Prognostic significance of WT1 expression in soft tissue sarcoma

Background Ferroptosis has exhibited great potential in the treatment of cancer and has gained widespread attention in soft tissue sarcoma (STS). The aim was to explore the immunological and prognostic significance of novel ferroptosis-related genes in STS. Methods We identified ferroptosis-related differentially expressed genes (DEGs) in STS to construct the networks of enrichment analysis and protein-protein interaction. Subsequently, hub genes with prognostic significance were localized and a series of prognostic and immune analyses were performed. Results 40 ferroptosis-related DEGs were identified, of which HELLS, STMN1 EPAS1, CXCL2, NQO1, and IL6 were classified as hub genes and were associated with the prognosis in STS patients. In the results of the immune analysis, PDCD1, CTLA4, TIGIT, IDO1 and CD27 exhibited consistent intense correlations as immune checkpoint genes, as well as macrophage, neutrophil, cytotoxic cell, dendritic cell, interdigitating dendritic cell and plasmacytoid dendritic cell as immune cells. EPAS1 and HELLS might be independent prognostic factors for STS patients, and separate prognostic models were constructed by using them. Conclusions We recognized novel ferroptosis-related genes with prognostic value in STS. Furthermore, we searched out potential immune checkpoints and critical immune cells.

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Determining the Prognostic Significance of Alternative Splicing Events in Soft Tissue Sarcoma Using Data From The Cancer Genome Atlas

SSRN Electronic Journal ◽

10.2139/ssrn.3324734 ◽

2019 ◽

Author(s):

Xia Yang ◽

Wen-ting Huang ◽

Rong-quan He ◽

Jie Ma ◽

Peng Lin ◽

...

Keyword(s):

Alternative Splicing ◽

Soft Tissue ◽

Soft Tissue Sarcoma ◽

Prognostic Significance ◽

Cancer Genome ◽

The Cancer Genome Atlas ◽

Cancer Genome Atlas ◽

Alternative Splicing Events ◽

Using Data ◽

Genome Atlas

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Long-term outcomes of patients with soft tissue sarcoma of the chest wall: Analysis of the prognostic significance of microscopic margins

Oncology Letters ◽

10.3892/ol.2017.7624 ◽

2017 ◽

Cited By ~ 3

Author(s):

Kamran Harati ◽

Jonas Kolbenschlag ◽

Jens Bohm ◽

Hiltrud Niggemann ◽

Hamid Joneidi‑Jafari ◽

...

Keyword(s):

Soft Tissue ◽

Soft Tissue Sarcoma ◽

Chest Wall ◽

Prognostic Significance ◽

Long Term Outcomes

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Determining the prognostic significance of alternative splicing events in soft tissue sarcoma using data from The Cancer Genome Atlas

Journal of Translational Medicine ◽

10.1186/s12967-019-2029-6 ◽

2019 ◽

Vol 17 (1) ◽

Cited By ~ 4

Author(s):

Xia Yang ◽

Wen-ting Huang ◽

Rong-quan He ◽

Jie Ma ◽

Peng Lin ◽

...

Keyword(s):

Alternative Splicing ◽

Soft Tissue ◽

Soft Tissue Sarcoma ◽

Prognostic Significance ◽

Cancer Genome ◽

The Cancer Genome Atlas ◽

Cancer Genome Atlas ◽

Alternative Splicing Events ◽

Using Data ◽

Genome Atlas

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Prognostic significance of a positive microscopic margin in high-risk extremity soft tissue sarcoma: implications for management.

Journal of Clinical Oncology ◽

10.1200/jco.1996.14.2.473 ◽

1996 ◽

Vol 14 (2) ◽

pp. 473-478 ◽

Cited By ~ 74

Author(s):

M J Heslin ◽

J Woodruff ◽

M F Brennan

Keyword(s):

High Risk ◽

Soft Tissue ◽

Soft Tissue Sarcoma ◽

Cox Model ◽

Statistical Significance ◽

Operating Time ◽

Prognostic Significance ◽

Rank Test ◽

High Grade ◽

Significant Difference

PURPOSE A positive microscopic margin (PMM) is a significant prognostic variable and leads to local recurrence (LR) in high-grade soft tissue sarcoma (STS) patients. Its effect on the rate of distant metastasis (DM) and tumor mortality (TM) remains controversial. PATIENTS AND METHODS One hundred sixty-eight primary, high-risk (high-grade, deep, > or = 5 cm) extremity STS patients were identified from our data base, of which 42 had a PMM. Limb-sparing surgery (LSS) was the primary surgical therapy in 144 patients; 24 received amputation (AMP). Statistical analysis was by log-rank test and Cox model. Significance was defined as a P value less than .05. RESULTS A PMM was a significant negative prognostic factor for both DM and TM (P = .002 and .002, respectively). However, those patients who received LSS with 28% PMMs showed no significant difference in the rate of DM or TM compared with patients who received AMP with only 8% PMMs (log-rank, P = .057 and .28, respectively). A PMM was significantly associated with > or = 1,000 mL blood loss and more than 3 hours of operating time (P < .006 and .001, respectively). CONCLUSION The strong statistical significance that relates a PMM to DM and TM in high-risk STS of the extremity is likely related to biologically aggressive tumors and LSS. Residual microscopic disease is not a guarantee of LR. The main problem in this group of patients is not LR, but DM and subsequent death. Therefore, to increase a disability with further surgery or amputate a patient's limb without clear evidence of LR in this group at high risk for distant recurrence is not recommended.

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