Rehabilitation Exercise Increases Physical Activity Levels in Severely Burned Children While Improving Aerobic Exercise Capacity and Strength

Swedish physical activity on prescription (PAP) is an evidence-based method to promote physical activity. However, few studies have investigated the effect of Swedish PAP on physical fitness, in which better cardiorespiratory fitness is associated with lower risks of all-cause mortality and diagnose-specific mortality. Direct measures of cardiorespiratory fitness, usually expressed as maximal oxygen uptake, are difficult to obtain. Hence, exercise capacity can be assessed from a submaximal cycle ergometer test, taking the linear relationship between heart rate, work rate, and oxygen uptake into account. The aim of this study was to evaluate exercise capacity in the long term, following PAP treatment with enhanced physiotherapist support in a nonresponding patient cohort. In total, 98 patients (48 women) with insufficient physical activity levels, with at least one component of the metabolic syndrome and nonresponding to a previous six-month PAP treatment, were randomized to PAP treatment with enhanced support from a physiotherapist and additional exercise capacity tests during a two-year period. A significant increase in exercise capacity was observed for the whole cohort at two-year follow-up (7.6 W, p ≤ 0.001), with a medium effect size (r = 0.34). Females (7.3 W, p = 0.025), males (8.0 W, p = 0.018) and patients ≥58 years old (7.7 W, p = 0.002) improved significantly, whereas a nonsignificant increase was observed for patients <58 years old (7.6 W, p = 0.085). Patients with insufficient physical activity levels who did not respond to a previous six-month PAP treatment can improve their exercise capacity following PAP treatment with enhanced support from a physiotherapist during a two-year period. Future studies should include larger cohorts with a control group to ensure valid estimations of exercise capacity and PAP.

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Aerobic exercise capacity is maintained over a 5-year period in mild-to-moderate chronic kidney disease: a longitudinal study

BMC Nephrology ◽

10.1186/s12882-020-02110-2 ◽

2020 ◽

Vol 21 (1) ◽

Author(s):

Helena Wallin ◽

Eva Jansson ◽

Carin Wallquist ◽

Britta Hylander Rössner ◽

Stefan H. Jacobson ◽

...

Keyword(s):

Physical Activity ◽

Chronic Kidney Disease ◽

Heart Rate ◽

Renal Function ◽

Aerobic Exercise ◽

Exercise Capacity ◽

Activity Level ◽

Peak Heart Rate ◽

Aerobic Exercise Capacity ◽

Over Time

Abstract Background Aerobic exercise capacity is reduced in non-dialysis chronic kidney disease (CKD), but the magnitude of changes in exercise capacity over time is less known. Our main hypothesis was that aerobic ExCap would decline over 5 years in individuals with mild-to-moderate CKD along with a decline in renal function. A secondary hypothesis was that such a decline in ExCap would be associated with a decline in muscle strength, cardiovascular function and physical activity. Methods We performed a 5-year-prospective study on individuals with mild-to-moderate CKD, who were closely monitored at a nephrology clinic. Fiftytwo individuals with CKD stage 2–3 and 54 age- and sex-matched healthy controls were included. Peak workload was assessed through a maximal cycle exercise test. Muscle strength and lean body mass, cardiac function, vascular stiffness, self-reported physical activity level, renal function and haemoglobin level were evaluated. Tests were repeated after 5 years. Statistical analysis of longitudinal data was performed using linear mixed models. Results Exercise capacity did not change significantly over time in either the CKD group or controls, although the absolute workloads were significantly lower in the CKD group. Only in a CKD subgroup reporting low physical activity at baseline, exercise capacity declined. Renal function decreased in both groups, with a larger decline in CKD (p = 0.05 between groups). Peak heart rate, haemoglobin level, handgrip strength, lean body mass and cardiovascular function did not decrease significantly over time in CKD individuals. Conclusions On a group level, aerobic exercise capacity and peak heart rate were maintained over 5 years in patients with well-controlled mild-to-moderate CKD, despite a slight reduction in glomerular filtration rate. In line with the maintained exercise capacity, cardiovascular and muscular function were also preserved. In individuals with mild-to-moderate CKD, physical activity level at baseline seems to have a predictive value for exercise capacity at follow-up.

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Does daily physical activity levels or functional exercise capacity provide additional prognostic information in idiopathic pulmonary fibrosis (IPF)?

10.1183/13993003.congress-2019.pa3419 ◽

2019 ◽

Author(s):

Suhani Patel ◽

Claire M Nolan ◽

Ruth E Barker ◽

Sarah E Jones ◽

Stephanie C Wynne ◽

...

Keyword(s):

Physical Activity ◽

Idiopathic Pulmonary Fibrosis ◽

Pulmonary Fibrosis ◽

Exercise Capacity ◽

Daily Physical Activity ◽

Activity Levels ◽

Prognostic Information ◽

Physical Activity Levels ◽

Functional Exercise ◽

Functional Exercise Capacity

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Physical activity levels in children and adolescents are reduced after the Fontan procedure, independent of exercise capacity, and are associated with lower perceived general health

Archives of Disease in Childhood ◽

10.1136/adc.2006.105239 ◽

2007 ◽

Vol 92 (6) ◽

pp. 509-514 ◽

Cited By ~ 123

Author(s):

B. W McCrindle ◽

R. V Williams ◽

S. Mital ◽

B. J Clark ◽

J. L Russell ◽

...

Keyword(s):

Physical Activity ◽

Children And Adolescents ◽

Exercise Capacity ◽

General Health ◽

Fontan Procedure ◽

Activity Levels ◽

Physical Activity Levels

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Aerobic exercise capacity is maintained over a 5-year period in mild-to-moderate chronic kidney disease: A longitudinal study

10.21203/rs.2.18456/v2 ◽

2020 ◽

Author(s):

Helena Wallin ◽

Eva Jansson ◽

Carin Wallquist ◽

Britta Hylander Rössner ◽

Stefan H Jacobson ◽

...

Keyword(s):

Physical Activity ◽

Chronic Kidney Disease ◽

Heart Rate ◽

Renal Function ◽

Aerobic Exercise ◽

Exercise Capacity ◽

Activity Level ◽

Peak Heart Rate ◽

Aerobic Exercise Capacity ◽

Over Time

Abstract Background: Aerobic exercise capacity is reduced in non-dialysis chronic kidney disease (CKD), but little is known about the magnitude of changes in exercise capacity over time. Our main hypothesis was that aerobic ExCap would decline over 5 years in individuals with mild-to-moderate CKD along with a decline in renal function. A secondary hypothesis was that such a decline in ExCap would be associated with a decline in muscle strength, cardiovascular function and physical activity. Methods: We performed a 5-year-prospective study on individuals with mild-to-moderate CKD, who were closely monitored at a nephrology clinic. Fiftytwo individuals with CKD stage 2–3 and 54 age- and sex-matched healthy controls were included. Peak workload was assessed through a maximal cycle exercise test. Muscle strength and lean body mass, cardiac function, vascular stiffness, self-reported physical activity level, renal function and haemoglobin level were evaluated. Tests were repeated after 5 years. Statistical analysis of longitudinal data was performed using linear mixed models.Results: Exercise capacity did not change significantly over time in either the CKD group or controls, although the absolute workloads were significantly lower in the CKD group. Only in a CKD subgroup reporting low physical activity at baseline, exercise capacity declined. Renal function decreased in both groups, with a faster decline in CKD (p = 0.05 between groups). Peak heart rate, haemoglobin level, handgrip strength, lean body mass and cardiovascular function did not decrease significantly over time in CKD individuals. Conclusions: On a group level, aerobic exercise capacity and peak heart rate were maintained over 5 years in patients with well-controlled mild-to-moderate CKD, despite a slight reduction in glomerular filtration rate, mirroring the lack of progression of cardiovascular and muscular dysfunction in this group. In patients with mild-to-moderate CKD, physical activity level at baseline seems to have a predictive value for exercise capacity at follow-up.

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A randomized trial of exercise on quality of life in men with metastatic prostate cancer: The ExPeCT Trial.

Journal of Clinical Oncology ◽

10.1200/jco.2019.37.31_suppl.97 ◽

2019 ◽

Vol 37 (31_suppl) ◽

pp. 97-97

Author(s):

Grainne Sheill ◽

Lauren Brady ◽

Emer M. Guinan ◽

Juliette M. Hussey ◽

Brian Hayes ◽

...

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Prostate Cancer ◽

Aerobic Exercise ◽

Metastatic Prostate Cancer ◽

Exercise Intervention ◽

Randomised Control Trial ◽

Activity Levels ◽

Physical Activity Levels

97 Background: All patients living with cancer, including those with metastatic cancer, are encouraged to be physically active. This paper examines the feasibility of an aerobic exercise intervention for men with metastatic prostate cancer. Methods: ExPeCT (Exercise, Prostate Cancer and Circulating Tumour Cells), was a multi-centre randomised control trial for men living with metastatic prostate cancer. Participants were randomized to either control or exercise arms. Participants in the exercise arm completed six- months of prescribed aerobic exercise. Quality of life assessments were completed at baseline, at 3 months and at 6 months using a standardised questionnaire derived from the Harvard Health Professionals Follow-up study. Physical activity was measured using a self-administered physical activity questionnaire. Exercise adherence data was collected via Polar heart rate monitors, worn by the patient for every exercise session undertaken. Results: A total of 61 patients were included (69.4±7.3 yr, Body Mass Index 29.2±5.8 kg/m2). The median time since diagnosis was 34 months (IQR 7-54). A total of 35 (55%) of participants had >1 region affected by metastatic disease. A total of 54 (81%) of participants completed the 3 month assessment and 52 (78%) of the participants completed the 6 month assessment. Adherence to the supervised sessions was 83% (329 out of 396 sessions attended). Participants were adherent to both the intensity (82%) and duration (83%) of the prescribed exercise programme during class sessions. No adverse events were reported by participants enrolled in this study. There was no significant difference in physical activity levels, sedentary time or quality of life between either group at baseline, 3 months or 6 months. Systolic blood pressure was significantly lower in the exercise group when compared to the control group at 3 months (p=.008) and 6 months (p=.011). Conclusions: The exercise intervention was tolerated well by a group of patients with a high burden of metastatic prostate cancer however did not lead to change in physical activity levels or quality of life. This trial provides proof of principle evidence for future exercise studies involving this patient group. Clinical trial information: NCT02453139.

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