scholarly journals Urinary bladder carcinoma with triplicate differentiations into giant cell sarcomatoid carcinoma, squamous cell carcinoma, and papillary urothelial transitional cell carcinoma: a case report

Cases Journal ◽  
2009 ◽  
Vol 2 (1) ◽  
Author(s):  
Tadashi Terada
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Bladder Carcinoma ◽  
Transitional Cell ◽  
Sarcomatoid Carcinoma ◽  
Urinary Bladder Carcinoma ◽  
Carcinoma Squamous Cell

scholarly journals Role of TGF-?1 in Urinary Bladder Carcinoma

2014 ◽  
Vol 11 (4) ◽  
pp. 1481-1485 ◽  
Author(s):  
Baghdad Science Journal
Keyword(s):  
Serum Level ◽  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Bladder Carcinoma ◽  
Transitional Cell ◽  
Serum Levels ◽  
Elisa Test ◽  
Urinary Bladder Carcinoma ◽  
Tumor Stages

The present study aimed to evaluate sera TGF- ?1 concentration in patients with urinary bladder carcinoma (UBC). All malignant of them was transitional cell carcinoma (TCC) type , patients with urinary bladder disorders (UBD ) and healthy control , and to study the correlation between sera TGF-?1 levels and tumor stages and grades in UBC patients . A direct ELISA test was used to quantify the seraTGF-?1 concentrations in sera of 58 patients with urinary bladder carcinoma UBC of different grades (G) and stages (T) all malignant of them was transitional cell carcinoma (TCC) type , 15 from patients with UBD and 15 healthy subjects . Sera levels of TGF-?1 were elevated in patients with UBC and UBD compared to healthy (P ? 0.01) .There was no association between tumor stages and serum level of TGF-?1 (P?0.05) . Whereas there was an association between serum levels of TFG-?1 and tumor grades (p ?0.05) . Increased serum level was found in high grades G?2 of patient with UBC .

scholarly journals Case report on a very rare tumour of the urinary bladder: paraganglioma

2020 ◽  
Vol 7 (11) ◽  
pp. 1753
Author(s):  
Soumish Sengupta ◽  
Ranjan K. Dey ◽  
Abhishek Sati ◽  
Kadambari Ghosh
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Bladder Carcinoma ◽  
Transitional Cell ◽  
Neuroendocrine Cells ◽  
Carcinoma Squamous Cell ◽  
Bladder Tumours

Urinary bladder tumours are usually of three types; urothelial carcinoma, squamous cell carcinoma and adenocarcinoma. Urothelial carcinoma is the most common type of bladder carcinoma and accounts for almost 90% of all bladder carcinoma. It is also known as transitional cell carcinoma. Squamous cell carcinoma accounts for 4% and adenocarcinomas 2% of all bladder carcinomas. Urinary bladder paragangliomas are a very rare variety of bladder tumours which account for less than 0.06% of all bladder tumours. They are clusters of neuroendocrine cells associated with sympathetic and parasympathetic nervous system. Paragangliomas are tumours arising from these chromaffin cells. They are most commonly seen in the head and neck and account for about 70% of all paragangliomas. The same type of tumour when found in the adrenal glands is referred to as a pheochromocytoma. Paraganglioma is usually seen in the age group of 30 and 50 years. The tumour is often slow growing and benign. These tumours may be functional or non-functional. Functional ones present with symptoms of catecholamine excess, which include hypertension, palpitations, diaphoresis, headache, and post-micturition syncope.

High-Grade Transitional Cell Carcinoma and Melanosis of Urinary Bladder: Case Report and Review of the Literature

Urology ◽  
2009 ◽  
Vol 73 (4) ◽  
pp. 928.e13-928.e15 ◽  
Author(s):  
Sharon L. Sanborn ◽  
Gregory MacLennan ◽  
Matthew M. Cooney ◽  
Ming Zhou ◽  
Lee E. Ponsky
Keyword(s):  
Case Report ◽  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
High Grade ◽  
Review Of The Literature

scholarly journals Expression of GATA3 and Cytokeratin 14 in Urinary Bladder Carcinoma (Histopathological and Immunohistochemical Study)

2021 ◽  
Vol 9 (A) ◽  
pp. 858-864
Author(s):  
Nora Elzohery ◽  
Nourelhoda Sayed Ismael ◽  
Rasha Ahmed Khairy ◽  
Somia A. M. Soliman
Keyword(s):  
Monoclonal Antibody ◽  
Squamous Cell Carcinoma ◽  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Bladder Carcinoma ◽  
Urinary Bladder Carcinoma ◽  
Immunohistochemical Expression ◽  
Immunohistochemical Marker ◽  
Cytokeratin 14

BACKGROUND: Urothelial carcinoma (UC) with squamous differentiation (SD) is the most common histologic variant of bladder carcinoma and its presence is associated with poor prognosis which may need early radical cystectomy to avoid progression and recurrence. It is difficult to detect few foci of SD, especially nonkeratinizing or early switch from urothelial to squamous epithelium on only morphological basis. Combination of GATA3 and Cytokeratin 14 (CK14) could be helpful in differentiating pure UC, UC with SD and pure squamous cell carcinoma (SCC). AIM: Assessment of GATA3 and CK14 expression in urinary bladder carcinoma and correlation with clinical and histopathological variables, for both diagnostic and prognostic purposes. MATERIALS AND METHODS: Sixty cases of archived paraffin blocks of urinary bladder carcinoma were tested for GATA3 and CK14 expression by immunohistochemistry using a rabbit monoclonal antibody against human CK 14 and mouse monoclonal antibody against GATA3, respectively. RESULTS: There is a significant correlation between GATA3 immunohistochemical expression and histological tumor subtypes of bladder carcinoma (p < 0.001), i.e. the GATA3 is a useful marker for urothelial origin especially in papillary UC. There is a significant correlation between GATA3 immunohistochemical expression and UC grade (p < 0.001). CK14 showed positive cytoplasmic staining in 9/14 (64.3%) cases of UC with SD and (13/13) (100%) cases of pure SCC and negative in 33/33(100%) cases of UC other than UC with SD. CK14 had sensitivity (64.3%) and specificity (100%) for areas of SD. CONCLUSION: GATA3 is a specific immunohistochemical marker for urothelial origin. CK14 is a highly specific and sensitive immunohistochemical marker of squamous cell carcinoma.

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