scholarly journals Exercise as a diagnostic and therapeutic tool for preventing cardiovascular morbidity in breast cancer patients– the BReast cancer EXercise InTervention (BREXIT) trial protocol

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Stephen J. Foulkes ◽  
Erin J. Howden ◽  
Yoland Antill ◽  
Sherene Loi ◽  
Agus Salim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Exercise Intervention ◽  
Cardiovascular Morbidity ◽  
Trial Protocol ◽  
Breast Cancer Patients ◽  
Therapeutic Tool

scholarly journals The effects of an individualized exercise intervention on body composition in breast cancer patients undergoing treatment

2007 ◽  
Vol 125 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Claudio Battaglini ◽  
Martim Bottaro ◽  
Carolyn Dennehy ◽  
Logan Rae ◽  
Edgar Shields ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Composition ◽  
Resistance Training ◽  
Cancer Treatment ◽  
Cancer Patients ◽  
Exercise Intervention ◽  
Exercise Group ◽  
Moderate Intensity ◽  
Control Group ◽  
Breast Cancer Patients

CONTEXT AND OBJECTIVE: Changes in metabolism have been reported in the majority of patients undergoing cancer treatment, and these are usually characterized by progressive change in body composition. The effects of aerobic exercise programs to combat the cancer and cancer treatment-related side effects, which include the negative changes in body composition, have been extensively reported in the literature. However, few resistance exercise intervention studies have hypothesized that breast cancer patients might benefit from this type of exercise. The purpose of this study was to determine whether exercise protocols that emphasize resistance training would change body composition and strength in breast cancer patients undergoing treatment. DESIGN AND SETTING: Randomized controlled trial, at the Campus Recreation Center and Rocky Mountain Cancer Rehabilitation Institute of the University of Northern Colorado, and the North Colorado Medical Center. METHODS: Twenty inactive breast cancer patients were randomly assigned to a 21-week exercise group (n = 10) or a control group (n = 10). The exercise group trained at low to moderate intensity for 60 minutes on two days/week. The primary outcome measurements included body composition (skinfold method) and muscle strength (one repetition maximum). RESULTS: Significant differences in lean body mass, body fat and strength (p = 0.004, p = 0.004, p = 0.025, respectively) were observed between the groups at the end of the study. CONCLUSION: The results suggest that exercise emphasizing resistance training promotes positive changes in body composition and strength in breast cancer patients undergoing treatment.

Psychological impact of exercise in women with breast cancer receiving adjuvant therapy: What is the optimal dose needed?

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 9074-9074
Author(s):  
Marion Carayol ◽  
Paquito Bernard ◽  
Julie Boiche ◽  
Francois Riou ◽  
Betty Mercier ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adjuvant Therapy ◽  
Cancer Patients ◽  
Dose Response ◽  
Exercise Intervention ◽  
Optimal Dose ◽  
Psychological Outcomes ◽  
Breast Cancer Patients ◽  
F Test ◽  
Exercise Interventions

9074 Background: Several meta-analyses have examined the role of exercise interventions in improving psychological outcomes in cancer survivors but most did not focus on adjuvant therapy period and did not investigate the optimal dose of exercise needed. Methods: The present meta-analysis examines the impact of exercise interventions delivered at this particular period on fatigue, anxiety, depression and quality-of-life (QoL) as well as dose-response relationships between volume of prescribed exercise and these psychological outcomes. Randomized controlled trials that proposed an exercise intervention to breast cancer patients undergoing chemotherapy and/or radiotherapy were systematically identified and coded. Standardized mean differences (SMDs) of psychological outcomes were weighted by the inverse of their variances to obtain a pooled estimate using random effects model. Linear and quadratic regressions were carried out to explore dose-response relationships. Results: In total, 17 studies involving 1380 participants and 20 exercise interventions were included. Intervention subjects significantly reduced their fatigue and depression levels showing pooled effect sizes (EF) and their associated 95% confidence interval (95%CI) of -0.28 [95%CI: -0.54; -0.03] and -0.28 [95%CI: -0.46; -0.09] respectively. Levels of anxiety also appeared to be reduced but pooled estimate did not reach significance (p=0.06). Significantly increased QoL was observed: EF=0.34 [95%CI: 0.07; 0.62] favouring intervention. Consistent and significant inverse associations of weekly and total volume of prescribed exercise were observed with fatigue (F test: p=0.04, R²=0.19 and p=0.009, R²=0.26 respectively) and QoL (F test: p=0.01, R²=0.14 and p=0.02, R²=0.29 respectively), implying that SMDs magnitude decreased as exercise dose increased. Conclusions: Exercise intervention enhanced fatigue, depression and QoL in breast cancer patients undergoing adjuvant therapy. Prescription of relatively low doses of exercise (<12 MET.h per week) consisting in approximately 90-120 min of weekly moderate physical exercise seems more efficacious in improving fatigue and QoL than higher doses.

scholarly journals A Longitudinal Study of a Multicomponent Exercise Intervention with Remote Guidance among Breast Cancer Patients

2020 ◽  
Vol 17 (10) ◽  
pp. 3425 ◽  
Author(s):  
Xiaosheng Dong ◽  
Xiangren Yi ◽  
Meng Ding ◽  
Zan Gao ◽  
Daniel J. McDonough ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mental Health ◽  
Physical Activity ◽  
Muscle Strength ◽  
Cancer Patients ◽  
Exercise Intervention ◽  
Breast Cancer Patients ◽  
Health Related ◽  
One Year

Purpose: Breast cancer patients in treatment suffer from long-term side effects that seriously influence their physical and mental health. The aim of this study was to examine effectiveness of a 12-week multicomponent exercise (ME) with remote guidance intervention on health-related outcomes after one year among breast cancer patients. Methods: In phases I–III, 60 patients (51.2 ± 7.9 years) with breast cancer (BC) who completed chemotherapy/postoperative radiotherapy within the previous four months to two years were randomly assigned to (1) multicomponent exercise with remote guidance (ME) and (2) usual care (UC). Eligible participants were approached to assess cancer-related quality of life (QOL), muscle strength, cardiorespiratory endurance, and physical activity (PA) barriers after one year. Results: The results demonstrated that, after one year, the ME group reported higher vitality-related QOL (5.776, 95% confidence interval [CI] 0.987, 10.565, effect size [ES] = 0.360), mental health-related QOL (9.938, 95% CI 4.146, 15.729, ES = 0.512), leg strength and endurance (2.880, CI 1.337, 4.423, ES = 0.557), and strength and endurance of upper extremities (2.745, 95% CI 1.076, 4.415, ES = 0.491) and lower physical activity (PA) hindrance (5.120, 95% CI 1.976, 8.264, ES = 0.486) than the UC group. Conclusions: The ME group observed significant differences from the UC group in QOL, muscle strength, cardiopulmonary endurance, and PA participation. These findings suggested that the multicomponent exercise intervention with remote guidance produced long-term health benefits for breast cancer patients.

An Effective Exercise Intervention Targeting Breast Cancer Patients at Greatest Risk of Cardiac Dysfunction

2018 ◽  
Vol 27 ◽  
pp. S298
Author(s):  
E. Howden ◽  
A. Bigaran ◽  
S. Foulkes ◽  
R. Beaudry ◽  
K. Janssens ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Cardiac Dysfunction ◽  
Exercise Intervention ◽  
Breast Cancer Patients

Exercise intervention in breast cancer patients with aromatase inhibitor-associated arthralgia: a pilot study

2013 ◽  
Vol 23 (4) ◽  
pp. 493-501 ◽  
Author(s):  
C.A. DeNysschen ◽  
H. Burton ◽  
F. Ademuyiwa ◽  
E. Levine ◽  
S. Tetewsky ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pilot Study ◽  
Aromatase Inhibitor ◽  
Cancer Patients ◽  
Exercise Intervention ◽  
Breast Cancer Patients

scholarly journals Resistance Exercise for Breast Cancer Patients? Evidence from the Last Decade

Breast Care ◽  
2021 ◽  
pp. 1-7
Author(s):  
Lars Gerland ◽  
Freerk T. Baumann ◽  
Timo Niels
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Resistance Training ◽  
Muscle Strength ◽  
Cancer Patients ◽  
Exercise Intervention ◽  
Large Field ◽  
Breast Cancer Patients ◽  
The Impact

<b><i>Background:</i></b> Breast cancer is associated with many therapy-induced side effects that impact patients’ lives from diagnosis to long-term survivorship. Physical activity has become an important and proven supportive measure in treating side effects like loss of muscle strength, fatigue, chemotherapy-induced peripheral neuropathy, lymphedema, and loss of quality of life. Resistance training (RT) is an established exercise intervention for breast cancer patients, but the correct type, timing, intensity, and duration of exercise remain unclear. It is necessary to investigate different resistance training interventions and their effects on breast cancer patients by covering all stages of treatment, beginning with prehabilitation, through the period of acute therapy, to long-term survivorship. <b><i>Conclusion:</i></b> Upon evaluation of randomized controlled trials (RCTs) from the past decade, RT was found to be feasible and safe. Furthermore, there is evidence on the impact of RT on muscle strength, CRF and QoL amongst other factors. Studies implementing mixes of aerobic and strength exercises are rather common, but RCTs of RT-only protocols remain scarce. Different strength training protocols at distinct stages of breast cancer treatment have been conducted, but with the complexity of treatments and the variety of training styles, a large field of study remains. <b><i>Key Messages:</i></b> Although the overall data on RT for breast cancer patients has increased, there are many different methodological approaches and testing measures as well as gaps in study documentation. There is still very little of the evidence that would facilitate the compilation of standardized and individualized guidelines.

scholarly journals Effects of Scheduled Exercise on Cancer-Related Fatigue in Women with Early Breast Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Anne Marie Lunde Husebø ◽  
Sindre Mikal Dyrstad ◽  
Ingvil Mjaaland ◽  
Jon Arne Søreide ◽  
Edvin Bru
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Exercise Intervention ◽  
Activity Level ◽  
Control Group ◽  
Activity Levels ◽  
Breast Cancer Patients ◽  
Cancer Related Fatigue

While physical activity during cancer treatment is found beneficial for breast cancer patients, evidence indicates ambiguous findings concerning effects of scheduled exercise programs on treatment-related symptoms. This study investigated effects of a scheduled home-based exercise intervention in breast cancer patients during adjuvant chemotherapy, on cancer-related fatigue, physical fitness, and activity level. Sixty-seven women were randomized to an exercise intervention group (n=33, performed strength training 3x/week and 30 minutes brisk walking/day) and a control group (n=34, performed their regular physical activity level). Data collection was performed at baseline, at completion of chemotherapy (Post1), and 6-month postchemotherapy (Post2). Exercise levels were slightly higher in the scheduled exercise group than in the control group. In both groups, cancer-related fatigue increased at Post1but returned to baseline at Post2. Physical fitness and activity levels decreased at Post1but were significantly improved at Post2. Significant differences between intervention and control groups were not found. The findings suggest that generally recommended physical activity levels are enough to relief cancer-related fatigue and restore physical capacity in breast cancer patients during adjuvant chemotherapy, although one cannot rule out that results reflect diminishing treatment side effects over time.

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