scholarly journals Domain-specific cognitive impairment in patients with COPD and control subjects

2016 ◽  
Author(s):  
Fiona Cleutjens ◽  
Frits Franssen ◽  
Martijn Spruit ◽  
Lowie Vanfleteren ◽  
Candy Gijsen ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Domain Specific ◽  
Control Subjects ◽  
And Control

scholarly journals Domain-specific cognitive impairment in patients with COPD and control subjects

2016 ◽  
Vol Volume 12 ◽  
pp. 1-11 ◽  
Author(s):  
Fiona AHM Cleutjens ◽  
Frits ME Franssen ◽  
Martijn A Spruit ◽  
Lowie EGW Vanfleteren ◽  
Candy Gijsen ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Domain Specific ◽  
Control Subjects ◽  
And Control

The Memory and Attention Test (MAT), an Adaptive, Computer-based Performance Test: Evaluation in Dementia, Mild Cognitive Impairment and Control Subjects

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
G. Adler ◽  
M. Bektas ◽  
P. Hoffmann
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Performance Test ◽  
Short Term Memory ◽  
Computerized Testing ◽  
Memory And Attention ◽  
Control Subjects ◽  
Computer Based ◽  
And Control

The Memory and Attention Test (MAT), a newly developed, adaptive, computer-based performance test was evaluated in a mixed group of patients with Alzheimer's dementia, subjects with mild cognitive impairment and control subjects at ages from 60 to 89 years.By means of the MAT, working memory and short-term memory are assessed in the verbal, figural and episodic domains by means of six independent tests individually adjusted to the subjects level of performance on the basis of intermediate results. Sustained attention is also assessed.For evaluation purposes, well established tests for the respective memory domains were applied. They were the Auditory Verbal and Learning Test (AVLT), the Benton Test, the delayed reproduction of the Taylor Figure, the subtests working memory and logical memory of the Wechsler Memory Scale (WMS) and the Alterskonzentrationstest (AKT), a test analogous to the d2 test, especially suited and standardized for older subjects. Acceptance of the MAT was assessed by means of a questionnaire developed for this purpose.Computerized testing was commonly well accepted by the subjects. There were highly significant positive correlations between performance in the MAT domains and performance in the respective reference assessments. Thus, the MAT may be a useful diagnostic tool for the assessment of dementia patients. It may be applied for early diagnosis, assessment of progression of disease and demonstration of treatment effects, particularly for disease-modifying treatments in Alzheimer's disease. Standardization relating to age and and education as well as the provision of versions in various languages are under way.

scholarly journals Cognitive Impairment After COVID-19—A Review on Objective Test Data

2021 ◽  
Vol 12 ◽  
Author(s):  
Rania Daroische ◽  
Mathilde S. Hemminghyth ◽  
Thomas H. Eilertsen ◽  
Monica H. Breitve ◽  
Luiza J. Chwiszczuk
Keyword(s):  
Cognitive Impairment ◽  
Language Impairment ◽  
Short Term Memory ◽  
Control Group ◽  
Disease Treatment ◽  
Domain Specific ◽  
Ovid Medline ◽  
Severity Of The Disease ◽  
And Control ◽  
Larger Sample

Objective: The aim was to conduct a review on the literature on objective cognitive impairment in patients after COVID-19.Methods: We performed a literature review and searched Ovid Medline in February 2021 based on a PECO scheme.Results: Twelve articles met all inclusion criteria. Total patient sample was <1,000. All studies on global cognitive function found impairment, ranging from 15 to 80% of the sampled patients. Seven studies on attention and executive functions reported impairment, with varying results depending on sub-domain and different tests. Three out of four studies reported memory difficulties, with two studies reporting short-term memory deficits. Although results indicate possible language impairment, only one study used domain-specific language tasks. Two out of four studies on visuospatial function did not report any impairment.Conclusion: Patients with recent SARS-CoV-2 infection appear to experience global cognitive impairment, impairment in memory, attention and executive function, and in particular verbal fluency. Based on the current results, we recommend clinicians to evaluate the need for cognitive assessment of patients with a recent COVID-19 infection, regardless of the severity of the disease, treatment methods and length of ICU stay. We need studies with larger sample and control group.

P1-144: qEEG in Alzheimer disease and control subjects: Longitudinal changes and possible follow-up of cognitive impairment

2006 ◽  
Vol 2 ◽  
pp. S138-S138
Author(s):  
Irina Raicher ◽  
Daniel Yasumasa Takahashi ◽  
Ricardo Nitrini ◽  
Renato Anghinah
Keyword(s):  
Cognitive Impairment ◽  
Alzheimer Disease ◽  
Longitudinal Changes ◽  
Control Subjects ◽  
And Control

Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects

Neurology ◽  
1997 ◽  
Vol 49 (5) ◽  
pp. 1306-1311 ◽  
Author(s):  
John Heitner ◽  
Dennis Dickson
Keyword(s):  
Cognitive Impairment ◽  
Matched Control ◽  
Senile Plaques ◽  
Strong Correlations ◽  
Alzheimer Type ◽  
Control Subjects ◽  
Glycated Proteins ◽  
Significant Difference ◽  
Postmortem Brains ◽  
And Control

Diabetics have impaired cognitive performance relative to age-matched control subjects, but the pathologic basis for this impairment is unknown. Because Alzheimer-type lesions, including both senile plaques and neurofibrillary tangles, contain glycated proteins and glycation is known to be increased in diabetes, we hypothesized that cognitive impairment in diabetes may be due in part to increased Alzheimer-type pathology. We measured the amount of Alzheimer-type pathology in postmortem brains of diabetics and age-matched control subjects with sensitive and specific histofluorescent and immunocytochemical methods. As expected, there were strong correlations between severity of senile plaques and neurofibrillary degeneration and age and also a strong correlation between the pathologic measures. On the other hand, there was no significant difference between diabetics and control subjects with respect to severity of Alzheimer-type pathology, on average, or with respect to age. This finding was true for diabetics with and without insulin dependence. The results confirm reports showing that diabetes is not a risk factor for Alzheimer-type pathology and suggest that factors other than Alzheimer's disease are responsible for cognitive impairment in diabetics.

Validation of a new symptom impact questionnaire for mild to moderate cognitive impairment

2006 ◽  
Vol 18 (1) ◽  
pp. 135-149 ◽  
Author(s):  
Lori Frank ◽  
Jennifer A. Flynn ◽  
Leah Kleinman ◽  
Mary Kay Margolis ◽  
Louis S. Matza ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Patient Reported Outcomes ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Neuropsychological Measures ◽  
Control Subjects ◽  
Patient Reported ◽  
Moderate Cognitive Impairment ◽  
And Control ◽  
Cognitively Intact

Background: Patient-reported outcomes assessment enhances the understanding of disease impact in a range of disorders. At mild levels of cognitive impairment the patient perspective on functioning, behavior and symptoms can be particularly valuable for syndrome characterization when clinical and neuropsychological findings are limited. We have evaluated the psychometric performance of the 55-item Patient-Reported Outcomes in Cognitive Impairment (PROCOG)©, a new patient-reported measure, to measure mild to moderate cognitive impairment symptoms and their impact from the perspective of patients with dementia of the Alzheimer's type (DAT) and mild cognitive impairment (MCI).Methods: The sample of 75 DAT patients, 78 MCI patients and 33 cognitively intact control subjects (> 64 years) was recruited through medical centers in the U.SA. Validity was assessed through correlation to the Quality of Life – Alzheimer's Disease (QOL-AD) and Centers for Epidemiologic Studies – Depression Scale (CES-D) and neuropsychological assessments (WAIS subscales and MMSE).Results: PROCOG scores for MCI patients were generally intermediate between DAT and control subjects. Internal consistency and test-retest reliability were acceptable. Correlations with the CES-D and QOL-AD were in the moderate to high range; correlations with the neuropsychological measures were low to moderate.Conclusions: The PROCOG demonstrated good to excellent psychometric properties among a sample of older adults with MCI and DAT as well as cognitively intact older adult control subjects and provides a method for collecting unique information on the patient experience of cognitive impairment. Subscales permit focused evaluation of domains relevant to the patient's experience of cognitive impairment.

The Effects of a Neutral Stimulus (Buzzer) on Motor Responses and Disfluencies in Normal Speakers

1969 ◽  
Vol 12 (1) ◽  
pp. 179-184 ◽  
Author(s):  
Richard R. Martin ◽  
Gerald M. Siegel
Keyword(s):  
College Students ◽  
Neutral Stimulus ◽  
Motor Responses ◽  
Control Subjects ◽  
And Control ◽  
Speaking Task

Seventy-two college students were divided into three groups: Button Push-Speech (BP-S), Speech-Button Push (S-BP), and Control. BP-S subjects pushed one of two buttons on signal for 8 min. During the last 4 min, depression of the criterion button caused a buzzer to sound. After the button-push task, subjects spoke spontaneously for 30 min. During the last 20 min, the buzzer was presented contingent upon each disfluency. S-BP subjects were run under the same procedures, but the order of button-push and speech tasks was reversed. Control subjects followed the same procedures as S-BP subjects, but no buzzer signal was presented at any time. Both S-BP and BP-S subjects emitted significantly fewer disfluencies during the last 20 min (Conditioning) than during the first 10 min (Baserate) of the speaking task. The frequency of disfluencies for Control subjects did not change significantly from Baserate to Conditioning. In none of the three groups did the frequency of pushes on the criterion button change significantly from minute to minute throughout the 8-min button-push session.

Tests for Platelet Changes, Acute Phase Reactants and Serum Lipids in Diabetes mellitus and Peripheral Vascular Disease

1982 ◽  
Vol 48 (03) ◽  
pp. 289-293 ◽  
Author(s):  
B A van Oost ◽  
B F E Veldhuyzen ◽  
H C van Houwelingen ◽  
A P M Timmermans ◽  
J J Sixma
Keyword(s):  
Diabetes Mellitus ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Acute Phase ◽  
Serum Lipids ◽  
Diabetic Patients ◽  
Peripheral Vascular ◽  
Acute Phase Reactants ◽  
Control Subjects ◽  
And Control

SummaryPlatelets tests, acute phase reactants and serum lipids were measured in patients with diabetes mellitus and patients with peripheral vascular disease. Patients frequently had abnormal platelet tests and significantly increased acute phase reactants and serum lipids, compared to young healthy control subjects. These differences were compared with multidiscriminant analysis. Patients could be separated in part from the control subjects with variables derived from the measurement of acute phase proteins and serum lipids. Platelet test results improved the separation between diabetics and control subjects, but not between patients with peripheral vascular disease and control subjects. Diabetic patients with severe retinopathy frequently had evidence of platelet activation. They also had increased acute phase reactants and serum lipids compared to diabetics with absent or nonproliferative retinopathy. In patients with peripheral vascular disease, only the fibrinogen concentration was related to the degree of vessel damage by arteriography.

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