Dual function of active constituents from bark of Ficus racemosa L in wound healing

Ficus racemosa (Family: Moracae) is a prominent plant in India and it was embedded in traditional medicinal texts of India as a wound healer. Hence to study its wound healing assets, the ethanolic leaves extract was studied on animals. Excision and incision wound models were used to study wound healing activity. For both models, extract was given in the form of ointment (5% and 10 % w/w). In the excision model, all extract treated animals showed significant (P<0.01) increase in percentage wound contraction. The incision wound model showed significant (P<0.01) increase in breaking strength when compared to control. In biochemical parameter, hydroxyproline level was significantly (P<0.01) increased in all drugs treated groups as compared to control in the excision wound model. Histopathological study also showed good regeneration of skin compared to control. Phytochemical study of the leaves showed presence of flovonoids and tannins which might be the key constituents for the wound healing activity.

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Medicinal & Biological Investigations of Ficus Racemosa

Forestry & Agriculture Review ◽

10.47285/far.v1i2.43 ◽

2020 ◽

Vol 1 (2) ◽

pp. 29-81

Author(s):

Abdul Kader Mohiuddin ◽

Sayra Akter Lia

Keyword(s):

Biological Activity ◽

Blood Glucose ◽

Medicinal Plant ◽

Southeast Asia ◽

Pharmacological Activity ◽

Glucose Concentration ◽

Blood Glucose Concentration ◽

Active Constituents ◽

Ficus Racemosa ◽

Different Parts

Ficus racemosa is a traditional medicinal plant found in Southeast Asia and Australia. It is commonly known as 'gular'or ‘Dumur’. Owing to the presence of β-sitosterol it decreases the blood glucose concentration. Many active constituents isolated from different parts of this plant exhibit useful pharmacological activity. The objective of this dissertation is to identify the biological activity of the roots of an indigenous medicinal plant, viz., Ficus racemosa (Family: Moraceae) and to evaluate the possible phytochemical and pharmacological profiles of the crude extracts. Some chemical and biological researches on this plant have been conducted out so far, focusing mainly on the plant's bark and root. That's why the objective of this framework is to assess the different possibilities of developing new therapeutic targets from this plant's fruit that could be crucial for the treatment of many diseases.

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Wound healing and anti-inflammatory activity of extract of Ficus racemosa linn bark in albino rats

International Journal of Basic & Clinical Pharmacology ◽

10.5455/2319-2003.ijbcp001212 ◽

2012 ◽

Vol 1 (1) ◽

pp. 111

Author(s):

Dimple Mehta ◽

Bhaven Kataria ◽

Sunita Chhaiya

Keyword(s):

Wound Healing ◽

Inflammatory Activity ◽

Albino Rats ◽

Ficus Racemosa ◽

Anti Inflammatory

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PHARMACOGNOSTIC AND PHYTOCHEMICAL SCREENING OF HELICTERES ISORA ROOTS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2016.v9s2.12178 ◽

2016 ◽

pp. 96 ◽

Cited By ~ 1

Author(s):

Veena Sharma ◽

Urmila Chaudhary

Keyword(s):

Amino Acids ◽

Wound Healing ◽

Moisture Content ◽

Cardiac Glycosides ◽

Water Soluble ◽

Phytochemical Screening ◽

Microbial Infection ◽

Active Constituents ◽

Standard Procedures ◽

Helicteres Isora

ABSTRACT Objective: Helicteres isora Linn. roots have been reported to use in microbial infection, diabetes, dysentery colic, scabies, wound healing, and gastropathy. The main objective of this study was preliminary phytochemical screening of various fractions of H. isora roots. Methods: In this study, pharmacognostic and phytochemical investigations on the various fractions of H. isora roots were carried out with the standard procedures. Results: The pharmacognostic analysis revealed moisture content (0.18%), total ash (4%), acid insoluble ash (1%), and water soluble ash (1.5%). The qualitative phytochemical screening revealed the presence of alkaloids, amino acids, proteins, carbohydrates, flavonoids, cardiac glycosides, saponin, steroids, terpenoids, and tannins. Conclusion: H. isora roots are a rich source of various biological active constituents. H. isora may be further investigated for the isolation of bioactive compound that could be developed into drug for the treatment of various human diseases. Keywords: Helicteres isora, Pharmacognostic, Phytochemical, Roots.

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Sericin: A Versatile Protein Biopolymer with Therapeutic Significance

Current Pharmaceutical Design ◽

10.2174/1381612826666200612165253 ◽

2020 ◽

Vol 26 (42) ◽

pp. 5414-5429 ◽

Cited By ~ 1

Author(s):

Rasika Suryawanshi ◽

Jovita Kanoujia ◽

Poonam Parashar ◽

Shubhini. A. Saraf

Keyword(s):

Amino Acids ◽

Wound Healing ◽

Clinical Trials ◽

Metabolic Pathways ◽

Dosage Forms ◽

Current Status ◽

Active Constituents ◽

Therapeutic Activities

Sericin is a unique proteinaceous biopolymer obtained from cocoons of Bombyx Mori. It has become very popular since it is bestowed with numerous health benefits. Sericin is composed of 18 types of amino acids, out of which 8 amino acids play a significant role in human metabolic pathways. Sericin is easily amenable to make into novel dosage forms and also has been conferred with numerous therapeutic activities such as wound healing, antihypertensive, neuro-protective, antitumor, anti-diabetic, anti-wrinkle, anti-ageing and antioxidant amongst various others. This review summarizes the current status of sericin, as a therapeutic moiety with a focus on active constituents as well as their proposed mechanism in the treatment of various chronic diseases. It also summarizes previous and current in-vitro, in-vivo, cell lines studies and clinical trials based pieces of evidence corroborating the therapeutic activities of sericin.

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