scholarly journals Composite Uremic Load and Physical Performance in Hemodialysis Patients: A Cross-Sectional Study

Toxins ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 135
Author(s):  
Karsten Vanden Wyngaert ◽  
Amaryllis H. Van Craenenbroeck ◽  
Els Holvoet ◽  
Patrick Calders ◽  
Wim Van Biesen ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Exercise Capacity ◽  
Physical Performance ◽  
Ridge Regression ◽  
Handgrip Strength ◽  
Cross Sectional Study ◽  
Uremic Toxins ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Impact

Impaired physical performance is common in patients on hemodialysis (HD) and is associated with poor prognosis. A patient relevant marker of adequacy of dialysis is lacking. Previous studies evaluated uremic toxicity by assessing the impact of different uremic toxins separately. However, such an approach is most likely not reflective of true uremic toxicity. Therefore, this cross-sectional study aimed to examine if the uremic syndrome, estimated as one composite of different uremic toxins (facilitated by ridge regression method) to reflect the kinetic behavior during dialysis, is associated with physical performance in patients on HD. Levels of p-cresyl glucuronide and sulfate, indole-acetic acid, indoxyl sulfate, uric acid, hippuric acid, and 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid were assessed and associated by ridge regression to muscle strength, functional exercise capacity, and measures of balance and coordination. 75 HD patients were included (mean age 68 years, 57% male). The composite of different uremic toxins (i.e., uremic load) explained 22% of the variance in handgrip strength. Although there was an association between full body muscle strength and the composite uremic load independent of nutritional status, age and gender, the predictive power of composite uremic load for muscle weakness is limited. Single uremic toxins as well as composite uremic load were not associated with exercise capacity, coordination, and balance, indicating that the degree of uremia does not predict physical performance in patients on HD.

scholarly journals Excessive daytime sleepiness with snoring or witnessed apnea is associated with handgrip strength: a population-based study

QJM ◽  
2019 ◽  
Vol 112 (11) ◽  
pp. 847-853
Author(s):  
X Cao ◽  
Y Gu ◽  
J Fu ◽  
T Q C Vu ◽  
Q Zhang ◽  
...  
Keyword(s):  
Body Weight ◽  
Muscle Strength ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Handgrip Strength ◽  
Cross Sectional Study ◽  
Analysis Of Covariance ◽  
Poor Sleep ◽  
Sectional Study ◽  
Cross Sectional

Abstract Background Sarcopenia is emerging as an important public health problem, and evidences have determined that poor sleep is associated with muscle strength, but the potential effects of excessive daytime sleepiness (EDS), snoring and witnessed apnea on handgrip strength have not been evaluated. Aim We aimed to examine the association between EDS, snoring, witnessed apnea and muscle strength in an adult population. Design Cross-sectional study. Methods This cross-sectional study comprised 19 434 adults. Handgrip strength was measured using a handheld digital dynamometer. EDS was assessed by Epworth Sleepiness Scale, snoring and witnessed apnea during sleep were reported through simple yes/no questions. Analysis of covariance was carried out to determine the association between EDS with snoring or witnessed apnea and muscle strength. Results The means (95% confidence interval) for average handgrip strength/body weight (kg/kg) across symptoms categories were 0.396 (0.333–0.472), 0.393 (0.330–0.467), 0.396 (0.333–0.471) and 0.386 (0.325–0.460) (P < 0.0001), respectively. Similar results were observed with maximal handgrip strength/body weight (kg/kg). Conclusions Self-reported EDS accompanied with snoring or apnea is associated with lowest handgrip strength, independently of confounding factors. Whether improvement of EDS, snoring and apnea, can ameliorate age-associated decline in muscle strength warrants further studies.

scholarly journals Association between Muscular Strength and Depressive Symptoms among Chinese Nursing Freshmen—A Cross-Sectional Study

2020 ◽  
Author(s):  
Liya Guo ◽  
Jianhua Cao ◽  
Yingke Li ◽  
Guang Yang ◽  
peng cheng ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Muscle Strength ◽  
Muscular Strength ◽  
Handgrip Strength ◽  
Cross Sectional Study ◽  
Activity Level ◽  
College Freshman ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female College

Abstract Increased physical activity level is related to lower risk of depressive symptoms, and an inverse association between muscular strength and risk of depressive symptoms among the elderly population. However, the association among younger adults is unclear. The aim of this study was to examine the association between muscle strength, using handgrip strength as a representative of skeletal muscle strength, and the risk of depressive symptoms among Chinese female college freshman. A cross-sectional study was conducted among 867 participants aged between 16-23 years. Handgrip strength was measured with a handheld digital Smedley dynamometer, and depressive symptoms were evaluated using the 20-item Zung self-rating depression scale (SDS) with 3 cut-off points to indicate elevated depressive symptoms. We found that 10.7% of participants (17.2% or 29.2%) were classified as having moderate to severe depressive symptoms using 50 as the cut-off point. After adjusting for these potential confounders, the adjusted odds ratios for moderate-to-severe depressive symptoms across tertile of relative handgrip strength were 1.00 (reference) for tertile 1, 0.61 (95% CI: 0.35, 1.04) for tertile 2, and 0.53 (95% CI: 0.39, 0.94) for tertile 3 (P for trend: 0.024). The significant associations remained when other cut-off points (SDS 48 or 45) were used. Interactions between the handgrip strength and potential confounders for depressive symptoms in the final models were insignificant. This study showed that handgrip strength is inversely and independently related to the risk of depressive symptoms among Chinese female college freshman. These results can help with the development of an effective intervention strategy against depression. For future research, it is important to explore the causality of the effects of handgrip strength on the depressive symptoms by intervention study.

scholarly journals Association between height-related polymorphism rs17081935 and reduced handgrip strength in relation to status of atherosclerosis: a cross-sectional study

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Yuji Shimizu ◽  
Shin-Ya Kawashiri ◽  
Kazuhiko Arima ◽  
Yuko Noguchi ◽  
Hirotomo Yamanashi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Muscle Strength ◽  
Handgrip Strength ◽  
Cross Sectional Study ◽  
Minor Allele ◽  
Inverse Association ◽  
Older Individuals ◽  
Sectional Study ◽  
Cross Sectional ◽  
A Minor

Abstract Background Aging is a process that increases oxidative stress. Increased oxidative stress leads to the development of atherosclerosis and mitochondrial dysfunction. Mitochondria contribute to energy production that might have a beneficial influence on maintaining muscle strength. Therefore, the height-related single nucleotide polymorphism (SNP) rs17081935, which is also reported to be associated with mitochondrial metabolism, might be associated with reduced muscle strength and this association might be affected by atherosclerosis status. To clarify those associations, a cross-sectional study of 1374 elderly Japanese individuals aged 60–89 years was conducted. Methods Logistic regression was used to clarify the association between rs17081935 and reduced handgrip strength. Since atherosclerosis might affect handgrip strength, participants were stratified by atherosclerosis status. Reduced handgrip strength was defined as being in the lowest quintile of handgrip strength (< 25.6 kg for men and < 16.1 kg for women). Results No significant associations were found between a minor allele of rs17081935 and reduced handgrip strength among elderly participants without atherosclerosis. A significant inverse association was observed among elderly participants with atherosclerosis. After adjusting for known cardiovascular risk factors and height, the adjusted odd ratio (OR) and 95% confidence interval (CI) for reduced handgrip strength and a minor allele of rs17081935 were 1.13 (0.86, 1.43) for elderly participants without atherosclerosis and 0.55 (0.36, 0.86) for those with atherosclerosis, respectively. Conclusion A minor allele of the height-related SNP rs17081935 was significantly inversely associated with reduced handgrip strength among older individuals with atherosclerosis, but not among those without atherosclerosis.

scholarly journals Handgrip Strength as a Predictor of Muscular Strength and Endurance: A Cross-sectional Study

2021 ◽  
Author(s):  
Shlesha Maulik Vaidya ◽  
Darshana M Nariya
Keyword(s):  
Muscle Strength ◽  
Muscular Strength ◽  
Handgrip Strength ◽  
Low Cost ◽  
Cross Sectional Study ◽  
Specific Reference ◽  
Sectional Study ◽  
Efficient Manner ◽  
Cross Sectional ◽  
Jump Test

Introduction: Reliable muscle strength measurement of individual muscle groups is time-consuming and so it would be convenient to have a single, quick and simple tool as an indicator of the general muscle strength. Handgrip strength might be an adequate measurement for generalised muscle strength. It has a low cost and may be used in a time-efficient manner in clinical setting. Aim: To determine if a handgrip dynamometer test is a valid predictor of both muscular strength and endurance and to provide a gender specific reference charts for handgrip and establish correlation between BMI and handgrip. Materials and Methods: It was a cross-sectional study, conducted from October 2017 to March 2018. Participants included 30 college students, 10 males and 20 females of 18 to 25 year age group. BMI of all subjects were measured. Handgrip strength was measured by adjustable handgrip dynamometer. Horizontal Jump Test (HJT) and Vertical Jump Test (VJT) were used to measure lower limb muscle strength. To evaluate the strength of the trunk, one minute curl-ups test was used. Aerobic power was measured by VO2max Cooper’s test. Results: Significant correlation found between handgrip strength and HJT (r=0.8226, r2=0.6767, p<0.05), handgrip strength and VJT (r=0.6917, r2=0.4764, p<0.05), handgrip strength and VO2 max (r=0.7204, r2=0.519, p<0.05), handgrip strength and BMI (r=-0.1341, r2=0.018, p<0.05), handgrip strength and one minute curls-up test (r=0.4368, r2=0.1908, p<0.05). Although there was weak correlation of handgrip strength with BMI and one minute curls-up test. Conclusion: Handgrip strength can be an effective tool for predicting muscular strength and endurance.

scholarly journals Association between Muscular Strength and Depressive Symptoms among Chinese Nursing Freshmen—A Cross-Sectional Study

2019 ◽  
Author(s):  
Zhongyu Ren ◽  
Liya Guo ◽  
Jianhua Cao ◽  
Yingke Li ◽  
Guang Yang ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Muscle Strength ◽  
Muscular Strength ◽  
Handgrip Strength ◽  
Cross Sectional Study ◽  
Activity Level ◽  
College Freshman ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female College

Abstract Increased physical activity level is related to lower risk of depressive symptoms, and an inverse association between muscular strength and risk of depressive symptoms among the elderly population. However, the association among younger adults is unclear. The aim of this study was to examine the association between muscle strength, using handgrip strength as a representative of skeletal muscle strength, and the risk of depressive symptoms among Chinese female college freshman. A cross-sectional study was conducted among 867 participants aged between 16-23 years. Handgrip strength was measured with a handheld digital Smedley dynamometer, and depressive symptoms were evaluated using the 20-item Zung self-rating depression scale (SDS) with 3 cut-off points to indicate elevated depressive symptoms. We found that 10.7% of participants (17.2% or 29.2%) were classified as having moderate to severe depressive symptoms using 50 as the cut-off point. After adjusting for these potential confounders, the adjusted odds ratios for moderate-to-severe depressive symptoms across tertile of relative handgrip strength were 1.00 (reference) for tertile 1, 0.61 (95% CI: 0.35, 1.04) for tertile 2, and 0.53 (95% CI: 0.39, 0.94) for tertile 3 (P for trend: 0.024). The significant associations remained when other cut-off points (SDS 48 or 45) were used. Interactions between the handgrip strength and potential confounders for depressive symptoms in the final models were insignificant. This study showed that handgrip strength is inversely and independently related to the risk of depressive symptoms among Chinese female college freshman. These results can help with the development of an effective intervention strategy against depression. For future research, it is important to explore the causality of the effects of handgrip strength on the depressive symptoms by intervention study.

Relationship between upper limb physical performance tests and muscle strength of scapular, shoulder and spine stabilizers: a cross-sectional study

2021 ◽  
Author(s):  
Agnes Ramos Guirelli ◽  
Júlia Maria dos Santos ◽  
Estêvão Mállon Gomes Cabral ◽  
João Pedro Camilo Pinto ◽  
Gabriel Alves De Lima ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Physical Performance ◽  
Upper Limb ◽  
Cross Sectional Study ◽  
Performance Tests ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Serum Vitamin D Level Associates With Handgrip Muscle Strength Among Ethiopian Schoolchildren: A Cross-Sectional Study

2017 ◽  
Vol 39 (1) ◽  
pp. 54-64 ◽  
Author(s):  
Tolassa Wakayo ◽  
Tefera Belachew ◽  
Susan J. Whiting
Keyword(s):  
Vitamin D ◽  
Muscle Strength ◽  
Linear Regression ◽  
Handgrip Strength ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Serum Vitamin D

Background: Despite varying serum levels of 25(OH)D among schoolchildren in Ethiopia, data are lacking whether this affects their muscle function as measured by handgrip strength of these children. Handgrip strength may be used as a proxy indicator of muscle strength and function. This study evaluated the association between serum levels of 25(OH)D and handgrip strength among schoolchildren in Ethiopia. Methods: The study used a data set from a school-based cross-sectional study conducted on a total of 174 randomly selected schoolchildren from urban (N = 89) and rural (N = 85) settings of Adama Town and Adama Woreda, respectively. Handgrip strength, serum 25(OH)D levels, and anthropometry were measured for each child following standard procedures, while data on demographic characteristics of children and their parents were collected using a structured interviewer-administered questionnaire. A multivariable linear regression model was used to determine the association between serum vitamin D level and handgrip strength after adjusting for other predictors. Results: The mean handgrip muscle strength of the students was 17.6 ± 6.9 kg. The average serum 25(OH)D for the group was 54.5 ± 15.8 nmol/L. On multivariable linear regression model, serum 25(OH)D level was significantly associated with handgrip strength (β = 0.06, P = .008) of the children after controlling for potential confounders. Other variables, female gender (β = −2.20, P = .004), age (β = 1.97, P < .001), height (β = .22, P < .001), weight (β = 0.33, P < .001), and triceps skinfold thickness (β = −0.19, P = .023), were identified to have significant association with handgrip strength of schoolchildren. Conclusion: Serum 25(OH)D levels had significant positive association with handgrip strength of Ethiopian schoolchildren. The results imply the need for incorporating school nutrition education on consumption of foods rich in important nutrients including vitamin D-rich foods in the school curricula and also enhancing behavioral change communication toward exposure to sunlight in the school to produce adequate vitamin D. Further longitudinal study involving a larger sample is recommended to confirm the findings.

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