scholarly journals Relationship between intima-media thickness of the common carotid artery and arterial stiffness in subjects with and without type 2 diabetes: a case-series report

2011 ◽  
Vol 10 (1) ◽  
pp. 3 ◽  
Author(s):  
Manuel Gómez-Marcos ◽  
José Recio-Rodríguez ◽  
María Patino-Alonso ◽  
Cristina Agudo-Conde ◽  
Leticia Gómez-Sánchez ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Carotid Artery ◽  
Arterial Stiffness ◽  
Common Carotid Artery ◽  
Case Series ◽  
Intima Media Thickness ◽  
Case Series Report ◽  
The Common ◽  
Series Report

A Comparative Study for an Assessment of Arterial Stiffness with Cardio-Ankle Vascular Index and Clinical Determinants between those Individuals with and without Diabetes

2021 ◽  
Vol 104 (8) ◽  
pp. 1285-1292
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Carotid Artery ◽  
Arterial Stiffness ◽  
Common Carotid Artery ◽  
Intima Media Thickness ◽  
Factors Associated ◽  
The Mean

Background: Arterial stiffness and dysfunction are clinical determinants in predicting long-term cardiovascular risk in type 2 diabetes (T2DM). Cardio-ankle vascular index (CAVI) is a novel tool in detecting atherosclerosis by measuring arterial stiffness along the aorta to tibial arteries. Objective: To compare clinical parameters between diabetes and non-diabetes groups. The present study explored clinical factors associated with CAVI of 8.0 or more in diabetes patients. Moreover, the study determined the correlation between CAVI and clinical predictors for long-term cardiovascular risk. Materials and Methods: The present study was a retrospective, cross-sectional study. The controls or non-diabetes were matched with the cases or diabetes in ratio 2:1 and aged matched in two groups, 40 years and older and less than 40 years old. Results: Two hundred fifty-two subjects were enrolled, 84 were diabetes and 168 were non-diabetes. The present study found those subjects with high body mass index (BMI) of 25.0 kg/m² or more and CAVI of 8.0 or more were the factors associated with greater risk of having diabetes than non-diabetes. Subjects with T2DM aged 40 years or older had 11.95 times greater risk of having CAVI of 8.0 or more than those younger than 40 years in T2DM (p=0.002). Known essential hypertension was another independent factor associated with 4.28 times greater risk of having CAVI of 8.0 or more than those without hypertension in T2DM (p=0.010). The present study found significant positive correlation between CAVI and the previously reported clinical markers, RAMA-EGAT score and the mean common carotid artery intima-media thickness, that predict long-term cardiovascular events in T2DM (Pearson’s correlation coefficient; r=0.6738 and 0.4207, respectively, p<0.05). Conclusion: Those subjects with CAVI of 8.0 or more and BMI of 25 kg/m² or more had significantly greater association with diabetes than nondiabetes. Age of 40 years or older and history of hypertension were independent risk of high CAVI of 8.0 or more in T2DM. CAVI also correlated with the previously reported clinical marker to predict long-term cardiovascular risk such as RAMA-EGAT score, the mean common carotid artery intima-media thickness in T2DM. Keywords: Type 2 diabetes; Cardio-ankle vascular index (CAVI); Arterial stiffness

PO17-487 ADEQUATELY TREATED TYPE 2 DIABETES IS ASSOCIATED WITH LOWER WALL SHEAR RATE OF THE COMMON CAROTID ARTERY

2007 ◽  
Vol 8 (1) ◽  
pp. 136 ◽  
Author(s):  
E. Chytilova ◽  
J. Malik ◽  
Z. Kasalova ◽  
R. Dolezalova ◽  
J. Housova ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Shear Rate ◽  
Carotid Artery ◽  
Common Carotid Artery ◽  
Wall Shear Rate ◽  
Lower Wall ◽  
The Common ◽  
Wall Shear

ROSIGLITAZONE TREATMENT OF TYPE 2 DIABETES IS ASSOCIATED WITH HIGHER WALL SHEAR RATE OF THE COMMON CAROTID ARTERY

2008 ◽  
Vol 9 (1) ◽  
pp. 76
Author(s):  
E. Chytilova ◽  
J. Malik ◽  
Z. Kasalova ◽  
R. Dolezalova ◽  
T. Stulc ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Shear Rate ◽  
Carotid Artery ◽  
Common Carotid Artery ◽  
Wall Shear Rate ◽  
The Common ◽  
Rosiglitazone Treatment ◽  
Wall Shear

scholarly journals Sitagliptin on carotid intima-media thickness in type 2 diabetes and hyperuricemia patients: a subgroup analysis of the PROLOGUE study

2021 ◽  
Vol 12 ◽  
pp. 204062232110269
Author(s):  
Yipin Zhao ◽  
Huawei Wang ◽  
Dazhi Ke ◽  
Wei Deng ◽  
Yingying Ji ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Carotid Artery ◽  
Conventional Therapy ◽  
Therapy Group ◽  
Controlled Trial ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Significant Difference

Background and Aims: Studies have shown that dipeptidyl peptidase-4 (DDP-4) inhibitors have anti-atherosclerotic effects. However, in the PROLOGUE study, sitagliptin failed to slow the progression of carotid intima-media thickness (CIMT) relative to conventional therapy. We conducted a post hoc analysis of the PROLOGUE study and compared the effects of sitagliptin and conventional therapy on changes in CIMT in subgroups with or without hyperuricemia. Methods: The PROLOGUE study was a randomized controlled trial of 442 patients with type 2 diabetes mellitus (T2DM). Patients were randomized to receive sitagliptin added therapy or conventional therapy. Based on the serum uric acid levels of all study populations in the PROLOGUE study, we divided them into hyperuricemia subgroup ( n = 104) and non-hyperuricemia subgroup ( n = 331). The primary outcome was changed in carotid intima-media thickness (CIMT) parameters compared with baseline during the 24 months treatment period. Results: In the hyperuricemia subgroup, compared with the conventional therapy group, the changes in the mean internal carotid artery (ICA)-IMT and max ICA-IMT at 24 months were significantly lower in the sitagliptin group [−0.233 mm, 95% confidence interval (CI) (−0.419 to 0.046), p = 0.015 and −0.325 mm, 95% CI (−0.583 to −0.068), p = 0.014], although there was no significant difference in the common carotid artery CIMT. Conclusion: The results of our analysis indicated that sitagliptin attenuated the progression of CIMT than conventional therapy in T2DM and hyperuricemia patients.

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