scholarly journals Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer: a case control study

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Masatoshi Nakagawa ◽  
Yoon Young Choi ◽  
Ji Yeong An ◽  
Hyunsoo Chung ◽  
Sang Hyuk Seo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Case Control Study ◽  
Early Stage ◽  
Case Control ◽  
Node Metastases ◽  
Control Study

scholarly journals Risk factors for gastric cancer and related serological levels in Fujian, China: hospital-based case–control study

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e042341
Author(s):  
Ping Yuan ◽  
Lan Lin ◽  
Kuicheng Zheng ◽  
Wen Wang ◽  
Sihan Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Case Control Study ◽  
Early Stage ◽  
Case Control ◽  
Early Stage Cancer ◽  
Control Subjects ◽  
H Pylori ◽  
Pickled Vegetables ◽  
Control Study

ObjectiveTo explore the relationships between gastric cancer and serum pepsinogen I (PG I), PG II, PG I/II ratio, gastrin 17 (G-17) and Helicobacter pylori infection, and to investigate dietary and lifestyle risk factors for gastric cancer in Fujian Province, China.DesignA hospital-based, 1:1 matched case–control study.SettingPatients with newly diagnosed gastric cancer were recruited from the Fujian Provincial Hospital and the No. 900 Hospital of the Joint Support Force of the Chinese People’s Liberation Army between July 2014 and December 2016.ParticipantsA total of 180 pairs of patients with gastric cancer and control subjects were recruited in the study, including 134 (74.4%) male pairs and 46 (25.6%) female pairs.Investigation and analysis measuresSerological indicators were tested with ELISA kits. Dietary, lifestyle and psychological factors were investigated through face-to-face questionnaire. Relationships between gastric cancer and these influencing factors were examined by Χ2 test and conditional logistic regression.ResultsSerum PG II and G-17 levels and H. pylori infection rate were higher in patients with gastric cancer than in control subjects (p<0.05), while PG I/II ratio was lower in patients with gastric cancer (p<0.05). Serum G-17 levels were higher in patients with corpus gastric cancer than in patients with antral gastric cancer (p<0.05). Serum PG II levels were higher in patients with advanced gastric cancer than in patients with early-stage cancer (p<0.05), however, PG I/II ratio was lower in patients with advanced-stage gastric cancer than in patients with early-stage cancer (p<0.05). Eating hot food (OR=2.32), eating pickled vegetables (OR=4.05) and often feel troubled (OR=2.21) were found to significantly increase the risk of gastric cancer (all p<0.05), while consuming onion or garlic (OR=0.35), drinking tea (OR=0.26), eating fresh fruits (OR=0.55), and high serum PG I (OR=0.99) or PG I/II ratio (OR=0.73) were found to be protective against gastric cancer.ConclusionStudy results showed that serum PG, G-17 and H. pylori antibodies could be useful indicators for early diagnosis of gastric cancer. Increase in serum G-17 level might indicate the location of gastric cancer. Increase in serum PG II level and decrease in PG I/II ratio might imply the clinical stage. Eating hot food, eating pickled vegetables and often feel troubled may be risk factors for gastric cancer, while eating fresh fruits, eating onion or garlic, and drinking tea may be protective factors against the disease.

Verification of the Utility of Palliative Radiotherapy for Hemostasis of Gastric Cancer Bleeding: a Case Control Study

2021 ◽  
Author(s):  
Hirofumi Sugita ◽  
Shinichi Sakuramoto ◽  
Yoshiaki Mihara ◽  
Kazuaki Matsui ◽  
Keiji Nishibeppu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Control Study ◽  
Palliative Radiotherapy ◽  
Case Control ◽  
Control Study

scholarly journals Serum Biomarker Signature-Based Liquid Biopsy for Diagnosis of Early-Stage Pancreatic Cancer

2018 ◽  
Vol 36 (28) ◽  
pp. 2887-2894 ◽  
Author(s):  
Linda D. Mellby ◽  
Andreas P. Nyberg ◽  
Julia S. Johansen ◽  
Christer Wingren ◽  
Børge G. Nordestgaard ◽  
...  
Keyword(s):  
Case Control Study ◽  
Early Stage ◽  
Stage Iv ◽  
The United States ◽  
Case Control ◽  
Stage I ◽  
Serum Biomarker ◽  
Patient Cohort ◽  
Biomarker Signature ◽  
Control Study

Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with a 5-year survival of < 10% because of diffuse symptoms leading to late-stage diagnosis. That survival could increase significantly if localized tumors could be detected early. Therefore, we used multiparametric analysis of blood samples to obtain a novel biomarker signature of early-stage PDAC. The signature was derived from a large patient cohort, including patients with well-defined early-stage (I and II) PDAC. This biomarker signature was validated subsequently in an independent patient cohort. Patients and Methods The biomarker signature was derived from a case-control study, using a Scandinavian cohort, consisting of 16 patients with stage I, 132 patients with stage II, 65 patients with stage III, and 230 patients with stage IV PDAC, and 888 controls. This signature was validated subsequently in an independent case-control cohort in the United States with 15 patients with stage I, 75 patients with stage II, 15 patients with stage III, and 38 patients with stage IV PDAC, and 219 controls. An antibody microarray platform was used to identify the serum biomarker signature associated with early-stage PDAC. Results Using the Scandinavian case-control study, a biomarker signature was created, discriminating samples derived from patients with stage I and II from those from controls with a receiver operating characteristic area under the curve value of 0.96. This signature, consisting of 29 biomarkers, was then validated in an independent case-control study in the United States. The biomarker signature could discriminate patients with stage I and II PDAC from controls in this independent patient cohort with a receiver operating characteristic area under the curve value of 0.96. Conclusion This serum biomarker signature might represent a tenable approach to detecting early-stage, localized PDAC if these findings are supported by a prospective validation study.

Ethnicity and H. Pylori as Risk Factors for Gastric Cancer in Malaysia: A Prospective Case Control Study

2007 ◽  
Vol 102 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Khean-Lee Goh ◽  
Phaik-Leng Cheah ◽  
Noorfaridah Md ◽  
Kia-Fatt Quek ◽  
Navaratnam Parasakthi
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Case Control Study ◽  
Case Control ◽  
H Pylori ◽  
Control Study ◽  
Prospective Case Control Study

scholarly journals Prediction of Lymph Node Metastases in Gastric Cancer by Serum APE1 Expression

2017 ◽  
Vol 8 (8) ◽  
pp. 1492-1497 ◽  
Author(s):  
Xi Wei ◽  
Yi-bo Li ◽  
Ying Li ◽  
Ben-cheng Lin ◽  
Xiao-Min Shen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Node Metastases
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