Retrospective cohort study on factors associated with mortality in high-risk pediatric critical care patients in the Netherlands

ObjectiveTo provide a comprehensive description of demographic, clinical and radiographic characteristics; treatment and case outcomes; and risk factors associated with in-hospital death of patients hospitalised with COVID-19 in Brazil.DesignRetrospective cohort study of hospitalised patients diagnosed with COVID-19.SettingData from all hospitals across Brazil.Participants522 167 hospitalised patients in Brazil by 14 December 2020 with severe acute respiratory illness, and a confirmed diagnosis for COVID-19.Primary and secondary outcome measuresPrevalence of symptoms and comorbidities was compared by clinical outcomes and intensive care unit (ICU) admission status. Survival was assessed using Kaplan Meier survival estimates. Risk factors associated with in-hospital death were evaluated with multivariable Cox proportional hazards regression.ResultsOf the 522 167 patients included in this study, 56.7% were discharged, 0.002% died of other causes, 30.7% died of causes associated with COVID-19 and 10.2% remained hospitalised. The median age of patients was 61 years (IQR, 47–73), and of non-survivors 71 years (IQR, 60–80); 292 570 patients (56.0%) were men. At least one comorbidity was present in 64.5% of patients and in 76.8% of non-survivors. From illness onset, the median times to hospital and ICU admission were 6 days (IQR, 3–9) and 7 days (IQR, 3–10), respectively; 15 days (IQR, 9–24) to death and 15 days (IQR, 11–20) to hospital discharge. Risk factors for in-hospital death included old age, Black/Brown ethnoracial self-classification, ICU admission, being male, living in the North and Northeast regions and various comorbidities. Age had the highest HRs of 5.51 (95% CI: 4.91 to 6.18) for patients≥80, compared with those ≤20.ConclusionsCharacteristics of patients and risk factors for in-hospital mortality highlight inequities of COVID-19 outcomes in Brazil. As the pandemic continues to unfold, targeted policies that address those inequities are needed to mitigate the unequal burden of COVID-19.

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Demographic and clinical factors associated with immune reconstitution in HIV/HBV co‐infected and HIV mono‐infected patients: a retrospective cohort study

HIV Medicine ◽

10.1111/hiv.13023 ◽

2020 ◽

Vol 21 (11) ◽

pp. 722-728

Author(s):

TY Jiang ◽

JH Hou ◽

B Su ◽

T Zhang ◽

Y Yang ◽

...

Keyword(s):

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Immune Reconstitution ◽

Clinical Factors ◽

Factors Associated

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Delayed adjuvant imatinib in patients with high risk of recurrence of gastrointestinal stromal tumor after radical surgery: a retrospective cohort study

Journal of Cancer Research and Clinical Oncology ◽

10.1007/s00432-021-03749-6 ◽

2021 ◽

Author(s):

Wan Qianyi ◽

Xu Mei ◽

Zhao Rui ◽

Wang Yong ◽

Wu Yutao ◽

...

Keyword(s):

Cohort Study ◽

High Risk ◽

Gastrointestinal Stromal Tumor ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Radical Surgery ◽

Stromal Tumor ◽

Adjuvant Imatinib ◽

Risk Of Recurrence

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Risk factors associated with increased discontinuation rate of trimethoprim–sulfamethoxazole used as a primary prophylaxis for Pneumocystis pneumonia: A retrospective cohort study

Pulmonary Pharmacology & Therapeutics ◽

10.1016/j.pupt.2021.101999 ◽

2021 ◽

Vol 67 ◽

pp. 101999

Author(s):

Toshihito Otani ◽

Kakuhiro Yamaguchi ◽

Shinjiro Sakamoto ◽

Yasushi Horimasu ◽

Takeshi Masuda ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Primary Prophylaxis ◽

Pneumocystis Pneumonia ◽

Discontinuation Rate ◽

Factors Associated

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Outcomes after Prehospital Traumatic Cardiac Arrest in the Netherlands: a Retrospective Cohort Study

Injury ◽

10.1016/j.injury.2021.02.088 ◽

2021 ◽

Author(s):

Thymen Houwen ◽

Zar Popal ◽

Marcel A.N. de Bruijn ◽

Anna-Marie R. Leemeyer ◽

Joost H. Peters ◽

...

Keyword(s):

Cardiac Arrest ◽

Cohort Study ◽

The Netherlands ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Traumatic Cardiac Arrest

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A foodborne outbreak of gastroenteritis caused by Norovirus and Bacillus cereus at a university in the Shunyi District of Beijing, China 2018: a retrospective cohort study

BMC Infectious Diseases ◽

10.1186/s12879-019-4570-6 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 4

Author(s):

Dongwan Chen ◽

Yongjin Li ◽

Jinchang Lv ◽

Xiufeng Liu ◽

Peng Gao ◽

...

Keyword(s):

Cohort Study ◽

High Risk ◽

Bacillus Cereus ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Rice Flour ◽

School Canteen ◽

Increased Risk ◽

Rectal Swabs ◽

Beijing China

Abstract Background On September 4, 2018, a boarding school in the Shunyi District of Beijing, China reported an outbreak of acute gastroenteritis. At least 209 suspected students caused of diarrhea and vomiting. The case was investigated, and control measures were taken to prevent further spread. Methods A retrospective cohort study was conducted among the school students and staff in order to test hypothesis that high risk of food served at the school canteen. We collected information on demographics, refectory records, person to person transmission by uniform epidemiological questionnaire. Risk ratios (RR) and 95% confidence intervals (CI) were calculated. Stool specimens of cases and canteen employees, retained food, water, and environmental swabs were investigated by laboratory analysis. Results We identified 209 cases (including 28 laboratory-confirmed cases) which occurred from August 29 to September 10. All cases were students, and the average age was 20, 52% were male. The outbreak lasted for 13 days, and peaked on September 5. Consumption of Drinks stall and Rice flour stall on September 1 (RR:3.4, 95%CI:1.5–7.8, and RR:7.6, 95%CI:2.8–20.2), Rice flour stall and Fish meal stall on September 2 (RR:4.0, 95%CI:1.2–13.6, and RR:4.6, 95%CI:1.7–12.5), muslim meal stall on September 4 (RR:2.7, 95%CI:1.3–5.4), Barbeque stall on September 5 (RR:3.0, 95%CI:1.2–7.0) were independently associated with increased risk of disease within the following 2 days. Among 35 specimens of rectal swabs or feces from students, 28 specimens were positive. Norovirus GI.6 alone was detected in 23 specimens, Bacillus cereus alone in 3 specimens and both norovirus GI.6 and Bacillus cereus in 2 specimens. Ten specimens of rectal swabs from canteen employees were positive for norovirus GI, and 2 specimens were positive for Bacillus cereus. Four retained food specimens were positive for Bacillus cereus, and environmental samples were negative for any viruses or bacteria. Conclusion Our investigation indicated that canteen employees were infected by two pathogens (norovirus and Bacillus cereus) and transmission may have been possible due to unhygienic practices. Student consumption of food or drink at high-risk stalls was determined as the probable cause of the outbreak.

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