scholarly journals Association of nephronophthisis 4 genetic variation with cardiorenal syndrome and cardiovascular events in Japanese general population: the Yamagata (Takahata) study

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
Y Otaki ◽  
T W Watanabe ◽  
J G Goto ◽  
Y S Saito ◽  
T A Aono ◽  
...  
Keyword(s):  
Risk Factor ◽  
General Population ◽  
Cardiovascular Events ◽  
Cardiorenal Syndrome ◽  
Health Study ◽  
Nucleotide Polymorphisms ◽  
Logistic Analysis ◽  
Cox Proportional Hazard Regression ◽  
Gene Variability ◽  
Stage Renal Disease

Abstract Background Nephronophthisis (NPHP) 4 gene encoding nephrocystin-4, which contributes to end-stage renal disease in children and young adults, is involved in the development of the heart and kidneys. Cardiorenal syndrome (CRS), which consists of bidirectional dysfunction of the heart and kidneys, is a risk factor for cardiovascular events. Single nucleotide polymorphisms (SNPs) within the NPHP4 gene are reportedly associated with kidney function, even in adults. However, the association of NPHP4 gene variability with CRS and cardiovascular events remains unknown. Purpose To examine whether NPHP4 gene variability is related to CRS and cardiovascular events in general population. Methods and results This prospective cohort study included 2,946 subjects who participated in a community-based health study with a 16-year follow-up period. We genotyped 11 SNPs within the NPHP4 gene whose minor allele frequency was greater than 0.1 in the Japanese population. The SNP rs12058375 was significantly associated with CRS and cardiovascular events. Multivariate logistic analysis demonstrated a significant association between the homozygous A-allele of rs12058375 with the presence of CRS. Haplotype analysis identified the haplotype with the A-allele of rs12058375 as an increased susceptibility factor for CRS. Kaplan-Meier analysis demonstrated that homozygous A-allele carriers of rs12058375 had the greatest risk of developing cardiovascular events among the NPHP4 variants. Multivariate Cox proportional hazard regression analysis revealed that the homozygous A-allele and heterozygous carriers of rs12058375 were associated with cardiovascular events after adjusting for confounding factors. The net reclassification index and integrated discrimination index were significantly improved by the addition of rs12058375 as a cardiovascular risk factor. Conclusion Genetic variations in the NPHP4 gene were associated with CRS and cardiovascular events in the general population, suggesting that it may facilitate the early identification of high-risk subjects with CRS and cardiovascular events. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Cystatin C as risk factor for cardiovascular events and all-cause mortality in the general population. The Tromsø Study

2011 ◽  
Vol 27 (7) ◽  
pp. 2780-2787 ◽  
Author(s):  
Ingrid Toft ◽  
Marit Solbu ◽  
Jens Kronborg ◽  
Ulla D. Mathisen ◽  
Bjørn O. Eriksen ◽  
...  
Keyword(s):  
Risk Factor ◽  
General Population ◽  
Cystatin C ◽  
Cardiovascular Events ◽  
All Cause Mortality

Abstract P217: Impact of Serum Potassium on Mortality and Kidney Outcomes in the Atherosclerosis Risk in Communities (ARIC) Study

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Yan Chen ◽  
Alex R Chang ◽  
Josef Coresh ◽  
Mara A McAdams-Demarco ◽  
Lesley A Inker ◽  
...  
Keyword(s):  
General Population ◽  
Serum Potassium ◽  
Adverse Outcomes ◽  
Atherosclerosis Risk In Communities ◽  
Renal Outcomes ◽  
Cox Proportional Hazard Regression ◽  
Stage Renal Disease ◽  
End Stage ◽  
Adjusted Model ◽  
Aric Study

Introduction: Little is known about whether abnormal values of serum potassium (K) are associated with mortality and adverse renal outcomes in the general population. Hypothesis: Abnormal K values are associated with higher risk of mortality and adverse renal outcomes, with stronger associations among persons taking medications that influence K levels. Methods: We studied 15,641 participants in the ARIC study. Cox proportional hazard regression was used to investigate the association of K at baseline (1987-1989), evaluated categorically (hypokalemia, <3.5 mmol/L; normokalemia, 3.5-5.4 mmol/L; hyperkalemia, ≥5.5 mmol/L) and continuously using linear spline terms (knots at 3.5 and 5.5 mmol/L), with mortality, incident chronic kidney disease (CKD), and end-stage renal disease (ESRD). We also evaluated whether kaliuretic diuretics modified the association between K and adverse outcomes. Results: Overall, 2.7% of the participants had hypokalemia, 2.1% had hyperkalemia and 19.1% were taking kaliuretic diuretics. In an unadjusted model, both hypo- and hyperkalemia were associated with mortality; in a fully adjusted model, hyperkalemia was significantly associated with mortality (HR: 1.24; 95% CI: 1.04-1.49) while hypokalemia was not (HR: 1.03; 95% CI: 0.89-1.20); however, hypokalemia was associated with mortality among people not taking kaliuretic diuretics (HR: 1.74; 95% CI: 1.31-2.30; p for interaction: <0.001). Neither hypo- nor hyperkalemia was associated with renal outcomes in the adjusted model; however, there was an interaction of kaliuretic diuretic use with hypokalemia, where hypokalemia was associated with significantly higher risk of CKD and ESRD in participants not using kaliuretic diuretics and lower risk in participants using kaliuretic diuretics (CKD: p for interaction: 0.001; ESRD: p for interaction: 0.002). Conclusions: Abnormal values of K were associated with death and adverse renal outcomes in the general population, particularly among participants not taking kaliuretic diuretics.

scholarly journals P1497INCIDSENCE OF CANCER IN HEMODIALYSIS-TREATED PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Ze'ev Katzir ◽  
Lusia Merkin ◽  
Ronen Brenner
Keyword(s):  
Risk Factor ◽  
General Population ◽  
Renal Disease ◽  
Cancer Incidence ◽  
Medical Center ◽  
Chronic Hemodialysis ◽  
Older Age ◽  
Annual Rate ◽  
Primary Malignancy ◽  
Stage Renal Disease

Abstract Background and Aims In recent decades, there has been an increase in the incidence and prevalence of patients with end stage renal disease (ESRD) worldwide. Previous studies have shown an increased incidence of malignancies among ESRD patients, compared to age-matched controls, although it was unclear whether different etiologies of ESRD ( diabetes, hypertension, cystic disease) confer different risk ratio. Our present study intends to re-examine relationships between ESRD, classified according to the etiology of renal disease, cancer incidence and types of malignancies in hemodialysis treated patients. Method We conducted a retrospective study, analyzing hemodialysis (HD) treated patients over the age of 18 at the Wolfson Medical Center in Holon, Israel, from 2008-2017. Patients diagnosed with cancer prior to dialysis or with history of transplantation were excluded. Data on etiology of chronic kidney disease and ESRD, comorbidities and cancer diagnosis was collected from patients' files and verified using the Israeli National Cancer Registry. A single, multivariate survival analysis was conducted to examine the relationship between the various predictors and the incidence of cancer. Results The study included 333 patients, 211 (63.4%) were males, mean age 67.2±13.1 years. The median follow was 4 years (95% CI: 2-6.5). Twenty eight (8.4%), developed primary malignancy during hemodialysis, annual rate: 2.1%, Vs 0.35% age-adjusted annual rate in Israeli general population. The average age of all patients diagnosed with cancer over the study period was higher than that of patients without cancer (72.3±7.7 Vs 66.7±13.4 years. P=0.001). The most common sites of malignancy were colon (33%), bladder (16.7%), kidney (10%) and prostate (10%). Older age was the only risk factor associated with the onset of malignancy. No statistically significant relationship was found between ESRD etiology, comorbidities and occurrence of malignancy. Conclusion Among our cohort of patients on chronic hemodialysis, annual cancer incidence rate is 6 times higher than age matched controls in the Israeli general population. Older age is a risk factor associated with onset of malignancy. We did not found associations between ESRD etiology, comorbidities and cancer incidence. This study constitutes a platform for a longer period multicenter study.

5945Single nucleotide polymorphisms of PAR2 gene is associated with subclinical myocardial damage in the general population

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
T Aono ◽  
T Watanabe ◽  
T Takahashi ◽  
S Kato ◽  
H Tamura ◽  
...  
Keyword(s):  
General Population ◽  
Vascular Inflammation ◽  
Experimental Studies ◽  
Myocardial Damage ◽  
Nucleotide Polymorphisms ◽  
Fatty Acid Binding ◽  
Logistic Analysis ◽  
The Impact ◽  
G Protein Coupled ◽  
Multivariate Logistic Analysis

Abstract Introduction The protease activated receptor (PAR) 2 is a G protein-coupled receptor and expressed in cardiomyocytes, vascular cells, and leukocytes. Experimental studies demonstrated that PAR2 signaling is associated with adverse cardiac remodeling, heart failure, vascular inflammation and atherosclerosis. Recently, we and others demonstrated that subclinical myocardial damage is associated with cardiovascular mortality in general population. However, the impact of single nucleotide polymorphisms (SNPs) of PAR2 gene on subclinical myocardial damage in general population is unclear. Purpose The aim of this study was to investigate whether SNPs of PAR2 gene is associated with subclinical myocardial damage in general population. Methods The present study included 2,926 apparently healthy subjects (aged ≥40) who participated in a community-based health checkup. We investigated 639 SNPs and measured serum heart-type fatty acid binding protein (H-FABP) as markers of subclinical myocardial damage. Results We found the association of SNPs rs616235 within a PAR2 gene with subclinical myocardial damage. The homozygous A-allele (AA), heterozygous (AG), and homozygous G-allele (GG) carriers of rs616235 were identified in 2084 (71%), 791 (27%), and 51 (2%) subjects, respectively. The prevalence rates of subclinical myocardial damage were 29% in AA carriers, 23% in AG carriers, and 18% in GG carriers. Multivariate logistic analysis showed that the homozygous (AA) of rs616235 was independently associated with subclinical myocardial damage (odds ratio: 1.330, 95% confidence interval: 1.077–1.641, P=0.0080) after adjustment for conventional cardiovascular risk factors. Conclusions Genetic variant of PAR2 gene was independently associated with subclinical myocardial damage in the general population.

scholarly journals Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Miyuki Yokoyama ◽  
Tetsu Watanabe ◽  
Yoichiro Otaki ◽  
Hiroki Takahashi ◽  
Takanori Arimoto ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
General Population ◽  
Cardiovascular Mortality ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Cost Effective ◽  
Health Check ◽  
Logistic Analysis ◽  
Cox Proportional Hazard Regression

Background. Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine aminotransferase (ALT). However, the association of AST/ALT ratio with brain natriuretic peptide (BNP) levels and cardiovascular mortality remains unclear in the general population. Methods and Results. This longitudinal cohort study included 3,494 Japanese subjects who participated in a community-based health check-up, with a 10-year follow-up. The AST/ALT ratio increased with increasing BNP levels. And multivariate logistic analysis showed that the AST/ALT ratio was significantly associated with a high BNP (≥100 pg/mL). There were 250 all-cause deaths including 79 cardiovascular deaths. Multivariate Cox proportional hazard regression analysis revealed that a high AST/ALT ratio (>90 percentile) was an independent predictor of all-cause and cardiovascular mortality after adjustment for confounding factors. Kaplan-Meier analysis demonstrated that cardiovascular mortality was higher in subjects with a high AST/ALT ratio than in those without. Conclusions. The AST/ALT ratio was associated with an increase in BNP and was predictive of cardiovascular mortality in a general population. Measuring the AST/ALT ratio during routine health check-ups may be a simple and cost-effective marker for cardiovascular mortality.

PM320 Multiorgan versus single organ atherosclerotic disease as a risk factor for cardiovascular events in patients with end-stage renal disease

Global Heart ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e127
Author(s):  
Luis Henrique Wolff Gowdak ◽  
Flavio J. de Paula ◽  
Luiz Antonio M. Cesar ◽  
Luiz Aparecido Bortolotto ◽  
Jose Jayme G. de Lima
Keyword(s):  
Risk Factor ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Cardiovascular Events ◽  
Atherosclerotic Disease ◽  
Stage Renal Disease ◽  
End Stage ◽  
Single Organ
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