scholarly journals Relationship of anabolic and catabolic biomarkers with muscle strength and physical performance in older adults: a population-based cross-sectional study

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Yongxia Meng ◽  
Hongmei Wu ◽  
Yi Yang ◽  
Huanmin Du ◽  
Yang Xia ◽  
...  
2019 ◽  
Vol 80 ◽  
pp. 65-69 ◽  
Author(s):  
Élvio R. Gouveia ◽  
Bruna R. Gouveia ◽  
Andreas Ihle ◽  
Matthias Kliegel ◽  
Adilson Marques ◽  
...  

2020 ◽  
Vol 135 ◽  
pp. 110923 ◽  
Author(s):  
Marcyo Câmara ◽  
Rodrigo Alberto Vieira Browne ◽  
Gabriel Costa Souto ◽  
Daniel Schwade ◽  
Ludmila Pereira Lucena Cabral ◽  
...  

Toxins ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 135
Author(s):  
Karsten Vanden Wyngaert ◽  
Amaryllis H. Van Craenenbroeck ◽  
Els Holvoet ◽  
Patrick Calders ◽  
Wim Van Biesen ◽  
...  

Impaired physical performance is common in patients on hemodialysis (HD) and is associated with poor prognosis. A patient relevant marker of adequacy of dialysis is lacking. Previous studies evaluated uremic toxicity by assessing the impact of different uremic toxins separately. However, such an approach is most likely not reflective of true uremic toxicity. Therefore, this cross-sectional study aimed to examine if the uremic syndrome, estimated as one composite of different uremic toxins (facilitated by ridge regression method) to reflect the kinetic behavior during dialysis, is associated with physical performance in patients on HD. Levels of p-cresyl glucuronide and sulfate, indole-acetic acid, indoxyl sulfate, uric acid, hippuric acid, and 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid were assessed and associated by ridge regression to muscle strength, functional exercise capacity, and measures of balance and coordination. 75 HD patients were included (mean age 68 years, 57% male). The composite of different uremic toxins (i.e., uremic load) explained 22% of the variance in handgrip strength. Although there was an association between full body muscle strength and the composite uremic load independent of nutritional status, age and gender, the predictive power of composite uremic load for muscle weakness is limited. Single uremic toxins as well as composite uremic load were not associated with exercise capacity, coordination, and balance, indicating that the degree of uremia does not predict physical performance in patients on HD.


2020 ◽  
Vol 128 (6) ◽  
pp. 508-517
Author(s):  
Julia C Schmidt ◽  
Sandra Vogt ◽  
Medea Imboden ◽  
Emmanuel Schaffner ◽  
Leticia Grize ◽  
...  

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