scholarly journals Increased nitrotyrosine in exhaled breath condensate in cystic fibrosis

2001 ◽  
Vol 17 (6) ◽  
pp. 1201-1207 ◽  
Author(s):  
B. Balint ◽  
S.A. Kharitonov ◽  
T. Hanazawa ◽  
L.E. Donnelly ◽  
P.L. Shah ◽  
...  
Author(s):  
Courtney M. Wheatley ◽  
Wayne J. Morgan ◽  
Nicholas A. Cassuto ◽  
William T. Foxx-Lupo ◽  
Cori L. Daines ◽  
...  

Impaired ion regulation and dehydration is the primary pathophysiology in cystic fibrosis (CF) lung disease. A potential application of exhaled breath condensate (EBC) collection is to assess airway surface liquid ionic composition at baseline and in response to pharmacological therapy in CF. Our aims were to determine if EBC could detect differences in ion regulation between CF and healthy and measure the effect of the albuterol on EBC ions in these populations. Baseline EBC Cl−, DLCO and SpO2 were lower in CF (n = 16) compared to healthy participants (n = 16). EBC Cl− increased in CF subjects, while there was no change in DLCO or membrane conductance, but a decrease in pulmonary-capillary blood volume in both groups following albuterol. This resulted in an improvement in diffusion at the alveolar-capillary unit, and removal of the baseline difference in SpO2 by 90-minutes in CF subjects. These results demonstrate that EBC detects differences in ion regulation between healthy and CF individuals, and that albuterol mediates increases in Cl− in CF, suggesting that the benefits of albuterol extend beyond simple bronchodilation.


2016 ◽  
Vol 16 (2) ◽  
pp. 550-558 ◽  
Author(s):  
Xiaoling Zang ◽  
María Eugenia Monge ◽  
Nael A. McCarty ◽  
Arlene A. Stecenko ◽  
Facundo M. Fernández

Author(s):  
Zuzanna Stachowiak ◽  
Irena Wojsyk-Banaszak ◽  
Katarzyna Jończyk-Potoczna ◽  
Joanna Goździk-Spychalska ◽  
Kamila Sobczak ◽  
...  

2005 ◽  
pp. 75-79
Author(s):  
E. Kh. Anaev ◽  
S. N. Avdeev ◽  
A. G. Chuchalin

Investigation of inflammatory markers in the exhaled breath condensate (EBC) is a non-invasive method for evaluation and monitoring of bronchopulmonary inflammation. Endogenous oxidative processes in the airways can be evaluated by pH measurement in the EBC. We examined 153 healthy volunteers (of them, 51 smokers) and 615 patients with lung pathology (of them, 131 asthma (BA) patients, 205 COPD patients, 43 patients with bronchiectasis, 72 patients with idiopathic lung fibrosis (ILF), 142 pneumonia patients, and 42 cystic fibrosis patients). EBC was collected with ECoScreen equipment (Erich Jaeger, Germany) using a standardized method. The EBC pH was measured using the f32 PH-meter (Beckman, USA) with a glass microelectrode. The average ECB pH was 6.16 ± 0.52 in BA, 6.35 ± 0.56 in COPD, 6.13 ± 0.46 in bronchiectasis, 5.98 ± 0.30 in ILF, 5.96 ± 0.37 in pneumonia, and 6.35 ± 0.23 in cystic fibrosis. It was significantly lower than in the healthy volunteers (6.97 ± 0.31, р < 0.0001). In patients with exacerbation of BA and COPD ECB pH was considerably lower compared with those in stable condition. A reliable growth of pH was noted in pneumonia patients after treatment of the disease. There was a correlation between ECB pH and severity of fibrotic and inflammatory disorders of lung tissue according to HRCT (r = –0.62, p = 0.01), lung diffusing capacity (r = 0.51, p = 0.01), Tiffeneau index (r = 0.68, p = 0.004) in ILF. Therefore, the ECB pH is a distinct marker of the airway inflammatory severity in lung pathology. The ECB pH monitoring can assess the inflammatory activity and efficacy of anti-inflammatory therapy in lung diseases.


Thorax ◽  
2011 ◽  
Vol 67 (3) ◽  
pp. 222-228 ◽  
Author(s):  
Paolo Montuschi ◽  
Debora Paris ◽  
Dominique Melck ◽  
Vincenzina Lucidi ◽  
Giovanni Ciabattoni ◽  
...  

2003 ◽  
Vol 167 (8) ◽  
pp. 1109-1112 ◽  
Author(s):  
Giovanna E. Carpagnano ◽  
Peter J. Barnes ◽  
Duncan M. Geddes ◽  
Margaret E. Hodson ◽  
Sergei A. Kharitonov

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