Efficacy of tibolone and raloxifene for the maintenance of skeletal muscle strength, bone mineral density, balance, body composition, cognitive function, mood/depression, anxiety and quality of life/well-being in late postmenopausal women ≥ 70 years: Study design of a randomized, double-blind, double-dummy, placebo-controlled, single-center trial

Osteoporosis and sarcopenia are two age-related diseases that affect the quality of life in the elderly. Initially, they were thought to be two independent diseases; however, recently, increasing basic and clinical data suggest that skeletal muscle and bone are both spatially and metabolically connected. The term “osteosarcopenia” is used to define a condition of synergy of low bone mineral density with muscle atrophy and hypofunction. Bone and muscle cells secrete several factors, such as cytokines, myokines, and osteokines, into the circulation to influence the biological and pathological activities in local and distant organs and cells. Recent studies reveal that extracellular vesicles containing microRNAs derived from senescent skeletal muscle and bone cells can also be transported and aid in regulating bone-muscle crosstalk. In this review, we summarize the age-related changes in the secretome and extracellular vesicle-microRNAs secreted by the muscle and bone, and discuss their interactions between muscle and bone cells during aging.

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Seven years of follow up of trabecular bone score, bone mineral density, body composition and quality of life in adults with growth hormone deficiency treated with rhGH replacement in a single center

Therapeutic Advances in Endocrinology and Metabolism ◽

10.1177/2042018816643908 ◽

2016 ◽

Vol 7 (3) ◽

pp. 93-100 ◽

Cited By ~ 10

Author(s):

Gonzalo Allo Miguel ◽

Alicia Serraclara Plá ◽

Myriam Lorena Partida Muñoz ◽

Guillermo Martínez Díaz-Guerra ◽

Federico Hawkins

Keyword(s):

Quality Of Life ◽

Bone Mineral Density ◽

Growth Hormone ◽

Body Composition ◽

Trabecular Bone Score ◽

Hormone Deficiency ◽

Single Center ◽

Mineral Density

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Faculty Opinions recommendation of Seven years of follow up of trabecular bone score, bone mineral density, body composition and quality of life in adults with growth hormone deficiency treated with rhGH replacement in a single center.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726429846.793538661 ◽

2017 ◽

Author(s):

Cesar Boguszewski

Keyword(s):

Quality Of Life ◽

Bone Mineral Density ◽

Growth Hormone ◽

Body Composition ◽

Trabecular Bone Score ◽

Hormone Deficiency ◽

Single Center ◽

Mineral Density

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Quality of life assessment (PedsQL) in children at risk of disuse osteoporosis: Decreases of appendicular bone mineral density is associated to a greater body pain

Bone ◽

10.1016/j.bone.2007.04.104 ◽

2007 ◽

Vol 40 (6) ◽

pp. S73

Author(s):

M.L. Reyes ◽

M. Hernández ◽

C. Samsó ◽

M.P. Palma ◽

R. Escobar ◽

...

Keyword(s):

Quality Of Life ◽

Bone Mineral Density ◽

At Risk ◽

Bone Mineral ◽

Life Assessment ◽

Children At Risk ◽

Disuse Osteoporosis ◽

Mineral Density ◽

Quality Of Life Assessment

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Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized, Placebo-Controlled Study

Nutrients ◽

10.3390/nu12041159 ◽

2020 ◽

Vol 12 (4) ◽

pp. 1159 ◽

Cited By ~ 1

Author(s):

Erin D. Lewis ◽

Joseph M. Antony ◽

David C. Crowley ◽

Amanda Piano ◽

Renu Bhardwaj ◽

...

Keyword(s):

Quality Of Life ◽

Irritable Bowel Syndrome ◽

Bifidobacterium Longum ◽

Well Being ◽

Lactobacillus Paracasei ◽

Controlled Study ◽

Double Blind ◽

Gi Symptoms ◽

Irritable Bowel

Specific probiotic strains can alleviate the gastrointestinal (GI) symptoms and psychiatric comorbidities of irritable bowel syndrome (IBS). In this randomized, double-blind, placebo-controlled study, the efficacy of Lactobacillus paracasei HA-196 (L. paracasei) and Bifidobacterium longum R0175 (B. longum) in reducing the GI and psychological symptoms of IBS was evaluated in 251 adults with either constipation (IBS-C), diarrhea (IBS-D), or mixed-pattern (IBS-M). Following a 2-week run-in period, participants were randomized to one of three interventions: L. paracasei (n = 84), B. longum (n = 83) or placebo (n = 81). IBS symptoms, stool frequency and consistency and quality of life were assessed by questionnaires. The differences from baseline in the severity of IBS symptoms at 4 and 8 weeks were similar between groups. Participants in this study were classified, after randomization, into subtypes according to Rome III. Within the L. paracasei group, complete spontaneous and spontaneous bowel movement frequency increased in participants with IBS-C (n = 10) after 8 weeks of supplementation (both p < 0.05) and decreased in participants with IBS-D (n = 10, p = 0.013). Both L. paracasei and B. longum supplementation improved the quality of life in emotional well-being and social functioning compared with baseline (all p < 0.05). In conclusion, L. paracasei and B. longum may reduce GI symptom severity and improve the psychological well-being of individuals with certain IBS subtypes.

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The risk of fracture and prevalence of osteoporosis is elevated in patients with idiopathic inflammatory myopathies: data from a single Hungarian center

10.21203/rs.2.20056/v1 ◽

2020 ◽

Author(s):

Anett Vincze ◽

Levente Bodoki ◽

Katalin Szabó ◽

Melinda Nagy-Vincze ◽

Orsolya Szalmás ◽

...

Keyword(s):

Quality Of Life ◽

Rheumatoid Arthritis ◽

Bone Mineral Density ◽

Fracture Risk ◽

Physical Function ◽

Inflammatory Myopathies ◽

Mineral Density ◽

Fracture Prevalence ◽

Prevalence Of Osteoporosis

Abstract Background: The prevalence of osteoporosis and risk of fractures is elevated in rheumatoid arthritis, but we have little information about the bone mineral density and fracture risk in patients with inflammatory myopathies. We intended to ascertain and compare fracture risk, bone mineral density (BMD) and the prevalence of vertebral fractures in patients with inflammatory myositis and rheumatoid arthritis (RA) and to assess the effect of prevalent fractures on the quality of life and functional capacity. Methods: Fifty-two patients with myositis and 43 patients with rheumatoid arthritis were included in the study. Fracture Risk was determined using FRAX® Calculation Tool developed by the University of Sheffield. Dual energy X-ray absorptiometry and bidirectional thoracolumbar radiographs were performed to assess BMD and vertebral fractures. Quality of life was measured with Short Form-36 (SF-36) and physical function assessment was performed using Health Assessment Questionnaire (HAQ). Results: We found a significantly elevated fracture risk in RA compared to myositis patients if the risk assessment was performed without the application of the BMD results. If BMD results and glucocorticoid dose adjustment were taken into account, the differences in fracture risk were no longer significant. The prevalence of osteoporosis was found to be significantly higher in the myositis group (7% vs. 13.5%, p: 0,045), but the fracture prevalence was similar in the two groups (75% vs. 68%). The fractures rates were associated with age in both groups, but not with cumulative dose of steroid and BMD results correlated with fracture prevalence only in the RA patients. The number of prevalent fractures was significantly correlated to poorer physical function in both groups, and poorer health status in the myositis group, but not in the RA group. Conclusions: Our findings suggest that inflammatory myopathies carry significantly elevated risk for osteoporosis and fractures. This higher risk is comparable to one detected with RA in studies and strongly affects the physical function and quality of life of patients. Therefore further efforts are required to make the fracture risk assessment reliable and to facilitate the use early preventive treatments.

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Effects of High-impact Exercises on Bone Mineral Density, Bone Turnover Marker, Quality of Life and Depressive Symptoms in Postmenopausal Women: A Randomized Controlled Trial

PM&R ◽

10.1016/j.pmrj.2013.08.020 ◽

2013 ◽

Vol 5 ◽

pp. S135-S135

Author(s):

Sina Esmaeilzadeh ◽

Ekin I. Sen ◽

Hande Basat ◽

Nurten Eskiyurt

Keyword(s):

Quality Of Life ◽

Bone Mineral Density ◽

Randomized Controlled Trial ◽

Depressive Symptoms ◽

Bone Turnover Marker ◽

Controlled Trial ◽

High Impact ◽

Mineral Density ◽

Randomized Controlled

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Metabolic and musculoskeletal effects of cystic fibrosis

10.1093/med/9780198702948.003.0009 ◽

2015 ◽

Author(s):

Uta Hill ◽

Jane Ashbrook ◽

Charles Haworth

Keyword(s):

Quality Of Life ◽

Bone Mineral Density ◽

Urinary Incontinence ◽

Bone Mineral ◽

Negative Impact ◽

Fragility Fractures ◽

Pulmonary Complications ◽

Mineral Density ◽

Airway Clearance

This chapter provides a comprehensive update on the prevention, recognition, and treatment of low bone mineral density in people with CF. As life expectancy improves, the extra-pulmonary complications of CF are becoming increasingly important to quality of life. Up to 25 per cent of CF patients have reduced bone mineral density in adulthood, leading to the development of fragility fractures which cause pain, thereby interfering with airway clearance and predisposing to pulmonary infection. Osteoporosis can be a relative contraindication for lung transplantation. Other important musculoskeletal issues including CF arthropathy, growth, and urinary incontinence are covered. CF arthropathy is a non-erosive episodic sero-negative arthritis, often difficult to treat and which may require specialist input. Urinary incontinence is common girls and women with CF and has a negative impact on quality of life and ability to complete therapies. The pathophysiology and management of urinary incontinence are discussed.

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