Asymptomatic hyperuricemia is not an independent risk factor for cardiovascular events or overall mortality in the general population of the Busselton Health Study

Abstract Background Nephronophthisis (NPHP) 4 gene encoding nephrocystin-4, which contributes to end-stage renal disease in children and young adults, is involved in the development of the heart and kidneys. Cardiorenal syndrome (CRS), which consists of bidirectional dysfunction of the heart and kidneys, is a risk factor for cardiovascular events. Single nucleotide polymorphisms (SNPs) within the NPHP4 gene are reportedly associated with kidney function, even in adults. However, the association of NPHP4 gene variability with CRS and cardiovascular events remains unknown. Purpose To examine whether NPHP4 gene variability is related to CRS and cardiovascular events in general population. Methods and results This prospective cohort study included 2,946 subjects who participated in a community-based health study with a 16-year follow-up period. We genotyped 11 SNPs within the NPHP4 gene whose minor allele frequency was greater than 0.1 in the Japanese population. The SNP rs12058375 was significantly associated with CRS and cardiovascular events. Multivariate logistic analysis demonstrated a significant association between the homozygous A-allele of rs12058375 with the presence of CRS. Haplotype analysis identified the haplotype with the A-allele of rs12058375 as an increased susceptibility factor for CRS. Kaplan-Meier analysis demonstrated that homozygous A-allele carriers of rs12058375 had the greatest risk of developing cardiovascular events among the NPHP4 variants. Multivariate Cox proportional hazard regression analysis revealed that the homozygous A-allele and heterozygous carriers of rs12058375 were associated with cardiovascular events after adjusting for confounding factors. The net reclassification index and integrated discrimination index were significantly improved by the addition of rs12058375 as a cardiovascular risk factor. Conclusion Genetic variations in the NPHP4 gene were associated with CRS and cardiovascular events in the general population, suggesting that it may facilitate the early identification of high-risk subjects with CRS and cardiovascular events. FUNDunding Acknowledgement Type of funding sources: None.

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Delta-glycated hemoglobin: A novel independent risk factor for cardiovascular events in patients without diabetes mellitus

Journal of Endocrinological Investigation ◽

10.1007/bf03346509 ◽

2009 ◽

Vol 32 (7) ◽

pp. 564-567 ◽

Cited By ~ 2

Author(s):

H. Diedrichs ◽

R. Pfister ◽

Z. Clement ◽

J. Hagemeister ◽

C. A. Schneider

Keyword(s):

Diabetes Mellitus ◽

Risk Factor ◽

Cardiovascular Events ◽

Independent Risk Factor ◽

Glycated Hemoglobin ◽

Hemoglobin A ◽

Glycated Hemoglobin A

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Cystatin C as risk factor for cardiovascular events and all-cause mortality in the general population. The Tromsø Study

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfr751 ◽

2011 ◽

Vol 27 (7) ◽

pp. 2780-2787 ◽

Cited By ~ 9

Author(s):

Ingrid Toft ◽

Marit Solbu ◽

Jens Kronborg ◽

Ulla D. Mathisen ◽

Bjørn O. Eriksen ◽

...

Keyword(s):

Risk Factor ◽

General Population ◽

Cystatin C ◽

Cardiovascular Events ◽

All Cause Mortality

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Perioperative Diastolic Dysfunction in Patients Undergoing Noncardiac Surgery Is an Independent Risk Factor for Cardiovascular Events

Anesthesiology ◽

10.1097/aln.0000000000001132 ◽

2016 ◽

Vol 125 (1) ◽

pp. 72-91 ◽

Cited By ~ 27

Author(s):

Ashraf Fayad ◽

Mohammed T. Ansari ◽

Homer Yang ◽

Terrence Ruddy ◽

George A. Wells

Keyword(s):

Risk Factor ◽

Adverse Events ◽

Diastolic Dysfunction ◽

Cardiovascular Events ◽

Independent Risk Factor ◽

Evidence Synthesis ◽

Noncardiac Surgery ◽

Cochrane Library ◽

Entire Body ◽

Google Search

Abstract Background The prognostic value of perioperative diastolic dysfunction (PDD) in patients undergoing noncardiac surgery remains uncertain, and the current guidelines do not recognize PDD as a perioperative risk factor. This systematic review aimed to investigate whether existing evidence supports PDD as an independent predictor of adverse events after noncardiac surgery. Methods Ovid MEDLINE, PubMed, EMBASE, the Cochrane Library, and Google search engine were searched for English-language citations in April 2015 investigating PDD as a risk factor for perioperative adverse events in adult patients undergoing noncardiac surgery. Two reviewers independently assessed the study risk of bias. Extracted data were verified. Random-effects model was used for meta-analysis, and reviewers’ certainty was graded. Results Seventeen studies met eligibility criteria; however, 13 contributed to evidence synthesis. The entire body of evidence addressing the research question was based on a total of 3,876 patients. PDD was significantly associated with pulmonary edema/congestive heart failure (odds ratio [OR], 3.90; 95% CI, 2.23 to 6.83; 3 studies; 996 patients), myocardial infarction (OR, 1.74; 95% CI, 1.14 to 2.67; 3 studies; 717 patients), and the composite outcome of major adverse cardiovascular events (OR, 2.03; 95% CI, 1.24 to 3.32; 4 studies; 1,814 patients). Evidence addressing other outcomes had low statistical power, but higher long-term cardiovascular mortality was observed in patients undergoing open vascular repair (OR, 3.00; 95% CI, 1.50 to 6.00). Reviewers’ overall certainty of the evidence was moderate. Conclusion Evidence of moderate certainty indicates that PDD is an independent risk factor for adverse cardiovascular outcomes after noncardiac surgery.

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Smoking as an independent risk factor for hepatocellular carcinoma: the Singapore Chinese Health Study

British Journal of Cancer ◽

10.1038/bjc.2011.360 ◽

2011 ◽

Vol 105 (9) ◽

pp. 1430-1435 ◽

Cited By ~ 72

Author(s):

W-P Koh ◽

K Robien ◽

R Wang ◽

S Govindarajan ◽

J-M Yuan ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Risk Factor ◽

Independent Risk Factor ◽

Health Study ◽

Singapore Chinese

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Uncomplicated post-dated pregnancy in one horn of bicornis bicollis uterus

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20183816 ◽

2018 ◽

Vol 7 (9) ◽

pp. 3890

Author(s):

Preet Kamal Bedi ◽

Arunima Saini ◽

Nisha Bhagat

Keyword(s):

Risk Factor ◽

General Population ◽

Preterm Labor ◽

Rare Case ◽

Independent Risk Factor ◽

Cervical Incompetence ◽

Uterine Anomalies ◽

Fetal Complications ◽

Mullerian Ducts ◽

Term Baby

Mullerian anomalies result from abnormal fusion of mullerian ducts (paramesonephric ducts). The prevalence of 1-10% is seen in general population. Patients with uterine anomalies have chances of infertility, miscarriage, preterm labor, cervical incompetence and are an independent risk factor for uterine rupture. Just a few pregnancies are carried forward till term without any maternal and fetal complications. Here we report a rare case of bicornuate uterus bicollis that successfully conceived, carried her pregnancy beyond her expected date of delivery (4 days overdue) and delivered a full-term baby without any significant complications.

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Left Ventricular Longitudinal Dyssynchrony by CMR Feature Tracking Is Related to Adverse Prognosis in Advanced Arrhythmogenic Cardiomyopathy

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2021.712832 ◽

2021 ◽

Vol 8 ◽

Author(s):

Yanyan Song ◽

Lu Li ◽

Xiuyu Chen ◽

Keshan Ji ◽

Minjie Lu ◽

...

Keyword(s):

Risk Factor ◽

Cardiovascular Events ◽

Feature Tracking ◽

Independent Risk Factor ◽

Task Force ◽

Global Longitudinal Strain ◽

Left Ventricular ◽

Primary Study ◽

Arrhythmogenic Cardiomyopathy ◽

Secondary Study

Objectives: Left ventricular (LV) involvement has been associated with unfavorable prognosis in arrhythmogenic cardiomyopathy (ACM). We aim to evaluate LV mechanics by cardiovascular magnetic resonance-feature tracking (CMR-FT) in ACM patients with right ventricular (RV) dysfunction.Methods: We retrospectively recruited ACM patients diagnosed according to the revised Task Force Criteria (rTFC) from January 2015 to July 2017. All patients underwent CMR examinations and collections of clinical, electrocardiographic data. The strain and dyssynchrony parameters of LV and RV were analyzed. These patients were followed, and primary study outcome was defined as a composite of cardiovascular events (arrhythmic events and heart transplantation), secondary study outcome included arrhythmic events.Results: Eighty-nine ACM patients (40.40 ± 13.98 years, 67.42% male) were included. LV and RV ejection fractions were 49.12 ± 12.02% and 22.28 ± 10.11%, respectively. During a median (IQR) follow-up for 18.20 (11.60-30.04) months, 30 patients experienced cardiovascular events which included 22 patients who experienced arrhythmic events. Patients with cardiovascular events had impaired LV global longitudinal strain (−10.82 ± 2.77 vs. −12.61 ± 3.18%, p = 0.010), impaired LV global circumferential strain (−11.81 ± 2.40 vs. −13.04 ± 2.83%, p = 0.044), and greater LV longitudinal dyssynchrony (LVLD) (80.98 ± 30.98 vs. 64.23 ± 25.51 ms, p = 0.012) than those without. After adjusting for age, sex, and other confounding factors, LVLD ≥89.15 ms was an independent risk factor for cardiovascular events (HR: 4.50, 95% CI: 1.94 to 10.42; p = 0.001) and for arrhythmic events (HR: 4.79, 95% CI: 1.74 to 13.20; p = 0.003).Conclusions: LVLD by CMR-FT was an independent risk factor for cardiovascular and arrhythmic events in ACM patients in advanced stage, which could provide prognostic value for this subtype.

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