scholarly journals Proton therapy versus photon radiation therapy for the management of a recurrent desmoid tumor of the right flank: a case report

2012 ◽  
Vol 7 (1) ◽  
Author(s):  
Whoon Jong Kil ◽  
R Charles Nichols ◽  
John W Kilkenny ◽  
Soon Y Huh ◽  
Meng Wei Ho ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Case Report ◽  
Proton Therapy ◽  
Desmoid Tumor ◽  
Photon Radiation ◽  
The Right

scholarly journals A New Proton Therapy Solution Provides Superior Cardiac Sparing Compared With Photon Therapy in Whole Lung Irradiation for Pediatric Tumor Patients

2021 ◽  
Vol 10 ◽  
Author(s):  
Xue Sha ◽  
Jinghao Duan ◽  
Xiutong Lin ◽  
Jian Zhu ◽  
Ruohui Zhang ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Proton Therapy ◽  
Target Volume ◽  
Photon Radiation ◽  
Intensity Modulated ◽  
Lung Irradiation ◽  
Dose Sparing ◽  
The Right ◽  
Whole Lung Irradiation ◽  
Cardiac Sparing

ObjectiveWhole lung irradiation (WLI) plays a crucial role in local control in pediatric patients with lung metastases and improves patient survival. The intention of this research was to explore the advantage of cardiac sparing between photons and protons during WLI. We also propose a new solution for cardiac sparing with proton techniques.MethodsEleven patients with pediatric tumors and pulmonary metastasis treated with 12 Gy WLI (all received volumetric-modulated arc therapy (VMAT)) in our institute between 2010 and 2019 were retrospectively selected. Each patient was replanned with intensity-modulated radiation therapy (IMRT), helical tomotherapy (HT), and two intensity-modulated proton radiotherapy (IMPT) plans (IMPT-1 and IMPT-2). IMPT-1 considered the whole lung as the planning target volume (PTV), utilizing the anteroposterior technique (0/180°). IMPT-2 was a new proton solution that we proposed in this research. This approach considered the unilateral lung as the PTV, and 3 ipsilateral fields were designed for each lung. Then, IMPT-2 was generated by summing two unilateral lung plans. The primary objective was to obtain adequate coverage (95% of the prescription dose to the PTV) while maximally sparing the dose to the heart. The PTV coverage, conformity index (CI), homogeneity index (HI), and dose–volume statistics of the heart and substructures were assessed by means of the averages of each comparison parameter.ResultsAll treatment techniques achieved the target volume coverage required by clinical practice. HT yielded the best coverage and homogeneity for the target structure compared with other techniques. The CI from IMRT was excellent. For photon radiation therapy, the HT plan afforded superior dose sparing for the V5, V6, V7, V8, and Dmean of the heart and Dmean of the right ventricle (RV). IMRT displayed the most notable dose reductions in the V9, V10, V11, and V12 of the heart and Dmean of the right atrium (RA). The VMAT plan was the least effective on the heart and substructures. However, compared with photon radiation therapy, IMPT-1 did not show an advantage for heart protection. Interestingly, IMPT-2 provided significant superiority in cardiac sparing, including maximum dose sparing for the V5, V6, V7, V8, V9 and Dmean of the heart and Dmean of the RA, RV, left atrium (LA) and left ventricle (LV) compared to all other techniques.ConclusionsConsidering the complex anatomical relation between target volumes and organs at risk (OARs), IMPT can provide a dose advantage for organs located outside of the target area rather than within or surrounding the area. It is hoped that advances in proton therapy (PT) plan design will lead to further improvements in radiotherapy approaches and provide the best treatment choice for individual patients.

The Main Directions of Clinical Application of Modern Proton Therapy

2019 ◽  
pp. 41-51
Author(s):  
А. Самойлов ◽  
A. Samoylov ◽  
Ж. Смирнова ◽  
Zh. Smirnova ◽  
В. Климанов ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Clinical Application ◽  
Proton Therapy ◽  
Clinical Studies ◽  
Photon Radiation ◽  
Proton Radiation ◽  
Proton Radiation Therapy ◽  
Current State ◽  
The Cost

This paper analyzes the current state of clinical application of proton radiation therapy (PRT) for the treatment of cancer. In particular, the indications for the use of PRT for the treatment of specific pathologies, the results and condition of randomized clinical studies of PRT compared to photon radiation therapy (PhRT) are considered, the cost of PRT is compared with the cost of PhRT. The focus is on discussing the results of PRT using in advanced countriesand Russia for the treatment of several common tumor sites. In the conclusion of the work, the ways of further improvement of radiobiology, dose delivering technology and dosimetric support of PRT are considered.

scholarly journals The Future of Proton Therapy

2021 ◽  
Author(s):  
Thomas J. FitzGerald ◽  
Linda Ding ◽  
R.T. Christopher Riberdy ◽  
Jack Bailey ◽  
Michael Anderegg ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Proton Therapy ◽  
Image Guidance ◽  
Standard Treatment ◽  
Intensity Modulation ◽  
Photon Radiation ◽  
Rapid Rate ◽  
Delivery Of Care ◽  
Process Improvements ◽  
The Future

Proton therapy is increasing in utilization worldwide at a rapid rate. With process improvements in costs, footprints, and continued advances in the delivery of care, including intensity modulation and image guidance, proton therapy may evolve into standard treatment with photon radiation therapy. This chapter reviews process improvements in proton therapy and the application in modern care.

Contralateral Trigeminal Dysaesthesias Associated with Second Cervical Nerve Compression: A Case Report

Cephalalgia ◽  
1990 ◽  
Vol 10 (5) ◽  
pp. 259-262 ◽  
Author(s):  
William S Rosenberg ◽  
Brooke Swearingen ◽  
Charles E Poletti
Keyword(s):  
Experimental Data ◽  
Radiation Therapy ◽  
Case Report ◽  
Metastatic Lesion ◽  
Cervical Lesion ◽  
Nerve Compression ◽  
Neural Pathways ◽  
Cervical Lesions ◽  
Cervical Nerve ◽  
The Right

This 70–year-old woman presented with a left C2 solitary metastatic lesion producing ipsilateral occipital pain associated with contralateral fronto-orbital dysaesthesias. Examination revealed analgesia in the left C2 dermatome and hyperaesthesia in the right forehead. These symptoms and findings resolved following a course of radiation therapy to the C2 metastasis. Ipsilateral trigeminal dysaesthesias produced by cervical lesions have been described, however, contralateral cervicogenic trigeminal dysaesthesias have not. Relevant experimental data are analysed; neural pathways are suggested by which a cervical lesion, especially at C2 or C3, may produce trigeminal dysaesthesias referred ipsilaterally or contralaterally.

scholarly journals Pubic Osteolysis in an Elderly Masquerading as Malignancy: A Case Report and Review of Literature

2021 ◽  
Vol 11 (4) ◽  
Author(s):  
Raju Vaishya ◽  
Parv Mittal ◽  
Abhishek Vaish ◽  
Robin Khosa
Keyword(s):  
Radiation Therapy ◽  
Case Report ◽  
Osteolytic Lesion ◽  
Insufficiency Fracture ◽  
Vitamin D Supplementation ◽  
Pubic Bone ◽  
Ct Guided ◽  
Pelvic Malignancies ◽  
The Right ◽  
Enhanced Computed Tomography

Introduction: A rapidly progressive destructive lesion characterizes pubic osteolysis (PO) in the pubic bone due to an inadequate fracture healing response. It may be seen in pelvic insufficiency fractures (IF) secondary to radiation therapy (RT) of pelvic malignancies, occurring even in the absence of significant trauma. Such a radiological picture may distract the clinician towards a malignant etiology and may affect the management. Case Report: A 79- year- old female, known case of carcinoma of the urinary bladder, underwent contrast-enhanced computed tomography (CT) (CECT) of the abdomen and pelvis as a routine follow- up and was found to have an osteolytic lesion in the right pubic bone, suggesting a malignant pathology. CT- guided biopsy did not reveal any malignant or infective etiology. The patient showed recovery with conservative management. Conclusion: Osteolytic lesions of the pubic bone can often occur following radiation for pelvic malignancies. It occurs due to impaired fracture reparative response by a bone afflicted by radiation therapy RT. It can be managed effectively with conservative analgesics, bisphosphonates, calcium, and Vitamin D supplementation. The radiographic picture can imitate malignant or infective lesions and provoke invasive testing for confirmation. The clinicians need to be conscious of this clinical entity to initiate proper treatment and avoid unnecessary investigations. Keywords: Pubic Osteolysis; Insufficiency Fracture; Radiation; Pelvis.

Soft Tissues Sarcoma with Acute Paraneoplastic Hepatic Dysfunction: Case Report

1996 ◽  
Vol 82 (5) ◽  
pp. 499-501 ◽  
Author(s):  
Giancarlo Bisagni ◽  
Corrado Boni ◽  
Giovanni Fornaciari ◽  
Franco Gherlinzoni
Keyword(s):  
Radiation Therapy ◽  
Case Report ◽  
Paraneoplastic Syndrome ◽  
Soft Tissues ◽  
Hepatic Dysfunction ◽  
Fibrous Histiocytoma ◽  
Laboratory Data ◽  
Distant Metastases ◽  
Complete Removal ◽  
The Right

A case of malignant fibrous histiocytoma of soft tissues of the right scapula associated with transitory hepatic dysfunction in the absence of liver metastases is reported. After primary radiation therapy, the patient manifested fever, anemia, thrombocytosis and hepatic dysfunction. All the abnormalities disappeared immediately after complete removal of the tumor. The patient was well, with no evidence of distant metastases, at more than 12 months later. It is concluded that the abnormalities of laboratory data were indirectly induced by the tumor, although the exact mechanism of this paraneoplastic syndrome was not clarified.

scholarly journals Hypofractionated Stereotactic Radiation Therapy for Metastatic Adenocarcinoma ex Goblet Cell Carcinoid of the Appendix: Case Report and Literature Review

2019 ◽  
Vol 12 (3) ◽  
pp. 807-813
Author(s):  
Joseph W. Clyde ◽  
Alan W. Katz
Keyword(s):  
Radiation Therapy ◽  
Case Report ◽  
Goblet Cell ◽  
Right Hemicolectomy ◽  
Goblet Cell Carcinoid ◽  
Stereotactic Radiation ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Gallium 68 ◽  
The Right

Adenocarcinoma ex-goblet carcinoid (ADA ex-GCC) is a rare and aggressive subtype of goblet cell carcinoid, a distinct tumor of the appendix characterized by both neuroendocrine and glandular differentiation. Patients often present with chronic abdominal pain or symptoms of acute appendicitis. Right hemicolectomy is the primary mode of treatment, and prophylactic salpingo-oophorectomy and hysterectomy is recommended in post-menopausal women due to the tumor’s propensity of transcoelemic spread, especially to the ovaries. In this case report, we describe a patient with ADA ex-GCC who was found to have oligometastic disease in the pelvis and treated with hypofractionated stereotactic body radiation therapy (HSRT). She initially underwent a right hemicolectomy followed by adjuvant capecitabine four years prior when her tumor was incidentally discovered on colonoscopy. She subsequently had a salpingo-oophorectomy for gynecologic tract metastatic disease and declined further chemotherapy. The patient was again discovered to have oligometastatic disease in the right pelvis adjacent to the rectum on a Gallium-68 dotatate PET/MRI, and was subsequently treated with HSRT to 39 Gy in 6.5 Gy daily fractions. The patient tolerated her radiation course without notable radiation-related toxicity, and she remains without disease progression nine months later.

125 Planning study comparing the use of photon radiation therapy to proton therapy for superior sulcus tumours (SSTs)

Lung Cancer ◽  
2016 ◽  
Vol 91 ◽  
pp. S45
Author(s):  
S. Wong ◽  
J. Alshaikhi ◽  
N. Lalli ◽  
P. Bhudia ◽  
D. D'Souza ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Proton Therapy ◽  
Photon Radiation ◽  
Planning Study ◽  
Superior Sulcus
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