scholarly journals Vector competence of Aedes albopictus for the Indian Ocean lineage (IOL) chikungunya viruses of the 2007 and 2017 outbreaks in Italy: a comparison between strains with and without the E1:A226V mutation

2018 ◽  
Vol 23 (22) ◽  
Author(s):  
Claudia Fortuna ◽  
Luciano Toma ◽  
Maria Elena Remoli ◽  
Antonello Amendola ◽  
Francesco Severini ◽  
...  
Keyword(s):  
Indian Ocean ◽  
Aedes Albopictus ◽  
Chikungunya Virus ◽  
Vector Competence ◽  
Mosquito Species ◽  
Italian Population ◽  
Emilia Romagna Region ◽  
The Indian Ocean ◽  
A226v Mutation

We compared the vector competence of an Italian population of Aedes albopictus for two strains of chikungunya virus (CHIKV), with and without E1:A226V mutation, responsible for outbreaks in 2007 in the Emilia Romagna region and 2017 in the Lazio and Calabria regions, respectively. Ae. albopictus showed similar vector competence for both viral strains indicating that E1:A226V mutation is not exclusively responsible for ability of CHIKV to replicate well in this mosquito species.

scholarly journals Chikungunya: epidemiology

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 82 ◽  
Author(s):  
Lyle R. Petersen ◽  
Ann M. Powers
Keyword(s):  
Public Health ◽  
Aedes Aegypti ◽  
Aedes Albopictus ◽  
Chikungunya Virus ◽  
Mosquito Species ◽  
Febrile Illness ◽  
Current Understanding ◽  
Global Public Health ◽  
Temperate Climates

Chikungunya virus is a mosquito-borne alphavirus that causes fever and debilitating joint pains in humans. Joint pains may last months or years. It is vectored primarily by the tropical and sub-tropical mosquito, Aedes aegypti, but is also found to be transmitted by Aedes albopictus, a mosquito species that can also be found in more temperate climates. In recent years, the virus has risen from relative obscurity to become a global public health menace affecting millions of persons throughout the tropical and sub-tropical world and, as such, has also become a frequent cause of travel-associated febrile illness. In this review, we discuss our current understanding of the biological and sociological underpinnings of its emergence and its future global outlook.

scholarly journals Complete Coding Sequence of a Chikungunya Virus Strain Imported into Slovenia from Thailand in Late 2018

2019 ◽  
Vol 8 (37) ◽  
Author(s):  
Samo Zakotnik ◽  
Misa Korva ◽  
Nataša Knap ◽  
Barbara Robnik ◽  
Nina Gorišek Miksić ◽  
...  
Keyword(s):  
Cell Culture ◽  
Phylogenetic Analysis ◽  
Envelope Protein ◽  
Viral Genome ◽  
Chikungunya Virus ◽  
Whole Genome ◽  
Reverse Transcription Pcr ◽  
The Indian Ocean ◽  
Complete Viral Genome ◽  
A226v Mutation

A case of chikungunya virus infection was imported from Thailand into Slovenia in late 2018. The infection was diagnosed using real-time reverse transcription-PCR, the virus was isolated in cell culture, and the whole genome was sequenced. Phylogenetic analysis of the nearly complete viral genome indicated that the virus belongs to the Indian Ocean lineage but does not possess the A226V mutation in the envelope protein E1.

scholarly journals Chikungunya: an emerging and spreading arthropod-borne viral disease.

2009 ◽  
Vol 3 (10) ◽  
pp. 744-752 ◽  
Author(s):  
Francesca Cavrini ◽  
Paolo Gaibani ◽  
Anna Maria Pierro ◽  
Giada Rossini ◽  
Maria Paola Landini ◽  
...  
Keyword(s):  
Developing Countries ◽  
Indian Ocean ◽  
Chikungunya Virus ◽  
Research Work ◽  
Viral Disease ◽  
La Réunion ◽  
Viremic Patient ◽  
The Indian Ocean ◽  
Clinical Pictures ◽  
Local Transmission

The infection caused by the virus Chikungunya is known since the last 50 years, but since the disease was mainly diffuse in geographical areas located in developing countries, a few research work have been made available until the appearance of an important epidemiological outbreak in 2005 in the island of La Reunion, that is part of metropolitan France even if located in the Southern Eastern part of the Indian Ocean. In 2007, a smaller outbreak of Chikungunya developed in the Northern Eastern part of Italy, where the local transmission has been made possible by the enormous population of Aedes albopictus and the presence of a viremic patient coming from the Indian Ocean area. Nowadays, Chikungunya is spreading in Southeast Asia countries, including Indonesia, Malaysia, Thailand and Singapore. This paper reviews different aspects of the disease caused by Chikungunya virus, including: history, epidemiology, biological and pathogenetic aspects, clinical pictures, diagnosis and treatment.

scholarly journals Tracking epidemic Chikungunya virus into the Indian Ocean from East Africa

2008 ◽  
Vol 89 (11) ◽  
pp. 2754-2760 ◽  
Author(s):  
M. Kariuki Njenga ◽  
L. Nderitu ◽  
J. P. Ledermann ◽  
A. Ndirangu ◽  
C. H. Logue ◽  
...  
Keyword(s):  
Indian Ocean ◽  
East Africa ◽  
Chikungunya Virus ◽  
Mosquito Vectors ◽  
East African ◽  
Genetic Elements ◽  
Coastal Kenya ◽  
New Variant ◽  
The Indian Ocean ◽  
African Clade

The largest documented outbreak of Chikungunya virus (CHIKV) disease occurred in the Indian Ocean islands and India during 2004–2007. The magnitude of this outbreak led to speculation that a new variant of the virus had emerged that was either more virulent or more easily transmitted by mosquito vectors. To study this assertion, it is important to know the origin of the virus and how the particular strain circulating during the outbreak is related to other known strains. This study genetically characterized isolates of CHIKV obtained from Mombasa and Lamu Island, Kenya, during 2004, as well as strains from the 2005 outbreak recorded in Comoros. The results of these analyses demonstrated that the virus responsible for the epidemic that spread through the Indian Ocean originated in coastal Kenya during 2004 and that the closest known ancestors are members of the Central/East African clade. Genetic elements that may be responsible for the scope of the outbreak were also identified.

scholarly journals Underdiagnosis of Chikungunya Virus Infections in Symptomatic Dutch Travelers Returning From the Indian Ocean Area: Table 1

2013 ◽  
Vol 20 (1) ◽  
pp. 44-46 ◽  
Author(s):  
Chantal B.E.M. Reusken ◽  
Jacinta Bakker ◽  
Johan H.J. Reimerink ◽  
Hana Zelena ◽  
Marion G.P. Koopmans
Keyword(s):  
Indian Ocean ◽  
Chikungunya Virus ◽  
Virus Infections ◽  
Ocean Area ◽  
The Indian Ocean

scholarly journals Blood Meals With Active and Heat-Inactivated Serum Modifies the Gene Expression and Microbiome of Aedes albopictus

2021 ◽  
Vol 12 ◽  
Author(s):  
Arley Calle-Tobón ◽  
Andres F. Holguin-Rocha ◽  
Celois Moore ◽  
Meagan Rippee-Brooks ◽  
Paula Rozo-Lopez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Aedes Albopictus ◽  
Control Strategies ◽  
Vector Competence ◽  
Mosquito Species ◽  
Normal Serum ◽  
Heat Inactivation ◽  
Global Public Health ◽  
Host Interaction ◽  
Asian Tiger

The Asian “tiger mosquito” Aedes albopictus is currently the most widely distributed disease-transmitting mosquito in the world. Its geographical expansion has also allowed the expansion of multiple arboviruses like dengue, Zika, and chikungunya, to higher latitudes. Due to the enormous risk to global public health caused by mosquitoes species vectors of human disease, and the challenges in slowing their expansion, it is necessary to develop new and environmentally friendly vector control strategies. Among these, host-associated microbiome-based strategies have emerged as promising options. In this study, we performed an RNA-seq analysis on dissected abdomens of Ae. albopictus females from Manhattan, KS, United States fed with sugar and human blood containing either normal or heat-inactivated serum, to evaluate the effect of heat inactivation on gene expression, the bacteriome transcripts and the RNA virome of this mosquito species. Our results showed at least 600 genes with modified expression profile when mosquitoes were fed with normal vs. heat-inactivated-containing blood. These genes were mainly involved in immunity, oxidative stress, lipid metabolism, and oogenesis. Also, we observed bacteriome changes with an increase in transcripts of Actinobacteria, Rhodospirillaceae, and Anaplasmataceae at 6 h post-feeding. We also found that feeding with normal blood seems to particularly influence Wolbachia metabolism, demonstrated by a significant increase in transcripts of this bacteria in mosquitoes fed with blood containing normal serum. However, no differences were observed in the virome core of this mosquito population. These results suggest that heat and further inactivation of complement proteins in human serum may have profound effect on mosquito and microbiome metabolism, which could influence interpretation of the pathogen-host interaction findings when using this type of reagents specially when measuring the effect of Wolbachia in vector competence.

scholarly journals Experimental risk assessment for chikungunya virus transmission based on vector competence, distribution and temperature suitability in Europe, 2018

2018 ◽  
Vol 23 (29) ◽  
Author(s):  
Anna Heitmann ◽  
Stephanie Jansen ◽  
Renke Lühken ◽  
Michelle Helms ◽  
Björn Pluskota ◽  
...  
Keyword(s):  
Central Europe ◽  
Chikungunya Virus ◽  
Vector Competence ◽  
Virus Transmission ◽  
Control Measures ◽  
Italian Population ◽  
Entomological Surveillance ◽  
Spatial Risk ◽  
Mosquito Saliva ◽  
Vector Distribution

Background Over the last decade, the abundant distribution of the Asian tiger mosquito Aedes albopictus in southern Europe and the import of chikungunya virus (CHIKV) by infected travellers has resulted in at least five local outbreaks of chikungunya fever in France and Italy. Considering the ongoing spread of Ae. albopictus to central Europe, we performed an analysis of the Europe-wide spatial risk of CHIKV transmission under different temperature conditions. Methods: Ae. albopictus specimens from Germany and Italy were orally infected with CHIKV from an outbreak in France and kept for two weeks at 18 °C, 21 °C or 24 °C. A salivation assay was conducted to detect infectious CHIKV. Results: Analyses of mosquito saliva for infectious virus particles demonstrated transmission rates (TRs) of > 35%. Highest TRs of 50% for the mosquito population from Germany were detected at 18 °C, while the Italian population had highest TRs of 63% at 18 °C and 21 °C, respectively. Temperature data indicated a potential risk of CHIKV transmission for extended durations, i.e. sufficiently long time periods allowing extrinsic incubation of the virus. This was shown for areas already colonised by Ae. albopictus, as well as for large parts of central Europe that are not colonised. Conclusion: The current risk of CHIKV transmission in Europe is not primarily restricted by temperature, which allows extrinsic incubation of the virus, but rather by the vector distribution. Accordingly, all European countries with established populations of Ae. albopictus should implement respective entomological surveillance and monitoring systems, as basis for suitable control measures.

scholarly journals The native European Aedes geniculatus mosquito species can transmit Chikungunya virus

2019 ◽  
Author(s):  
Jorian Prudhomme ◽  
Albin Fontaine ◽  
Guillaume Lacour ◽  
Jean-Charles Gantier ◽  
Laure Diancourt ◽  
...  
Keyword(s):  
Chikungunya Virus ◽  
Vector Competence ◽  
Mosquito Species ◽  
Cumulative Distribution ◽  
Mosquito Vector ◽  
Indigenous Species ◽  
Chikv Infection ◽  
Invasive Mosquito ◽  
Virus Emergence

AbstractEurope is the world’s leading tourism destination and is receiving every year travelers from areas with active arbovirus transmission. There is thus a threat of mosquito-borne virus emergence in Europe due to the presence of the invasive mosquito vector Aedes albopictus. Little attention has been paid about the possible role of indigenous mosquito species as vectors of emerging arboviruses. Here, we assessed the vector competence dynamic of Ae. geniculatus, a European anthropophilic mosquito species, for chikungunya virus (CHIKV) in comparison with Ae. albopictus.We revealed that Ae. geniculatus was highly susceptible to CHIKV infection and could transmit the virus. By specifically exploring the vector competence dynamic in both mosquito species, we revealed that the cumulative distribution of CHIKV incubation period in Ae. geniculatus was delayed by several days as compared to Ae. albopictus.Our results strengthen the importance of considering indigenous species as potential vectors for emerging arboviruses. They also revealed the importance of considering variation in arbovirus dissemination or transmission dynamics in mosquitoes when performing vector competence assays. We will discuss the implications of our results on a CHIKV outbreak dynamic in a theoretical framework.Sentence summaryThe European mosquito Aedes geniculatus is highly susceptible to CHIKV infection but disseminate and transmit the virus several days later than Ae. albopictus.

scholarly journals Vector competence of Italian Aedes albopictus populations for the chikungunya virus (E1-226V)

2018 ◽  
Vol 12 (4) ◽  
pp. e0006435 ◽  
Author(s):  
Francesco Severini ◽  
Daniela Boccolini ◽  
Claudia Fortuna ◽  
Marco Di Luca ◽  
Luciano Toma ◽  
...  
Keyword(s):  
Aedes Albopictus ◽  
Chikungunya Virus ◽  
Vector Competence
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