scholarly journals Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yingchao Chen ◽  
Jing Cheng ◽  
Yi Chen ◽  
Ningjian Wang ◽  
Fangzhen Xia ◽  
...  
Keyword(s):  
Vitamin D ◽  
Uric Acid ◽  
Chinese Population ◽  
Serum Vitamin ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Serum Vitamin D

scholarly journals Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study

2020 ◽  
Author(s):  
Yingchao Chen ◽  
Jing Cheng ◽  
Yi Chen ◽  
Ningjian Wang ◽  
Fangzhen Xia ◽  
...  
Keyword(s):  
Uric Acid ◽  
Chinese Population ◽  
Eastern China ◽  
Serum Vitamin ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Drinking Status

Abstract Background Uric acid (UA) is the end product of purine metabolism, which is thought to be related to many human diseases, such as nephrolithiasis, gout, cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome. However, the relationship between serum UA (SUA) and 25(OH)D is still unclear in the eastern Chinese population. Methods We did a population-based observational investigation, which included 12,770 residents living in eastern China. Ultimately, data from 9,220 subjects were analyzed. Serum 25(OH)D, SUA, fasting plasma glucose(FPG), fasting insulin, HbA1c and other metabolic parameters were tested. Waist circumference (WC), weight and height were also measured. Questionnaires were collected from these subjects for information on smoking and drinking status. Results We enrolled 9,220 Chinese adults, including 3,681 males (age 55.57±13.23 years) and 5,539 females (age 54.31±12.83 years). The levels of SUA were 352.07±79.25 nmol/L and 269.29±64.68 nmol/L in males and females, respectively. The proportion of adults with hyperuricemia (HUA) was 12.26% in the total population. Levels of SUA were positively associated with 25(OH)D, and the incidence of HUA increased 9.4% for every 10 nmol/L increase in 25(OH)D (P<0.001). Conclusions SUA was positively associated with 25(OH)D in the eastern Chinese population. Higher levels of serum 25(OH)D may be a potential predictor of HUA.

scholarly journals Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study

2020 ◽  
Author(s):  
Yingchao Chen ◽  
Jing Cheng ◽  
Yi Chen ◽  
Ningjian Wang ◽  
Fangzhen Xia ◽  
...  
Keyword(s):  
Uric Acid ◽  
Chinese Population ◽  
Eastern China ◽  
Serum Vitamin ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Drinking Status

Abstract Background Uric acid (UA) is the end product of purine metabolism, which is thought to be related to many human diseases, such as nephrolithiasis, gout, cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome. However, the relationship between serum UA (SUA) and 25(OH)D is still unclear in the eastern Chinese population. Methods We did a population-based observational investigation, which included 12,770 residents living in eastern China. Ultimately, data from 9,220 subjects were analyzed. Serum 25(OH)D, SUA, fasting plasma glucose(FPG), fasting insulin, HbA1c and other metabolic parameters were tested. Waist circumference (WC), weight and height were also measured. Questionnaires were collected from these subjects for information on smoking and drinking status. Results We enrolled 9,220 Chinese adults, including 3,681 males (age 55.57±13.23 years) and 5,539 females (age 54.31±12.83 years). The levels of SUA were 352.07±79.25 nmol/L and 269.29±64.68 nmol/L in males and females, respectively. The proportion of adults with hyperuricemia (HUA) was 12.26% in the total population. Levels of SUA were positively associated with 25(OH)D, and the incidence of HUA increased 9.4% for every 10 nmol/L increase in 25(OH)D (P<0.001). Conclusions SUA was positively associated with 25(OH)D in the eastern Chinese population. Higher levels of serum 25(OH)D may be a potential predictor of HUA.

scholarly journals Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study

Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1075
Author(s):  
Masliza Hanuni Mat Ali ◽  
Tuan Salwani Tuan Ismail ◽  
Wan Norlina Wan Azman ◽  
Najib Majdi Yaacob ◽  
Norhayati Yahaya ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Thyroid Diseases ◽  
Z Score ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Thyroid hormones have a catabolic effect on bone homeostasis. Hence, this study aimed to evaluate serum vitamin D, calcium, and phosphate and bone marker levels and bone mineral density (BMD) among patients with different thyroid diseases. This cross-sectional study included patients with underlying thyroid diseases (n = 64, hyperthyroid; n = 53 euthyroid; n = 18, hypothyroid) and healthy controls (n = 64). BMD was assessed using z-score and left hip and lumbar bone density (g/cm2). The results showed that the mean serum vitamin D Levels of all groups was low (<50 nmol/L). Thyroid patients had higher serum vitamin D levels than healthy controls. All groups had normal serum calcium and phosphate levels. The carboxy terminal collagen crosslink and procollagen type I N-terminal propeptide levels were high in hyperthyroid patients and low in hypothyroid patients. The z-score for hip and spine did not significantly differ between thyroid patients and control groups. The hip bone density was remarkably low in the hyperthyroid group. In conclusion, this study showed no correlation between serum 25(OH)D levels and thyroid diseases. The bone markers showed a difference between thyroid groups with no significant difference in BMD.

scholarly journals Dietary Magnesium Intake Affects the Association Between Serum Vitamin D and Type 2 Diabetes: A Cross-Sectional Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Weichao Huang ◽  
Xiaoman Ma ◽  
Hualiang Liang ◽  
Haojia Li ◽  
Jiayu Chen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Magnesium Intake ◽  
Serum Vitamin D ◽  
Low Magnesium ◽  
Dietary Magnesium

Introduction: Circulating vitamin D concentrations have been associated with the risk of type 2 diabetes (T2D). Magnesium has also been reported to be associated with lower T2D risk. Besides, magnesium is an essential cofactor for vitamin D activation. However, the effect of dietary magnesium intake on the association between vitamin D and the risk of T2D has not been studied comprehensively. Therefore, we designed this cross-sectional study to assess the effect modification of magnesium intake on the association between vitamin D and risk of T2D.Research Design and Methods: The present study analyzed data from the National Health and Nutrition Examination Survey (NHANES) continuously from 2007 to 2014, involving 10,249 participants. By having stratified participants based on magnesium intake category (low magnesium intake &lt;267 mg/day; high magnesium intake: ≥267 mg/day), we further evaluated the difference (interaction test) between the relationship of vitamin D with the risk of T2D among low magnesium intake participants and high magnesium intake participants using weighted multivariable logistic regression.Results: In this cross-sectional study, the association of serum vitamin D with the incidence of T2D appeared to differ between the low magnesium intake group and the high magnesium intake group (OR: 0.968, 95%Cl: 0.919–1.02 vs. OR: 0.925, 95%Cl: 0.883–0.97). Furthermore, there was evidence of interaction between vitamin D levels and magnesium intake on decreasing the incidence of T2D (p-value for interaction = 0.001).Conclusions: The results of our study indicated that magnesium intake might affect the association of serum vitamin D with the risk of T2D. Such a finding requires further randomized controlled trials to provide more evidence.

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