scholarly journals The global burden and attributable risk factors of chronic lymphocytic leukemia in 204 countries and territories from 1990 to 2019: analysis based on the global burden of disease study 2019

2022 ◽  
Vol 21 (1) ◽  
Author(s):  
Yiyi Yao ◽  
Xiangjie Lin ◽  
Fenglin Li ◽  
Jie Jin ◽  
Huafeng Wang
Keyword(s):  
Risk Factors ◽  
Chronic Lymphocytic Leukemia ◽  
Burden Of Disease ◽  
Disease Burden ◽  
Attributable Risk ◽  
Lymphocytic Leukemia ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Epidemiological Characteristics ◽  
The Impact

Abstract Background Chronic lymphocytic leukemia (CLL) is the most prevalent subtype of leukemia in Western countries, causing a substantial health burden on patients and society. Comprehensive evaluation of the epidemiological characteristics of CLL is warranted, especially in the current context of global population aging. The main objective of this study is evaluating the disease burden of CLL at global, regional, and national levels from 1990 to 2019. As secondary objectives, we studied the influence of demographic factors and performed risk factor analysis. We hope this study could provide evidence for the evaluation of the effectiveness of previous prevention strategies and the formulation of future global health policies. Results Based on data of CLL between 1990 to 2019 from the Global Burden of Disease (GBD) study 2019, we depicted the age, gender, and regional structure of the CLL burden population and described the impact of social development on the disease burden of CLL. The distribution and changing trends of attributable risk factors were also investigated. The global burden of CLL has increased dramatically. A high incidence has been achieved in males and elder people. Countries and territories with high social-demographic index (SDI) tended to have higher global burden than low-SDI region. Of risk factors, high body mass index and smoking were the major contributors for CLL-related mortality and disability adjusted life-years (DALYs). Conclusion In summary, the global CLL burden continues to rise over the past 30 years. The relocation of medical resource should be considered on a global scale. Graphical Abstract

The Global Burden and Attributable Risk Factors of Chronic Lymphocytic Leukemia in 204 Countries and Territories from 1990 to 2019: Analysis Based on the Global Burden of Disease Study 2019.

2021 ◽  
Author(s):  
Yiyi Yao ◽  
Xiangjie Lin ◽  
Fenglin Li ◽  
Jie Jin ◽  
Huafeng Wang
Keyword(s):  
Risk Factors ◽  
Chronic Lymphocytic Leukemia ◽  
Burden Of Disease ◽  
Population Aging ◽  
High Body Mass Index ◽  
Lymphocytic Leukemia ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Life Years ◽  
Epidemiological Characteristics

Abstract Chronic lymphocytic leukemia (CLL) is the most prevalent subtype of leukemia in Western countries. Evaluation of the epidemiological characteristics of CLL is warranted, especially in the current context of global population aging. CLL data including incidence, mortality, and disability adjusted life-years (DALYs) were extracted and estimated annual percentage changes (EAPCs) were calculated from the 2019 Global Burden of Disease (GBD) study. Social-demographic index (SDI) was collected to investigate the impaction of social development degree on epidemiological trends and risk analysis. The global incidence of CLL has increased dramatically from 40,537 in 1990 to 103,467 in 2019. A high incidence has been achieved in males and elder people. Countries and territories with high SDI tended to have higher global burden than low-SDI region. Of the risk factors, high body mass index and smoking were the major contributors for CLL-related mortality and DALYs. In summary, the global CLL burden continues to rise over the past 30 years. Although most of the CLL incidence and death occurred in high-SDI regions, the CLL burden tends to grow rapidest in middle-SDI regions compared with high-/low-SDI regions. Therefore, it is necessary to pay special attention on taking further measures to alleviate the growing burden of CLL.

scholarly journals Global burden of breast cancer and attributable risk factors in 195 countries and territories, from 1990 to 2017: results from the Global Burden of Disease Study 2017

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Na Li ◽  
Yujiao Deng ◽  
Linghui Zhou ◽  
Tian Tian ◽  
Si Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Burden Of Disease ◽  
Attributable Risk ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Cancer Burden ◽  
Cancer Data ◽  
Life Years ◽  
Incident Cases

Abstract Background Statistical data on the incidence, mortality, and burden of breast cancer and the relevant risk factors are valuable for policy-making. We aimed to estimate breast cancer incidence, deaths, and disability-adjusted life years (DALYs) by country, gender, age group, and social-demographic status between 1990 and 2017. Methods We extracted breast cancer data from the 2017 Global Burden of Disease (GBD) study from 1990 through 2017 in 195 countries and territories. Data about the number of breast cancer incident cases, deaths, DALYs, and the age-standardized rates were collected. We also estimated the risk factors attributable to breast cancer deaths and DALYs using the comparative risk assessment framework of the GBD study. Results In 2017, the global incidence of breast cancer increased to 1,960,681 cases. The high social-development index (SDI) quintile included the highest number of breast cancer death cases. Between 2007 and 2017, the ASDR of breast cancer declined globally, especially in high SDI and high middle SDI countries. The related DALYs were 17,708,600 in 2017 with high middle SDI quintile as the highest contributor. Of the deaths and DALYs, alcohol use was the greatest contributor in most GBD regions and other contributors included high body mass index (BMI) and high fasting plasma glucose. Conclusion The increasing global breast cancer burden is mainly observed in lower SDI countries; in higher SDI countries, the breast cancer burden tends to be relieving. Therefore, steps against attributable risk factors should be taken to reduce breast cancer burden in lower SDI countries.

scholarly journals Alcohol‐attributed disease burden in four Nordic countries: a comparison using the Global Burden of Disease, Injuries and Risk Factors 2013 study

Addiction ◽  
2016 ◽  
Vol 111 (10) ◽  
pp. 1806-1813 ◽  
Author(s):  
Emilie E. Agardh ◽  
Anna‐Karin Danielsson ◽  
Mats Ramstedt ◽  
Astrid Ledgaard Holm ◽  
Finn Diderichsen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Burden Of Disease ◽  
Disease Burden ◽  
Nordic Countries ◽  
Global Burden Of Disease ◽  
Global Burden

scholarly journals The burden of non-communicable diseases attributable to high BMI in Brazil, 1990–2017: findings from the Global Burden of Disease Study

2020 ◽  
Vol 18 (S1) ◽  
Author(s):  
Mariana Santos Felisbino-Mendes ◽  
Ewerton Cousin ◽  
Deborah Carvalho Malta ◽  
Ísis Eloah Machado ◽  
Antonio Luiz Pinho Ribeiro ◽  
...  
Keyword(s):  
Burden Of Disease ◽  
Disease Burden ◽  
Communicable Diseases ◽  
Overweight And Obesity ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Non Communicable Diseases ◽  
Prevalence Of Obesity ◽  
The Impact ◽  
High Bmi

Abstract Background The prevalence and burden of disease resulting from obesity have increased worldwide. In Brazil, more than half of the population is now overweight. However, the impact of this growing risk factor on disease burden remains inexact. Using the 2017 Global Burden of Disease (GBD) results, this study sought to estimate mortality and disability-adjusted life years (DALYs) lost to non-communicable diseases caused by high body mass index (BMI) in both sexes and across age categories. This study also aimed to describe the prevalence of overweight and obesity throughout the states of Brazil. Methods Age-standardized prevalence of overweight and obesity were estimated between 1990 and 2017. A comparative risk assessment was applied to estimate DALYs and deaths for non-communicable diseases and for all causes linked to high BMI. Results The prevalence of overweight and obesity increased during the period of analysis. Overall, age-standardized prevalence of obesity in Brazil was higher in females (29.8%) than in males (24.6%) in 2017; however, since 1990, males have presented greater rise in obesity (244.1%) than females (165.7%). Increases in prevalence burden were greatest in states from the North and Northeast regions of Brazil. Overall, burden due to high BMI also increased from 1990 to 2017. In 2017, high BMI was responsible for 12.3% (8.8–16.1%) of all deaths and 8.4% (6.3–10.7%) of total DALYs lost to non-communicable diseases, up from 7.2% (4.1–10.8%), and 4.6% (2.4-6.0%) in 1990, respectively. Change due to risk exposure is the leading contributor to the growth of BMI burden in Brazil. In 2017, high BMI was responsible for 165,954 deaths and 5,095,125 DALYs. Cardiovascular disease and diabetes have proven to be the most prevalent causes of deaths, along with DALYs caused by high BMI, regardless of sex or state. Conclusions This study demonstrates increasing age-standardized prevalence of obesity in all Brazilian states. High BMI plays an important role in disease burdens in terms of cardiovascular diseases, diabetes, and all causes of mortality. Assessing levels and trends in exposures to high BMI and the resulting disease burden highlights the current priority for primary prevention and public health action initiatives focused on obesity.

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