scholarly journals Serum Concentrations of KL-6 in Patients with IPF and Lung Cancer and Serial Measurements of KL-6 in IPF Patients Treated with Antifibrotic Therapy

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 689
Author(s):  
Miriana d’Alessandro ◽  
Laura Bergantini ◽  
Paolo Cameli ◽  
Maria Pieroni ◽  
Rosa Metella Refini ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Pulmonary Fibrosis ◽  
High Serum ◽  
Serum Concentrations ◽  
Serum Samples ◽  
Progressive Decline ◽  
Antifibrotic Therapy ◽  
Severe Comorbidity ◽  
Serial Serum ◽  
Serial Evaluation

Background: Krebs von den Lungen-6 (KL-6) was suggested as ILD biomarker including idiopathic pulmonary fibrosis (IPF). Lung cancer is one of the most severe comorbidity of IPF patients. This study aims to serially analyze KL-6 in IPF patients after 24 months of Nintedanib and to first investigate the biomarker behavior in IPF associated with adenocarcinoma. Materials and methods: One hundred and forty-two ILD patients (median (IQR), 69 (63–75) years; 86 males) were retrospectively enrolled. Serial serum samples were collected from IPF patients before starting antifibrotic therapy and after 12 months. Serum KL-6 levels were measured by KL-6 reagent assay (Fujirebio Europe, UK). Results: Increased KL-6 concentrations were identified in IPF-LC patients than IPF, fibrotic hypersensitivity pneumonitis, and pulmonary fibrosis associated with autoimmune disease groups. A cut-off value was calculated to distinguish IPF and IPF-LC patients. IPF patients monitored for 24 months with Nintedanib showed persisted increased levels of KL-6 with a progressive decline of FVC percentages. Conclusion: This preliminary study offers a first demonstration that very high serum concentrations of KL-6 in IPF-LC patients are associated with poor prognosis. Moreover, serial evaluation of serum KL-6 in IPF patients over 24 months of Nintedanib treatment revealed that most patients experienced a stabilization of lung function parameters and of serum concentrations of KL-6.

scholarly journals Pharmacokinetics of Intravenous Levofloxacin Administered at 750 Milligrams in Obese Adults

2011 ◽  
Vol 55 (7) ◽  
pp. 3240-3243 ◽  
Author(s):  
Aaron M. Cook ◽  
Craig Martin ◽  
Val R. Adams ◽  
R. Scott Morehead
Keyword(s):  
Standard Dose ◽  
Normal Weight ◽  
Serum Concentrations ◽  
Serum Samples ◽  
Obese Adults ◽  
Time Curve ◽  
Physiochemical Properties ◽  
Concentration Time ◽  
Optimal Dosing ◽  
Serial Serum

ABSTRACTThe physiochemical properties of levofloxacin suggest that it is an agent which may exhibit altered pharmacokinetics in obese individuals. The purpose of this study was to describe the pharmacokinetics of a single 750-mg intravenous dose of levofloxacin in both hospitalized and ambulatory obese individuals. The hypothesis was that a standard dose of levofloxacin in obese individuals would achieve serum concentrations likely to be therapeutic. A single levofloxacin dose of 750 mg was infused over 90 min, and seven serial serum samples were subsequently obtained to evaluate the pharmacokinetics after the first dose. The peak concentrations of levofloxacin were comparable to those seen with normal-weight individuals. However, the area under the concentration-time curve and clearance were quite variable. Accelerated clearance was evident in the ambulatory obese individuals. Further investigation of the effects of obesity on the pharmacokinetics of levofloxacin is necessary to ensure optimal dosing.

Serum concentrations of KL-6 in patients with IPF and lung cancer and serial measurements of KL-6 in IPF patients treated with antifibrotic therapy

2021 ◽  
Author(s):  
Miriana d'Alessandro ◽  
Laura Bergantini ◽  
Paolo Cameli ◽  
Maria Pieroni ◽  
Rosa Metella Refini ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Serum Concentrations ◽  
Antifibrotic Therapy ◽  
Serial Measurements

High Serum Concentrations of Sialyl Lewisx Predict Multilevel N2 Disease in Non–Small-Cell Lung Cancer

2006 ◽  
Vol 13 (7) ◽  
pp. 1010-1018 ◽  
Author(s):  
Shinjiro Mizuguchi ◽  
Kiyotoshi Inoue ◽  
Takashi Iwata ◽  
Tatsuya Nishida ◽  
Nobuhiro Izumi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
High Serum ◽  
Small Cell ◽  
Serum Concentrations ◽  
Sialyl Lewisx ◽  
Small Cell Lung ◽  
N2 Disease

Relationship between Serum Concentrations and Urinary Excretions of Monoclonal Free Light Chains (mFLC) Detectable as Bence Jones Proteins (BJP) by Immunofixation Electrophoresis (IFE) in Patients with Multiple Myeloma (MM).

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 5060-5060
Author(s):  
M.R. Nowrousian ◽  
D. Brandhorst ◽  
C. Sammet ◽  
M. Kellert ◽  
R. Daniels ◽  
...  
Keyword(s):  
Renal Function ◽  
Reference Range ◽  
High Serum ◽  
Serum Concentrations ◽  
Serum Samples ◽  
Paired Samples ◽  
Upper Limit ◽  
Median Serum ◽  
Positive Urine ◽  
Automated Immunoassay

Abstract Introduction. mFLC are important markers for the diagnosis and monitoring of MM. This study for the first time determines serum concentrations of mFLC which are required to produce renal overflow and BJP in urine detectable by IFE and evaluates the relationship between urinary excretions of mFLC and renal function. Patients and methods. 378 paired samples of serum and 24-h-urine from 82 patients were evaluated during the course of their disease. Serum FLC concentrations were measured nephelometrically using an automated immunoassay. Urine samples were tested for clonal bands using agarose gel electrophoresis, scanning densitometry and visual checking of electrophoretic gels. BJP were identified by urine IFE. Results. Among the 378 serum samples, 173 (46%) were normal and 205 (54%) were abnormal for FLC k/l ratios, indicating the presence of mFLC, 98 of kappa and 107 of lambda type. In 98 serum samples with mFLC kappa, 48 (49%) were associated with negative urine IFE analysis and 50 (51%) had positive urine tests. The median serum kappa concentrations were 40 mg/L (range 6–710) for negative urines and 113 mg/L (range 7–39500) for positive urines (p=0.001), indicating an almost threefold greater median value which was approximately six times the upper limit of the reference range (3.3.–19.4 mg/L) for samples with positive urine IFE analysis. In 107 serum samples with mFLC lambda, 70 (65%) were negative in urine and 37 (35%) were positive. The median serum concentrations associated with negative urine IFE tests were 44 mg/L (range 3–561) and were 278 mg/L (range 5–7060) for positive urines (p=0.0001), indicating an almost sixfold difference. This was approximately 2.5-fold greater than for kappa, and approximately 11 times the upper limit of the reference range (5.7–26.3 mg/L) for samples with positive urine IFE analysis. Renal excretions of mFLC, in addition, were determined primarily by serum concentrations for lambda, but by serum concentrations, renal function and, probably, molecular changes for kappa. For both, renal excretions significantly decreased at high serum concentrations combined with renal dysfunction. Conclusion. Based on these results, relatively high serum concentrations of mFLC are required to produce renal overflow and positive urine IFE tests for BJP. Furthermore, urine excretions of mFLC are determined primarily by serum concentrations, but also by renal function, particularly for kappa.

Long-term studies of Serum Concentrations of reproductively related Steriod Hormones in individual captive Carcharhinids

1992 ◽  
Vol 43 (1) ◽  
pp. 273 ◽  
Author(s):  
LEL Rasmussen ◽  
FL Murru
Keyword(s):  
Steroid Hormones ◽  
Mature Female ◽  
Serum Concentrations ◽  
Carcharhinus Plumbeus ◽  
Short Term ◽  
Serum Samples ◽  
Negaprion Brevirostris ◽  
Serial Serum ◽  
Long Term Studies

Valuable information on maturity and reproductive status can be obtained by the measurement of the concentrations of steroid hormones in the serum of captive carcharhinid sharks. The sharks at Sea World of Florida, Orlando, Florida, include mature females of several species of placental sharks. Serial serum samples from four mature female Carcharhinus plumbeus, one maturing female C. leucas, and one mature and one nearly mature female Negaprion brevirostris were used to determine serum concentrations of 17�-oestradiol, progesterone, testosterone and dihydrotestosterone. The data from these mature placental sharks were then compared with concentrations measured in immature female and male conspecifics and in mature female Eugomphodus taurus (family Odontaspididae). Evidence of repetitive cyclical patterns was obtained from a mature female N. brevirostris. This shark was monitored from June 1988 to July 1990 by means of more than 50 samples that were often obtained at weekly intervals. Concentrations of 17�-oestradiol in the serum of this shark varied in a cyclical fashion, with the highest values obtained in Year 1 (1988-89) being during April (the normal mating season) and those in Year 2 (1989-90) being during June. Concomitant elevations of testosterone concentrations were observed either simultaneously or immediately before or after maximal oestradiol concentrations were noted. Progesterone concentrations were low except for definitive spikes that immediately preceded the maximal concentrations of testosterone and 17�-oestradiol. These periodicities suggest, for placental sharks, that consistently rising oestradiol concentrations may set in motion preovulatory events, that testosterone may be important for the initiation of subsequent ovulatory events, and that transitory elevations of progesterone concentrations may have specific short-term roles. These cyclical changes in the concentrations of steroid hormones observed in captive elasmobranchs support observations of hormone concentrations during reproduction in wild carcharhinids.

scholarly journals Prostate-specific antigen concentrations in serum in acute illnesses

1996 ◽  
Vol 42 (11) ◽  
pp. 1785-1788 ◽  
Author(s):  
S A Honda ◽  
A P Goldstein ◽  
T Morita ◽  
C Sugiyama ◽  
L Cody ◽  
...  
Keyword(s):  
Prostate Specific Antigen ◽  
Acute Phase ◽  
Specific Antigen ◽  
Rank Correlation ◽  
Care Facility ◽  
High Serum ◽  
Serum Concentrations ◽  
Blood Proteins ◽  
Serum Samples ◽  
Acute Phase Reactants

Abstract In light of recent studies showing that prostate-specific antigen (PSA) complexes with certain blood proteins, we studied the effects of acute-phase reactants and alpha 2-macroglobulin (A2MG) on serum concentrations of PSA. Serum samples were obtained from 419 men admitted to an acute-care facility. Various acute-phase reactants-including C-reactive protein, alpha 1-acid glycoprotein, alpha 1-antitrypsin, and alpha 1-antichymotrypsin-and A2MG were measured with a Beckman Array analyzer in parallel with determinations of PSA concentrations by two methods, the Hybritech Tandem RIA and the Abbott PSA IMx. Evaluation by Spearman rank correlation revealed a significant negative correlation of A2MG with PSA values (P < 0.01) and (as expected) a positive correlation of age with PSA values (P < 0.001). The former correlation suggests the possibility that patients with high serum concentrations of A2MG may give falsely decreased results for PSA concentrations in serum.

Alterations in serum thyroid hormones in euthyroid children with circulating anti-thyroid antibodies

1982 ◽  
Vol 99 (4) ◽  
pp. 500-507 ◽  
Author(s):  
Salvador Villalpando ◽  
Ignacia Cisneros ◽  
Guadalupe García-Bulnes ◽  
Bárbara Urquieta ◽  
Lourdes Mondragón ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Age Distribution ◽  
Serum Levels ◽  
Paper Electrophoresis ◽  
Cross Reactivity ◽  
High Serum ◽  
Thyroid Antibodies ◽  
Serum Concentrations ◽  
Serum Samples ◽  
Scanty Information

Abstract. Anti-thyroid antibodies are frequently found in otherwise normal populations (4.5–25.8%); however, there is scanty information about thyroid function status in affected individuals. In this report, the serum concentrations of TSH, T3, T4, rT3 and TBG and the titre of anti-thyroglobulin and anti-microsomal antibodies (haemagglutination technique) were studied in 520 healthy school children (260 boys and 260 girls) aged 6.0–17.9 years. Titres equal or greater than 1:16 of one or both antibodies were detected in 58 boys and in 77 girls (in 33 boys and in 24 girls with, and in 25 boys and 43 girls without, associated abnormalities in the serum concentrations of one or several hormones). The age distribution of thyroid antibodies followed a trimodal pattern with peaks at 7, 11 and 16–17 years in both sexes. The most striking finding was an abnormally elevated T3 concentration in 22 boys and 5 girls with positive antibodies, with no symptoms of thyroid dysfunction and with no clear relationship with simultaneous abnormalities in TSH, T4 or rT3; however, in 5 boys the TBG serum levels were increased. Serum from these patients was incubated with [125I]T3 before free radioactivity was precipitated with dextran-coated charcoal and the aliquots were analyzed by paper electrophoresis. Serum samples with high T3 levels bound significantly more radioactivity than normal or T3-free serum (P < 0.001) and an abnormal peak of radioactivity was present in the gamma globulin fraction, in the former but not in the latter two types of sera. The presence of high serum T3 levels in the absence of clinical symptoms of hyperthyroidism was probably due to sequestration of T3 by the anti-thyroglobulin antibody, which may have cross-reactivity with T3 and T4, as has previously been demonstrated both in animals and humans.

scholarly journals Chemotherapy in idiopathic pulmonary fibrosis and small-cell lung cancer with poor lung function

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiyue Zhang ◽  
Wei Li ◽  
Chunyan Li ◽  
Jie Zhang ◽  
Zhenzhong Su
Keyword(s):  
Lung Cancer ◽  
Lung Function ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
High Resolution Computed Tomography ◽  
Chemotherapeutic Regimen

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with unclear pathogenesis. IPF is considered as a risk factor for lung cancer. Compared to other lung cancers, small-cell lung cancer (SCLC) has a lower incidence, but has a more aggressive course. Patients with IPF and SCLC have a lower survival rate, more difficult treatment, and poorer prognosis. Case presentation Case 1 was of a 66-year-old man with IPF for 5 years, who was admitted to our hospital for dyspnea. Case 2 was of a 68-year-old woman, who presented with chest pains, cough, and dyspnea. Both patients had extremely poor lung function. High-resolution computed tomography and pathology revealed that both patients had IPF and SCLC. Chemotherapy comprising nedaplatin (80 mg/m2) and etoposide (100 mg for 5 days) was initiated for both patients. Antifibrotic agents were continued during the chemotherapeutic regimen. Both patients showed improvement in their condition after treatment. Conclusion The favorable outcomes in these 2 cases suggests that chemotherapy is worth considering in the management of patients having SCLC and IPF with poor lung function.

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