scholarly journals 123I-ADAM SPET imaging of serotonin transporter in patients with epilepsy and comorbid depression

BMC Neurology ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Maarika Liik ◽  
Malle Paris ◽  
Liina Vahter ◽  
Katrin Gross-Paju ◽  
Sulev Haldre
Keyword(s):  
Serotonin Transporter ◽  
Comorbid Depression ◽  
Patients With Epilepsy ◽  
Spet Imaging

scholarly journals Differences in Incidence and Risks of Suicide Attempt and Suicidal Drug Overdose between Patients with Epilepsy with and without Comorbid Depression

2019 ◽  
Vol 16 (22) ◽  
pp. 4533
Author(s):  
Chi-Yu Lin ◽  
Tomor Harnod ◽  
Cheng-Li Lin ◽  
Wei-Chih Shen ◽  
Chia-Hung Kao
Keyword(s):  
Suicide Attempt ◽  
Drug Overdose ◽  
Research Database ◽  
Comorbid Depression ◽  
Hazard Ratios ◽  
Increased Risk ◽  
Crucial Information ◽  
The Government ◽  
Using Data ◽  
Patients With Epilepsy

Objective: To determine the differences in the incidences and risks of suicide attempt (SA) and suicidal drug overdose (SDO) between patients with epilepsy with and without comorbid depression by using data from Taiwan’s National Health Insurance Research Database. Methods: We analyzed data of patients (≥20 years) who had received epilepsy diagnoses between 2000 and 2012; the diagnosis date of epilepsy was defined as the index date. The epilepsy patients were divided into the cohorts, with and without comorbid depression, and compared against a cohort from the non-affected population. We calculated adjusted hazard ratios and the corresponding 95% confidence intervals for SA and SDO in the three cohorts after adjustment for age, sex, and comorbidities. Results: The incidences of SA and SDO in the cohort with epilepsy and depression were 42.9 and 97.4 per 10,000 person-years, respectively. The epilepsy with depression cohort had 21.3 times of SA risk; and 22.9 times of SDO risk than did the comparison cohort had a 6.03-fold increased risk of SA and a 2.56-fold increased risk of SDO than did the epilepsy patients without depression. Moreover, patients’ age <65 years, and female sex would further increase the risk of SA in patients with epilepsy and comorbid depression. Conclusion: Risks of SA and SDO in patients with epilepsy are proportionally increased when depression is coexisted. Our findings provide crucial information for clinicians and the government for suicide prevention and to question whether prescribing a large number of medications to patients with epilepsy and depression is safe.

Association of Serotonin Transporter Gene (5-HTTLPR/rs25531) Polymorphism with Comorbidities of Panic Disorder

2020 ◽  
pp. 1-9
Author(s):  
Shunsuke Tanahashi ◽  
Hisashi Tanii ◽  
Yoshiaki Konishi ◽  
Takeshi Otowa ◽  
Tsukasa Sasaki ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Personality Traits ◽  
Serotonin Transporter ◽  
Comorbid Depression ◽  
Significant Interaction Effect ◽  
Neo Personality Inventory ◽  
Allelic Gene ◽  
Anxious State ◽  
The Relationship ◽  
Genotype A

<b><i>Introduction:</i></b> Panic disorder (PD) has many comorbidities such as depression, bipolar disorder (BPD), and agoraphobia (AG). PD is a moderately heritable anxiety disorder whose pathogenesis is not well understood. Recently, a tri-allelic serotonin transporter (5-HTTLPR/rs25531) polymorphism was reported to be more sensitive to personality traits compared to the bi-allelic 5-HTTLPR polymorphism. We hypothesized that the 5-HTTLPR/rs25531 polymorphism may lead to a pathological anxious state depending on the presence or absence of a comorbidity in PD. <b><i>Methods:</i></b> In this study, we investigated the relationship between comorbidities in PD and tri-allelic 5-HTTLPR polymorphisms. A total of 515 patients with PD (148 males, 367 females) were genotyped, and the Revised NEO Personality Inventory as well as anxiety-related psychological tests were administered. Depression, BPD, and AG were diagnosed as comorbidities. <b><i>Results:</i></b> For the tri-allele 5-HTTLPR genotype, a significant interaction effect was found between openness to experience and comorbid depression. Examination of the interaction between AG and the tri-allelic 5-HTTLPR genotype revealed that L’ allele carriers are associated with higher trait anxiety than the S’S’ genotype group in PD without AG. <b><i>Conclusion:</i></b> Some anxiety and personality traits can be characterized by the tri-allelic gene effect of 5-HTTLPR. These results suggest that tri-allelic 5-HTTLPR genotypes have genetic effects on the presence of comorbidities of PD.

scholarly journals Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study

2021 ◽  
Vol 15 ◽  
Author(s):  
Nathália Stela Visoná de Figueiredo ◽  
Anaclara Prada Jardim ◽  
Lenon Mazetto ◽  
Jeana Torres Corso Duarte ◽  
Sandra Mara Comper ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Hippocampal Neurons ◽  
Hippocampal Sclerosis ◽  
Mesial Temporal Lobe Epilepsy ◽  
Histopathological Study ◽  
Comorbid Depression ◽  
Neuronal Density ◽  
Mesial Temporal Lobe ◽  
Patients With Epilepsy

Depression is the most frequent psychiatric comorbidity seen in mesial temporal lobe epilepsy (MTLE) patients with hippocampal sclerosis (HS). Moreover, the HS is the most frequent pathological hallmark in MTLE-HS. Although there is a well-documented hippocampal volumetric reduction in imaging studies of patients with major depressive disorder, in epilepsy with comorbid depression, the true role of the hippocampus is not entirely understood. This study aimed to verify if patients with unilateral MTLE-HS and the co-occurrence of depression have differences in neuronal density of the hippocampal sectors CA1–CA4. For this purpose, we used a histopathological approach. This was a pioneering study with patients having both clinical disorders. However, we found no difference in hippocampal neuronal density when depression co-occurs in patients with epilepsy. In this series, CA1 had the lowest counting in both groups, and HS ILAE Type 1 was the most prevalent. More studies using histological assessments are needed to clarify the physiopathology of depression in MTLE-HS.

Hypermethylation of the serotonin transporter gene promoter in panic disorder–Epigenetic imprint of comorbid depression?

2019 ◽  
Vol 29 (10) ◽  
pp. 1161-1167 ◽  
Author(s):  
Miriam A. Schiele ◽  
Leonie Kollert ◽  
Klaus-Peter Lesch ◽  
Volker Arolt ◽  
Peter Zwanzger ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Serotonin Transporter ◽  
Gene Promoter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Comorbid Depression

scholarly journals A COMPREHENSIVE REVIEW ON COMORBID DEPRESSION IN PATIENTS WITH EPILEPSY

2017 ◽  
Vol 10 (12) ◽  
pp. 30
Author(s):  
Keziya Ann Mammen ◽  
Sathesh Kumar S
Keyword(s):  
Normal Population ◽  
Management Strategies ◽  
Well Being ◽  
Clinical Findings ◽  
Comorbid Depression ◽  
Comprehensive Review ◽  
Epileptic Patients ◽  
The Common ◽  
Patients With Epilepsy

Epilepsy is one of the common neurological disorders that are seen worldwide. It can also affect a person’s social, mental, and physiological well-being and thus restricts and disables the common living of man. Depression as such has been well reported in patients with epilepsy, and also depression itself remains a factor that can lead to the development of epilepsy. Increased rates of suicidal tendencies are also associated with depression both in men and women. Depression is further extended in affecting the quality of life in epileptic patients. Depressive rates are found to have a higher value in epileptic patients when compared with the normal population. This article aims to produce a comprehensive review of the epidemiological considerations, clinical findings and management strategies for depression associated with epilepsy.

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