Serum concentrations of KL-6 in patients with IPF and lung cancer and serial measurements of KL-6 in IPF patients treated with antifibrotic therapy

2021 ◽  
Author(s):  
Miriana d'Alessandro ◽  
Laura Bergantini ◽  
Paolo Cameli ◽  
Maria Pieroni ◽  
Rosa Metella Refini ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Serum Concentrations ◽  
Antifibrotic Therapy ◽  
Serial Measurements

scholarly journals Serum Concentrations of KL-6 in Patients with IPF and Lung Cancer and Serial Measurements of KL-6 in IPF Patients Treated with Antifibrotic Therapy

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 689
Author(s):  
Miriana d’Alessandro ◽  
Laura Bergantini ◽  
Paolo Cameli ◽  
Maria Pieroni ◽  
Rosa Metella Refini ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Pulmonary Fibrosis ◽  
High Serum ◽  
Serum Concentrations ◽  
Serum Samples ◽  
Progressive Decline ◽  
Antifibrotic Therapy ◽  
Severe Comorbidity ◽  
Serial Serum ◽  
Serial Evaluation

Background: Krebs von den Lungen-6 (KL-6) was suggested as ILD biomarker including idiopathic pulmonary fibrosis (IPF). Lung cancer is one of the most severe comorbidity of IPF patients. This study aims to serially analyze KL-6 in IPF patients after 24 months of Nintedanib and to first investigate the biomarker behavior in IPF associated with adenocarcinoma. Materials and methods: One hundred and forty-two ILD patients (median (IQR), 69 (63–75) years; 86 males) were retrospectively enrolled. Serial serum samples were collected from IPF patients before starting antifibrotic therapy and after 12 months. Serum KL-6 levels were measured by KL-6 reagent assay (Fujirebio Europe, UK). Results: Increased KL-6 concentrations were identified in IPF-LC patients than IPF, fibrotic hypersensitivity pneumonitis, and pulmonary fibrosis associated with autoimmune disease groups. A cut-off value was calculated to distinguish IPF and IPF-LC patients. IPF patients monitored for 24 months with Nintedanib showed persisted increased levels of KL-6 with a progressive decline of FVC percentages. Conclusion: This preliminary study offers a first demonstration that very high serum concentrations of KL-6 in IPF-LC patients are associated with poor prognosis. Moreover, serial evaluation of serum KL-6 in IPF patients over 24 months of Nintedanib treatment revealed that most patients experienced a stabilization of lung function parameters and of serum concentrations of KL-6.

scholarly journals Serum Concentrations of Cytokines and Lung Cancer Survival in African Americans and Caucasians

2009 ◽  
Vol 18 (1) ◽  
pp. 215-222 ◽  
Author(s):  
Lindsey Enewold ◽  
Leah E. Mechanic ◽  
Elise D. Bowman ◽  
Yun-Ling Zheng ◽  
Zhipeng Yu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
African Americans ◽  
Cancer Survival ◽  
Serum Concentrations ◽  
Lung Cancer Survival

scholarly journals Clinical Significance and Prognostic Value of Serum Dickkopf-1 Concentrations in Patients with Lung Cancer

2009 ◽  
Vol 55 (9) ◽  
pp. 1656-1664 ◽  
Author(s):  
Shi L e Sheng ◽  
Gang Huang ◽  
Bin Yu ◽  
Wen Xin Qin
Keyword(s):  
Lung Cancer ◽  
Neuron Specific Enolase ◽  
Small Cell ◽  
Cytokeratin 19 ◽  
Healthy Controls ◽  
Serum Concentrations ◽  
Small Cell Lung ◽  
Increased Sensitivity ◽  
Cytokeratin 19 Fragment ◽  
Dickkopf 1

Abstract Background: Dickkopf-1 (DKK1), a secreted protein, is known as a negative regulator of the Wnt signaling pathway, which has been implicated in the development of several types of cancers. Clinical significance of serum DKK1 in lung cancer remains to be determined. Methods: A novel time-resolved immunofluorometric assay was developed. By use of this method, we investigated the serum concentrations of DKK1 in 592 patients with malignancies, 72 patients with benign lung disease, and 120 healthy controls. Serum cytokeratin 19 fragment and neuron-specific enolase values were obtained. Results: Serum DKK1 concentrations were significantly higher in patients with lung cancer than in patients with other malignant tumors or benign lung diseases and healthy controls. Serum concentrations of DKK1 were decreased significantly in groups of patients with gastric cancer, colorectal cancer, ovarian cancer, and cervical adenocarcinoma compared with healthy controls. Application of both DKK1 and cytokeratin 19 fragment increased sensitivity, correctly identifying 89.6% of the non–small cell lung cancer patients as positive. The use of both DKK1 and neuron-specific enolase increased sensitivity to detect small cell lung cancer to 86.2%. DKK1 concentrations increased with stage, tumor class, and presence of lymph node and distant metastases, regardless of histology and patient age and sex. Patients with a DKK1 concentration of 22.6 μg/L or higher had a statistically significantly diminished survival compared with patients whose DKK1 values were lower. Conclusions: DKK1 was preferentially expressed in lung cancer. Increasing concentrations of DKK1were significantly associated with tumor progression and decreased survival in patients with lung cancer. .

Serum concentrations of sex hormone binding globulin in lung cancer

BMJ ◽  
1986 ◽  
Vol 293 (6556) ◽  
pp. 1238-1238
Author(s):  
T. Spector ◽  
W S L Stebbings
Keyword(s):  
Lung Cancer ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Serum Concentrations ◽  
Hormone Binding

scholarly journals Determination of multiple vitamins in 178 patients undergoing chemotherapy for lung cancer

2021 ◽  
Author(s):  
lanqing liang ◽  
wei yu ◽  
boning cai ◽  
qianqian wang ◽  
xiang huang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Vitamin A ◽  
Vitamin C ◽  
Serum Vitamin ◽  
Disease Status ◽  
Vitamin B2 ◽  
Serum Concentrations ◽  
Pathological Type ◽  
Before And After

IntroductionThe aim of the study was to investigate the changes in serum concentrations of nine vitamins in patients undergoing chemotherapy for lung cancer and explore their clinical values and influencing factors.Material and methodsPatients receiving chemotherapy for lung cancer in our centre from February 2018 to May 2020 were enrolled in this study. Serum concentrations of the nine vitamins including vitamins A, D, E, B9, B12, B1, C, B2, and B6 were measured in all subjects, and the changes in the concentrations of these vitamins were compared before and after 2 cycles of chemotherapy. In addition, the potential correlations of serum vitamin levels with age, gender, pathological type, and disease status were analysed.ResultsIn the 178 patients with lung cancer, there were different degrees of vitamin A, vitamin D, vitamin C, and in particular, vitamin B2 deficiencies. Before chemotherapy, the concentrations of vitamin A and vitamin C were significantly different between males and females and among patients in different clinical stages (both p < 0.05), the concentrations of vitamin C and vitamin B2 significantly differed among different pathological types of lung cancer (p < 0.05), and vitamin D level was significantly related to the disease status (p < 0.05). In addition, the proportion of vitamin B2 deficiency differed significantly among different pathological types (p < 0.05). There were significant differences in the concentrations of vitamins D, C, and B2 before and after chemotherapy (all p < 0.05). There was a correlation between the change of serum vitamin B1 concentration before and after chemotherapy and the change of body mass index (p < 0.05).ConclusionsDuring chemotherapy, lung cancer patients are more likely to develop vitamins A, D, C, and B2 deficiencies. Different vitamin deficiencies are related to gender, clinical stage, pathological type, and disease status. Vitamin determination and reasonable supplementation of nutrients in patients undergoing chemotherapy for lung cancer can help improve the nutritional status and increase chemotherapy tolerance.

High Serum Concentrations of Sialyl Lewisx Predict Multilevel N2 Disease in Non–Small-Cell Lung Cancer

2006 ◽  
Vol 13 (7) ◽  
pp. 1010-1018 ◽  
Author(s):  
Shinjiro Mizuguchi ◽  
Kiyotoshi Inoue ◽  
Takashi Iwata ◽  
Tatsuya Nishida ◽  
Nobuhiro Izumi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
High Serum ◽  
Small Cell ◽  
Serum Concentrations ◽  
Sialyl Lewisx ◽  
Small Cell Lung ◽  
N2 Disease
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