scholarly journals Tuberculosis elimination: where are we now?

2018 ◽  
Vol 27 (148) ◽  
pp. 180035 ◽  
Author(s):  
Alberto Matteelli ◽  
Adrian Rendon ◽  
Simon Tiberi ◽  
Seif Al-Abri ◽  
Constantia Voniatis ◽  
...  

Tuberculosis (TB) still represents a major public health issue in spite of the significant impact of the efforts made by the World Health Organization (WHO) and partners to improve its control. In 2014 WHO launched a new global strategy (End TB) with a vision of a world free of TB, and a 2035 goal of TB elimination (defined as less than one incident case per million). The aim of this article is to summarise the theoretical bases of the End TB Strategy and to analyse progresses and persistent obstacles on the way to TB elimination.The evolution of the WHO recommended strategies of TB control (Directly Observed Therapy, Short Course (DOTS), Stop TB and End TB) are described and the concept of TB elimination is discussed. Furthermore, the eight core activities recently proposed by WHO as the milestones to achieve TB elimination are discussed in detail. Finally, the recently published experiences of Cyprus and Oman on their way towards TB elimination are described, together with the regional experience of Latin America.New prevention, diagnostic and treatment tools are also necessary to increase the speed of the present TB incidence decline.

2003 ◽  
Vol 7 (14) ◽  
Author(s):  

To mark world TB day, 24 March 2003, the World Health Organization (WHO) has published the seventh annual report on global tuberculosis (TB) control. This report aims to share information from national TB control programmes, and includes data on case notifications and treatment outcomes. It also provides analysis of plans, finances and constraints on DOTS (directly observed treatment-short course) expansion for the 22 high burden countries in order to assess progress toward global targets for case detection (70%) and treatment success (85%).


2003 ◽  
Vol 7 (12) ◽  
Author(s):  
A Infuso ◽  
D Falzon ◽  
J Veen

The theme of World TB day 2003 - "DOTS cured me – it will cure you too!" promotes the worldwide expansion of directly observed treatment-short course (DOTS), a multi pronged TB control strategy including the adoption of standardised patient management and the evaluation of treatment outcome of TB patients. Treatment outcome is a core surveillance indicator recommended to assess the implementation of DOTS. In recent years, DOTS has been adopted increasingly in European countries, especially in the East. The EuroTB annual report 2000 (in press, http://www.eurotb.org/) includes data on treatment outcome for TB cases notified in 1999 in 30 of the 51 countries of the World Health Organization (WHO) European Region. The WHO Global Tuberculosis Control report, available from 24 March 2003 at http://www.who.int/gtb/publications/globrep/index.html, contains current information on the DOTS situation in Europe and the rest of the world.


2005 ◽  
Vol 38 (1) ◽  
pp. 57-67 ◽  
Author(s):  
IAN HARPER

This paper argues for the inclusion of ethnography as a research methodology for understanding the effects of public health policy. To do this, the implementation of DOTS (Directly Observed Therapy, Short-course) – the World Health Organization (WHO) prescribed policy for the control of the infectious disease tuberculosis – is explored in the context of Nepal. A brief history of DOTS and its implementation in Nepal is outlined, and the way it has been represented by those within the Nepal Tuberculosis Programme (NTP) is described. This is followed by an outline of the research done in relation to this, and the ethnographic methods used. These ethnographic data are then interpreted and analysed in relation to two specific areas of concern. Firstly, the effects around the epidemiological uses of ‘cases’ is explored; it is argued that a tightening of the definitional categories so necessary for the programme to be stabilized for comparative purposes has profound material effects in marginalizing some from treatment. Secondly, the paper examines some of the implications and effects relating to the way that the ‘directly observed’ component was implemented. The discussion explores how current debate on DOTS has been played out in some medical journals. It argues for the importance of ethnography as a method for understanding certain questions that cannot be answered by particular, and increasingly dominant, research ideologies informed by randomized controlled trials. This raises important issues about the nature of ‘evidence’ in debates on the relationship of research to policy.


2021 ◽  
Vol 11 (3) ◽  
pp. 1-2

Every year on 24 March, World Tuberculosis Day is commemorated annually, for raising the public awareness regarding devastating consequences of tuberculosison health and economic aspects of life. This helps to launch efforts to end the globalepidemic of tuberculosis. On the date of 24th March in 1882, Dr. Robert Koch announced about the discovery of bacterium that causes tuberculosis.1 It was held on 24th March 1982 first time by The World Health Organization at the 100th anniversary of Dr. Koch’s discovery. The target 3.3 of SDG calls for, by 2030, ending the epidemics of tuberculosis, malaria, AIDS, combat other communicable and water-borne diseases. A large number of people 1.7 billion, roughly 23% of the world's population suffered from tuberculosis. In the world, each year 1.5 million people died due to TB, proving it a leading infectious killer disease. Thirty countries having the high burden of TB, accounted for 87% of new TB cases during 2019.2 Among these, two thirds of the total cases were in India, Indonesia, China, Bangladesh, Philippines, Pakistan, Nigeria, and South Africa. An estimated 510,000 new TB cases are emerging each year in Pakistan. Among these about, 15 000 are developing drug resistant TB cases. Pakistan is bearing 61% of the TB burden in the EMRO. Tuberculosis is preventable and curable disease. The causative agent of tuberculosis, Mycobacterium tuberculosis, most often affect the lungs. The vaccine for tuberculosis (TB) disease is called BCG (Bacille Calmette-Guérin). In 1921, first patient was vaccinated with BCG vaccine, 13 years were spent in the making the vaccine. In countries where TB is common, BCG vaccine is given to infants and small children. It does not always protect people from getting TB. BCG vaccine is included in national Expanded Program on Immunization (EPI) in Pakistan and given at birth. To make TB free Pakistan through universal access to quality TB care, National TB Control Program (NTP) is striving for achieving Zero TB death by reducing 50% prevalence of TB in general population by 2025. The mode of transmission of TB from person to person is through the air. The TB germs are propelled into the air,when people with lung TB cough, sneeze or spit carelessly due to lack of awareness that they are participating in the spread of disease and weakening the efforts. These germs are when inhaled by other people, resulting in lung infection, which is called primary TB. From primary TB infection, majority of people recover withoutany further evidence of the disease. For years the infection may stay inactive (latent). People with TB infection are not contagious, do not have any symptoms, and do not put their friends, co-workers and family at risk. Many people who have latent TB infection never develop TB disease. In these people, the TB bacteria remain inactive for a lifetime without causing disease. But in other people, especially people who have weak immune systems, the bacteria become active, multiply, and cause TB disease. There is good news for people with TB disease! It can almost always be treated and cured with medicine. But the medicine must be taken as directed by Physician. The relapse rate differs by a country's incidence and control: 0–27% of TB relapses occur within 2 years after treatment completion and most relapses occur within 5 years; however, some relapses occur 15 years after treatment. A person who has genital tuberculosis can infect others through sexual contact. The most common means of spreading genital TB can be through blood or lymph. Hence, sexual contact can spread genital tuberculosis. Genital tuberculosis can spread to any other body organ, once it enters the body. Consuming a diet high in nutritious foods and beverages is a smart way to support and protect lung health. Coffee, dark leafy greens, fatty fish, peppers, tomatoes, olive oil, oysters, blueberries, and pumpkin are just some examples of foods and drinks that have been shown to benefit lung function. Milk can be used by TB patient. It is also a great source of protein, providing strength necessary to perform day-to-day activities. Directly observed treatment, short-course (DOTS, also known as TB-DOTS) is the name given to the tuberculosis (TB) control strategy recommended by the World Health Organization. According to WHO, "The most cost-effective way to stop the spread of TB in communities with a high incidence is by curing it. The usual treatment is: two antibiotics (isoniazid and rifampicin) for 6 months, two additional antibiotics (pyrazinamide and ethambutol) for the first 2 months of the 6-month treatment period. Groups with high rates of TB transmission are homeless persons, injection drug users, and persons with HIV infection are more susceptible for TB and persons who have immigrated from areas of the world with high rates of TB. The disease is prevalent mainly in the underprivileged sections of the society. The lack of knowledge in the masses and the communities is a factor that contributes largely to the spread of the disease. The theme of World TB Day 2020 was “It's TIME to end TB” and in 2021 it is,” Am I stopping TB” highlighting the importance of awareness. It is the time to fuel the awareness program with full energy, resources and ways. In such a scenario, there is always a need for new and innovative ideas to create mass awareness about tuberculosis. The more focus of this awareness campaign should be very much targeted towards people living in an area where there are a lot of people are with TB, or have been homeless or live in poorly ventilated or overcrowded housing and sufferers of a weakened immune system.


Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4199
Author(s):  
Ruben Turé ◽  
Albertino Damasceno ◽  
Mouhammed Djicó ◽  
Nuno Lunet

Overweight and obesity affect a large proportion of the population and are important causes of death in both developed and low- and middle-income countries. In Guinea-Bissau, there are no previous population-based studies assessing this phenomenon. Therefore, we aimed to quantify the prevalence of underweight, overweight, and obesity among adults in Bissau. A stratified and cluster sample of 935 adults was assembled in 2021 and was evaluated using standardized questionnaires and anthropometric measurements, following the World Health Organization Stepwise Approach to Chronic Disease Risk Factor Surveillance. Underweight, obesity, and overweight were defined by body mass index based on the World Health Organization definitions. The prevalence of overweight and obesity was 48.7% among women and 25.0% among men. The proportion of women with abdominal obesity was 14 times higher than it was in men (35.3% vs. 2.5%). The prevalence of overweight and obesity increased with age and income. Underweight was more prevalent in the age group of 18 to 24 years (18.4% in women and 28.9% in men) and was less frequent among individuals with higher socioeconomic status. In conclusion, the prevalence of overweight and obesity is similar to the trends that are observed in many other urbanized populations in Africa and is already a major public health issue in urban Guinea-Bissau.


2018 ◽  
Vol 1 (1) ◽  
pp. 663-672
Author(s):  
Miguel Ángel Rissetto ◽  
Miguel Prat

According to the World Health Organization, the number of traffic accidents worldwide reaches 1.25 million people involved in them. This is one of the main causes of death of people between 15 and 29 years old. Most of these deaths are in emergent countries where the rapid economic development has occurred together with an increased use of vehicles. Apart from being a public health issue, the injuries caused by these accidents are an economic-like problem especially in low and medium income countries where their GDP shows about a 3% economical decrease. Argentine has one of the highest mortality index in the world. In 2017 there were 7.213 deaths (provisional figure obtained up to January 11, 2018). This shows a daily rate of 20 deaths and a month rate of 600 deaths. These indexes raise the need of solving this problem including about 120.000 injured people which occurred annually and the significant material losses. This project comes out with the design of a device to place in old and new cars in order to prevent frontal collisions in Argentine roads, especially in roads with only two lines. This system will first join different types of cameras and sensors operated with a software that will alert the driver in advance in various ways, for example, when a vehicle is coming frontally and the overtake is not possible. The devise could use other technologies such as chips (RID types or similar ones), GPS, laser lights and others considered appropriate to make the device more complete, effective and economically accessible.


2019 ◽  
pp. 6-11
Author(s):  
Mrinmay Das

Suicide is a global phenomenon and occurs throughout the life span. It is recognised as a critical public health issue by the World Health Organization (WHO) in its Comprehensive Mental Health Action Plan 2013-2020.1 In the year 2016, it was estimated that globally 817000 population committed suicide. This means world wide one person commits suicide in every 40 seconds.


2020 ◽  
Vol 21 (10) ◽  
pp. 3565
Author(s):  
Steven Ascoët ◽  
Michel De Waard

It is now more than a century since Albert Calmette from the Institut Pasteur changed the world of envenomation by demonstrating that antibodies raised against animal venoms have the ability to treat human victims of previously fatal bites or stings. Moreover, the research initiated at that time effectively launched the discipline of toxicology, first leading to the search for toxic venom components, followed by the demonstration of venoms that also contained compounds of therapeutic value. Interest from pharmaceutical companies to treat envenomation is, however, declining, mainly for economic reasons, and hence, the World Health Organization has reclassified this public health issue to be a highest priority concern. While the production, storage, and safety of antivenom sera suffer from major inconveniences, alternative chemical and technological approaches to the problem of envenomation need to be considered that bypass the use of antibodies for toxin neutralization. Herein, we review an emerging strategy that relies on the use of aptamers and discuss how close—or otherwise—we are to finding a viable alternative to the use of antibodies for the therapy of human envenomation.


2020 ◽  
Vol 12 (9) ◽  
pp. 3727 ◽  
Author(s):  
Marko Hakovirta ◽  
Navodya Denuwara

In January 2020, the World Health Organization (WHO) declared the outbreak of a new coronavirus disease, COVID-19, to be a public health emergency of international concern. Currently, in several countries globally, this pandemic continues to enforce the temporary closure of all nonessential shops and services aside from supermarkets and pharmacies. Workers in countries that are at a high risk of infection have been asked to work from home, as cities have been placed under lockdown. Even curfews to combat the spread of the virus have been imposed in several countries, with all this signaling an unprecedented disruption of commerce. Companies are facing various challenges regarding health and safety, supply chain, labor force, cash flow, consumer demand and marketing. People in the thousands are dying every day from the virus’s symptoms, while a public health issue has forced the world to come to a halt and rethink what a sustainable future for our planet and existence is. These drastic recent events have raised the deliberation by the authors to redefine the concept of sustainability.


Author(s):  
Annalisa Guarini ◽  
Miguel Pérez Pereira ◽  
Anneloes van Baar ◽  
Alessandra Sansavini

As indicated by the World Health Organization, preterm birth is a relevant public health issue, being one of the leading causes of death in children under five years of age [...]


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