scholarly journals Glycated hemoglobin predicts coronary artery disease in non-diabetic adults

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Mohammed Ewid ◽  
Hossam Sherif ◽  
Syed Muhammad Baqui Billah ◽  
Nazmus Saquib ◽  
Wael AlEnazy ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Saudi Arabia ◽  
Coronary Artery ◽  
Glycated Hemoglobin ◽  
Demographic Data ◽  
Predictive Biomarkers ◽  
Low Risk ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Artery Disease

Abstract Background Coronary artery disease (CAD) is a major cause of morbidity and mortality worldwide. Due to increased CAD risk factors in Saudi Arabia, research on more feasible and predictive biomarkers is needed. We aimed to evaluate glycated hemoglobin (HbA1c) as a predictor of CAD in low-risk profile non-diabetic patients living in the Al Qassim region of Saudi Arabia. Methods Thirty-eight patients with no history of CAD were enrolled in this cross-sectional study. They provided demographic data, and their HbA1c estimation followed the National Glycohemoglobin Standardization Program parameters. All patients underwent coronary computed tomography angiography (CCTA) for evaluation of chest pain. The extent of coronary artery stenosis (CAS) was quantified as percentage for each patient based on plaques detected in CCTA. Results Mean blood pressure of the patients was (91.2 ± 11.9 mmHg), BMI (28.3 ± 5.8 kg/m2), serum cholesterol level (174 ± 33.1 mg/dl), and HbA1c levels (mean 5.7 ± 0.45, median 5.7 and range 4.7–6.4%). Eighteen patients showed no CAS (47.4%), 12 showed minimal stenosis (31.6%), 3 showed mild stenosis (7.9%), 3 showed moderate stenosis (7.9%) and 2 showed severe stenosis (5.3%). A moderate correlation was detected between HbA1c and CAS percentages (r = 0.47, p < 0.05) as well as between HbA1c and the number of affected coronary vessels (r = 0.53, p < 0.001). Conclusion Glycated hemoglobin can be used as a predictive biomarker for CAD in non-diabetic low-risk patients.

scholarly journals The Relationship Between Adiponectin Serum Level and Coronary Artery Disease in Type 2 Diabetic Patients

2021 ◽  
Author(s):  
Zahra Mazloum Khorasani ◽  
Saeed Choobkar ◽  
Ramin Khameneh Bagheri ◽  
Mina AkbariRad ◽  
Abdollah Firoozi
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Level ◽  
Demographic Data ◽  
Diabetic Patients ◽  
Type 2 Diabetics ◽  
Increased Risk ◽  
Artery Disease

Adiponectin is an adipocytokine that has a higher serum level in healthy people. In type 2 diabetes, insulin resistance, hypertension, MI, and dyslipidemia, the serum level of adiponectin is lower than 4 µg/mL. Adiponectin is proved to have a protective role against atherosclerotic changes where its low serum levels in type 2 diabetes can lead to the progression of atherosclerotic lesions. In this study, we aimed to survey the possible effects of adiponectin in the development of coronary artery disease in type 2 diabetics. Thirty diabetic cases with coronary artery disease, 30 diabetic cases without known coronary artery disease, and a group of 30 healthy volunteers, all of them were between 18-65-year-old, were entered ourstudy. We gathered demographic data by performing a physical examination followed by filling a checklist and a set of laboratory tests. All the groups were sex and age-matched (P=0.284 and P=0.163 respectively). CAD group had the lowest HBA1C (P<0.001). Both LDL and HDL were also lower in the CAD group (P<0.001). Adiponectin was also lower in the CAD group when compared to other groups (P<0.008) or when compared with only normal diabetics (P<0.002). We found a correlation between adiponectin and HDL (r=0.348, P=0.008), suggesting each unit of reduction in serum level of adiponectin could increase the chance of coronary artery disease by 38% in diabetics. In this study, we showed that the lower serum level of adiponectin is correlated with an increased risk of coronary artery disease in type 2 diabetics.

Frequency of Vitamin D deficiency in Coronary artery disease patients following up in tertiary care cardiac center in Lahore

2021 ◽  
Vol 15 (10) ◽  
pp. 2559-2560
Author(s):  
Attaullah Khan Niazi ◽  
Muhammed Muneeb ◽  
Kanza Sana Umer ◽  
Ammar Hameed Khan ◽  
Kiran Manzar ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Vitamin D ◽  
Coronary Artery ◽  
Vitamin D Deficiency ◽  
Large Scale ◽  
Demographic Data ◽  
Tertiary Care ◽  
Cross Sectional ◽  
Artery Disease ◽  
Cardiac Center

Aim: To find out frequency of Vit. D deficiency in Coronary artery disease following up in tertiary care cardiac center Method: It is Purposive Cross-sectional study, Duration study period of two months in which 228 patients attended out clinic and underwent admission at department of cardiology & cardiovascular surgery, Data collection tool (a struc-tured questionnaire) consists of demographic data, Vitamin d3 level, details of medications and co-angulation factors, ECG findings and expected Echocardiogram findings Result: The subjects were severely deficient in vitamin D and its levels were inversely correlated with most of the com-ponents of metabolic syndrome. A Vitamin D deficiency is stirring the Pakistan rural population regardless of their age, gender, and the results of this study’s result have showed that this vitamin D deficiency is crucial in Pakistan. However, large scale studies are required to verify our findings. Keywords: Cardiovascular disease, Vitamin D. deficiency, Coronary artery disease, Malnutrition

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