scholarly journals Adverse body composition and lipid parameters in patients with prolactinoma: a case-control study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Anna Sophia Posawetz ◽  
Christian Trummer ◽  
Marlene Pandis ◽  
Felix Aberer ◽  
Thomas R. Pieber ◽  
...  
Keyword(s):  
Body Composition ◽  
Lipid Metabolism ◽  
Fat Mass ◽  
Case Control Study ◽  
Case Control ◽  
Metabolic Parameters ◽  
Metabolic Effects ◽  
Dopamine Agonist Therapy ◽  
Glucose And Lipid Metabolism ◽  
Control Study

Abstract Background Hyperprolactinaemia might cause adverse metabolic effects. The aim of our study was to compare parameters of body composition, glucose and lipid metabolism between untreated patients with prolactinoma and controls and to assess changes after initiation of cabergoline. Methods Case-control study with a retrospectively analyzed follow-up in patients with prolactinoma after initiation of cabergoline therapy. Results 21 patients with prolactinoma (9 micro- and 12 macroprolactinomas; 7 females) and 30 controls were analyzed. Patients with prolactinoma had significantly higher BMI than controls; fat mass did not differ between groups. Only men - but not women - with prolactinoma had significantly higher fat mass at all six sites measured compared to controls. Levels of LDL (130 (107–147.5) vs. 94.5 (80–127.5) mg/dl, p < 0.001) were significantly higher, levels of HDL (56 ± 16.7 vs. 69.2 ± 14.6 mg/dl, p = 0.004) significantly lower than in controls. Fasting glucose, HOMA-IR, HbA1c, adiponectin, CRP, and homocysteine did not differ between groups. After a median of 10 weeks (IQR 7–18 weeks) after initiation of cabergoline, total (from 212.5 ± 36.2 to 196.9 ± 40.6 mg/dl, p = 0.018) and LDL cholesterol (130 (107–147.5) to 106.5 (94.3–148) mg/dl, p = 0.018) had significantly decreased. Analyzing men and women separately, this change occurred in men only. Conclusions Reasons for the association between prolactin and metabolic parameters include direct effects of prolactin on adipose tissue, hyperprolactinaemia-triggered hypogonadism and dopamine-agonist therapy per se. Altered lipid metabolism in patients with prolactinoma might imply an increased cardiovascular risk, highlighting the necessity to monitor metabolic parameters in these patients.

Descriptive analysis of body composition and phase angle (PA) in achondroplastic patients: Case-control study

2020 ◽  
Author(s):  
Vegas-Aguilar Isabel Mª ◽  
Cornejo Pareja Isabel Maria ◽  
Gea Antonio Leiva ◽  
Francisco J Tinahones ◽  
García-Almeida Jose Manuel
Keyword(s):  
Body Composition ◽  
Phase Angle ◽  
Case Control Study ◽  
Descriptive Analysis ◽  
Case Control ◽  
Control Study

scholarly journals An unfavorable body composition is common in early arthritis patients: A case control study

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0193377 ◽  
Author(s):  
Samina A. Turk ◽  
Dirkjan van Schaardenburg ◽  
Maarten Boers ◽  
Sylvia de Boer ◽  
Cindy Fokker ◽  
...  
Keyword(s):  
Body Composition ◽  
Case Control Study ◽  
Case Control ◽  
Early Arthritis ◽  
Control Study

scholarly journals Body composition indices in a sample of female adolescents with postural deformity: a case control study

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Dina Golalizadeh ◽  
Vahideh Toopchizadeh ◽  
Negar Fasaie ◽  
Neda Dolatkhah
Keyword(s):  
Body Composition ◽  
Case Control Study ◽  
Case Control ◽  
Female Adolescents ◽  
Composition Analysis ◽  
Inverse Association ◽  
Body Composition Analysis ◽  
Postural Deformity ◽  
Postural Disorders ◽  
Control Study

Abstract Objectives Normal posture is considered to be an indicative of good musculoskeletal health in school aged adolescents. Little is known about the body composition indices in relation with postural deformities in adolescents. The aim of this study was to assess relation of body composition analysis indices with postural deformities in a sample of female high school adolescents. Results In this case–control study, 37 eligible female adolescents with any postural deformities and 33 normal posture subjects enrolled in the study by random cluster sampling. Body composition analysis performed by bioelectrical impedance analysis (BIA) method to quantity body fat mass (BFM), soft lean mass (SLM) and lean body mass (LBM). The binary logistic regressions were performed to evaluate the associations of body composition indices which were significantly different between two groups at significance level of 0.05 with postural disorders in the two groups. There was no significant difference between subjects with postural disorders with their normal controls concerning demographic variables. We observed an inverse association between postural deformity risk and LBM (OR = 0.803; 95% CI 0.690–0.934) and SLM (OR = 0.774; 95% CI 0.649–0.922) after adjusting the analysis by height of participants.

scholarly journals Nutritional status, body composition, and quality of life in community-dwelling sarcopenic and non-sarcopenic older adults: A case-control study

2017 ◽  
Vol 36 (1) ◽  
pp. 267-274 ◽  
Author(s):  
Sjors Verlaan ◽  
Terry J. Aspray ◽  
Juergen M. Bauer ◽  
Tommy Cederholm ◽  
Jaimie Hemsworth ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Body Composition ◽  
Nutritional Status ◽  
Case Control Study ◽  
Case Control ◽  
Community Dwelling ◽  
Control Study

scholarly journals Association of BsmI variant of vitamin D receptor gene with polycystic ovary syndrome: A case-control study

2020 ◽  
Author(s):  
Nasim Ramezani ◽  
Maryam Ostadsharif ◽  
Hashem Nayeri
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Vitamin D Receptor ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Case Control ◽  
Metabolic Parameters ◽  
Genotypic Frequency ◽  
Ovary Syndrome ◽  
Control Study

Background: Polycystic ovarian syndrome (PCOS) is an endocrine disorder that affects women’s fertility and causes alterations such as obesity, insulin resistance, menstrual irregularities, and polycystic ovaries. The results of the studies show that the issue of vitamin D and vitamin D receptor (VDR) is controversial for PCOS susceptibility. Objective: To investigate the association of BsmI polymorphism in the VDR gene with metabolic parameters in obese PCOS women. Materials and Methods: In this case-control study, 38 obese subjects with PCOS and 40 unrelated obese individuals were evaluated to determine the allelic and genotypic frequency of BsmI variant by Polymerase Chain Reaction Restriction Fragment Length Polymorphism method. Body Mass Index, parathyroid hormone, phosphorus, and calcium were evaluated in all participants. Results: BsmI (rs1544410), (A/G) AA, AG, GG, A, and G percentage of genotypic/allelic frequencies were 65.8, 26.3, 7.9, 78.9, and 21.1 in cases and 57.5, 40, 2.5, 77.5, and 22.5 in controls, respectively. Statistical analysis revealed that the differences in genotypic (p = 0.31)/allelic (p = 0.83) frequencies and dominant (p = 0.45)/recessive (p = 0.35) models between the cases and controls were not significant. This study indicates no association between the BsmI genotypes and metabolic parameters. Conclusion: It can be concluded that VDR BsmI (rs1544410) Intron 8 (A > G) was not associated with obesity along with PCOS susceptibility in the studied groups. Key words: Vitamin D receptor, Polycystic ovary syndrome, Genetic association study.

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