scholarly journals A new approach for the large-scale generation of mature dendritic cells from adherent PBMC using roller bottle technology

2008 ◽  
Vol 6 (1) ◽  
pp. 1 ◽  
Author(s):  
Ryan E Campbell-Anson ◽  
Diane Kentor ◽  
Yi J Wang ◽  
Kathryn M Bushnell ◽  
Yufeng Li ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Large Scale ◽  
Roller Bottle ◽  
New Approach

Scientific-methodological approach to the substantiation of the rational seasonal scenario of using combine harvesters by large-scale agricultural producers

2020 ◽  
pp. 205-217
Author(s):  
V. Skibchyk ◽  
V. Dnes ◽  
R. Kudrynetskyi ◽  
O. Krypuch
Keyword(s):  
Large Scale ◽  
System Analysis ◽  
Methodological Approach ◽  
Production Unit ◽  
Agricultural Producers ◽  
New Approach ◽  
Rational Use ◽  
Road Map ◽  
Analysis And Synthesis ◽  
Combine Harvesters

Аnnotation Purpose. To increase the efficiency of technological processes of grain harvesting by large-scale agricultural producers due to the rational use of combine harvesters available on the farm. Methods. In the course of the research the methods of system analysis and synthesis, induction and deduction, system-factor and system-event approaches, graphic method were used. Results. Characteristic events that occur during the harvesting of grain crops, both within a single production unit and the entire agricultural producer are identified. A method for predicting time intervals of use and downtime of combine harvesters of production units has been developed. The roadmap of substantiation the rational seasonal scenario of the use of grain harvesters of large-scale agricultural producers is developed, which allows estimating the efficiency of each of the scenarios of multivariate placement of grain harvesters on fields taking into account influence of natural production and agrometeorological factors on the efficiency of technological cultures. Conclusions 1. Known scientific and methodological approaches to optimization of machine used in agriculture do not take into account the risks of losses of crops due to late harvesting, as well as seasonal natural and agrometeorological conditions of each production unit of the farmer, which requires a new approach to the rational use of rational seasonal combines of large agricultural producers. 2. The developed new approach to the substantiation of the rational seasonal scenario of the use of combined harvesters of large-scale agricultural producers allows taking into account the costs of harvesting of grain and the cost of the lost crop because of the lateness of harvesting at optimum variants of attraction of additional free combine harvesters. provides more profit. 3. The practical application of the developed road map will allow large-scale agricultural producers to use combine harvesters more efficiently and reduce harvesting costs. Keywords: combine harvesters, use, production divisions, risk, seasonal scenario, large-scale agricultural producers.

Solid Lipid Nanoparticles: A Promising Drug Delivery Technology

2009 ◽  
Vol 2 (2) ◽  
pp. 509-516
Author(s):  
S. Pragati ◽  
S. Kuldeep ◽  
S. Ashok ◽  
M. Satheesh
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Large Scale ◽  
Colloidal Particles ◽  
Scale Up ◽  
Lipid Nanoparticles ◽  
Scale Production ◽  
Research Activity ◽  
New Approach ◽  
Solid Lipid

One of the situations in the treatment of disease is the delivery of efficacious medication of appropriate concentration to the site of action in a controlled and continual manner. Nanoparticle represents an important particulate carrier system, developed accordingly. Nanoparticles are solid colloidal particles ranging in size from 1 to 1000 nm and composed of macromolecular material. Nanoparticles could be polymeric or lipidic (SLNs). Industry estimates suggest that approximately 40% of lipophilic drug candidates fail due to solubility and formulation stability issues, prompting significant research activity in advanced lipophile delivery technologies. Solid lipid nanoparticle technology represents a promising new approach to lipophile drug delivery. Solid lipid nanoparticles (SLNs) are important advancement in this area. The bioacceptable and biodegradable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. Supplemented with small size which prolongs the circulation time in blood, feasible scale up for large scale production and absence of burst effect makes them interesting candidates for study. In this present review this new approach is discussed in terms of their preparation, advantages, characterization and special features.

Modeling Extinction

2003 ◽  
Author(s):  
M. E. J. Newman ◽  
R. G. Palmer
Keyword(s):  
Evolutionary Biology ◽  
Large Scale ◽  
Competitive Exclusion ◽  
Applied Mathematics ◽  
Santa Fe ◽  
New Approach ◽  
Self Organized ◽  
Self Organized Criticality ◽  
Extinction Events ◽  
Mass Extinction Events

Developed after a meeting at the Santa Fe Institute on extinction modeling, this book comments critically on the various modeling approaches. In the last decade or so, scientists have started to examine a new approach to the patterns of evolution and extinction in the fossil record. This approach may be called "statistical paleontology," since it looks at large-scale patterns in the record and attempts to understand and model their average statistical features, rather than their detailed structure. Examples of the patterns these studies examine are the distribution of the sizes of mass extinction events over time, the distribution of species lifetimes, or the apparent increase in the number of species alive over the last half a billion years. In attempting to model these patterns, researchers have drawn on ideas not only from paleontology, but from evolutionary biology, ecology, physics, and applied mathematics, including fitness landscapes, competitive exclusion, interaction matrices, and self-organized criticality. A self-contained review of work in this field.

scholarly journals Controllability and Observability of a Large Scale Thermodynamical System via Connectability Approach

2010 ◽  
Author(s):  
Virdiansyah Permana ◽  
Rahmat Shoureshi
Keyword(s):  
Graph Theory ◽  
Lie Algebra ◽  
Large Scale ◽  
Point Of View ◽  
Rank Condition ◽  
Computational Point ◽  
New Approach ◽  
Class System ◽  
Necessary And Sufficient ◽  
Controllability And Observability

This study presents a new approach to determine the controllability and observability of a large scale nonlinear dynamic thermal system using graph-theory. The novelty of this method is in adapting graph theory for nonlinear class and establishing a graphic condition that describes the necessary and sufficient terms for a nonlinear class system to be controllable and observable, which equivalents to the analytical method of Lie algebra rank condition. The directed graph (digraph) is utilized to model the system, and the rule of its adaptation in nonlinear class is defined. Subsequently, necessary and sufficient terms to achieve controllability and observability condition are investigated through the structural property of a digraph called connectability. It will be shown that the connectability condition between input and states, as well as output and states of a nonlinear system are equivalent to Lie-algebra rank condition (LARC). This approach has been proven to be easier from a computational point of view and is thus found to be useful when dealing with a large system.

Linguistically Annotated Reordering: Evaluation and Analysis

2010 ◽  
Vol 36 (3) ◽  
pp. 535-568 ◽  
Author(s):  
Deyi Xiong ◽  
Min Zhang ◽  
Aiti Aw ◽  
Haizhou Li
Keyword(s):  
Large Scale ◽  
Statistical Machine Translation ◽  
Training Data ◽  
Linguistic Knowledge ◽  
Analysis Method ◽  
Complementary Information ◽  
New Approach ◽  
Parse Trees ◽  
New Challenges ◽  
Insight Into

Linguistic knowledge plays an important role in phrase movement in statistical machine translation. To efficiently incorporate linguistic knowledge into phrase reordering, we propose a new approach: Linguistically Annotated Reordering (LAR). In LAR, we build hard hierarchical skeletons and inject soft linguistic knowledge from source parse trees to nodes of hard skeletons during translation. The experimental results on large-scale training data show that LAR is comparable to boundary word-based reordering (BWR) (Xiong, Liu, and Lin 2006), which is a very competitive lexicalized reordering approach. When combined with BWR, LAR provides complementary information for phrase reordering, which collectively improves the BLEU score significantly. To further understand the contribution of linguistic knowledge in LAR to phrase reordering, we introduce a syntax-based analysis method to automatically detect constituent movement in both reference and system translations, and summarize syntactic reordering patterns that are captured by reordering models. With the proposed analysis method, we conduct a comparative analysis that not only provides the insight into how linguistic knowledge affects phrase movement but also reveals new challenges in phrase reordering.

Structuring School Structure

1978 ◽  
Vol 48 (1) ◽  
pp. 32-64 ◽  
Author(s):  
Hugh Mehan
Keyword(s):  
Research Methods ◽  
Field Observation ◽  
Large Scale ◽  
School Effects ◽  
School Structure ◽  
Classroom Organization ◽  
New Approach ◽  
School Structures ◽  
School Events

In this article Hugh Mehan calls for a new approach to the study of schooling. He notes that the research methods that dominated the study of school effects in the last two decades—large-scale surveys and field observation—have failed to examine the processes by which school participants create school structures. The approach Mehan advocates, "constitutive ethnography," would give equal attention to the processes as well as the outcomes of structuring activities. He outlines the method of constitutive ethnography and illustrates its application in studies of classroom organization, testing encounters, and counseling sessions. Mehan concludes by calling for "constitutive career studies" of individuals as they participate in a range of school events.

A new approach for the acceleration of large-scale serial quantum chemical calculations of docking complexes

2018 ◽  
Vol 67 (6) ◽  
pp. 1100-1103 ◽  
Author(s):  
N. A. Anikin ◽  
A. M. Andreev ◽  
M. B. Kuz’minskii ◽  
A. S. Mendkovich
Keyword(s):  
Quantum Chemical Calculations ◽  
Quantum Chemical ◽  
Large Scale ◽  
New Approach

Repression of Islamists and Authoritarian Survival in the Arab World: A Case Study of Egypt

2021 ◽  
Author(s):  
Jean Lachapelle
Keyword(s):  
Large Scale ◽  
Arab World ◽  
Muslim Brotherhood ◽  
Supporting Evidence ◽  
State Repression ◽  
New Approach ◽  
The Muslim Brotherhood ◽  
Authoritarian Survival

This chapter explores the causes of state repression against Islamist organizations in the Arab world. Advancing a rich literature on state repression, authoritarianism, and Islamist politics, it proposes a new approach that centers on the role of non-Islamist audiences for explaining the repression of Islamists. Specifically, the chapter argues that when society is divided between non-Islamists and Islamists, an autocrat can repress Islamists to signal a commitment to non-Islamists to protect them from perceived threats by Islamists. It provides supporting evidence from Egypt, which shows how large-scale repression directed at the Muslim Brotherhood after the coup of 2013 served to cultivate the support of non-Islamists.

Sign in / Sign up

Export Citation Format

Share Document