Association between dietary inflammatory potential and risk of developing gestational diabetes: a prospective cohort study

Abstract Background Limited and inconsistent data are available regarding the relationship between the dietary inflammatory potential (DIP) and risk of gestational diabetes mellitus (GDM). Objective The present prospective study aimed to evaluate the association between DIP score during the first trimester of pregnancy and risk of developing GDM among Iranian women. Methods In this prospective cohort study, 812 pregnant women aged 20–40 years, who were in their first trimester, were recruited and followed up until week 24–28 of gestation. Dietary intakes of study subjects were examined using an interviewer-administered validated 117-item semi-quantitative food frequency questionnaire (FFQ). DIP score was calculated from 29 available food parameters based on earlier literature. The results of a fasting plasma glucose concentration and a 50-g, 1-h oral glucose tolerance test, between the 24th and 28th week of gestation, were used to diagnose GDM. The risk of developing GDM across quartiles of DIP score was estimated using Cox regression in several models. Results At study baseline, mean (SD) age and BMI of study participants were 29.4 (±4.84) y and 25.14 (±4.08) kg/m2, respectively. No significant association was found between DIP score and risk of GDM in the crude model (RR: 1.01; 95% CIs: 0.71–1.45). When we adjusted for age the association did not alter (RR: 1.04; 95% CIs: 0.72–1.48). Even after further adjustment for maternal weight gain we failed to find a significant association between DIP score and risk of GDM (RR: 0.97; 95% CIs: 0.66–1.41). Conclusion We found no significant association between DIP and risk of developing GDM. Further longitudinal studies among other populations are needed to elucidate the association between DIP score and GDM.

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C-reactive protein as a screening test for gestational diabetes mellitus in first-trimester of pregnancy: a prospective cohort study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20184922 ◽

2018 ◽

Vol 7 (12) ◽

pp. 4798 ◽

Cited By ~ 1

Author(s):

Tarek A. Farghaly ◽

Neveen A. Helmy ◽

Ahmed M. Abbas ◽

Abdel Ghaffar M. Ahmed

Keyword(s):

Diabetes Mellitus ◽

Cohort Study ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

First Trimester ◽

Oral Glucose ◽

C Reactive Protein ◽

Reactive Protein

Background: The current study aims to determine if increased inflammation identified by increased C-reactive protein (CRP) level is associated with the subsequent development of gestational diabetes mellitus (GDM).Methods: A prospective cohort study conducted at a tertiary University Hospital included 496 booking for their antenatal care visit between 10-12 weeks of gestation. They were tested for presence of CRP in blood. All women without a history of antenatal type 1 or type 2 diabetes undergo routine GDM screening with the 50-g oral glucose-loading test (GLT) between 24 and 28 weeks 'gestation. Women whose 1-h post-loading plasma glucose level >7.8 mmol/l (>140 mg/dl) undergo a diagnostic, fasting, 100-g, 3-h oral glucose tolerance test (OGTT) within 1-2 weeks following the GLT.Results: Among these 496 women, a total of 27 women (5.4%) were diagnosed as GDM and 10 women (2.0%) were diagnosed as IGT at week 24-28. The CRP was positive and higher in the GDM diagnosed group (p=0.000) compared to those who did not develop GDM. CRP was positively correlated with diagnosis of GDM (r=0.438, p=0.012).Conclusions: There is an association between first-trimester inflammation, marked by increased CRP levels and subsequent risk of GDM.

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High prevalence and heterogeneity of Dysglycemia in patients with tuberculosis from Peru: a prospective cohort study

BMC Infectious Diseases ◽

10.1186/s12879-019-4416-2 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Roger I. Calderon ◽

Maria B. Arriaga ◽

Kattya Lopez ◽

Nadia N. Barreda ◽

Oswaldo M. Sanabria ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Laboratory Tests ◽

Diagnostic Performance ◽

Tolerance Test ◽

Oral Glucose ◽

Poor Agreement ◽

Household Contacts ◽

High Prevalence

Abstract Background The accuracy of different laboratory tests for diagnosis of diabetes mellitus (DM) and prediabetes (preDM) in populations exposed to tuberculosis (TB) remains poorly understood. Here, we examined the prevalence of DM and preDM in TB affected people in Lima, Peru. Methods A prospective cohort study of patients affected TB and their household contacts (HHC), was conducted between February and November 2017 in Lima, Peru. Fasting plasma glucose (FPG), HbA1c and oral glucose tolerance test (OGTT) were used to detect DM and preDM in a prospective cohort of TB patients (n = 136) and household contacts (n = 138). Diagnostic performance of the laboratory tests was analyzed. Potential effects of sociodemographic and clinical factors on detection of dysglycemia were analyzed. Results In TB patients, prevalence of DM and preDM was 13.97 and 30.88% respectively. Lower prevalence of both DM (6.52%) and preDM (28.99%) were observed in contacts. FPG, HbA1c and OGTT had poor agreement in detection of preDM in either TB cases or contacts. TB-DM patients had substantially lower hemoglobin levels, which resulted in low accuracy of HbA1c-based diagnosis. Classic sociodemographic and clinical characteristics were not different between TB patients with or without dysglycemia. Conclusion High prevalence of DM and preDM was found in both TB patients and contacts in Lima. Anemia was strongly associated with TB-DM, which directly affected the diagnostic performance of HbA1c in such population.

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Optimal maternal neck and waist circumference cutoff values for prediction of gestational diabetes mellitus at the first trimester in Turkish population; a prospective cohort study

Gynecological Endocrinology ◽

10.1080/09513590.2020.1750003 ◽

2020 ◽

Vol 36 (11) ◽

pp. 1002-1005

Author(s):

Necati Hancerliogullari ◽

Hatice Kansu-Celik ◽

Z. Asli Oskovi-Kaplan ◽

Burcu Kisa ◽

Yaprak Engin-Ustun ◽

...

Keyword(s):

Diabetes Mellitus ◽

Cohort Study ◽

Waist Circumference ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Turkish Population ◽

First Trimester ◽

Cutoff Values

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Bihormonal dysregulation of insulin and glucagon contributes to glucose intolerance development at one year post-delivery in women with gestational diabetes: a prospective cohort study using an early postpartum 75-g glucose tolerance test

Endocrine Journal ◽

10.1507/endocrj.ej20-0795 ◽

2021 ◽

Author(s):

Riyoko Shigeno ◽

Ichiro Horie ◽

Masaki Miwa ◽

Ayako Ito ◽

Ai Haraguchi ◽

...

Keyword(s):

Cohort Study ◽

Gestational Diabetes ◽

Glucose Tolerance ◽

Glucose Intolerance ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Glucose Tolerance Test ◽

Tolerance Test ◽

Early Postpartum ◽

One Year

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Red Blood Cells in The First Trimester and The Risk of Gestational Diabetes: A Prospective Cohort Study

10.21203/rs.3.rs-156418/v1 ◽

2021 ◽

Author(s):

Jiajing Jia ◽

Ying Yang ◽

Minjin Zhang ◽

Li Lin ◽

Yequn Chen ◽

...

Keyword(s):

Cohort Study ◽

Gestational Diabetes ◽

Blood Cell ◽

Pregnant Women ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Hematological Parameters ◽

First Trimester ◽

Logistic Regression Models ◽

Increased Risk

Abstract Background: This research aimed to assess the potential association of gestational diabetes (GDM) with early trimester hematological parameters including hemoglobin (Hb), red blood cell (RBC), white blood cell (WBC), and platelet count (PLT) through a prospective cohort study.Methods: The prospective cohort included pregnant women subjected to prenatal examination at Shantou and Beijing hospitals in China from March 2014 to December 2015. Data were collected since the first perinatal visit in obstetrics clinics, and then participants were followed up at 24, 32, 36 gestational weeks and the time of delivery, respectively. Multivariable adjusted logistic regression models were conducted to estimate odds ratio (OR) and its corresponding 95% confidence interval (95% CI).Results: A total of 1004 pregnant women with singletons, less than 12 gestational weeks, and without history of chronic disease were eligible for analysis. The incidence of GDM was 18.82%, and the mean age was 29.50 ± 3.84 years. Total of 187 (18.63%) women who had abnormal RBC level and 222 (22.11%) had abnormal Hb in the first trimester of pregnancy. After multivariable adjustment, each unit increment in numeric RBC or Hb was associated with 177% and 4% increased risk for GDM. The risk for GDM was significantly increased with higher RBC (OR: 2.00 for RBC>4.55×1012 /L) and Hb (OR: 2.14 for Hb>139 g/L) levels in the first trimester.Conclusions: Elevated RBC and Hb in the first trimester are associated with increasing risk of GDM. Further evidence are warranted to confirm these possible causal relationships.

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