Maternal Anxiety and Infants Birthweight and Length of Gestation. A sibling design

Abstract Background The overall aim of this study is to examine the effect of prenatal maternal anxiety on birthweight and gestational age, controlling for shared family confounding using a sibling comparison design. Methods The data on 77,970 mothers and their 91,165 children from the population-based Mother, Father and Child Cohort Study and data on 12,480 pairs of siblings were used in this study. The mothers filled out questionnaires for each unique pregnancy, at 17th and 30th week in pregnancy. Gestational age and birth weight was extracted from the Medical Birth Registry of Norway (MBRN). Associations between prenatal maternal anxiety (measured across the 17th and 30th weeks) and birth outcomes (birthweight and gestational age) were examined using linear regression with adjustment for shared-family confounding in a sibling comparison design. Results In the population level analysis the maternal anxiety score during pregnancy was inversely associated with new-born’s birthweight (Beta = -63.8 95% CI: -92.6, -35.0) and gestational age (Beta = -1.52, 95% CI: -2.15, -0.89) after adjustment for several covariates. The association of the maternal anxiety score with birthweight was no longer significant, but remained for maternal anxiety at 30th week with gestational age (Beta = -1.11, 95% CI: -1.82, -0.4) after further adjusting for the shared-family confounding in the sibling comparison design. Conclusion No association was found for maternal prenatal anxiety with birth weight after multiple covariates and family environment were controlled. However, there was an association between prenatal maternal anxiety at 30th week only with gestational age, suggesting a timing effect for maternal anxiety in third trimester.

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Sexual violence and neonatal outcomes: a Norwegian population-based cohort study

BMJ Open ◽

10.1136/bmjopen-2014-005935 ◽

2014 ◽

Vol 4 (10) ◽

pp. e005935 ◽

Cited By ~ 4

Author(s):

Lena Henriksen ◽

Berit Schei ◽

Siri Vangen ◽

Mirjam Lukasse

Keyword(s):

Cohort Study ◽

Birth Weight ◽

Sexual Violence ◽

Gestational Age ◽

Population Based ◽

Neonatal Outcomes ◽

Gestational Length ◽

Birth Registry ◽

Maternal Characteristics ◽

Behavioural Factors

ObjectiveThe objective of this study was to explore the association between sexual violence and neonatal outcomes.DesignNational cohort study.SettingWomen were recruited to the Norwegian Mother and Child Cohort Study (MoBa) while attending routine ultrasound examinations from 1999 to 2008.PopulationA total of 76 870 pregnant women.MethodsSexual violence and maternal characteristics were self-reported in postal questionnaires during pregnancy. Neonatal outcomes were retrieved from the Medical Birth Registry of Norway (MBRN). Risk estimations were performed with linear and logistic regression analysis. Outcome measures: gestational age at birth, birth weight, preterm birth (PTB), low birth weight (LBW) and small for gestational age (SGA).ResultsOf 76 870 women, 18.4% reported a history of sexual violence. A total of 4.7% delivered prematurely, 2.7% had children with a birth weight <2500 g and 8.1% children were small for their gestational age. Women reporting moderate or severe sexual violence (rape) had a significantly reduced gestational length (2 days) when the birth was provider-initiated in an analysis adjusted for age, parity, education, smoking, body mass index and mental distress. Those exposed to severe sexual violence had a significantly reduced gestational length of 0.51 days with a spontaneous start of birth. Crude estimates showed that severe sexual violence was associated with PTB, LBW and SGA. When controlling for the aforementioned sociodemographic and behavioural factors, the association was no longer significant.ConclusionsSexual violence was not associated with adverse neonatal outcomes. Moderate and severe violence had a small but significant effect on gestational age; however, the clinical influence of this finding is most likely limited. Women exposed to sexual violence in this study reported more of the sociodemographic and behavioural factors associated with PTB, LBW and SGA compared with non-abused women.

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Comparison of adverse perinatal outcomes between Asians and Caucasians: a population-based retrospective cohort study in Ontario

BMC Pregnancy and Childbirth ◽

10.1186/s12884-020-03467-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Na Zeng ◽

Erica Erwin ◽

Wendy Wen ◽

Daniel J. Corsi ◽

Shi Wu Wen ◽

...

Keyword(s):

Cohort Study ◽

Birth Weight ◽

Preterm Birth ◽

Cesarean Section ◽

Gestational Age ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Perinatal Outcomes ◽

Population Based ◽

Adverse Perinatal Outcomes

Abstract Background Racial disparities in adverse perinatal outcomes have been studied in other countries, but little has been done for the Canadian population. In this study, we sought to examine the disparities in adverse perinatal outcomes between Asians and Caucasians in Ontario, Canada. Methods We conducted a population-based retrospective cohort study that included all Asian and Caucasian women who attended a prenatal screening and resulted in a singleton birth in an Ontario hospital (April 1st, 2015-March 31st, 2017). Generalized estimating equation models were used to estimate the independent adjusted relative risks and adjusted risk difference of adverse perinatal outcomes for Asians compared with Caucasians. Results Among 237,293 eligible women, 31% were Asian and 69% were Caucasian. Asians were at an increased risk of gestational diabetes mellitus, placental previa, early preterm birth (< 32 weeks), preterm birth, emergency cesarean section, 3rd and 4th degree perineal tears, low birth weight (< 2500 g, < 1500 g), small-for-gestational-age (<10th percentile, <3rd percentile), neonatal intensive care unit admission, and hyperbilirubinemia requiring treatment, but had lower risks of preeclampsia, macrosomia (birth weight > 4000 g), large-for-gestational-age neonates, 5-min Apgar score < 7, and arterial cord pH ≤7.1, as compared with Caucasians. No difference in risk of elective cesarean section was observed between Asians and Caucasians. Conclusion There are significant differences in several adverse perinatal outcomes between Asians and Caucasians. These differences should be taken into consideration for clinical practices due to the large Asian population in Canada.

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Bacterial vaginosis in early pregnancy is associated with low birth weight and small for gestational age, but not with spontaneous preterm birth: A population-based study on Danish women

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.1080/14767050500361604 ◽

2006 ◽

Vol 19 (1) ◽

pp. 1-7 ◽

Cited By ~ 15

Author(s):

Poul Thorsen ◽

Ida Vogel ◽

Jørn Olsen ◽

Bernard Jeune ◽

Jes G. Westergaard ◽

...

Keyword(s):

Birth Weight ◽

Preterm Birth ◽

Low Birth Weight ◽

Bacterial Vaginosis ◽

Early Pregnancy ◽

Gestational Age ◽

Small For Gestational Age ◽

Population Based ◽

Spontaneous Preterm Birth ◽

Population Based Study

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Retinopathy of Prematurity: A New Epidemic?

PEDIATRICS ◽

10.1542/peds.83.4.486 ◽

1989 ◽

Vol 83 (4) ◽

pp. 486-492

Author(s):

Donna L. Gibson ◽

Samuel B. Sheps ◽

Martin T. Schechter ◽

Sandra Wiggins ◽

Andrew Q. McCormick

Keyword(s):

British Columbia ◽

Birth Weight ◽

Retinopathy Of Prematurity ◽

Population Level ◽

Population Based ◽

Standardized Incidence Ratio ◽

Canadian Province ◽

Annual Population ◽

Diagnostic Changes ◽

Increases In Risk

This study provides the first empiric evidence for the existence of a new epidemic of retinopathy of prematurity-induced blindness. Data from a population-based register of handicapping conditions in the Canadian province of British Columbia, and a birth weight-specific census of live-born infants in British Columbia, were used to determine annual, population-level incidences of retinopathy of prematurity-induced blindness during 1952 to 1983. Changes in incidence since the end of the original epidemic (1954) were determined by subdividing the 29-year period (1955 to 1983) into two intervals (1955 to 1964 and 1965 to 1983). Standardized incidence ratio analyses revealed a marginally significant increase in the overall incidence of retinopathy of prematurity-induced blindness in the later as compared with the earlier period. Infants weighing 750 to 999 g at birth had a significantly increased standardized incidence ratio of 3.07 (95% confidence interval 1.26, 11.06). No increases in risk were observed in heavier or lighter weight infants. Because ascertainment and diagnostic changes do not explain the weight-specific increases in incidence, these results provide the first population-level evidence for a new epidemic.

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Population-based reference for birth weight for gestational age in northern China

Early Human Development ◽

10.1016/j.earlhumdev.2014.01.007 ◽

2014 ◽

Vol 90 (4) ◽

pp. 177-187 ◽

Cited By ~ 4

Author(s):

Zhe Liu ◽

Jinliang Zhang ◽

Baoxin Zhao ◽

Xiaoping Xue ◽

Lizhen Xu ◽

...

Keyword(s):

Birth Weight ◽

Gestational Age ◽

Northern China ◽

Population Based

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Associations of Birth Weight for Gestational Age with Child Health and Neurodevelopment among Term Infants: A Nationwide Japanese Population-Based Study

The Journal of Pediatrics ◽

10.1016/j.jpeds.2020.06.075 ◽

2020 ◽

Vol 226 ◽

pp. 135-141.e4

Author(s):

Kei Tamai ◽

Takashi Yorifuji ◽

Akihito Takeuchi ◽

Yu Fukushima ◽

Makoto Nakamura ◽

...

Keyword(s):

Birth Weight ◽

Child Health ◽

Gestational Age ◽

Japanese Population ◽

Population Based ◽

Term Infants ◽

Population Based Study

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Fetal growth and psychiatric and socioeconomic problems: population-based sibling comparison

The British Journal of Psychiatry ◽

10.1192/bjp.bp.113.143693 ◽

2014 ◽

Vol 205 (5) ◽

pp. 355-361 ◽

Cited By ~ 39

Author(s):

Quetzal A. Class ◽

Martin E. Rickert ◽

Henrik Larsson ◽

Paul Lichtenstein ◽

Brian M. D'Onofrio

Keyword(s):

Birth Weight ◽

Fetal Growth ◽

Population Based ◽

Autism Spectrum ◽

Swedish Population ◽

Unmeasured Confounding ◽

Lower Birth Weight ◽

Sibling Comparison ◽

Increased Risk ◽

Socioeconomic Problems

BackgroundIt is unclear whether associations between fetal growth and psychiatric and socioeconomic problems are consistent with causal mechanisms.AimsTo estimate the extent to which associations are a result of unmeasured confounding factors using a sibling-comparison approach.MethodWe predicted outcomes from continuously measured birth weight in a Swedish population cohort (n = 3 291 773), while controlling for measured and unmeasured confounding.ResultsIn the population, lower birth weight (⩽2500 g) increased the risk of all outcomes. Sibling-comparison models indicated that lower birth weight independently predicted increased risk for autism spectrum disorder (hazard ratio for low birth weight = 2.44, 95% CI 1.99–2.97) and attention-deficit hyperactivity disorder. Although attenuated, associations remained for psychotic or bipolar disorder and educational problems. Associations with suicide attempt, substance use problems and social welfare receipt, however, were fully attenuated in sibling comparisons.ConclusionsResults suggest that fetal growth, and factors that influence it, contribute to psychiatric and socioeconomic problems.

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Birth weight by gestational age and risk of childhood acute leukemia: a population-based study 1961–2002

Leukemia & Lymphoma ◽

10.3109/10428194.2010.546915 ◽

2011 ◽

Vol 52 (4) ◽

pp. 709-712 ◽

Cited By ~ 5

Author(s):

Svetlana V. Glinianaia ◽

Mark S. Pearce ◽

Judith Rankin ◽

Tanja Pless-Mulloli ◽

Louise Parker ◽

...

Keyword(s):

Birth Weight ◽

Acute Leukemia ◽

Gestational Age ◽

Population Based ◽

Population Based Study ◽

Childhood Acute Leukemia

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Risk of intellectual disability in children born appropriate-for-gestational-age at term or post-term: impact of birth weight for gestational age and gestational age

European Journal of Epidemiology ◽

10.1007/s10654-019-00590-7 ◽

2019 ◽

Vol 35 (3) ◽

pp. 273-282 ◽

Cited By ~ 1

Author(s):

Ruoqing Chen ◽

Kristina Tedroff ◽

Eduardo Villamor ◽

Donghao Lu ◽

Sven Cnattingius

Keyword(s):

Intellectual Disability ◽

Birth Weight ◽

Low Birth Weight ◽

Gestational Age ◽

Cox Regression ◽

Population Analysis ◽

Comparison Analysis ◽

Sibling Comparison ◽

Increased Risk ◽

Appropriate For Gestational Age

AbstractChildren born small for gestational age have a higher risk of intellectual disability. We investigated associations of birth weight for gestational age percentile and gestational age with risk of intellectual disability in appropriate-for-gestational-age (AGA) children. We included 828,948 non-malformed term or post-term AGA singleton children (including 429,379 full siblings) born between 1998 and 2009 based on data from the Swedish Medical Birth Register. Diagnosis of intellectual disability after 3 years of age was identified through the Patient Register. Using Cox regression models, we calculated hazard ratios (HRs) with 95% confidence intervals (CIs) of intellectual disability among children with different birth weight percentiles and gestational age in the whole population and in a subpopulation of full siblings. A total of 1688 children were diagnosed with intellectual disability during follow-up. HRs (95% CIs) of intellectual disability for the low birth weight percentile groups (10th–24th and 25th–39th percentiles, respectively) versus the reference group (40th–59th percentiles) were 1.43 (1.22–1.67) and 1.28 (1.10–1.50) in population analysis and 1.52 (1.00–2.31) and 1.44 (1.00–2.09) in sibling comparison analysis. The increased risk for low birth weight percentiles in population analysis was stable irrespective of gestational age. A weak U-shaped association between gestational age and intellectual disability was observed in population analysis, although not in sibling comparison analysis. These findings suggest that among AGA children born at term or post-term, lower birth weight percentiles within the normal range are associated with increased risk of intellectual disability, regardless of gestational age.

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Birth outcomes of cases with different congenital heart defects - a population-based study

International Journal of Health ◽

10.14419/ijh.v3i1.4406 ◽

2015 ◽

Vol 3 (1) ◽

pp. 7

Author(s):

Attila Vereczkey ◽

Balázs Gerencsér ◽

Andrew E Czeizel ◽

István Szabó

Keyword(s):

Birth Weight ◽

Birth Outcomes ◽

Gestational Age ◽

Intrauterine Growth Restriction ◽

Congenital Heart ◽

Low Birthweight ◽

Heart Defects ◽

Population Based ◽

Intrauterine Growth ◽

Gestational Age At Delivery

Background: In general, previous epidemiological studies evaluated congenital heart defects (CHDs) together. The aim of the present study was to identify possible etiological factors of different CHD-entities, because the underlying causes are unclear in the vast majority of patients.Objectives: Different CHD-entities as homogeneously as possible with confirmed diagnoses were analyzed in the population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities.Methods: 3,750 live-born singleton CHD-patients were analyzed according to birth outcomes, i.e. gestational age at delivery and birth weight, the rate of preterm birth, low birthweight and small for gestational age.Results: The major findings of the study showed that cases with different CHD-entities had shorter gestational age at delivery and lower mean birth weight, and these variables associated with a higher rate of preterm birth and particularly with a much higher rate of low birthweight and small for gestational age. This study showed the importance of sex in the birth outcomes of some CHD-entities. The question is why several CHD-entities manifested more frequently in newborns with intrauterine growth restriction because fetal heart has a passive role before birth without pulmonary circulation.Conclusions: The birth outcomes of cases indicate the effect of CHDs for fetal development. In addition maternal confounders have to consider. Finally, CHDs and intrauterine growth restriction as two developmental errors may have a common route, thus fetal growth and birthweight associated gene polymorphisms may have a role in the origin of CHDs.

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