scholarly journals Quality of life assessment in patients with heart failure: validity of the German version of the generic EQ-5D-5L™

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Sigrid Boczor ◽  
Anne Daubmann ◽  
Marion Eisele ◽  
Eva Blozik ◽  
Martin Scherer
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Heart Failure ◽  
Discriminant Validity ◽  
Effect Sizes ◽  
Sf 36 ◽  
Eta Squared ◽  
Related Quality ◽  
Health Related

Abstract Background Chronic heart failure patients typically suffer from tremendous strain and are managed mainly in primary care. New care concepts adapted to the severity of heart failure are a challenge and need to consider health-related quality of life aspects. This is the first psychometric validation of the German EQ-5D-5L™ as a generic instrument for assessing health-related quality of life (HRQOL) in a primary care heart failure patient sample. Methods Confirmatory factor analysis (CFA) was performed on the baseline EQ-5D-5L™ data from the RECODE-HF study (responses to all items from n = 3225 of 3778 patients). Basic CFA models for HRQOL were calculated based on the EQ-5D-5L™ items using the maximum likelihood (ML) and the asymptotic distribution-free method. In an extended CFA, physical activity and depression were added. The basic CFA ML model was verified for the reduced number of cases of the extended CFA model (n = 3064). In analyses of variance the association of the EQ-5D-5L™ visual analogue scale (VAS) and both the German and the British EQ-5D-5L™ crosswalk index with the SF-36 measure of general health were examined. The discriminant validity was analysed using Pearson’s chi-squared tests applying the New York Heart Association classification, for the VAS and indices analyses of variance were calculated. Results In the basic CFA models the root mean square error of approximation was 0.095 with the ML method, and 0.081 with the asymptotic distribution-free method (Comparative Fit Index > 0.90 for both). Physical activity and depression were confirmed as influential factors in the extended model. The VAS and indices were strongly associated with the SF-36 measure of general health (partial eta-squared 0.525/0.454/0.481; all p <  0.001; n = 3155/3210/3210, respectively), also for physical activity and depression when included together (partial eta-squared 0.050, 0.200/0.047, 0.213/0.051 and 0.270; all p <  0.001; n = 3015/n = 3064/n = 3064, respectively). The discriminant validity analyses showed p-values < 0.001 and small to moderate effect sizes for all EQ-5D-5L™ items. Analyses of variance demonstrated moderate effect sizes for the VAS and indices (0.067/0.087/0.084; all p <  0.001; n = 3110/3171/3171). Conclusion The German EQ-5D-5L™ is a suitable method for assessing HRQOL in heart failure patients.

scholarly journals The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

2020 ◽  
Vol 17 (10) ◽  
pp. 3728
Author(s):  
Alba Marcos-Delgado ◽  
Tania Fernández-Villa ◽  
Miguel Ángel Martínez-González ◽  
Jordi Salas-Salvadó ◽  
Dolores Corella ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Health Related Quality ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related

The main objective of this study was to examine the relationship between the level of physical activity (PA) and the degree of obesity with health-related quality of life (HRQoL) in individuals with metabolic syndrome (MetS) who participated in the Predimed-Plus study. A total of 6875 subjects between 55 and 75 years of age with MetS were selected and randomized in 23 Spanish centers. Subjects were classified according to categories of body mass index (BMI). PA was measured with the validated Registre Gironí del Cor (REGICOR) questionnaire and subjects were classified according to their PA level (light, moderate, vigorous) and the HRQoL was measured with the validated short-form 36 (SF-36) questionnaire. By using the ANOVA model, we found a positive and statistically significant association between the level of PA and the HRQoL (aggregated physical and mental dimensions p < 0.001), but a negative association with higher BMI in aggregated physical dimensions p < 0.001. Furthermore, women obtained lower scores compared with men, more five points in all fields of SF-36. Therefore, it is essential to promote PA and body weight control from primary care consultations to improve HRQoL, paying special attention to the differences that sex incurs.

The impact of telehealth care on health-related quality of life of patients with heart failure: Results from the Danish TeleCare North heart failure trial

2019 ◽  
Vol 26 (7-8) ◽  
pp. 452-461 ◽  
Author(s):  
Simon L Cichosz ◽  
Flemming W Udsen ◽  
Ole Hejlesen
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Health Related Quality ◽  
Primary Analysis ◽  
Sf 36 ◽  
Patients With Heart Failure ◽  
Related Quality ◽  
Health Related ◽  
The Impact

Aim The aim of this study was to assess the impact on health-related quality of life (HRQoL) of a telehealth care solution compared with usual practice of patients with heart failure (HF). Methods A randomized controlled trial with a telehealth care solution (Telekit) as the intervention (with a focus on self-empowerment achieved by engaging patients in their own illness through self-monitoring) combined with usual care and usual care as the control. The primary outcome was a change in HRQoL as measured by the Short Form-36 (SF-36) questionnaire Physical Component Summary (PCS) score. Secondary outcomes were changes in HRQoL as measured by the SF-36 questionnaire Mental Component Summary (MSC) score and the HF disease-specific questionnaire Kansas City Cardiomyopathy Questionnaire 12 (KCCQ12) score, all of which were assessed from baseline to approximately 12 months’ follow-up between the two groups. Outcomes were assessed via unadjusted and adjusted analyses. Results At baseline, 299 (145 interventions, 154 controls) patients were enrolled. In the primary analysis ( n = 299), the adjusted intervention effects were PCS –0.81 (95% CI −2.7–1.1), MCS 4.66 (95% CI 1.8–7.5) and KCCQ12 3.67 (95% CI −0.7–8.1). Only the change in MCS was statistically significant. An unadjusted analysis replicated the primary analysis. Complete case analyses ( n = 193) generally resulted in a lower intervention effect on the PCS score, but the difference remained statistically insignificant. Conclusions Only the MCS score was significantly higher in the telehealth care group compared to the control group. ClinicalTrials.gov (NCT02860013), July 28, 2016

scholarly journals A Comparison of Short-Term Changes in Health-Related Quality of Life in Thyroid Carcinoma Patients Undergoing Diagnostic Evaluation with Recombinant Human Thyrotropin Compared with Thyroid Hormone Withdrawal

2006 ◽  
Vol 91 (3) ◽  
pp. 878-884 ◽  
Author(s):  
Pamela R. Schroeder ◽  
Bryan R. Haugen ◽  
Furio Pacini ◽  
Christoph Reiners ◽  
Martin Schlumberger ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Whole Body ◽  
Short Term ◽  
Body Scanning ◽  
Sf 36 ◽  
Patients With Heart Failure ◽  
Related Quality ◽  
Health Related

Abstract Context: Thyroid carcinoma requires lifelong monitoring with serum thyroglobulin, radioactive iodine whole body scanning, and other imaging modalities. Levothyroxine (l-T4) withdrawal for thyroglobulin measurement and whole body scanning increases these tests’ sensitivities but causes hypothyroidism. Recombinant human TSH (rhTSH) enables testing without l-T4 withdrawal. Objective: Our objective was to examine the impact of short-term hypothyroidism on the health-related quality of life (HRQOL) of patients after rhTSH vs.l-T4 withdrawal. Design, Setting, and Patients: In this multicenter study, the SF-36 Health Survey was administered to 228 patients at three time points: on l-T4, after rhTSH, and after l-T4 withdrawal. Interventions: Interventions included administration of rhTSH on l-T4 and withdrawal from thyroid hormone. Main Outcome Measures: Mean SF-36 scores were compared during the two interventions and with the U.S. general population and patients with heart failure, depression, and migraine headache. Results: Patients had SF-36 scores at or above the norm for the general U.S. population in six of eight domains at baseline on l-T4 and in seven of eight domains after rhTSH. Patients’ scores declined significantly in all eight domains after l-T4 withdrawal when compared with the other two periods (P &lt; 0.0001). Patients’ HRQOL scores while on l-T4 and after rhTSH were at or above those for patients with heart failure, depression, and migraine in all eight domains. After l-T4 withdrawal, patients’ HRQOL scores were significantly below congestive heart failure, depression, and migraine headache norms in six, three, and six of the eight domains, respectively. Conclusions: Short-term hypothyroidism after l-T4 withdrawal is associated with a significant decline in quality of life that is abrogated by rhTSH use.

scholarly journals The association of pulmonary function, physical activity, cardiorespiratory fitness, Borg dyspnea scales and health related quality of life in patients with resected lung cancer

2021 ◽  
Author(s):  
Xinping Li ◽  
Yi Chen ◽  
Shuangchun Liu ◽  
Mingsheng Zhang
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Lung Cancer ◽  
Pulmonary Function ◽  
Cardiorespiratory Fitness ◽  
Health Related Quality ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related

Abstract Background Understanding the determinants of quality of life for the patients after lung resection would be beneficial to affect the prevention programs and the treatment strategies. This novel study aims to explore the relationship between pulmonary function, physical activity, cardiorespiratory fitness (CRF), dyspnea, and the health-related quality of life (HRQoL) of patients with resected lung cancer. Methods A cross-sectional study design with 38 lung cancer survivors after surgery for one month was conducted. We assessed CRF by measuring maximal oxygen consumption (VO2max) and anaerobic threshold (VT).Forced vital capacity (FVC) was measured using a spirometer. Physical activity, dyspnea, and HRQoLwereinvestigated by 6-minute walking distance (6MWD), Borg dyspnea scales, and the SF-36 Health Survey (SF-36), respectively.Data analyses were conducted using SmartPLS to examine path analyses between the measures. Results There was a significant relationship between CRF andHRQoL in this cohort of cancer survivors.FVC (f2 = 0.265) and 6MWD (f2 = 0.389) have a medium to large effect size on the perceived CRF while CRF (f2 = 0.467) was found to have large effect sizes on perceived QoL. More importantly, our results showed that CRF positively and significantly mediated the paths betweenFVC, 6MWD, andHRQoL[β = 0.22 (0.457*0.474),P < 0.01; β = 0.28 (0.525*0.540), P < 0.01; respectively]. Conclusions Pulmonary function, physical activity, and dyspnea had an indirect effect on the quality of life in patients with resected lung cancer. Furthermore, CRF mediates pulmonary function and physical activity to produces an impact on their quality of life.

scholarly journals QUALIDADE DE VIDA RELACIONADA À SAÚDE (HRQL) DE ADULTOS ENTRE 50 E 80 ANOS PRATICANTES DE ATIVIDADE FÍSICA REGULAR: APLICAÇÃO DO SF-36

2011 ◽  
Vol 16 (esp) ◽  
Author(s):  
Andréa Kruger Gonçalves ◽  
Adriane Ribeiro Teixeira ◽  
Cíntia De la Rocha Freitas ◽  
Eliane Jost Blessmann ◽  
Laysla Roedel ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Short Form ◽  
Well Being ◽  
Health Related Quality ◽  
Cross Sectional ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related

A qualidade de vida relacionada à saúde-HRQL possui um caráter multidimensional com integração da saúde física, do bem-estar psicológico e da satisfação social. O objetivo foi avaliar a qualidade de vida relacionada à saúde (HRQL) de participantes de meia-idade e de idosos de um projeto de atividade física regular. O tipo de estudo foi descritivo, com corte transversal, sendo que a amostra foi composta por 40 adultos com idade entre 50 e 80 anos, integrantes do CELARI da ESEF/UFRGS. O instrumento utilizado foi o SF-36 e a análise empregada utilizou a estatística descritiva e o teste de correlação de Pearson. A pontuação dos domínios por ordem decrescente foi: AS, AF, AE, EGS, CF, SM, VIT, DOR. Houve correlação positiva significativa entre a maioria dos domínios do SF-36. As correlações não significativas ocorreram entre EGS x AS, SM x AF. A idade apenas correlacionou-se com o domínio EGS. A HRQL da amostra mostrou-se com valores superiores, ao ser comparada com a de outros estudos. Os valores atingiram no mínimo 70% de pontuação, na média dos domínios. Os resultados indicaram um nível satisfatório de HRQL e relação entre os domínios do SF-36. palavras-chave Envelhecimento. Qualidade de Vida. Atividade Física. Saúde. abstract The health-related quality of life – HRQOL is a multidimensional issue with integration of physical health, psychological well-being and social satisfaction factors. The aim of this study was to evaluate the health-related quality of life – HRQOL in ageing people who practice regular physical activity. This study was a descriptive cross-sectional and  the sample included 40 adults, aged between 50 and 80 years, attending a University Extension Program. The instrument used was the Brazilian version of Short Form-36. Descriptive statistical analysis was used to summarize HRQL data and Pearson’s correlation for comparison between domains. The score of the domains in descending order were: AS, AF, AE, EGS, CF, SM, VIT, DOR. There was a significant positive correlation between the majority of SF-36. The correlations were not significant between EGS x AS, SM x AF. The age was correlated only with the EGS field. The HRQL of the sample proved to be higher, when compared with other studies. The values ​​reached a minimum score of 70% in average scores. The results indicated a satisfactory level of HRQOL and a significant relationship between different aspects of health-related quality of life. keywords Aging. Quality of Life. Physical Activity. Health.

scholarly journals The Association of Pulmonary Function, Physical Activity, Cardiorespiratory Fitness, Borg Dyspnea Scales and Health Related Quality of Life in Patients With Resected Lung Cancer

2021 ◽  
Author(s):  
Xinping Li ◽  
Yi Chen ◽  
Shuangchun Liu ◽  
Mingsheng Zhang
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Lung Cancer ◽  
Pulmonary Function ◽  
Cardiorespiratory Fitness ◽  
Health Related Quality ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related

Abstract Purpose This novel study aims to explore the relationship between pulmonary function, physical activity, cardiorespiratory fitness (CRF), dyspnea, and the health-related quality of life (HRQoL) of patients with resected lung cancer. Methods A cross-sectional study design with 38 lung cancer survivors after surgery for one month was conducted. We assessed CRF by measuring maximal oxygen consumption (VO2max) and anaerobic threshold (VT). Forced vital capacity (FVC) was measured using a spirometer. Physical activity, dyspnea, and HRQoL were investigated by 6-minute walking distance (6MWD), Borg dyspnea scales, and the SF-36 Health Survey (SF-36), respectively. Data analyses were conducted using SmartPLS to examine path analyses between the measures. Results There was a significant relationship between CRF and HRQoL in this cohort of cancer survivors. FVC (f2 = 0.265) and 6MWD (f2 = 0.389) have a medium to large effect size on the perceived CRF while CRF (f2 = 0.467) was found to have large effect sizes on perceived QoL. More importantly, our results showed that CRF positively and significantly mediated the paths between FVC, 6MWD, and HRQoL [β = 0.22 (0.457*0.474),P < 0.01; β = 0.28 (0.525*0.540), P < 0.01; respectively]. Conclusions Pulmonary function, physical activity, and dyspnea had an indirect effect on the quality of life in patients with resected lung cancer. Furthermore, CRF mediates pulmonary function and physical activity to produce an impact on their quality of life.

scholarly journals Health-related quality of life among the elderly with heart failure: a generic measurement

2010 ◽  
Vol 128 (4) ◽  
pp. 192-196 ◽  
Author(s):  
Izabel Cristina Ribeiro da Silva Saccomann ◽  
Fernanda Aparecida Cintra ◽  
Maria Cecilia Bueno Jayme Gallani
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Elderly People ◽  
Left Ventricular Ejection ◽  
Health Related Quality ◽  
Elderly Individuals ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related

CONTEXT AND OBJECTIVE: Health-related quality-of-life (HRQoL) instruments have been greatly used among patients with heart failure (HF), although few of them are specific for elderly people. Among the generic instruments, the Medical Study 36-item Short-Form Health Survey (SF-36) is widely used. The aim here was to evaluate HRQoL among elderly individuals with HF through this generic instrument. DESIGN AND SETTING: Cross-sectional study at two university hospitals in São Paulo, Brazil. METHODS: 170 elderly people with HF who were being followed up as outpatients were interviewed. To evaluate HRQoL, SF-36 was used. RESULTS: The sample was composed of subjects with a mean age of 67.5 (± 6.2) years, with a diagnosis of HF for 65.9 (± 42.4) months, in functional class I (38.8%; 66) or II (42.9%; 73) and with reduced left ventricular ejection fraction (LVEF) (51.2%). The mental and social HRQoL domains did not seem to be compromised, since they presented high scores. Patients with HF typically had impaired physical capacity, which may explain the lower scores in the physical domain. Cronbach's alpha coefficients were greater than 0.77 for all dimensions, except for general health status. CONCLUSION: The HRQoL measurements using SF-36 presented a high level of reliability when applied to Brazilian elderly individuals with HF. This population presented lower scores for the functional capacity and physical dimensions. This provides support for intervention studies aiming towards optimization of HRQoL in this group.

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