Association of Serotonin Transporter Gene (5-HTTLPR/rs25531) Polymorphism with Comorbidities of Panic Disorder

2020 ◽  
pp. 1-9
Author(s):  
Shunsuke Tanahashi ◽  
Hisashi Tanii ◽  
Yoshiaki Konishi ◽  
Takeshi Otowa ◽  
Tsukasa Sasaki ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Personality Traits ◽  
Serotonin Transporter ◽  
Comorbid Depression ◽  
Significant Interaction Effect ◽  
Neo Personality Inventory ◽  
Allelic Gene ◽  
Anxious State ◽  
The Relationship ◽  
Genotype A

<b><i>Introduction:</i></b> Panic disorder (PD) has many comorbidities such as depression, bipolar disorder (BPD), and agoraphobia (AG). PD is a moderately heritable anxiety disorder whose pathogenesis is not well understood. Recently, a tri-allelic serotonin transporter (5-HTTLPR/rs25531) polymorphism was reported to be more sensitive to personality traits compared to the bi-allelic 5-HTTLPR polymorphism. We hypothesized that the 5-HTTLPR/rs25531 polymorphism may lead to a pathological anxious state depending on the presence or absence of a comorbidity in PD. <b><i>Methods:</i></b> In this study, we investigated the relationship between comorbidities in PD and tri-allelic 5-HTTLPR polymorphisms. A total of 515 patients with PD (148 males, 367 females) were genotyped, and the Revised NEO Personality Inventory as well as anxiety-related psychological tests were administered. Depression, BPD, and AG were diagnosed as comorbidities. <b><i>Results:</i></b> For the tri-allele 5-HTTLPR genotype, a significant interaction effect was found between openness to experience and comorbid depression. Examination of the interaction between AG and the tri-allelic 5-HTTLPR genotype revealed that L’ allele carriers are associated with higher trait anxiety than the S’S’ genotype group in PD without AG. <b><i>Conclusion:</i></b> Some anxiety and personality traits can be characterized by the tri-allelic gene effect of 5-HTTLPR. These results suggest that tri-allelic 5-HTTLPR genotypes have genetic effects on the presence of comorbidities of PD.

scholarly journals The application of personality traits model on the freight forwarding service industry

2016 ◽  
Vol 1 (3) ◽  
pp. 231-252 ◽  
Author(s):  
Kuo-Chung Shang ◽  
Ching-Cheng Chao ◽  
Taih-Cherng Lirn
Keyword(s):  
Job Performance ◽  
Personality Traits ◽  
Task Performance ◽  
Psychological Assessment ◽  
Contextual Performance ◽  
Logistics Industry ◽  
Content Type ◽  
Neo Personality Inventory ◽  
Freight Forwarding ◽  
The Relationship

Purpose The purpose of this study aims to investigate the relationship between employees’ personality traits and their job performances (including task performance and contextual performance) of Taiwanese freight forwarders by using responses from a NEO Personality Inventory-Revised Form (NEO-PI-R) questionnaire survey. Design/methodology/approach One of the most popular personality trait model is the five-factor model (FFM), which includes the big five domains, namely, openness, conscientiousness, extraversion, agreeableness and neuroticism (OCEAN). Each of these five domains includes six facets. Previous researchers have used OCEAN factors to describe the relationship between human personality and job performance. NEO Personality Inventory is a professional psychological assessment instrument published by psychological assessment resources. Multivariate analysis technique and regression technique are used to analyze surveyees’ responses. Findings Research results reveal the following four issues. The seniority of employees in a company has a positive relationship with their conscientiousness. Employees with higher score on the facets of the neuroticism domain have a negative correlation with their task performance and contextual performance. The relationship between employees’ openness to experience and job performance (both task performance and contextual performance) is not significant. Employees’ seniority has a positive correlation with both their task performance and contextual performance. In a nutshell, freight forwarding industry in Taiwan can use the facets in the neuroticism domain to screen and recruit appropriate job applicants. In addition, retaining senior employees could increase a forwarder’s task performance and contextual performance by their high degree of conscientiousness. Originality/value FFM model is a psychological theory dealing with the personality traits and human behavior. Freight forwarding is a labor-intensive business and is one of the most important sectors in the logistics industry. According the authors’ knowledge, the application of FFM on the logistics industry is simply not existed.

scholarly journals The relationship between burnout, personality traits and coping strategies in a corporate pharmaceutical group

2003 ◽  
Vol 29 (4) ◽  
Author(s):  
K. Storm ◽  
S. Rothmann
Keyword(s):  
Personality Traits ◽  
Coping Strategies ◽  
Personality Inventory ◽  
Openness To Experience ◽  
Personal Accomplishment ◽  
Neo Personality Inventory ◽  
Pharmaceutical Group ◽  
Neo Personality Inventory Revised ◽  
And Coping ◽  
The Relationship

The objective of this research was to determine the relationship between burnout, personality traits and coping strategies. A survey design was used. The study population consisted of 131 employees in a corporate pharmaceutical group. The Maslach Burnout Inventory, NEO Personality Inventory Revised and COPE were administered. Active coping strategies were associated with Emotional Stability, Extraversion, Openness to Experience and Conscientiousness, while passive coping strategies were associated with Neuroticism, low Agreeableness and low Conscientiousness. Emotional Stability, Extraversion, Openness to Experience, Agreeableness and Conscientiousness were associated with lower emotional exhaustion and depersonalisation and higher personal accomplishment. Constructive coping strategies were associated with personal accomplishment. Opsomming Die doelstelling van hierdie navorsing was om te bepaal of daar ’n verband tussen uitbranding, persoonlikheidstrekke en coping-strategieë bestaan. ’n Opnameontwerp is gebruik. Die ondersoekgroep het bestaan uit 131 werknemers van ’n korporatiewe apteekgroep. Drie vraelyste is gebruik, naamlik die Maslach-Uitbrandingsvraelys, die NEO Personality Inventory Revised en die COPE. Aktiewe coping-strategieë is geassosieer met Emosionele Stabiliteit, Ekstroversie, Openheid vir Ervaring en Konsensieusheid, terwyl passiewe coping-strategieë geassosieer is met Neurotisisme, lae Inskiklikheid en lae Konsensieusheid. Emosionele Stabiliteit, Ekstroversie, Openheid vir Ervaring, Inskiklikheid en Konsensieusheid is geassosieer met lae emosionele uitputting, lae depersonalisasie en hoë persoonlike bereiking. Konstruktiewe coping-strategieë is geassosieer met persoonlike bereiking.

Relationship Between Personality Traits and Nursing Professionalism

2020 ◽  
Vol 6 (3) ◽  
pp. 157-162
Author(s):  
Behnam Masmouei ◽  
◽  
Hossein Bazvand ◽  
Mehdi Harorani ◽  
Mohammad-Rafi Bazrafshan ◽  
...  
Keyword(s):  
Personality Traits ◽  
Big Five ◽  
Sampling Method ◽  
Professional Behavior ◽  
Teaching Hospitals ◽  
Big Five Personality ◽  
Patient Relationship ◽  
Cross Sectional ◽  
Neo Personality Inventory ◽  
The Relationship

Background: Professionalism is among the major concepts of nursing. Besides, nursing professionalism is often associated with attitudes, knowledge, and behaviors that underlie the successful clinical practice. Personality traits can affect various aspects of an individual’s life. Accordingly, the present study aimed to determine the relationship between personality traits and nursing professionalism. Methods: A cross-sectional correlational study was conducted on 205 nurses in teaching hospitals of Khoramabad City, Iran, in 2017. The study subjects were recruited by the stratified sampling method. NEO Personality Inventory and Goze Professional Behavior questionnaire were used to collect the required information. Then, the obtained data were analyzed by SPSS using descriptive and inferential statistics. Results: Nursing professionalism had a direct relationship with extraversion (r=0.330, P<0.05), conscientiousness (r=0.333, P<0.05), and agreeableness (r=0.172, P=0.014); it also had an inversed relationship with neuroticism (r=- 0.161, P=0.021). Conclusion: The Big Five personality traits are strongly related to nursing professionalism; with conscientiousness and extraversion as the most pronounced traits. Nurses’ attitudes are partly rooted in their personality traits and these attitudes affect the nurse-patient relationship. Therefore, it is suggested that these characteristics be considered in appointing nurses in different departments.

scholarly journals Relationship between Personality Traits and Intelligence among Youth

2017 ◽  
Vol 4 (3) ◽  
Author(s):  
Dr. Madhu Anand ◽  
Dr. Ritu
Keyword(s):  
Gender Differences ◽  
Personality Traits ◽  
Personality Inventory ◽  
Future Research ◽  
Neo Personality Inventory ◽  
Significant Relationships ◽  
Raven's Standard Progressive Matrices ◽  
Age Range ◽  
The Relationship

Present study examines the relationship between personality traits and intelligence. Further, find gender differences in personality traits and intelligence. The sample consists of 275 youth (141 boys and 133 girls) with the age range of 17 to 28 years (mean age 21.66 ± 2.47). Participants completed the NEO Personality Inventory and Raven’s Standard Progressive Matrices. The results showed that personality traits such as neuroticism, agreeableness and extraversion have significant relationships with intelligence. Furthermore, results showed that girls were higher on neuroticism and extraversion in comparison to boys. Implications, limitations of the study and suggestions for future research are also discussed.

Relationship Between Leukocyte Telomere Length and Personality Traits in Healthy Subjects

2015 ◽  
Vol 30 (2) ◽  
pp. 291-295 ◽  
Author(s):  
R. Sadahiro ◽  
A. Suzuki ◽  
M. Enokido ◽  
Y. Matsumoto ◽  
N. Shibuya ◽  
...  
Keyword(s):  
Personality Traits ◽  
Telomere Length ◽  
Dna Sequences ◽  
Healthy Subjects ◽  
Single Copy ◽  
Stepwise Multiple Regression ◽  
Leukocyte Telomere Length ◽  
Neo Personality Inventory ◽  
Character Inventory ◽  
The Relationship

AbstractBackground:It has been shown that certain personality traits are related to mortality and disease morbidity, but the biological mechanism linking them remains unclear. Telomeres are tandem repeat DNA sequences located at the ends of chromosomes, and shorter telomere length is a predictor of mortality and late-life disease morbidity. Thus, it is possible that personality traits influence telomere length. In the present study, we examined the relationship of leukocyte telomere length with personality traits in healthy subjects.Subjects and methods:The subjects were 209 unrelated healthy Japanese who were recruited from medical students at 4th–5th grade. Assessment of personality traits was performed by the Revised NEO Personality Inventory (NEO-PI-R) and the Temperament and Character Inventory (TCI). Leukocyte relative telomere length was determined by a quantitative real-time PCR method for a ratio of telomere/single copy gene.Results:In the stepwise multiple regression analysis, shorter telomere length was related to lower scores of neuroticism (P < 0.01) and conscientiousness (P < 0.05) of the NEO-PI-R, and lower scores of harm avoidance (P < 0.05) and reward dependence (P < 0.05) of the TCI.Conclusions:The present study suggests that leukocyte telomere length is associated with some personality traits, and this association may be implicated in the relationship between personality traits and mortality.

Hypermethylation of the serotonin transporter gene promoter in panic disorder–Epigenetic imprint of comorbid depression?

2019 ◽  
Vol 29 (10) ◽  
pp. 1161-1167 ◽  
Author(s):  
Miriam A. Schiele ◽  
Leonie Kollert ◽  
Klaus-Peter Lesch ◽  
Volker Arolt ◽  
Peter Zwanzger ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Serotonin Transporter ◽  
Gene Promoter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Comorbid Depression

scholarly journals Investigating the Relationship Between Big Five Personality Traits and Cultural Intelligence on Football Coaches

2017 ◽  
Vol 6 (3) ◽  
pp. 116-131 ◽  
Author(s):  
Hassan Fahim Devin
Keyword(s):  
Personality Traits ◽  
Big Five ◽  
Cultural Intelligence ◽  
Big Five Personality Traits ◽  
Big Five Personality ◽  
Football Coaches ◽  
Neo Personality Inventory ◽  
Significant Difference ◽  
Neo Five Factor Inventory ◽  
The Relationship

Abstract In this descriptive – correlative study we examined the relationship between big five personality traits with cultural intelligence in 113 active soccer coaches in the city of Mashhad in north-eastern of Iran. Anget. al (2004) cultural intelligence (CI) and Costa & McCrae (1992) Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI questionnaires were used to obtain coaches’ rate of cultural intelligence and personality traits. The results of the study revealed a significant positive relationship between personality traits (except for neuroticism) with Cultural intelligence. A significant reverse relationship was observed between neuroticism and Cultural intelligence. A significant difference was observed between coaches with A and B coaching degree, in comparison with C and D coaching degree in terms of cultural intelligence. No significant difference was observed between these two groups regarding personality traits. Our results show that some of the personality characteristics are crucial and related to a capability to function effectively in diverse settings.

scholarly journals Personality Traits Relate to Chronotype at Both the Phenotypic and Genetic Level

2021 ◽  
Author(s):  
Anita Lenneis ◽  
Uku Vainik ◽  
Maris Teder-Laving ◽  
Liisi Ausmees ◽  
Sakari Lemola ◽  
...  
Keyword(s):  
Personality Traits ◽  
Factor Model ◽  
Five Factor Model ◽  
Association Studies ◽  
Genetic Correlations ◽  
Genome Wide Association Studies ◽  
Neo Personality Inventory ◽  
Genome Wide ◽  
Genetic Level ◽  
The Relationship

Introduction: Diurnal preferences have been linked to personality but often with mixed results. The present study examines the relationships between sleep timing (chronotype), diurnal preferences and the Five-Factor Model of personality traits at the phenotypic and genetic level. Methods: Self- and informant-reports of the NEO Personality Inventory-3, self-reports of the Munich Chronotype Questionnaire, and DNA samples were available for 2,515 Estonian adults (Mage = 45.76 years; 59% females). Genetic correlations were obtained through summary statistics of genome-wide association studies. Results: Results showed that higher Conscientiousness and lower Openness to Experience were significant predictors of earlier chronotype. At the level of facets, we found that more straightforward (A2) and excitement-seeking (E5), yet less self-disciplined (C5) people were more likely to have later chronotypes. The nuance-level Polypersonality score was correlated with chronotype at r = .28 (p &lt; .001). Conscientiousness and Openness were genetically related with diurnal preferences. The polygenic score for morningness-eveningness significantly predicted the Polypersonality score. Conclusion: Phenotypic measures of chronotype and personality showed significant associations at all three of levels of the personality hierarchy. Our findings indicate that the relationship between personality and morningness-eveningness is partly due to genetic factors. Future studies are necessary to further refine the relationship.

Lack of association between the serotonin transporter promoter polymorphism (5-HTTLPR) and personality traits in asymptomatic patients with panic disorder

2008 ◽  
Vol 431 (2) ◽  
pp. 173-178 ◽  
Author(s):  
Cláudia Wachleski ◽  
Carolina Blaya ◽  
Giovanni Abrahão Salum ◽  
Verônica Vargas ◽  
Sandra Leistner-Segal ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Personality Traits ◽  
Serotonin Transporter ◽  
Promoter Polymorphism ◽  
Asymptomatic Patients ◽  
Serotonin Transporter Promoter Polymorphism

scholarly journals THE RELATIONSHIP BETWEEN TOLERANCE AND INTOLERANCE OF AMBIGUITY AND BIG FIVE PERSONALITY TRAITS

Reflexio ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 91-114
Author(s):  
M. V. Zlobina
Keyword(s):  
Personality Traits ◽  
Big Five ◽  
Intolerance Of Uncertainty ◽  
Big Five Personality Traits ◽  
Big Five Personality ◽  
Neo Personality Inventory ◽  
Uncertainty Intolerance ◽  
Tolerance Of Uncertainty ◽  
Relationship Of ◽  
The Relationship

The paper presents the preliminary results of testing the relationship of tolerance of uncertainty, intolerance of uncertainty and interpersonal intolerance of uncertainty and personality traits on a sample of 87 people. A review of foreign studies on the relationship between these constructs is given. Revised NEO Personality Inventory [Orel, Senin, 2004] and the New Questionnaire of Tolerance of Uncertainty [Kornilova, 2010] was used in order to test the relationship between personality traits and tolerance of uncertainty, intolerance of uncertainty and interpersonal intolerance of uncertainty.

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