Risk factors of dengue fever in an urban area in Vietnam: a case-control study

Abstract Background Dengue is a mosquito-borne flavivirus present in many metropolitan cities of tropical countries. Methods During and after the dengue season (September 2018 to January 2019), we conducted a case-control study in order to determine the risk factors for dengue fever in Hanoi city, Vietnam. 98 dengue patients and 99 patients with other acute infections, such as Hepatitis B virus infection, were recruited at Department of Infectious Disease of Bach Mai national hospital in Hanoi. Patients were interviewed using a structured questionnaire covering demographic, housing, environmental factors and knowledge, attitude, and practice on dengue prevention and control. Univariate analysis and multivariable logistic regression were used to determine the risk factors of dengue status. Results The mean score of knowledge items and practice items was only 7.9 out of total 19 points and 3.9 out of total 17 points, respectively. While the mean score of attitude items was 4.8 out of total 6 points. Multivariable logistic regression indicated that older patients had lesser risk of getting dengue infection as compared to younger adults aged 16–30, and patients living in peri-urban districts were less likely to suffer of dengue fever than patients living in central urban districts (OR = 0.31; 95% CI 0.13–0.75). This study could not find any association with occupation, water storage habit, knowledge, attitude, or practice on dengue prevention. Conclusions All patients had a relatively low level of knowledge and practice on dengue prevention and control. However, the attitude of the participants was good. We found that age group and living district were the risk factors correlated with the dengue status. Communication programs on raising dengue awareness should be repeated all year round and target particular groups of adolescents, younger adults, landlords and migrants from other provinces to improve their knowledge and encourage them to implement preventive measures against dengue fever.

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Risk Factors of Dengue Fever in an Urban Area in Vietnam: A Case-Control Study

10.21203/rs.3.rs-80925/v1 ◽

2020 ◽

Author(s):

Thang Nguyen-Tien ◽

Do Duy Cuong ◽

Le Xuan Luat ◽

Dinh Thi Hai ◽

Mats Lindeborg ◽

...

Keyword(s):

Risk Factors ◽

Dengue Fever ◽

Prevention And Control ◽

Case Control Study ◽

Case Control ◽

Younger Adults ◽

The Mean ◽

Dengue Prevention ◽

And Control ◽

Control Study

Abstract Background: Dengue is a mosquito-borne flavivirus present in many metropolitan cities of tropical countries. Methods: During and after the dengue season (September 2018 to January 2019), we conducted a case-control study in order to determine the risk factors for dengue fever in Hanoi city, Vietnam. 98 dengue patients and 99 patients with other acute infections were recruited at Department of Infectious Disease of Bach Mai national hospital in Hanoi. Patients were interviewed using a structured questionnaire covering demographic, housing, environmental factors and knowledge, attitude, and practice on dengue prevention and control. Results: The mean score of knowledge items and practice items was only 7.9 out of total 19 points and 3.9 out of total 17 points, respectively. While the mean score of attitude items was 4.8 out of total 6 points. Multivariable logistic regression indicated that older patients had lesser risk of getting dengue infection as compared to younger adults aged 16-30, and patients living in peri-urban districts were less likely to suffer of dengue fever than patients living in central urban districts (OR = 0.31; 95% CI 0.13-0.75). This study could not find any association with occupation, water storage habit, knowledge, attitude, or practice on dengue prevention. Conclusions: All patients had a relatively low level of knowledge and practice on dengue prevention and control. However, the attitude of the participants was good. We found that age group and living district were the risk factors correlated with the dengue status. Communication programs on raising dengue awareness should be repeated all year round and target particular groups of adolescents, younger adults, landlords and migrants from other provinces to improve their knowledge and encourage them to implement preventive measures against dengue fever.

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Risk factors associated with an outbreak of dengue fever/dengue haemorrhagic fever in Hanoi, Vietnam

Epidemiology and Infection ◽

10.1017/s0950268814002647 ◽

2014 ◽

Vol 143 (8) ◽

pp. 1594-1598 ◽

Cited By ~ 10

Author(s):

D. T. T. TOAN ◽

L. N. HOAT ◽

W. HU ◽

P. WRIGHT ◽

P. MARTENS

Keyword(s):

Risk Factors ◽

Dengue Fever ◽

Case Control Study ◽

Dengue Haemorrhagic Fever ◽

Haemorrhagic Fever ◽

Dengue Transmission ◽

Control Programmes ◽

Dengue Prevention ◽

And Control ◽

Control Study

SUMMARYDengue fever/dengue haemorrhagic fever (DF/DHF) appears to be emerging in Hanoi in recent years. A case-control study was performed to investigate risk factors for the development of DF/DHF in Hanoi. A total of 73 patients with DF/DHF and 73 control patients were included in the study. The risk factor analysis indicated that living in rented housing, living near uncovered sewers, and living in a house discharging sewage directly into to ponds were all significantly associated with DF/DHF. People living in rented houses were 2·2 times more at risk of DF/DHF than those living in their own homes [adjusted odds ratio (aOR) 2·2, 95% confidence interval (CI) 1·1–4·6]. People living in an unhygienic house, or in a house discharging sewage directly to the ponds were 3·4 times and 4·3 times, respectively, more likely to be associated with DF/DHF (aOR 3·4, 95% CI 1–11·7; aOR 4·3, 95% CI 1·1–16·9). These results contribute to the understanding of the dynamics of dengue transmission in Hanoi, which is needed to implement dengue prevention and control programmes effectively and efficiently.

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Risk Factors Associated With Dengue Fever Outbreak in Taiz Governorate, Yemen, 2018: Case-control Study

10.21203/rs.3.rs-624873/v1 ◽

2021 ◽

Author(s):

Abdulkareem Ali Hussein Nassar ◽

Amr Abdulaziz Torbosh ◽

Yassin Abdulmalik Mahyoub ◽

Mohammed Abdullah Al Amad

Keyword(s):

Risk Factors ◽

Dengue Fever ◽

Case Control Study ◽

Significant Risk ◽

Case Fatality ◽

Case Control ◽

Case Definition ◽

P Value ◽

Factors Associated ◽

Control Study

Abstract Background: Dengue Fever (DF) is a significant health problem in Yemen especially in the coastal areas. On November 6, 2018, Taiz governorates surveillance officer notified the Ministry of Public Health and Population on an increase in the number of suspected DF in Al Qahirah and Al Mudhaffar districts, Taiz governorate. On November 7, 2018, Field Epidemiology Training Program sent a team to perform an investigation. The aims were to confirm and describe the outbreak by person, place and time in Taiz governorate, and identify its risk factors.Methodology: Descriptive and case-control study (1:2 ratio) were conducted. WHO case definition was used to identify cases in Al Qahirah or Al Mudhaffar districts during August-November 2018. Control was selected from the same districts who did not suffer from DF. Predesigned questionnaire was used to collect data related to sociodemographic, behavioral and environmental characteristics. Bivariate and multivariate backward stepwise analyses were used. The adjusted odds ratios (aOR) and 95% confidence intervals (95%CI) were calculated. A P value < 0.05 was considered as the cut point for statistically significant. Epi info version 7.2 was used.Results: A total of 50 DF cases were found. Almost 52% were males and 76% were <30 years of age. The overall attack rate was 1/10,000 of the population. Case fatality rate was 4%. In multivariate analysis, not working (aOR = 26.6, 95% CI: 6.8–104.7), not using mosquito repellent (aOR = 13.9, 95% CI:1.4–136.8), wearing short sleeves/pants (aOR = 27.3, 95% CI: 4.8–156.8), poor sanitation (aOR = 5.4, 95% CI: 1.4–20.3), presence of outdoor trees (aOR = 13.2, 95% CI: 2.8–63.0) and houses without window nets (aOR = 15.7, 95% CI: 3.9–63.4) were statistically significant risk factors associated with DF outbreak. Eleven 11 (58%) of blood samples were positive for DF IgM.Conclusions: DF outbreak in Al Qahirah and Al Mudhaffar districts, Taiz governorate was confirmed. This study provides evidence-based information regarding the identified risk factors that contributed to the occurrence of this outbreak. Raising community awareness on the importance of personal protection measures and improving the sanitation services are strongly recommended.

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Risk Factors for Mumps at a University with a Large Mumps Outbreak

Public Health Reports ◽

10.1177/003335490912400311 ◽

2009 ◽

Vol 124 (3) ◽

pp. 419-426 ◽

Cited By ~ 15

Author(s):

Angela S. Huang ◽

Margaret M. Cortese ◽

Aaron T. Curns ◽

Rebecca H. Bitsko ◽

Hannah T. Jordan ◽

...

Keyword(s):

Risk Factors ◽

Case Control Study ◽

Multivariate Analyses ◽

Health Department ◽

Mmr Vaccine ◽

Large Outbreak ◽

The Mean ◽

And Gender ◽

And Control ◽

Control Study

Objectives. Routine measles-mumps-rubella (MMR) vaccine use has greatly decreased the incidence of mumps in the U.S. However, a resurgence of mumps occurred in 2006. We investigated the large outbreak at a university and assessed risk factors for disease. Methods. We described the outbreak and conducted a case-control study. We interviewed case students (identified from student health service and health department records) and control students (selected from a randomly ordered administrative list) and assessed their vaccination status. We compared case students with ≥2 MMR doses and control students with ≥2 MMR doses in univariate and multivariate analyses. Results. The mean age of the 174 case students was 20.9 years; 65% were women. Ninety-seven case students and 147 control students were enrolled in the study. Two-dose MMR coverage was 99% among case and control students with complete records. Only 33% of case students reported exposure to someone with mumps. Case students were more likely than control students to be aged 18 to 19 years (vs. aged 22 years, adjusted odds ratio [AOR] = 5.55; 95% confidence interval [CI] 2.09, 14.74), to report exposure to mumps (AOR=2.31, 95% CI 1.13, 4.73), and to have worked/volunteered on campus (AOR=2.91, 95% CI 1.33, 6.33). Also, women in dormitories had increased odds of mumps compared with men in dormitories. Conclusion. High two-dose MMR coverage was not sufficient to prevent the outbreak. Further study is needed to better understand the effects of dormitory residency and gender on mumps transmission. Clinicians should be vigilant for mumps in young adults presenting with parotitis regardless of immunization history.

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Maternal consumption of cigarette during pregnancy and low birth weight: case-control study

Research Society and Development ◽

10.33448/rsd-v9i8.6538 ◽

2020 ◽

Vol 9 (8) ◽

pp. e692986538

Author(s):

Priscilla Perez da Silva Pereira ◽

Ana Claudia Morais Godoy Figueiredo ◽

Fabiana Araújo Figueiredo da Mata ◽

Roberta Borges Silva ◽

Mauricio Gomes Pereira ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Low Income ◽

Case Control Study ◽

Case Control ◽

Logistic Regression Models ◽

Maternal Consumption ◽

The Mean ◽

And Control ◽

Control Study

The birth weight of newborn is an indicator that reflects maternal health conditions and the healthcare quality delivered during pregnancy. The aim of this study is to analyze the association between maternal consumption of cigarette during pregnancy and Low Birth Weight (LBW) in the Northeast of Brazil. Case-control study with the group of cases composed of 402 mothers with newborns with a birth weight <2,500 grams, and control composed of 1,210 mothers with newborns with weight ≥2,500 grams. Data were collected based on self-reported information by mothers and complemented with hospital records. Simple linear regression and logistic regression models were conducted. Majority of women were brown/ black, married, of low income and almost half of them had less than nine years of education. The consumption of 10 or more cigarettes a day was associated with LBW. For each cigarette added to the daily cigarette consumption there was a reduction of 18.6 grams in birth weight. Among mothers who smoked more than ten cigarettes per day, the mean reduction in birth weight was 283.1 grams. This study reinforces that LBW is associated with the maternal consumption of cigarettes.

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Prevalence, Risk Factors and Outcome of Preterm Births at University of Maiduguri Teaching Hospital (UMTH), Maiduguri, Nigeria: A 2-year Case-Control Study

International Journal of Research and Review ◽

10.52403/ijrr.20210610 ◽

2021 ◽

Vol 8 (6) ◽

pp. 67-73

Author(s):

Obetta Hillary Ikechukwu ◽

Babagana Bako ◽

Nweze Sylvester Onuegunam

Keyword(s):

Risk Factors ◽

Preterm Birth ◽

Prevalence Rate ◽

Case Control Study ◽

Birth Outcome ◽

Preterm Births ◽

Case Control ◽

Reproductive Age ◽

The Mean ◽

Control Study

Background: Preterm birth (PTB) is an important cause of perinatal morbidity and mortality in developing societies like Nigeria. It poses huge long-term medical and financial burdens for the affected children, their families, the health care system and society at large. Objective: The objective of this study was to determine the prevalence, risk factors and birth outcome of PTB at UMTH, Nigeria. Methodology: A two-year case-control study of cases of preterm births at the UMTH, from 1st January, 2016 to 31st December, 2017 was undertaken. For each PTB, the next term delivery was taken as control. Information on socio-demographic characteristics, risk factors, gestational ages at presentation and delivery, and birth outcome were obtained from the women’s case files with proforma and compared with that of the control. Statistical analysis was done using Statistical Package for the Social Sciences (SPSS) software Version 23. The statistical significance was set at P<0.05. Results: During the period under review, there were 6,171 deliveries and preterm births constituted 291 births giving a prevalence rate of 4.7% or 47 per 1000 deliveries. The mean ages for the cases and controls were similar 26.4± 6.1 vs 26.5± 5.3 with (F=0.15, P=0.7) while the mean parity were 3.0±2.6 and 3.2±2.5 with (F=4.6, P=0.03). Nulliparity was commoner among the cases 61(24.6%) compared to the controls 34(13..7%) with X2 = 9.69, P=0.001. Similarly, 96(38.7%) of the cases were unbooked compared to 44(17.7%) among the conrols X2 = 26.9, P=0.000. About 20% of the cases had no formal education compared to 13% of the control. Preterm birth was associated with unbooking status (OR=1.82, CI: 1.40-2.36), nulliparity (OR = 2.05, CI: 1.29-3.26), previous preterm delivery (OR = 95.2, CI: 13.10-691.99) and pregnancy induced hypertension (OR = 25.45, CI: 9.13-70.92). Antepartum haemorrhage (OR = 13.89, CI: 4.92-39.25), twin gestation (OR = 18.18, CI: 2.40-137.68), Polyhydramnios (OR = 2.02, CI: 1.85-2.22) and PROM (OR = 5.39, CI: 2.87-10.15) were other risk factors independently associated with PTB. The perinatal mortality in PTB was 43(16.2%). Conclusion: The prevalence rate of PTB at the UMTH is 4.7% and is associated with previous PTB, unbooked status, twin gestation, polyhydramnious, APH and PIH. Efforts should be intensified on educating women of reproductive age group on the benefits of antenatal booking in pregnancy and quality antenatal care as this would provide ample opportunity for early detection and proper management of women at risk. Keywords: Preterm birth, Risk factors, Neonatal outcome, Maiduguri.

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Risk factors for bleeding in haemato-oncology patients—a nested case–control study: The BITE study protocol (Bleeding In Thrombocytopenia Explained)

BMJ Open ◽

10.1136/bmjopen-2019-034710 ◽

2020 ◽

Vol 10 (6) ◽

pp. e034710 ◽

Cited By ~ 1

Author(s):

Loes L Cornelissen ◽

Camila Caram-Deelder ◽

Johanna G van der Bom ◽

Rutger A Middelburg ◽

Jaap Jan Zwaginga

Keyword(s):

Risk Factors ◽

Case Control Study ◽

Conditional Logistic Regression ◽

Case Control ◽

Source Population ◽

Bleeding Events ◽

Oncological Patients ◽

Nested Case Control ◽

And Control ◽

Control Study

IntroductionHaemato-oncological patients often receive platelet count driven prophylactic platelet transfusions to prevent bleeding. However, many prophylactically transfused patients still bleed. More knowledge on risk factors for bleeding is therefore needed. This will enable identification of bleeding risk profiles on which future transfusion policy can be optimised. The present BITE study (Bleeding In Thrombocytopenia Explained) aims to identify clinical conditions and biomarkers that are associated with clinically relevant bleeding events.Methods and analysisA matched case–control study nested in a cohort of haemato-oncological patients in the Netherlands. We collect a limited number of variables from all eligible patients, who together form the source population. These patients are followed for the occurrence of clinically relevant bleeding. Consenting patients of the source population form the cohort. Cases from the cohort are frequency matched to selected control patients for the nested case–control study. Of both case and control patients more detailed clinical data is collected.Study populationAdult haemato-oncological patients, who are admitted for intensive chemotherapeutic treatment or stem cell transplantation, or who received such treatments in the past and are readmitted for disease or treatment-related adverse events.Statistical analysisBleeding incidences will be calculated for the total source population, as well as for different subgroups. The association between potential risk factors and the occurrence of bleeding will be analysed using conditional logistic regression, to account for matching of case and control patients.Ethics and disseminationThe study was approved by the Medical Research Ethics Committee Leiden Den Haag and Delft, and the Radboudumc Committee on Research Involving Human Subjects. Approval in seven other centres is foreseen. Patients will be asked for written informed consent and data is coded before analyses, according to Dutch privacy law. Results will be published in peer-reviewed journals.Trial registration numberNL62499.058.17. NCT03505086; Pre-results.

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Maternal SNPs in the p53 Pathway: Risk Factors for Trisomy 21?

Disease Markers ◽

10.1155/2013/302920 ◽

2013 ◽

Vol 34 (1) ◽

pp. 41-49 ◽

Cited By ~ 5

Author(s):

Juliano André Boquett ◽

Ana Paula Carneiro Brandalize ◽

Lucas Rosa Fraga ◽

Lavínia Schuler-Faccini

Keyword(s):

Risk Factors ◽

Case Control Study ◽

Case Control ◽

Regulatory Pathway ◽

P53 Family ◽

Combined Genotypes ◽

The Individual ◽

And Control ◽

Control Study

The p53 family and its regulatory pathway play an important role as regulators of developmental processes, limiting the propagation of aneuploid cells. Its dysfunction or imbalance can lead to pathological abnormalities in humans. The aim of this study was to evaluate the effect of maternal polymorphismsTP53c.215G>C (P72R),TP734 c.-30G>A and 14 c.-20C>T,MDM2c.14+309T>G (SNP309),MDM4c.753+572C>T andUSP7c.2719-234G>A as risk factors for Down Syndrome (DS) birth. A case-control study was conducted with 263 mothers of DS children and 196 control mothers. The distribution of these genotypic variants was similar between case and control mothers. However, the combined allelesTP53C andMDM2G, andTP53C andUSP7A increased the risk of having offspring with DS (OR = 1.84 and 1.77; 95% CI;P< 0.007 and 0.018, respectively). These results suggest that, although the individual polymorphisms were not associated with DS birth, the effect of the combined genotypes amongTP53,MDM2andUSP7genes indicates a possible role ofTP53and its regulatory pathway as a risk factor for aneuploidy.

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A community based case-control study to determine the risk factors of dengue fever in Bangladesh

10.1101/2021.08.24.21262563 ◽

2021 ◽

Author(s):

Md. Sahidur Rahman ◽

Fatema Mehejabin ◽

Rumana Rashid

Keyword(s):

Risk Factors ◽

Dengue Fever ◽

Potential Risk ◽

Case Control Study ◽

Dengue Infection ◽

Significant Risk ◽

Case Control ◽

College Hospital ◽

Tropical Country ◽

Control Study

In a tropical country like Bangladesh where the climatic condition favors the growth of Aedes mosquito vectors, the success of dengue prevention depends largely on the proper identification and controlling of the socio-demographic and lifestyle-related risk factors. A case-control study including 150 cases and 150 controls were conducted aimed to explore the potential risk and protective factors and their association with dengue virus infection in the Chattogram district of Bangladesh. Cases were confirmed for dengue patients admitted in Chattogram medical college hospital and Bangladesh institute of tropical and infectious diseases during August and September 2019. Whereas, controls were non-dengue patients admitted in other departments of the same hospitals through gender age and location matching. The questionnaire data were collected through telephone-based interviews which included information regarding general demography, daily life activities, housing with its surroundings status. Chi-square and binary logistic regression were performed for identifying potential risk factors and their association with the occurrences of dengue fever. The study found that travel history to the high incidence area, the place of staying most of the time, living in 21 to 40 years old houses, and the temporary residence of the city were statistically significant risk factors for getting the dengue infection. On contrary, Quality of indoor daylight, ventilation, bus stand/garage, stagnant water, and any construction site around 250 meters of the house did not show significant association with dengue fever.

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