scholarly journals COVID-19 convalescent plasma clears SARS-CoV-2 refractory to remdesivir in an infant with congenital heart disease

2020 ◽  
Vol 4 (18) ◽  
pp. 4278-4281 ◽  
Author(s):  
Zahidee Rodriguez ◽  
Andi L. Shane ◽  
Hans Verkerke ◽  
Christopher Lough ◽  
Matthew G. Zimmerman ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Effective Treatment ◽  
Treatment Option ◽  
Congenital Heart ◽  
Effective Treatment Option ◽  
Immune Systems ◽  
Key Points ◽  
Donor Variability

Key Points COVID-19 convalescent plasma (CP) may be a safe and effective treatment option in SARS-CoV-2 infection refractory to remdesivir. Infants may benefit from CP despite developing immune systems and donor variability emphasizes the need for characterization prior to use.

scholarly journals Retinoid agonist Am80-enhanced neutrophil bactericidal activity arising from granulopoiesis in vitro and in a neutropenic mouse model

Blood ◽  
2013 ◽  
Vol 121 (6) ◽  
pp. 996-1007 ◽  
Author(s):  
Wanjing Ding ◽  
Hiroyuki Shimada ◽  
Lin Li ◽  
Rahul Mittal ◽  
Xiaokun Zhang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Effective Treatment ◽  
Treatment Option ◽  
Bactericidal Activity ◽  
Cost Effective ◽  
Effective Treatment Option ◽  
New Therapy ◽  
Cost Effective Treatment ◽  
Key Points

Key PointsNeutrophils mobilized by Am80 display greater bactericidal activity than those by G-CSF. These findings suggest a molecular rationale for developing new therapy for neutropenia by using Am80 as a cost-effective treatment option.

scholarly journals Mechanical Valve Replacement for Congenital Heart Disease Complicated by Native Pulmonary Valve Endocarditis: A Case Report and Literature Review

2018 ◽  
Vol 21 (2) ◽  
pp. 096
Author(s):  
Qing Wang ◽  
Yan Gao ◽  
Wang Xi ◽  
Hua Shen ◽  
Jing Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Case Report ◽  
Valve Replacement ◽  
Congenital Heart ◽  
Pulmonary Valve ◽  
Mechanical Valve ◽  
Key Points ◽  
Common Risk Factors

Congenital heart disease (CHD) is one of the most common risk factors for infective endocarditis. However, it is rare to find a CHD patient complicated by isolated pulmonary valve endocarditis. Here, we report an adult patient with congenital heart disease complicated by native pulmonary valve endocarditis who underwent a mechanical valve replacement. We also review previous literature to examine key points in the treatment of such patients.

Acute Kidney Injury

2020 ◽  
Keyword(s):  
Acute Kidney Injury ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Serum Creatinine ◽  
Early Identification ◽  
Urine Output ◽  
Congenital Heart ◽  
Kidney Injury ◽  
Key Points

Key Points Awareness and early identification are important. Serum creatinine and urine output are key to assessing acute kidney injury. Congenital heart disease, sepsis, and nephrotoxic medications are major causes.

Prenatal Counseling and Care for Single-Ventricle Heart Disease: One Center’s Model for Care

2015 ◽  
Vol 35 (5) ◽  
pp. 53-61 ◽  
Author(s):  
Terra Lafranchi ◽  
Patricia Lincoln
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Single Ventricle ◽  
Care Center ◽  
Prenatal Counseling ◽  
Term Care ◽  
Key Points ◽  
Care Family ◽  
Prenatal Imaging

Advances in prenatal imaging allow early detection of single-ventricle congenital heart disease, which may enhance prenatal care and maximize care options and decision making. Boston Children’s Hospital’s Advanced Fetal Care Center and fetal cardiology program provide prenatal counseling and care for single-ventricle congenital heart disease. Key points for optimal prenatal counseling and education include explanation of the diagnosis, delivery, the first surgery, cardiac neurodevelopmental issues, feeding and growth issues, quality of life and long-term care, family stressors, and fetal cardiac intervention. Such counseling and education help families make the difficult decisions required in this situation.

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