scholarly journals Long-term effects of alcohol consumption on cognitive function in seniors: a cohort study in China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lizhen Han ◽  
Jinzhu Jia

Abstract Background In the context of increasing global aging, the long-term effects of alcohol consumption on cognitive function in older adults were analyzed in order to provide rationalized health recommendations to the elderly population. Methods The study used the Chinese Longitudinal Healthy Longevity Survey (CLHLS) dataset, from which 5354 Chinese seniors aged 65–112 years were selected as the subjects, spanning the years 1998–2018. Data on alcohol, diet, activity, and cognition were collected by questionnaire and cognitive levels were judged by the Mini-Mental State Examination scale (also referenced to the Functional Assessment Staging Test). Data cleaning and preprocessing was implemented by R software. The dynamic Cox model was applied for model construction and data analysis. Results The results of the dynamic Cox model suggested that seniors who drank alcohol were at higher risk of cognitive decline compared to those who never drank (HR = 1.291, 95%CI: 1.175–1.419). The risk was similarly exacerbated by perennial drinking habits (i.e., longer drinking years, HR = 1.008, 95%CI: 1.004–1.013). Compared to non-alcoholic beverages, liquor (≥ 38°), liquor (< 38°), wine and rice wine all showed negative effects. Whereas, the risk of cognitive decline was relatively lower in seniors who consumed liquors (< 38°) and rice wine compared to the high-level liquor (HR: 0.672 (0.508, 0.887) and 0.732 (0.559, 0.957), respectively). Conclusions Alcohol consumption has a negative and long-term effects on cognitive function in seniors. For the elderly, we suggested that alcohol intake should be avoided as much as possible.

2021 ◽  
Author(s):  
Lizhen Han ◽  
Jinzhu Jia

Abstract Background In the context of increasing global aging, the long-term effects of alcohol consumption on cognitive function in older adults were analyzed in order to provide rationalization recommendations and data support. Methods 5,354 Chinese seniors aged 65–112 years were selected as the subjects, and their participation in the survey covered the time span from 1998–2018. Data cleaning and preprocessing was implemented by R software. The dynamic Cox model was applied for model construction and data analysis. Results The results of the dynamic Cox model suggested that seniors who drank alcohol were at higher risk of cognitive decline compared to those who never drank, and the effect was long-term. The risk was similarly exacerbated by perennial drinking habits. Compared to the liquor (≥ 38°), seniors who consumed liquors (< 38°) and rice wine had a relatively lower risk of cognitive decline. In addition, associations between marital status, frequency of food intake, activity participation and cognitive performance in seniors were also confirmed. Conclusions Alcohol consumption has a negative and long-term effects on cognitive function in seniors. For the elderly, we suggested that alcohol intake should be avoided as much as possible.


2019 ◽  
Vol 74 (6) ◽  
pp. e13-e24 ◽  
Author(s):  
Yujun Liu ◽  
Margie E Lachman

Abstract Objectives This study assesses whether childhood socioeconomic status (SES) is related to cognitive function and cognitive change at mid and later life and explores the buffering effects of parenting style and adulthood SES. Method Data were derived from the 3 waves of the Midlife in the United States (MIDUS) study, a national survey including 7,108 participants aged from 24 to 75 years at baseline. We used multiple regression and multilevel models to investigate the associations between childhood SES, adulthood SES, and cognitive performance and change at midlife and the role of parents’ affection and discipline. Results Low childhood SES was associated with lower cognitive function and more cognitive decline at mid and later life. Adulthood SES moderated the effect of childhood SES on cognitive function. Interactions showed that paternal discipline was positively related to cognitive function among participants with low childhood SES, and negatively related to cognitive function among participants with high childhood SES. High paternal affection was associated with less cognitive decline at mid and later life. Discussion The findings advance the understanding of the long-term consequences of SES and psychosocial factors in early life that can lead to optimal cognitive function in middle and old age.


Healthcare ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 991
Author(s):  
Nan Xiang ◽  
Erpeng Liu ◽  
Huwei Li ◽  
Xigang Qin ◽  
Hang Liang ◽  
...  

Few studies have examined the effects of widowhood on cognitive function in Chinese elderly individuals. We conducted a longitudinal study to assess the association between widowhood and cognitive function and further explored gender differences in this association and the impact of widowhood duration. The analytical sample consisted of 5872 Chinese elderly people who participated in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) and were followed up from 2005 to 2014. We used the Chinese version of the Mini-Mental State Examination (MMSE) to assess cognitive function. Widowhood duration was calculated from the self-reported year at which the spouse passed away. Multilevel growth models were employed to estimate the association between widowhood and cognitive function while adjusting for many demographic and socioeconomic characteristics. Widowhood status was associated with cognitive decline among Chinese elderly individuals after adjusting for covariates (B = −0.440, 95% CI −0.727 to −0.152), and this association was only statistically significant among men (B = −0.722, 95% CI −1.104 to −0.339). Being widowed for 5 years or less (B = −0.606, 95% CI −1.112 to −0.100), 16–20 years (B = −0.937, 95% CI −1.685 to −0.190), and 21+ years (B = −1.401, 95% CI −1.967 to −0.834) predicted worse cognitive function in men, while being widowed for more than 21+ years (B = −0.655, 95% CI −1.186 to −0.124) was associated with cognitive decline in women. More attention should be directed towards widowed men and long-term widowed elderly individuals.


Stroke ◽  
2021 ◽  
Author(s):  
Jessica W. Lo ◽  
John D. Crawford ◽  
David W. Desmond ◽  
Hee-Joon Bae ◽  
Jae-Sung Lim ◽  
...  

Background and Purpose: Poststroke cognitive impairment is common, but the trajectory and magnitude of cognitive decline after stroke is unclear. We examined the course and determinants of cognitive change after stroke using individual participant data from the Stroke and Cognition Consortium. Methods: Nine longitudinal hospital-based cohorts from 7 countries were included. Neuropsychological test scores and normative data were used to calculate standardized scores for global cognition and 5 cognitive domains. One-step individual participant data meta-analysis was used to examine the rate of change in cognitive function and risk factors for cognitive decline after stroke. Stroke-free controls were included to examine rate differences. Based on the literature and our own data that showed short-term improvement in cognitive function after stroke, key analyses were restricted to the period beginning 1-year poststroke to focus on its long-term effects. Results: A total of 1488 patients (mean age, 66.3 years; SD, 11.1; 98% ischemic stroke) were followed for a median of 2.68 years (25th–75th percentile: 1.21–4.14 years). After an initial period of improvement through up to 1-year poststroke, decline was seen in global cognition and all domains except executive function after adjusting for age, sex, education, vascular risk factors, and stroke characteristics (−0.053 SD/year [95% CI, −0.073 to −0.033]; P <0.001 for global cognition). Recurrent stroke and older age were associated with faster decline. Decline was significantly faster in patients with stroke compared with controls (difference=−0.078 SD/year [95% CI, −0.11 to −0.045]; P <0.001 for global cognition in a subgroup analysis). Conclusions: Patients with stroke experience cognitive decline that is faster than that of stroke-free controls from 1 to 3 years after onset. An increased rate of decline is associated with older age and recurrent stroke.


1998 ◽  
Vol 33 (11) ◽  
pp. 2303-2321 ◽  
Author(s):  
Chudley E. Werch ◽  
Deborah M. Pappas ◽  
Joan M. Carlson ◽  
Carlo C. Diclemente

1993 ◽  
Vol 72 (1) ◽  
pp. 211-216 ◽  
Author(s):  
William C. Gross

Respondents (86 men and 141 women) enrolled in classes at a large university in the Midwest participated in this study, designed to examine the role gender and age play in the consumption of alcoholic beverages. The hypotheses that age and gender would produce significant effects were supported. Men reported significantly greater alcohol consumption than did women. In addition, there was a significant interaction between gender and age. Women under legal drinking age had higher rates of consumption than women of legal drinking age or older, while the opposite pattern was found for men. The long-term pattern of alcohol consumption may be different for men than for women. During the college years, women seem to moderate their consumption. Finally, these results indicate that illegal, underage drinking by men and women occurs at a high rate. Research should be designed to evaluate the extent of the problem.


2021 ◽  
pp. 1-30
Author(s):  
Yu Fu ◽  
Michael Sherris ◽  
Mengyi Xu

Abstract China and the US are two contrasting countries in terms of functional disability and long-term care. China is experiencing declining family support for long-term care and developing private long-term care insurance. The US has a more developed public aged care system and private long-term care insurance market than China. Changes in the demand for long-term care are driven by the levels, trends and uncertainty in mortality and functional disability. To understand the future potential demand for long-term care, we compare mortality and functional disability experiences in China and the US, using a multi-state latent factor intensity model with time trends and systematic uncertainty in transition rates. We estimate the model with the Chinese Longitudinal Healthy Longevity Survey (CLHLS) and the US Health and Retirement Study (HRS) data. The estimation results show that if trends continue, both countries will experience longevity improvement with morbidity compression and a declining proportion of the older population with functional disability. Although the elderly Chinese have a shorter estimated life expectancy, they are expected to spend a smaller proportion of their future lifetime functionally disabled than the elderly Americans. Systematic uncertainty is shown to be significant in future trends in disability rates and our model estimates higher uncertainty in trends for the Chinese elderly, especially for urban residents.


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