BSA-Coated Gold Nanorods for NIR-II Photothermal Therapy

Abstract The second near infrared window is considered to be the optimal optical window for medical imaging and therapy as the deep tissue penetration. A series gold nanorods with large aspect ratio have been synthesized. Strong plasma absorption in the second near infrared window from 1000 nm to 1300 nm could be observed. The biocompatibility of the synthesized gold nanorods is dramatically improved via coating by bovine serum albumin (BSA), while the optical properties of which remains. The breast cancer tumor-bearing mouse could be well treated by the prepared gold nanorods with the NIR-II light intensity as low as 0.75 W/cm2. In summary, these results prove the feasibility of using low dose to treat tumor in the NIR-II region.

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BSA-Coated Gold Nanorods for NIR-II Photothermal Therapy

Nanoscale Research Letters ◽

10.1186/s11671-021-03627-7 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Shubi Zhao ◽

Yiqun Luo ◽

Zong Chang ◽

Chenchen Liu ◽

Tong Li ◽

...

Keyword(s):

Aspect Ratio ◽

Gold Nanorods ◽

Near Infrared ◽

Large Aspect Ratio ◽

Long Wavelength ◽

Cancer Tumor ◽

Wavelength Absorption ◽

Low Cytotoxicity ◽

Plasma Absorption ◽

Infrared Window

AbstractThe second near infrared window is considered to be the optimal optical window for medical imaging and therapy as its capability of deep tissue penetration. The preparation of the gold nanorods with long wavelength absorption and low cytotoxicity is still a challenge. A series gold nanorods with large aspect ratio have been synthesized. Strong plasma absorption in the second near infrared window from 1000 to 1300 nm could be observed. The biocompatibility of the synthesized gold nanorods is dramatically improved via coating by bovine serum albumin (BSA), while the optical properties of which remains. The breast cancer tumor-bearing mouse could be well treated by the prepared gold nanorods with the NIR-II light intensity as low as 0.75 W/cm2. In summary, these results demonstrate the feasibility of using low illumination dose to treat tumor in the NIR-II region via the large aspect ratio gould nanoparticles.

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Semiconducting polymer-based nanoparticles for photothermal therapy at the second near-infrared window

Chemical Communications ◽

10.1039/c8cc07583b ◽

2018 ◽

Vol 54 (96) ◽

pp. 13599-13602 ◽

Cited By ~ 18

Author(s):

Zuwu Wei ◽

Ming Wu ◽

Shanyou Lan ◽

Jiong Li ◽

Xiaolong Zhang ◽

...

Keyword(s):

Light Absorption ◽

Photothermal Therapy ◽

Near Infrared ◽

Strong Light ◽

Semiconducting Polymer ◽

Optical Window ◽

Photothermal Conversion ◽

Infrared Window

We designed novel diketopyrrolopyrrole polymer based nanoparticles (DPP-IID-FA), which exhibited strong light absorption and excellent photothermal conversion in the NIR optical window, and displayed high biocompatibility and photostability.

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The impact of size and surface ligand of gold nanorods on liver cancer accumulation and photothermal therapy in the second near-infrared window

Journal of Colloid and Interface Science ◽

10.1016/j.jcis.2020.01.026 ◽

2020 ◽

Vol 565 ◽

pp. 186-196 ◽

Cited By ~ 8

Author(s):

Huang Yang ◽

Hongpeng He ◽

Zongrui Tong ◽

Haibing Xia ◽

Zhengwei Mao ◽

...

Keyword(s):

Liver Cancer ◽

Gold Nanorods ◽

Photothermal Therapy ◽

Near Infrared ◽

Surface Ligand ◽

The Impact ◽

Infrared Window

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Photothermal Therapy Using Gold Nanorods and Near-Infrared Light in a Murine Melanoma Model Increases Survival and Decreases Tumor Volume

Journal of Nanomaterials ◽

10.1155/2014/450670 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 19

Author(s):

Mary K. Popp ◽

Imane Oubou ◽

Colin Shepherd ◽

Zachary Nager ◽

Courtney Anderson ◽

...

Keyword(s):

Light Source ◽

Gold Nanorods ◽

Photothermal Therapy ◽

Near Infrared ◽

Tumor Volume ◽

Infrared Light ◽

Led Light ◽

Murine Melanoma ◽

Nir Light ◽

Melanoma Model

Photothermal therapy (PTT) treatments have shown strong potential in treating tumors through their ability to target destructive heat preferentially to tumor regions. In this paper we demonstrate that PTT in a murine melanoma model using gold nanorods (GNRs) and near-infrared (NIR) light decreases tumor volume and increases animal survival to an extent that is comparable to the current generation of melanoma drugs. GNRs, in particular, have shown a strong ability to reach ablative temperatures quickly in tumors when exposed to NIR light. The current research tests the efficacy of GNRs PTT in a difficult and fast growing murine melanoma model using a NIR light-emitting diode (LED) light source. LED light sources in the NIR spectrum could provide a safer and more practical approach to photothermal therapy than lasers. We also show that the LED light source can effectively and quickly heatin vitroandin vivomodels to ablative temperatures when combined with GNRs. We anticipate that this approach could have significant implications for human cancer therapy.

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