scholarly journals Altered characteristics of silica nanoparticles in bovine and human serum: the importance of nanomaterial characterization prior to its toxicological evaluation

2013 ◽  
Vol 10 (1) ◽  
pp. 56 ◽  
Author(s):  
Emilia Izak-Nau ◽  
Matthias Voetz ◽  
Stefanie Eiden ◽  
Albert Duschl ◽  
Victor F Puntes
Keyword(s):  
Human Serum ◽  
Silica Nanoparticles ◽  
Toxicological Evaluation ◽  
Nanomaterial Characterization

Human serum albumin binding to silica nanoparticles – effect of protein fatty acid ligand

2014 ◽  
Vol 16 (21) ◽  
pp. 10157-10168 ◽  
Author(s):  
Joo Chuan Ang ◽  
Mark J. Henderson ◽  
Richard A. Campbell ◽  
Jhih-Min Lin ◽  
Peter N. Yaron ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Time Dependence ◽  
Human Serum ◽  
Silica Nanoparticles ◽  
Albumin Binding ◽  
Acid Ligand ◽  
Human Serum Albumin Binding ◽  
Albumin Adsorption

Fat containing and defatted human serum albumin adsorption to silica nanoparticles have different structures and time dependence to form.

Physicochemical and toxicological evaluation of silica nanoparticles suitable for food and consumer products collected by following the EC recommendation

2015 ◽  
Vol 408 (1) ◽  
pp. 271-286 ◽  
Author(s):  
Catia Contado ◽  
Jorge Mejia ◽  
Omar Lozano García ◽  
Jean-Pascal Piret ◽  
Elise Dumortier ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Consumer Products ◽  
Toxicological Evaluation

scholarly journals Toxicological Evaluation of Luminescent Silica Nanoparticles as New Drug Nanocarriers in Different Cancer Cell Lines

Materials ◽  
2018 ◽  
Vol 11 (8) ◽  
pp. 1310 ◽  
Author(s):  
Gonçalo Marcelo ◽  
Jessica Ariana-Machado ◽  
Maria Enea ◽  
Helena Carmo ◽  
Benito Rodríguez-González ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cell Lines ◽  
Mesoporous Silica Nanoparticles ◽  
Ir Absorption ◽  
Drug Release Profile ◽  
Toxicological Evaluation ◽  
Significant Toxicity ◽  
Absorption And Emission Spectroscopy

Luminescent mesoporous silica nanoparticles, CdTeQDs@MNs@PEG1, SiQDs@Isoc@MNs and SiQDs@Isoc@MNs@PEG2, were successfully synthetized and characterized by SEM, TEM, XRD, N2 nitrogen isotherms, 1H NMR, IR, absorption, and emission spectroscopy. Cytotoxic evaluation of these nanoparticles was performed in relevant in vitro cell models, such as human hepatoma HepG2, human brain endothelial (hCMEC/D3), and human epithelial colorectal adenocarcinoma (Caco-2) cell lines. None of the tested nanoparticles showed significant cytotoxicity in any of the three performed assays (MTT/NR/ LDH) compared with the respective solvent and/or coating controls, excepting for CdTeQDs@MNs@PEG1 nanoparticles, where significant toxicity was noticed in hCMEC/D3 cells. The results presented reveal that SiQDs-based mesoporous silica nanoparticles are promising nanoplatforms for cancer treatment, with a pH-responsive drug release profile and the ability to load 80% of doxorubicin.

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