEIDA ◽

MARCELO BORDALO RODRIGUES ◽

MARCIA UCHÔA DE REZENDE ◽

ANDRÉ PEDRINELLI ◽

ARNALDO JOSÉ HERNANDEZ

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Case Series ◽

Meniscal Repair ◽

Resonance Imaging ◽

Level Of Evidence ◽

Meniscal Suture ◽

Imaging Results ◽

Magnetic Resonance Imaging Mri

ABSTRACT Objective To clinically and radiologically evaluate patients who received meniscal suture using the outside-in technique, comparing magnetic resonance imaging (MRI), arthro-magnetic resonance imaging (arthro-MRI), and arthro-computed tomography (arthro-CT) to evaluate the healing of meniscal sutures. Methods We evaluated eight patients with an average follow-up of 15 months. The evaluation analyzed clinical parameters using the Lysholm and IKDC scores as well as MRI, arthro-MRI, and arthro-CT imaging. Results At the end of the follow-up period, mean Lysholm score was 89.5 and mean IKDC score was 78.6. In the MRI, signs of meniscal healing were observed in 50% of the cases. The arthro-MRI and arthro-CT showed signs of healing in 75% of cases. There was a positive correlation between arthro-MRI and arthro-CT results in all the cases studied (kappa correlation index=1). Conclusion Meniscal suture using the outside-in technique presented good or excellent results in 87.5% of our patients. The arthro-CT and arthro-MRI showed the same level of accuracy in detecting healing of the sutured region of the meniscus. Level of Evidence IV; Case series.

Download Full-text

Treatment of osteochondral lesions of the talus with autologous collagen-induced chondrogenesis: clinical and magnetic resonance evaluation at one-year follow-up

Joints ◽

10.11138/jts/2016.4.2.080 ◽

2016 ◽

Vol 04 (02) ◽

pp. 080-086 ◽

Cited By ~ 9

Author(s):

Federico Usuelli ◽

Miriam Grassi ◽

Luigi Manzi ◽

Vincenzo Guarrella ◽

Michele Boga ◽

...

Keyword(s):

Magnetic Resonance ◽

Case Series ◽

Clinical Results ◽

Lesion Size ◽

Osteochondral Lesions ◽

Level Of Evidence ◽

Imaging Results ◽

American Orthopaedic ◽

One Year

Purpose: the aim of this study is to report the clinical and imaging results recorded by a series of patients in whom osteochondral lesions of the talus (OLTs) were repaired using the autologous collagen-induced chondrogenesis (ACIC) technique with a completely arthroscopic approach. Methods: nine patients (mean age 37.4±10 years) affected by OLTs (lesion size 2.1±0.9 cm2) were treated with the ACIC technique. The patients were evaluated clinically both preoperatively and at 12 months after surgery using the American Orthopaedic Foot and Ankle Society Ankle-Hindfoot Scale (AOFAS) and a visual analog scale (VAS). For morphological evaluation, the magnetic resonance observation of cartilage repair tissue (MOCART) score was used. Results: the AOFAS score improved from 51.4±11.6 preoperatively to 71.8±20.6 postoperatively, while the VAS value decreased from 6.9±1.8 to 3.2±1.9. The mean MOCART score was 51.7±16.6 at 12 months of follow-up; these scores did not directly correlate with the clinical results. Conclusions: use of the ACIC technique for arthroscopic repair of OLTs allowed satisfactory clinical results to be obtained in most of the patients as soon as one year after surgery, with no major complications or delayed revision surgery. ACIC is a valid and lowinvasive surgical technique for the treatment of chondral and osteochondral defects of the talus. Level of evidence: therapeutic case series, level IV.

Download Full-text

Long-term outcomes of lumbar microdiscectomy in the pediatric population: a large single-institution case series

Journal of Neurosurgery Pediatrics ◽

10.3171/2019.6.peds18716 ◽

2019 ◽

Vol 24 (5) ◽

pp. 549-557

Author(s):

Malia McAvoy ◽

Heather J. McCrea ◽

Vamsidhar Chavakula ◽

Hoon Choi ◽

Wenya Linda Bi ◽

...

Keyword(s):

Conservative Management ◽

Functional Outcomes ◽

Pediatric Patients ◽

Clinical Presentation ◽

Case Series ◽

Csf Leak ◽

Single Institution ◽

The Mean

OBJECTIVEFew studies describe long-term functional outcomes of pediatric patients who have undergone lumbar microdiscectomy (LMD) because of the rarity of pediatric disc herniation and the short follow-up periods. The authors analyzed risk factors, clinical presentation, complications, and functional outcomes of a single-institution series of LMD patients over a 19-year period.METHODSA retrospective case series was conducted of pediatric LMD patients at a large pediatric academic hospital from 1998 to 2017. The authors examined premorbid risk factors, clinical presentation, physical examination findings, type and duration of conservative management, indications for surgical intervention, complications, and postoperative outcomes.RESULTSOver the 19-year study period, 199 patients underwent LMD at the authors’ institution. The mean age at presentation was 16.0 years (range 12–18 years), and 55.8% were female. Of these patients, 70.9% participated in competitive sports, and among those who did not play sports, 65.0% had a body mass index greater than 25 kg/m2. Prior to surgery, conservative management had failed in 98.0% of the patients. Only 3 patients (1.5%) presented with cauda equina syndrome requiring emergent microdiscectomy. Complications included 4 cases of postoperative CSF leak (2.0%), 1 case of a noted intraoperative CSF leak, and 3 cases of wound infection (1.5%). At the first postoperative follow-up appointment, minimal or no pain was reported by 93.3% of patients. The mean time to return to sports was 9.8 weeks. During a mean follow-up duration of 8.2 years, 72.9% of patients did not present again after routine postoperative appointments. The total risk of reoperation was a rate of 7.5% (3.5% of patients underwent reoperation for the same level; 4.5% underwent adjacent-level decompression, and one patient [0.5%] ultimately underwent a fusion).CONCLUSIONSMicrodiscectomy is a safe and effective treatment for long-term relief of pain and return to daily activities among pediatric patients with symptomatic lumbar disc disease in whom conservative management has failed.

Download Full-text

Clinical Implications of Bone Bruise Patterns Accompanying Anterior Cruciate Ligament Tears

Sports Health A Multidisciplinary Approach ◽

10.1177/19417381211029583 ◽

2021 ◽

pp. 194173812110295

Author(s):

Patrick Ward ◽

Peter Chang ◽

Logan Radtke ◽

Robert H. Brophy

Keyword(s):

Magnetic Resonance Imaging ◽

Anterior Cruciate Ligament ◽

Magnetic Resonance ◽

Functional Outcomes ◽

Cruciate Ligament ◽

Acl Injury ◽

Bone Bruise ◽

Resonance Imaging ◽

Bone Bruises ◽

Anterior Cruciate

Background: Anterior cruciate ligament (ACL) tears are common injuries; they are often associated with concomitant injuries to other structures in the knee, including bone bruises. While there is limited evidence that bone bruises are associated with slightly worse clinical outcomes, the implications of bone bruises for the articular cartilage and the risk of developing osteoarthritis (OA) in the knee are less clear. Recent studies suggest that the bone bruise pattern may be helpful in predicting the presence of meniscal ramp lesions. Evidence Acquisition: A literature review was performed in EMBASE using the keyword search phrase (acl OR (anterior AND cruciate AND ligament)) AND ((bone AND bruise) OR (bone AND contusion) OR (bone AND marrow AND edema) OR (bone AND marrow AND lesion) OR (subchondral AND edema)). Study Design: Clinical review. Level of Evidence: Level 4. Results: The literature search returned 93 articles of which 25 were ultimately included in this review. Most studies identified a high prevalence of bone bruises in the setting of acute ACL injury. Individual studies have found relationships between bone bruise volume and functional outcomes; however, these results were not supported by systematic review. Similarly, the literature has contradictory findings on the relationship between bone bruises and the progression of OA after ACL reconstruction. Investigations into concomitant injury found anterolateral ligament and meniscal ramp lesions to be associated with bone bruise presence on magnetic resonance imaging. Conclusion: Despite the ample literature identifying the prevalence of bone bruises in association with ACL injury, there is little evidence to correlate bone bruises to functional outcomes or progression of OA. Bone bruises may best be used as a marker for concomitant injury such as medial meniscal ramp lesions that are not always well visualized on magnetic resonance imaging. Further research is required to establish the longitudinal effects of bone bruises on ACL tear recovery. Strength of Recommendation Taxonomy: 2.

Download Full-text

Autologous Matrix-Induced Chondrogenesis for Treatment of Focal Cartilage Defects in the Knee: A Follow-up Study

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967120981872 ◽

2021 ◽

Vol 9 (2) ◽

pp. 232596712098187

Author(s):

Justus Gille ◽

Ellen Reiss ◽

Moritz Freitag ◽

Jan Schagemann ◽

Matthias Steinwachs ◽

...

Keyword(s):

Repeated Measures ◽

Demographic Data ◽

Case Series ◽

Defect Size ◽

Lysholm Score ◽

Outcome Analysis ◽

Cartilage Defects ◽

Chondral Defects ◽

The Mean

Background: Autologous matrix-induced chondrogenesis (AMIC) is a well-established treatment for full-thickness cartilage defects. Purpose: To evaluate the long-term clinical outcomes of AMIC for the treatment of chondral lesions of the knee. Study Design: Case series; Level of evidence, 4. Methods: A multisite prospective registry recorded demographic data and outcomes for patients who underwent repair of chondral defects. In total, 131 patients were included in the study. Lysholm, Knee injury and Osteoarthritis Outcome Score (KOOS), and visual analog scale (VAS) score for pain were used for outcome analysis. Across all patients, the mean ± SD age of patients was 36.6 ± 11.7 years. The mean body weight was 80.0 ± 16.8 kg, mean height was 176.3 ± 7.9 cm, and mean defect size was 3.3 ± 1.8 cm2. Defects were classified as Outerbridge grade III or IV. A repeated-measures analysis of variance was used to compare outcomes across all time points. Results: The median follow-up time for the patients in this cohort was 4.56 ± 2.92 years. Significant improvement ( P < .001) in all scores was observed at 1 to 2 years after AMIC, and improved values were noted up to 7 years postoperatively. Among all patients, the mean preoperative Lysholm score was 46.9 ± 19.6. At the 1-year follow-up, a significantly higher mean Lysholm score was noted, with maintenance of the favorable outcomes at 7-year follow-up. The KOOS also showed a significant improvement of postoperative values compared with preoperative data. The mean VAS had significantly decreased during the 7-year follow-up. Age, sex, and defect size did not have a significant effect on the outcomes. Conclusion: AMIC is an effective method of treating chondral defects of the knee and leads to reliably favorable results up to 7 years postoperatively.

Download Full-text