scholarly journals Impact of bronchoalveolar lavage lymphocytosis on the effects of anti-inflammatory therapy in idiopathic non-specific interstitial pneumonia, idiopathic pleuroparenchymal fibroelastosis, and unclassifiable idiopathic interstitial pneumonia

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Akira Yamagata ◽  
Machiko Arita ◽  
Hiromasa Tachibana ◽  
Fumiaki Tokioka ◽  
Chikatoshi Sugimoto ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Interstitial Pneumonia ◽  
Prognostic Value ◽  
Idiopathic Interstitial Pneumonia ◽  
Classification And Regression Tree ◽  
Rank Test ◽  
Pleuroparenchymal Fibroelastosis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
The Impact

Abstract Background Idiopathic non-specific interstitial pneumonia (iNSIP), idiopathic pleuroparenchymal fibroelastosis (iPPFE), and unclassifiable idiopathic interstitial pneumonia (IIP) are IIPs with chronic fibrotic phenotypes, and unlike idiopathic pulmonary fibrosis, they have often been treated with anti-inflammatory drugs, including corticosteroids and immunosuppressants. However, the impact of bronchoalveolar lavage (BAL) lymphocytosis on the effects of anti-inflammatory therapy has never been evaluated. This study aimed to elucidate whether BAL lymphocytosis can be used to predict the efficacy of anti-inflammatory drugs for iNSIP, iPPFE, and unclassifiable IIP. Methods Japanese patients diagnosed with iNSIP, iPPFE, and unclassifiable IIP by multidisciplinary discussion were identified using the nationwide registry. Eligible patients were stratified into four groups with and without BAL lymphocytosis and anti-inflammatory therapy to compare overall survival (OS) and changes in lung function. BAL lymphocytosis was defined as a lymphocyte differential count > 15%, and the cut-off was corroborated by survival classification and regression tree analysis. Results Overall, 186 patients (37 iNSIP, 16 iPPFE, and 133 unclassifiable IIP) were analyzed. Limited to patients treated with anti-inflammatory drugs (n = 123), patients with BAL lymphocytosis had a better prognosis [hazard ratio (HR), 0.26; 95% confidence interval (CI), 0.11–0.63; P = 0.003], higher slope of forced vital capacity (FVC) % predicted for 2 years, and longer OS (log-rank test, P = 0.012) than those without BAL lymphocytosis. On multivariate analysis, BAL lymphocytosis (HR 0.31; 95% CI 0.13–0.75; P = 0.009) was a prognostic factor for OS, along with age and FVC % predicted. Conversely, for patients managed without anti-inflammatory therapy (n = 63), the presence or absence of BAL lymphocytosis had no prognostic value. Conclusions BAL lymphocytosis is associated with good outcomes in patients treated with anti-inflammatory drugs, but has no prognostic value when anti-inflammatory drugs are not used. BAL lymphocytosis may provide a predictive biomarker for identifying patients with iNSIP, iPPFE and unclassifiable IIP who are likely to benefit from anti-inflammatory drugs.

scholarly journals Idiopathic pleuroparenchymal fibroelastosis – A rare idiopathic interstitial pneumonia

2016 ◽  
Vol 17 ◽  
pp. 8-11 ◽  
Author(s):  
Balamugesh Thangakunam ◽  
Barney T.J. Isaac ◽  
Devasahayam Jesudas Christopher ◽  
Deepak Burad
Keyword(s):  
Interstitial Pneumonia ◽  
Idiopathic Interstitial Pneumonia ◽  
Pleuroparenchymal Fibroelastosis

The Impact of Nonsteroidal Anti-inflammatory Drugs on Older Adult Trauma Patients With Hip Fractures

2020 ◽  
Vol 255 ◽  
pp. 583-593
Author(s):  
Krista L. Haines ◽  
Matthew Fuller ◽  
Justin G. Vaughan ◽  
Vijay Krishnamoorthy ◽  
Karthik Raghunathan ◽  
...  
Keyword(s):  
Older Adult ◽  
Hip Fractures ◽  
Trauma Patients ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
The Impact

scholarly journals The impact of non-pharmacological treatments for diseases of the locomotor system on the prescribed drug use and lifestyles of the patients in the sanatoria in Busko-Zdroj

2015 ◽  
Vol 28 (4) ◽  
pp. 273-277
Author(s):  
Milena Korczak ◽  
Jacek Owczarek
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Drug Use ◽  
Pharmacological Treatments ◽  
Locomotor System ◽  
The Third ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
The Impact

Abstract The article is the result of research on the impact of non-pharmacological therapies for diseases of the locomotor system on the prescribed drug use and lifestyles of the patients of the sanatoria in Busko-Zdroj. The reported research uses primary and secondary measures. The former includes the assessment of the impact of non-pharmacological sanatorium treatments for locomotor system diseases on the use of prescribed drug regimes, while the latter is aimed at assessing the patients’ quality of life. The research was conducted on adult patients of both genders in the sanatoria in Busko-Zdroj. The subjects were patients suffering from disorders of the musculoskeletal system such as rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, osteoporosis and discopathies. The research included two visits, the first at the start of the research and the second at the end of the research. The patients were examined for a period of three consecutive weeks. The study involved 170 patients, 50% of them were women and 50% men. A decline in the use of painkillers and anti-inflammatory drugs makes a very interesting finding. After the first week, as many as 38% of the examined patients limited the use of painkillers and/or anti-inflammatory drugs. After the second week, 62% of the patients reduced the use of the drugs, and after the third week of treatment, up to 90% of the patients did so. The improvement of patients’ lives is noticeable in the psychological, physical and motor fields.

scholarly journals Impact of Anti-Inflammatory Drugs on Pyogenic Vertebral Osteomyelitis: A Prospective Cohort Study

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Aurélien Dinh ◽  
Maxime Jean ◽  
Frédérique Bouchand ◽  
Benjamin Davido ◽  
Alexis Descatha ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Diagnostic Delay ◽  
Vertebral Osteomyelitis ◽  
Diagnosis Delay ◽  
Cure Rate ◽  
Pyogenic Vertebral Osteomyelitis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
A Prospective Study ◽  
The Impact

Objective. Pyogenic vertebral osteomyelitis (PVO) are frequently misdiagnosed and patients often receive anti-inflammatory drugs for their back pain. We studied the impact of these medications. Methods. We performed a prospective study enrolling patients with PVO and categorized them depending on their drugs intake. Then, we compared diagnosis delay, clinical presentation at hospitalization, incidence of complications, and cure rate. Results. In total, 79 patients were included. Multivariate analysis found no correlation between anti-inflammatory drug intake and diagnosis delay, clinical presentation, complications, or outcome. Conclusion. Anti-inflammatory drugs intake does not affect diagnostic delay, severity at diagnosis, or complications of PVO.

scholarly journals Analysis of non-steroidal anti-inflammatory drug use in hospitalized patients and perception of their risk

2013 ◽  
Vol 6 (3) ◽  
pp. 141-144 ◽  
Author(s):  
Zoltán Varga ◽  
Milan Kriška ◽  
Viera Kristová ◽  
Miriam Petrová
Keyword(s):  
Adverse Effects ◽  
Questionnaire Study ◽  
Pharmacological Agents ◽  
Analgesic Treatment ◽  
Increased Risk ◽  
Chi Squared ◽  
History Of ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
The Impact

ABSTRACT Non-steroidal anti-inflammatory drugs (NSAIDs) belong to the most widely prescribed and used pharmacological agents worldwide. Data gathered in the last decade show increased incidence of thrombotic events during NSAID administration. Analysis of NSAID usage and assessment of risk for development of cardiovascular adverse effects is needed for improving patient safety. For limiting the impact of adverse effects on the health of patients, NSAID users should be informed about the possible adverse effects and their symptoms to ensure early detection and treatment discontinuation. In the presented study, we retrospectively analyzed the administration of NSAIDs in a group of patients (n=428) in need of analgesic treatment hospitalized at a department of internal medicine. Factors increasing the risk for cardiovascular adverse effects were also investigated. A separate questionnaire study was conducted to gather information concerning the knowledge of hospitalized NSAID users (n=251) about adverse effects of the medication used. For purpose of comparison, we conducted a similar study in a group of 234 random respondents from a shopping center. Data were evaluated using descriptive statistics, Student´s t-test and chi-squared test. Our results suggest that the majority of patients treated with NSAIDs have factors indicating increased risk of development of adverse effects, most commonly arterial hypertension (58.2% of patients). The results of our questionnaire study show limited knowledge of NSAID users about the risk of the therapy. Nearly half of the respondents were unaware of any adverse effects. We consider as alarming that only a limited number of respondents were informed by their physician or pharmacist about the possible risks of treatment. In conclusion, we found that hospitalized NSAID users often have a history of diseases predisposing to the development of cardiovascular adverse effects of NSAIDs. Despite this, their knowledge about the risk of treatment is insufficient.

Time Trends of the Impact of Helicobacter pylori Infection and Nonsteroidal Anti-Inflammatory Drugs on Peptic Ulcer Bleeding in Japanese Patients

Digestion ◽  
2015 ◽  
Vol 91 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Tomohiro Nagasue ◽  
Shotaro Nakamura ◽  
Shuji Kochi ◽  
Koichi Kurahara ◽  
Hiroki Yaita ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Time Trends ◽  
Japanese Patients ◽  
Ulcer Bleeding ◽  
Peptic Ulcer Bleeding ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
The Impact
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