Protocol for long-term effect of pulmonary rehabilitation under nintedanib in IPF

BackgroundPulmonary rehabilitation (PR) causes short-term improvement in exercise capacity, dyspnea, and health-related quality of life in idiopathic pulmonary fibrosis (IPF); however, long-term maintenance of the improvement is difficult. Nintedanib, an antifibrotic drug, has been shown to delay the worsening of pulmonary function in IPF. Therefore, the concomitant use of nintedanib with PR is anticipated to contribute to the long-term maintenance of the PR effects. The long-term effect of PR under nintedanib treatment in IPF (FITNESS) study is a multicenter, randomised, prospective, parallel-group, open-label trial.MethodsThe study will enroll 82 patients with IPF who have been treated with nintedanib. Patients in the PR group will receive a programmed short-term induction PR program, followed by a maintenance home-based PR program, while patients in the control group will receive usual outpatient care. Patients in both groups will continue to receive nintedanib treatment throughout the study period. The primary endpoint of the study is to compare the change in the 6-min walk distance from the baseline to 12-months between the PR and control groups. The main secondary endpoint is endurance exercise time, measured using a bicycle ergometer.DiscussionFITNESS is the first randomised controlled study to evaluate the long-term effects of PR in IPF treated with nintedanib. This study will address the hypothesis that concomitant use of nintedanib contributes to the maintenance of long-term effects of PR, thus leading to a comprehensive therapeutic approach of “nintedanib and PR” in the antifibrotic era.

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Brassinosteroid-induced de-etiolation of Arabidopsis thaliana seedlings resembles the long-term effects of cytokinins

Functional Plant Biology ◽

10.1071/pp98010 ◽

1998 ◽

Vol 25 (6) ◽

pp. 719 ◽

Cited By ~ 2

Author(s):

Jie Luo ◽

Ji-Chu Chen ◽

Yu-Ju Zhao

Keyword(s):

Arabidopsis Thaliana ◽

Term Effect ◽

Hypocotyl Elongation ◽

Long Term Effects ◽

Short Term ◽

Expression Of Genes ◽

Long Term Effect ◽

In The Wild ◽

Positive Regulators

Cytokinins can cause de-etiolation of Arabidopsis thaliana (L.) Heynh. seedlings growing in the dark. Brassinosteroids (BRs) have been considered to regulate negatively the de-etiolation in dark-grown Arabidopsis seedlings. We show here that epi-brassinolide (epi-BL) can partially produce the phenotype of de-etiolation as caused by treatment with cytokinins in the dark, including the development of leaves and epicotyls in the wild-type and the BR-deficient mutant det2. But BRs cannot inhibit hypocotyl elongation, nor restore all the inhibition caused by cytokinins and light. We have found that there are distinct short term and long term phases of induction of de-etiolation by cytokinins. The short-term effect is probably coupled to ethylene in the inhibition of the hypocotyl elongation; the long-term effect causes morphogenesis of leaves and epicotyls. BRs can only regulate de-etiolation in the long term. We propose that the inhibition of hypocotyl elongation of det2 in darkness is caused by the absence of BR-dependent elongation rather than the inhibition caused by the expression of genes for photomorphogenesis. We propose that BRs resemble cytokinins in regulating de-etiolation as positive regulators, and that the inhibition of hypocotyl elongation and the development of leaves and epicotyls in de-etiolation are independent processes.

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Long-term regulation of hexose uptake by isoproterenol in cultured 3T3 adipocytes

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1985.248.6.e706 ◽

1985 ◽

Vol 248 (6) ◽

pp. E706-E711 ◽

Cited By ~ 2

Author(s):

J. P. van Putten ◽

H. M. Krans

Keyword(s):

Protein Synthesis ◽

Prolonged Exposure ◽

Term Effect ◽

Long Term Effects ◽

Fat Cell ◽

Short Term ◽

Long Term Effect ◽

Short Term Exposure ◽

Hexose Uptake

Catecholamines are known to have short-term regulatory effects on fat cell hexose uptake. We examined the long-term effects of catecholamines on the insulin-sensitive 2-deoxyglucose (dGlc) uptake in cultured 3T3-L1 adipocytes. Prolonged exposure (48 h) to isoproterenol (beta-adrenergic agonist) stimulated the basal dGlc uptake up to 90%. The effect was specific, time, concentration, and protein synthesis dependent and reversible. The effect of insulin was unaltered and superimposed on the increase in basal dGlc uptake. The long-term effect of isoproterenol was mimicked by epinephrine, dibutyryl cAMP (DBcAMP), and 1-methyl-3-isobutylxanthine (IBMX). By contrast, short-term exposure to isoproterenol (and epinephrine) induced a protein synthesis-independent increase in basal dGlc uptake (30%) not accompanied by an increase in insulin responsiveness. Moreover, on short-term basis, DBcAMP and IBMX suppressed both the basal and insulin-stimulated uptake up to 50%. Determination of the intracellular nonphosphorylated dGlc during the uptake and of the hexokinase activity revealed that the long-term effect of isoproterenol was most likely due to alterations low in dGlc transport. In conclusion, long-term regulators of hexose uptake are in cultured 3T3-L1 adipocytes, isoproterenol, and other cAMP stimulators. The long-term effect is independent from the short-term regulatory effect of the agents and from the effect of insulin.

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Short-term and long-term effect of diaphragm biofeedback training in gastroesophageal reflux disease: an open-label, pilot, randomized trial

Diseases of the Esophagus ◽

10.1111/dote.12390 ◽

2015 ◽

Vol 29 (7) ◽

pp. 829-836 ◽

Cited By ~ 4

Author(s):

X. Sun ◽

W. Shang ◽

Z. Wang ◽

X. Liu ◽

X. Fang ◽

...

Keyword(s):

Gastroesophageal Reflux Disease ◽

Gastroesophageal Reflux ◽

Randomized Trial ◽

Reflux Disease ◽

Term Effect ◽

Biofeedback Training ◽

Short Term ◽

Open Label ◽

Long Term Effect

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Short- and Long-Term Effects of Auxiliary Labels on Patient Knowledge of Precautionary Drug Information

Drug Intelligence & Clinical Pharmacy ◽

10.1177/106002808802200605 ◽

1988 ◽

Vol 22 (6) ◽

pp. 470-474 ◽

Cited By ~ 7

Author(s):

Candace S. Brown ◽

Brenda L. Solovitz ◽

Stephen G. Bryant ◽

Brock G. Guernsey ◽

Seymour Fisher

Keyword(s):

Drug Information ◽

Controlled Study ◽

Control Group ◽

Long Term Effects ◽

Short Term ◽

Short And Long Term ◽

Time Periods ◽

Experimental Group ◽

Over Time

The purpose of this study was to determine the efficacy of auxiliary prescription labels in educating outpatients about medicines at two different time periods. Five hundred fifty-nine patients were randomly assigned either to an experimental group or a control group; each person in the experimental group received a prescription bottle to which one study auxiliary label (“sticker”) had been affixed, and those in the control group received bottles with no study sticker attached. Patients were interviewed by telephone approximately one week or two months after prescription pick up. Patients who had the study sticker affixed to their prescription bottle were significantly more knowledgeable after one week about precautionary information than those patients who did not receive stickers; however, sticker-group patients receiving the delayed interview incorrectly attributed many precautions to their medication. This is the first controlled study to document that auxiliary labels increase short-term knowledge about medications, and to suggest that the same labels may result in an inappropriate generalization over time.

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On Time Effect of Preschool Education: Social Analysis Based on CUCDS

Complexity ◽

10.1155/2021/2855542 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

Bohan Yan ◽

Yongjun Feng ◽

Ning Cai

Keyword(s):

Cognitive Ability ◽

Chinese Language ◽

Preschool Education ◽

Term Effect ◽

Long Term Effects ◽

Short Term ◽

Long Term Effect ◽

Children Development ◽

The Impact

Cognitive ability is an important aspect of children’s development, but there is still room for discussion about the impact of preschool education on children’s cognitive ability. Based on the data of China Urbanization and Children Development Survey (CUCDS) of Tsinghua University, this paper categorizes cognitive ability into Chinese language cognition and mathematical cognition. It is discovered that the impact of preschool education on children’s cognitive development differs depending on the cognitive ability and the length of time. In particular, preschool education has both short-term and long-term effects on children’s Chinese cognitive ability, while there is only a short-term effect on the development of children’s mathematical cognitive ability without long-term effect.

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Lichtenstein inguinal hernia repairs with porcine small intestine submucosa: a 5- year follow-up. a prospective randomized controlled study

Regenerative Biomaterials ◽

10.1093/rb/rbaa055 ◽

2021 ◽

Author(s):

Baoshan Li ◽

Xin Zhang ◽

Yi Man ◽

Jiadong Xie ◽

Wei Hu ◽

...

Keyword(s):

Chronic Pain ◽

Inguinal Hernia ◽

Hernia Repair ◽

Term Effect ◽

Control Group ◽

Small Intestine Submucosa ◽

Long Term Effect ◽

Porcine Small Intestine Submucosa

Abstract Porcine small intestine submucosa (SIS) biologic patch has been used in inguinal hernia repair. However, there are little data available to assess the long-term effect after repair. This study aimed to explore the long-term effect of SIS patch in open inguinal hernia repair. Sevent-six patients with unilateral inguinal hernia were treated with Lichtenstein tension-free hernia repair using SIS patch (Beijing Datsing Bio-Tech Co., Ltd.) and Surgisis patch (COOK, USA) in Tianjin Union Medical Center and China-Japan Friendship Hospital. In the trial, the long-term efficacy of the treatment group and the control group were compared. A total of 66 patients in both groups received long-term follow-up (> 5 years) after surgery, with a follow-up rate of 86.8%. During the follow-up period, there was one case of recurrence, one case of chronic pain in the control group. There was no statistically significant difference (P > 0.05) in terms of recurrence, chronic pain, foreign body sensation and infection between the two groups of patients. After long-term observations, it has been found that the porcine small intestinal submucosa (SIS) biological patch is safe and effective for inguinal hernia Lichtenstein repair, and has a low recurrence rate and complication rate.

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Controlled trial of the short- and long-term effect of psychological treatment of post-partum depression

The British Journal of Psychiatry ◽

10.1192/bjp.182.5.412 ◽

2003 ◽

Vol 182 (5) ◽

pp. 412-419 ◽

Cited By ~ 255

Author(s):

Peter J. Cooper ◽

Lynne Murray ◽

Anji Wilson ◽

Helena Romaniuk

Keyword(s):

Primary Care ◽

Postnatal Depression ◽

Post Partum ◽

Psychodynamic Therapy ◽

Term Effect ◽

Short Term ◽

Post Partum Depression ◽

Maternal Mood ◽

Long Term Effect

BackgroundPsychological interventions for postnatal depression can be beneficial in the short term but their longer-term impact is unknown.AimsTo evaluate the long-term effect on maternal mood of three psychological treatments in relation to routine primary care.MethodWomen with post-partum depression (n=193) were assigned randomly to one of four conditions: routine primary care, non-directive counselling, cognitive–behavioural therapy or psychodynamic therapy. They were assessed immediately after the treatment phase (at 4.5 months) and at 9, 18 and 60 months post-partum.ResultsCompared with the control, all three treatments had a significant impact at 4.5 months on maternal mood (Edinburgh Postnatal Depression Scale, EPDS). Only psychodynamic therapy produced a rate of reduction in depression (Structured Clinical Interview for DSM–III–R) significantly superior to that of the control. The benefit of treatment was no longer apparent by 9 months post-partum. Treatment did not reduce subsequent episodes of post-partum depression.ConclusionsPsychological intervention for post-partum depression improves maternal mood (EPDS) in the short term. However, this benefit is not superior to spontaneous remission in the long term.

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