Chikungunya virus with E1-A226V mutation causing two outbreaks in 2010, Guangdong, China

A case of chikungunya virus infection was imported from Thailand into Slovenia in late 2018. The infection was diagnosed using real-time reverse transcription-PCR, the virus was isolated in cell culture, and the whole genome was sequenced. Phylogenetic analysis of the nearly complete viral genome indicated that the virus belongs to the Indian Ocean lineage but does not possess the A226V mutation in the envelope protein E1.

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Vector competence of Aedes albopictus for the Indian Ocean lineage (IOL) chikungunya viruses of the 2007 and 2017 outbreaks in Italy: a comparison between strains with and without the E1:A226V mutation

Eurosurveillance ◽

10.2807/1560-7917.es.2018.23.22.1800246 ◽

2018 ◽

Vol 23 (22) ◽

Cited By ~ 11

Author(s):

Claudia Fortuna ◽

Luciano Toma ◽

Maria Elena Remoli ◽

Antonello Amendola ◽

Francesco Severini ◽

...

Keyword(s):

Indian Ocean ◽

Aedes Albopictus ◽

Chikungunya Virus ◽

Vector Competence ◽

Mosquito Species ◽

Italian Population ◽

Emilia Romagna Region ◽

The Indian Ocean ◽

A226v Mutation

We compared the vector competence of an Italian population of Aedes albopictus for two strains of chikungunya virus (CHIKV), with and without E1:A226V mutation, responsible for outbreaks in 2007 in the Emilia Romagna region and 2017 in the Lazio and Calabria regions, respectively. Ae. albopictus showed similar vector competence for both viral strains indicating that E1:A226V mutation is not exclusively responsible for ability of CHIKV to replicate well in this mosquito species.

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Chikungunya fever in two German tourists returning from the Maldives, September, 2009

Eurosurveillance ◽

10.2807/ese.15.13.19531-en ◽

2010 ◽

Vol 15 (13) ◽

Author(s):

M Pfeffer ◽

I Hanus ◽

T Löscher ◽

T Homeier ◽

G Dobler

Keyword(s):

Sri Lanka ◽

Aedes Albopictus ◽

Chikungunya Virus ◽

Molecular Characterisation ◽

Asian Tiger Mosquito ◽

Chikungunya Fever ◽

Coding Sequence ◽

Asian Tiger ◽

Virus Isolates ◽

A226v Mutation

This report describes the first isolation and molecular characterisation of a chikungunya virus from two German tourists who became ill after a visit to the Maldives in September 2009. The virus contained the E1 A226V mutation, shown to be responsible for an adaptation to the Asian tiger mosquito Aedes albopictus. The E1 coding sequence was identical to chikungunya virus isolates from Sri Lanka and showed three nt-mismatches to the only available E1 nt sequence from the Maldives.

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Presence of the A226V Mutation in Autochthonous and Imported Italian Chikungunya Virus Strains

Clinical Infectious Diseases ◽

10.1086/589925 ◽

2008 ◽

Vol 47 (3) ◽

pp. 428-429 ◽

Cited By ~ 33

Author(s):

Licia Bordi ◽

Fabrizio Carletti ◽

Concetta Castilletti ◽

Roberta Chiappini ◽

Vittorio Sambri ◽

...

Keyword(s):

Chikungunya Virus ◽

Virus Strains ◽

A226v Mutation

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A226V mutation in virus during the 2007 chikungunya outbreak in Kerala, India

Journal of General Virology ◽

10.1099/vir.0.83628-0 ◽

2008 ◽

Vol 89 (8) ◽

pp. 1945-1948 ◽

Cited By ~ 103

Author(s):

N. Pradeep Kumar ◽

Rajan Joseph ◽

T. Kamaraj ◽

P. Jambulingam

Keyword(s):

Molecular Evolution ◽

Aedes Albopictus ◽

Chikungunya Virus ◽

The State ◽

Contributing Factors ◽

Chikv Infection ◽

Chikungunya Fever ◽

Rubber Plantations ◽

Kerala State ◽

A226v Mutation

Kerala State in India was gripped by a renewed and widespread outbreak of Chikungunya virus (CHIKV) infection during 2007. Here, we report the A226V mutation in the glycoprotein envelope 1 (E1) gene of the virus among isolates collected from the three worst-affected districts of the state during this outbreak. This mutation had already been suggested to be directly responsible for a significant increase in CHIKV infectivity in Aedes albopictus. The badly affected districts in Kerala State during 2007 have abundant rubber plantations, which supported prolific breeding of Ae. albopictus mosquitoes. The abundance of Ae. albopictus in the region and molecular evolution of CHIKV may be contributing factors for the renewed epidemic of chikungunya fever during 2007.

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