scholarly journals Lymphogranuloma venereum is on the rise in Belgium among HIV negative men who have sex with men: surveillance data from 2011 until the end of June 2017

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Irith De Baetselier ◽  
Achilleas Tsoumanis ◽  
Ruth Verbrugge ◽  
Bénédicte De Deken ◽  
Hilde Smet ◽  
...  
Keyword(s):  
Lymphogranuloma Venereum ◽  
Surveillance Data ◽  
Sex With Men ◽  
Hiv Negative

Lymphogranuloma venereum presenting as penile ulcer in two HIV-negative gay men

2019 ◽  
Vol 30 (5) ◽  
pp. 515-518 ◽  
Author(s):  
Stephen C Davies ◽  
Jane Shapiro ◽  
Nicholas B Comninos ◽  
David J Templeton
Keyword(s):  
Human Immunodeficiency Virus ◽  
Chlamydia Trachomatis ◽  
Gay Men ◽  
Lymphogranuloma Venereum ◽  
Immunodeficiency Virus ◽  
Sex With Men ◽  
Hiv Negative

An epidemic of lymphogranuloma venereum among men who have sex with men (MSM) has persisted in Australia for over a decade and virtually all diagnoses are made from rectal samples. We discuss two cases of human immunodeficiency virus-negative MSM who presented with a penile ulcer. The diagnosis can be made by ensuring a swab of any such ulcer is tested for Chlamydia trachomatis.

scholarly journals Investigating the decline in Lymphogranuloma venereum diagnoses in men who have sex with men in the United Kingdom since 2016: an analysis of surveillance data

Sexual Health ◽  
2020 ◽  
Vol 17 (4) ◽  
pp. 344
Author(s):  
Hester Allen ◽  
Rachel Pitt ◽  
Megan Bardsley ◽  
Christa Smolarchuk ◽  
Ann Sullivan ◽  
...  
Keyword(s):  
Laboratory Data ◽  
Lymphogranuloma Venereum ◽  
Surveillance Data ◽  
Multiple Sources ◽  
Policy And Practice ◽  
Management Guidelines ◽  
Asymptomatic Patients ◽  
Sexually Transmissible Infections ◽  
Sex With Men ◽  
The Uk

Abstract Background Following an upward trajectory in Lymphogranuloma venereum (LGV) diagnoses in the UK from 2004 to 2016, with annual diagnoses increasing from 28 to 904, diagnoses fell to 641 in 2017; this was inconsistent with the upward trend in other bacterial sexually transmissible infections (STIs) between 2016 and 2017. An analysis of surveillance data from multiple sources to investigate the possible factors contributing to this decline in LGV was performed. Methods: LGV tests and diagnoses in the UK from 2004 to 2018 were captured through laboratory data from the LGV Reference Laboratories and laboratories conducting in-house LGV testing. These data and clinical diagnoses data from England were analysed alongside the national management guidelines issued over the course of the epidemic. Results: LGV diagnoses increased between 2004 and 2015 and then decreased between 2016 and 2018. LGV testing increased from 2010 to 2018 (2690–10850). Test positivity halved between 2015 (14.8%, 929–6272) and 2018 (7.3%, 791–10850). Peaks in LGV testing and diagnoses appeared to coincide with the publication of national LGV management guidelines and changes to clinical practice. The proportion of LGV diagnoses among HIV-positive men who have sex with men (MSM) fell between 2013 and 2018 (74–48%). Conclusions: The fall in diagnoses and positivity were likely due to increasing earlier clinical diagnosis and treatment. Changes to the national management guidelines, the clinical policy and practice of some larger clinics and potentially changes to the guidelines for the treatment of chlamydia broadened the scope of testing and increased testing in asymptomatic patients which, in combination, likely had a positive effect on the control of LGV infection.

scholarly journals Increasing trends of lymphogranuloma venereum among HIV-negative and asymptomatic men who have sex with men, the Netherlands, 2011 to 2017

2020 ◽  
Vol 25 (14) ◽  
Author(s):  
Fleur van Aar ◽  
Michelle M Kroone ◽  
Henry JC de Vries ◽  
Hannelore M Götz ◽  
Birgit HB van Benthem
Keyword(s):  
The Netherlands ◽  
Lymphogranuloma Venereum ◽  
Hiv Positive ◽  
Multivariable Logistic Regression Analysis ◽  
Universal Testing ◽  
Multivariable Models ◽  
Sex With Men ◽  
Increasing Trends ◽  
Asymptomatic Men ◽  
Hiv Negative

Introduction Lymphogranuloma venereum (LGV), an invasive form of Chlamydia trachomatis infection, has been reported among (mainly HIV-positive) men who have sex with men (MSM) since 2003. In the Netherlands, LGV testing recommendations changed from selective to universal testing in 2015. Changes in tested populations could have led to incomparable LGV positivity rates over time. Aim We investigated LGV trends among MSM attending Centres for Sexual Health using surveillance data between 2011 and 2017. Methods LGV positivity was calculated among MSM tested for rectal Chlamydia infection and MSM tested specifically for LGV. With multivariable logistic regression analysis, the association between years and LGV was adjusted for testing indicators and determinants. Results We included 224,194 consultations. LGV increased from 86 in 2011 to 270 in 2017. Among LGV-positives, proportions of HIV-negative and asymptomatic MSM increased from 17.4% to 45.6% and from 31.4% to 49.3%, respectively, between 2011 and 2017. Among MSM tested for rectal chlamydia, LGV positivity increased from 0.12% to 0.33% among HIV-negatives and remained stable around 2.5% among HIV-positives. Among LGV-tested MSM, LGV positivity increased from 2.1% to 5.7% among HIV-negatives and from 15.1% to 22.1% among HIV-positives. Multivariable models showed increased odds ratios and significant positive associations between years and LGV. Conclusions Although increased testing and changes in LGV incidence are difficult to disentangle, we found increasing LGV trends, especially when corrected for confounding. LGV was increasingly attributed to HIV-negative and asymptomatic MSM, among whom testing was previously limited. This stresses the importance of universal testing and continuous surveillance.

scholarly journals Confirmed inguinal lymphogranuloma venereum genovar L2c in a man who had sex with men, Slovenia, 2015

2016 ◽  
Vol 21 (5) ◽  
Author(s):  
Mojca Matičič ◽  
Irena Klavs ◽  
Jerneja Videčnik Zorman ◽  
Darja Vidmar Vovko ◽  
Rok Kogoj ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Anal Intercourse ◽  
Lymphogranuloma Venereum ◽  
Clinical Samples ◽  
Recommended Treatment ◽  
Insertive Anal Intercourse ◽  
Immunodeficiency Virus ◽  
Inguinal Lymphadenopathy ◽  
Sex With Men ◽  
Hiv Negative

A laboratory-confirmed lymphogranuloma venereum (LGV) case in Slovenia was reported in 2015, in a human immunodeficiency virus (HIV)-negative man presenting with inguinal lymphadenopathy. He reported unprotected insertive anal intercourse with two male partners in Croatia. Variant L2c of Chlamydia trachomatis was detected in clinical samples. Although the patient was eventually cured, the recommended treatment regimen with doxycycline had to be prolonged.

scholarly journals P3.27 Lymphogranuloma venereum in sweden 2004–2016: increased rates among hiv-negative men who have sex with men and changed genotypes

2017 ◽  
Author(s):  
Björn Herrmann ◽  
Jenny Isaksson ◽  
Ola Carlsson ◽  
Åsa Airell ◽  
Susanne Strömdahl ◽  
...  
Keyword(s):  
Lymphogranuloma Venereum ◽  
Sex With Men ◽  
Hiv Negative

scholarly journals Rapid Increase in Lymphogranuloma Venereum among HIV-Negative Men Who Have Sex with Men, England, 2019

2021 ◽  
Vol 27 (10) ◽  
pp. 2695-2699
Author(s):  
Mateo Prochazka ◽  
Hannah Charles ◽  
Hester Allen ◽  
Michelle Cole ◽  
Gwenda Hughes ◽  
...  
Keyword(s):  
Lymphogranuloma Venereum ◽  
Sex With Men ◽  
Hiv Negative

scholarly journals Longitudinal Event-Level Sexual Risk and Substance Use among Gay, Bisexual, and Other Men Who Have Sex with Men

2021 ◽  
Vol 18 (6) ◽  
pp. 3183
Author(s):  
Jordan M. Sang ◽  
Zishan Cui ◽  
Paul Sereda ◽  
Heather L. Armstrong ◽  
Gbolahan Olarewaju ◽  
...  
Keyword(s):  
Substance Use ◽  
Sexual Risk ◽  
Health Study ◽  
Anal Sex ◽  
Study Objective ◽  
Condomless Anal Sex ◽  
Gamma Hydroxybutyrate ◽  
Sex With Men ◽  
Hiv Negative

(1) Background: Condomless anal sex and substance use are associated with STI risk among gay, bisexual, and other men who have sex with men (gbMSM). Our first study objective was to describe event-level sexual risk and substance use trends among gbMSM. Our second study objective was to describe substances associated with event-level sexual risk. (2) Methods: Data come from the Momentum Health Study in Vancouver, British Columbia and participants were recruited from 2012–2015, with follow-up until 2018. Stratified by self-reported HIV status, we used generalized estimating equations to assess trends of sexual event-level substance use and assessed interactions between substance use and time period on event-level higher risk sex defined as condomless anal sex with an HIV serodifferent or unknown status partner. (3) Results: Event-level higher risk anal sex increased across the study period among HIV-negative/unknown (baseline prevalence: 13% vs. study end prevalence: 29%) and HIV-positive gbMSM (baseline prevalence: 16% vs. study end prevalence: 38%). Among HIV-negative/unknown gbMSM, event-level erectile drug use increased, while alcohol use decreased over the study period. Overall, interactions between substance use and time on higher risk anal sex were not statistically significant, regardless of serostatus. However, we found a number of time-specific significant interactions for erectile drugs, poppers, Gamma-hydroxybutyrate (GHB), crystal methamphetamine and ecstasy/MDMA use among HIV-negative/unknown gbMSM. (4) Conclusion: Significant differences in substance use trends and associated risks exist and are varied among gbMSM by serostatus. These findings provide a more comprehensive understanding of the effects of event-level substance use on sexual risk through longitudinal follow-up of nearly six years.

Food Insecurity Partially Mediates the Association Between Drug Use and Depressive Symptoms among Men who have Sex with Men in Los Angeles, California

2021 ◽  
pp. 1-26
Author(s):  
David A. Wiss ◽  
Marjan Javanbakht ◽  
Michael J. Li ◽  
Michael Prelip ◽  
Robert Bolan ◽  
...  
Keyword(s):  
Food Security ◽  
Depressive Symptoms ◽  
High Risk ◽  
Los Angeles ◽  
Drug Use ◽  
Food Insecurity ◽  
Hiv Positive ◽  
Sex With Men ◽  
The Relationship ◽  
Hiv Negative

Abstract Objective: To understand the relationship between drug use, food insecurity (FI), and mental health among men who have sex with men (MSM). Design: Cohort study (2014-2019) with at least one follow-up. Setting: Visits at 6-month intervals included self-assessment for FI and depressive symptoms. Urine testing results confirmed drug use. Factors associated with FI were assessed using multiple logistic regression with random effects for repeated measures. General structural equation modeling tested whether FI mediates the relationship between drug use and depressive symptoms. Participants: Data were from HIV-positive and high-risk HIV negative MSM in Los Angeles, CA (n=431; 1,192 visits). Results: At baseline, FI was reported by 50.8% of participants, depressive symptoms in 36.7%, and 52.7% of urine screening tests were positive for drugs (i.e., marijuana, opioids, methamphetamine, cocaine, ecstasy). A positive drug test was associated with a 96% increase in the odds of being food insecure (95% CI: 1.26-3.07). Compared to those with high food security, individuals with very low food security have a nearly 7-fold increase in the odds of reporting depressive symptoms (95% CI: 3.71-11.92). Findings showed 14.9% of the association between drug use (exposure) and depressive symptoms (outcome) can be explained by FI (mediator). Conclusion: The prevalence of FI among this cohort of HIV-positive and high-risk HIV-negative MSM was high; the association between drug use and depressive symptoms was partially mediated by FI. Findings suggest that enhancing access to food and nutrition may improve mood in the context of drug use, especially among MSM at risk for HIV-transmission.

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