Corticosteroid effect on murine hemopoietic precursor cells in vivo
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Abstract The effect of methylprednisolone on murine hemopoietic colony formation in diffusion chambers implanted in mice was evaluated. A dose-dependent increase in granulocytic colony (CFU-DG) formation from murine marrow was observed. This effect could be abrogated by administration of progesterone. These studies suggest that the murine early granulocytic precursors (CFU-DG) have receptors that mediate proliferation-promoting signals triggered by glucocorticoids. Erythroid colony formation (CFU- DE) was not effected by methylprednisolone administration.
2008 ◽
Vol 145
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pp. 133-136
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1996 ◽
Vol 271
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pp. L1014-L1022
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2018 ◽
Vol 11
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pp. 394
1995 ◽
Vol 269
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pp. H1955-H1964
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2015 ◽
Vol 60
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pp. 301-306
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