BSA-Coated Gold Nanorods for NIR-II Photothermal Therapy

The second near infrared window is considered to be the optimal optical window for medical imaging and therapy as its capability of deep tissue penetration. The preparation of the gold nanorods with long wavelength absorption and low cytotoxicity is still a challenge. A series gold nanorods with large aspect ratio have been synthesized. Strong plasma absorption in the second near infrared window from 1000 to 1300 nm could be observed. The biocompatibility of the synthesized gold nanorods is dramatically improved via coating by bovine serum albumin (BSA), while the optical properties of which remains. The breast cancer tumor-bearing mouse could be well treated by the prepared gold nanorods with the NIR-II light intensity as low as 0.75 W/cm2. In summary, these results demonstrate the feasibility of using low illumination dose to treat tumor in the NIR-II region via the large aspect ratio gould nanoparticles.

BSA-Coated Gold Nanorods for NIR-II Photothermal Therapy

The second near infrared window is considered to be the optimal optical window for medical imaging and therapy as the deep tissue penetration. A series gold nanorods with large aspect ratio have been synthesized. Strong plasma absorption in the second near infrared window from 1000 nm to 1300 nm could be observed. The biocompatibility of the synthesized gold nanorods is dramatically improved via coating by bovine serum albumin (BSA), while the optical properties of which remains. The breast cancer tumor-bearing mouse could be well treated by the prepared gold nanorods with the NIR-II light intensity as low as 0.75 W/cm2. In summary, these results prove the feasibility of using low dose to treat tumor in the NIR-II region.

Comparison of transient absorption of laser ablation plasma with fundamental plasma absorption relations

Nanosecond pulsed laser ablation plasmas were studied by time resolved shadowgraphy coupled with normal imaging, followed by laser probing and plasma spectroscopy in the 5-25 J/cm2 fluence regime. We describe methods for imaging and probing that allow us to determine variations in the distribution of ejecta in the plume and monitor the optical absorption using a probe laser to obtain a measure of the linear absorption coefficient of the plasma. Experimental determination of absorber distribution also corresponds well to the theoretical prediction of density increase near the emitted shockwave edge. We finally demonstrate that fundamental plasma correlations can accurately describe the absorption of light by the plasma near the ablation wavelength. We observed good agreement in peak attenuation, directly measuring 65% peak absorption and compared to a calculation of 57% using a simple model of the plasma, but a 10 ns shift in peak attenuation time. The shift in dip times is explained both by experimental error and a fundamental imprecision in the model proposed for the expansion.

The impact of micelle size and increased absorption of ubiquinone using a novel delivery system (AquaCelle®)

Aim: The objective of this study was to determine whether the use of a self-emulsifying drug delivery system AquaCelle®, could improve the absorption of CoQ10. Materials & methods: Fifty-seven healthy males and females completed this study with the primary outcome as change in plasma absorption of CoQ10 over a 10-h period. Results: All AquaCelle groups significantly increased CoQ10 concentrations up to three-times that of the standard CoQ10 supplement. Ubiquinone with AquaCelle achieved an equivalent absorption to ubiquinol. Conclusion: The novel delivery system AquaCelle demonstrates superior absorption for the supply of ubiquinone when compared with a standard ubiquinone extract. These results further indicate that ubiquinone with AquaCelle absorbs as effectively as the typically superior absorbing ubiquinol at the same 100 mg dose.