scholarly journals BSA-Coated Gold Nanorods for NIR-II Photothermal Therapy

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Shubi Zhao ◽  
Yiqun Luo ◽  
Zong Chang ◽  
Chenchen Liu ◽  
Tong Li ◽  
...  
Keyword(s):  
Aspect Ratio ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Large Aspect Ratio ◽  
Long Wavelength ◽  
Cancer Tumor ◽  
Wavelength Absorption ◽  
Low Cytotoxicity ◽  
Plasma Absorption ◽  
Infrared Window

AbstractThe second near infrared window is considered to be the optimal optical window for medical imaging and therapy as its capability of deep tissue penetration. The preparation of the gold nanorods with long wavelength absorption and low cytotoxicity is still a challenge. A series gold nanorods with large aspect ratio have been synthesized. Strong plasma absorption in the second near infrared window from 1000 to 1300 nm could be observed. The biocompatibility of the synthesized gold nanorods is dramatically improved via coating by bovine serum albumin (BSA), while the optical properties of which remains. The breast cancer tumor-bearing mouse could be well treated by the prepared gold nanorods with the NIR-II light intensity as low as 0.75 W/cm2. In summary, these results demonstrate the feasibility of using low illumination dose to treat tumor in the NIR-II region via the large aspect ratio gould nanoparticles.

scholarly journals BSA-Coated Gold Nanorods for NIR-II Photothermal Therapy

2021 ◽  
Author(s):  
Shubi Zhao ◽  
Yiqun Luo ◽  
Zong Chang ◽  
Chenchen Liu ◽  
Tong Li ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Low Dose ◽  
Near Infrared ◽  
Deep Tissue ◽  
Optical Window ◽  
Tumor Bearing ◽  
Cancer Tumor ◽  
Plasma Absorption ◽  
Infrared Window

Abstract The second near infrared window is considered to be the optimal optical window for medical imaging and therapy as the deep tissue penetration. A series gold nanorods with large aspect ratio have been synthesized. Strong plasma absorption in the second near infrared window from 1000 nm to 1300 nm could be observed. The biocompatibility of the synthesized gold nanorods is dramatically improved via coating by bovine serum albumin (BSA), while the optical properties of which remains. The breast cancer tumor-bearing mouse could be well treated by the prepared gold nanorods with the NIR-II light intensity as low as 0.75 W/cm2. In summary, these results prove the feasibility of using low dose to treat tumor in the NIR-II region.

scholarly journals Facile formulation of a long-wavelength cyanine for optical imaging in the second near-infrared window

2020 ◽  
Vol 8 (15) ◽  
pp. 4199-4205
Author(s):  
Hailey I. Kilian ◽  
Homan Kang ◽  
Nikhila Nyayapathi ◽  
Takeshi Fukuda ◽  
Eeswar Adluru ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Near Infrared ◽  
Simple Formulation ◽  
Long Wavelength ◽  
Infrared Window

A dozen commercial NIR-II dyes are screened for simple formulation and one is applied for in vivo optical imaging in mice.

Synthesis and characterisation of long wavelength-absorbing donor/acceptor-substituted methine dyes

2016 ◽  
Vol 71 (6) ◽  
pp. 651-658
Author(s):  
Christoph Heichert ◽  
Horst Hartmann
Keyword(s):  
Spectral Range ◽  
Near Infrared ◽  
Long Wavelength ◽  
Iminium Salts ◽  
Infrared Spectral Range ◽  
Active Methylene Compounds ◽  
Infrared Spectral ◽  
Wavelength Absorption ◽  
Donor Acceptor ◽  
Active Methylene

AbstractBy the reaction of aromatic or heteroaromatic formyl compounds or their corresponding iminium salts with active methylene compounds a series of new methine dyes with long-wavelength absorption in the near-infrared spectral range were prepared.

scholarly journals Large aspect ratio gold nanorods (LAR-GNRs) for mid-infrared pulse generation with a tunable wavelength near 3 μm

2019 ◽  
Vol 27 (4) ◽  
pp. 4886 ◽  
Author(s):  
Hongyu Luo ◽  
Zhe Kang ◽  
Ying Gao ◽  
Hanlin Peng ◽  
Jianfeng Li ◽  
...  
Keyword(s):  
Aspect Ratio ◽  
Gold Nanorods ◽  
Pulse Generation ◽  
Large Aspect Ratio ◽  
Mid Infrared ◽  
Tunable Wavelength

One-Step Synthesis of Large-Aspect-Ratio Single-Crystalline Gold Nanorods by Using CTPAB and CTBAB Surfactants

2007 ◽  
Vol 13 (10) ◽  
pp. 2929-2936 ◽  
Author(s):  
Xiaoshan Kou ◽  
Shuzhuo Zhang ◽  
Chia-Kuang Tsung ◽  
Zhi Yang ◽  
Man Hau Yeung ◽  
...  
Keyword(s):  
Aspect Ratio ◽  
Gold Nanorods ◽  
Large Aspect Ratio ◽  
Single Crystalline ◽  
One Step

scholarly journals NeoR, a near-infrared absorbing rhodopsin

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Matthias Broser ◽  
Anika Spreen ◽  
Patrick E. Konold ◽  
Enrico Peter ◽  
Suliman Adam ◽  
...  
Keyword(s):  
Near Infrared ◽  
Fluorescence Yield ◽  
Visual Orientation ◽  
Light Activation ◽  
Long Wavelength ◽  
Wavelength Absorption ◽  
Retinal Chromophore ◽  
Fluorescent State ◽  
Photochemical Properties ◽  
High Fluorescence

Abstract The Rhizoclosmatium globosum genome encodes three rhodopsin-guanylyl cyclases (RGCs), which are predicted to facilitate visual orientation of the fungal zoospores. Here, we show that RGC1 and RGC2 function as light-activated cyclases only upon heterodimerization with RGC3 (NeoR). RGC1/2 utilize conventional green or blue-light-sensitive rhodopsins (λmax = 550 and 480 nm, respectively), with short-lived signaling states, responsible for light-activation of the enzyme. The bistable NeoR is photoswitchable between a near-infrared-sensitive (NIR, λmax = 690 nm) highly fluorescent state (QF = 0.2) and a UV-sensitive non-fluorescent state, thereby modulating the activity by NIR pre-illumination. No other rhodopsin has been reported so far to be functional as a heterooligomer, or as having such a long wavelength absorption or high fluorescence yield. Site-specific mutagenesis and hybrid quantum mechanics/molecular mechanics simulations support the idea that the unusual photochemical properties result from the rigidity of the retinal chromophore and a unique counterion triad composed of two glutamic and one aspartic acids. These findings substantially expand our understanding of the natural potential and limitations of spectral tuning in rhodopsin photoreceptors.

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