scholarly journals Investigation of the vitamin D nutritional status in women with gestational diabetes mellitus in Beijing

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Yanping Liu ◽  
Qiaer Jin ◽  
Yuanyuan Bao ◽  
Shanshan Li ◽  
Jing Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Nutritional Status ◽  
Gestational Diabetes Mellitus

scholarly journals Relationship Between Vitamin D Levels of Women with Gestational Diabetes Mellitus and Birthweight of Their Newborns: Preliminary Results (P11-020-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Patricia Padilha ◽  
Claudia Saunders ◽  
Elisabete Queiroz ◽  
Barbara Nascimento ◽  
Thaissa Lima ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Birth Weight ◽  
Gestational Diabetes ◽  
Nutritional Status ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Rio De Janeiro ◽  
Vitamin D Levels ◽  
The Mean

Abstract Objectives To evaluate the relationship between vitamin D levels in women with gestational diabetes and the birth weight of their newborns. Methods This is a cross-sectional study nested in a controlled clinical trial performed in a public maternity hospital in Rio de Janeiro, with a sample composed of adult pregnant women diagnosed with gestational diabetes mellitus, without other chronic morbidities. The nutritional status of vitamin D was classified as 25(OH)D, being classified as: sufficient between 30 and 100 ng/mL; insufficient: between 20 and 29 ng/mL; and deficient below 20 ng/mL. In this analysis, the data regarding the vitamin D levels at the beginning of the study (T0) of the research were considered, and the dependent variable was the birth weight. Pearson's correlation was performed to evaluate the degree of correlation between two continuous variables, being considered as a level of statistical significance the value of P < 0.05. Results The mean maternal age was 35.4 (± 5.9) years (N = 11), and among these, 18.2% (n = 2) had adequate nutritional status, 27.3% (n = 3), overweight and 54, 5% (n = 6), obesity, according to pre-gestational BMI. Among the factors admitted as a risk for hypovitaminosis D (BMI > 25kg/m², brown/black skin color, marital status (married) and occupation), 45.5% (n = 5) presented 3 or more of them. As for nutritional status of vitamin D, 63.6% (n = 7) had insufficiency, 27.3% (n = 3), deficiency and 9.1% (n = 1), sufficiency. The initial mean concentration of 25(OH)D was 21.2 n/mL. It was observed that 72.7% (n = 8) of the pregnant women presented no gestational intercurrences at delivery or in the puerperium, while 18.4% (n = 2) presented unfavorable outcomes. The mean birth weight was 2842.5 (± 1251.1) grams and the mean gestational age at birth was 36.2 (± 6.5) weeks. With respect to neonatal outcomes was observed a significant positive correlation (r = 0, 900; P = 0.037) between serum levels of 25(OH)D at baseline and birthweight. Conclusions Preliminary data indicated that best status of vitamin D is related to higher birthweight values. Funding Sources FAPERJ (FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DO RIO DE JANEIRO).

scholarly journals Association between the rs1544410 polymorphism in the vitamin D receptor (VDR) gene and insulin secretion after gestational diabetes mellitus

PLoS ONE ◽  
2020 ◽  
Vol 15 (5) ◽  
pp. e0232297
Author(s):  
Nael Shaat ◽  
Anastasia Katsarou ◽  
Bushra Shahida ◽  
Rashmi B. Prasad ◽  
Karl Kristensen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Insulin Secretion ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Vitamin D Receptor ◽  
Vdr Gene

scholarly journals The Role of Vitamin D in the Development of Diabetes Post Gestational Diabetes Mellitus: A Systematic Literature Review

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1733
Author(s):  
Amélie Keller ◽  
Carmen Varela Vazquez ◽  
Rojina Dangol ◽  
Peter Damm ◽  
Berit Lilienthal Heitmann ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Literature Review ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Systematic Literature Review ◽  
Observational Studies ◽  
Vitamin D Supplementation ◽  
Diabetes Development ◽  
High Degree

Women diagnosed with gestational diabetes mellitus (GDM) are more likely to later develop diabetes. Evidence from some previous reviews suggests that low vitamin D status during pregnancy increases the risk of developing GDM, but whether vitamin D during pregnancy also influences the risk of diabetes post GDM is less well studied. Thus, the aim of this systematic literature review was to summarize the current available literature on that topic. This review considered observational studies and randomized controlled trials (RCTs). Five databases were searched. The risk of bias of the included studies was assessed. A total of six studies were included: three observational studies and three RCTs. Findings were inconsistent across the six included studies. However, when considering RCTs only, the findings more strongly suggested that vitamin D supplementation during and after pregnancy did not have an influence on markers of diabetes development or diabetes development post GDM. This systematic review highlights inconsistent findings on the associations between vitamin D supplementation or concentration during and after pregnancy and markers of diabetes development or diabetes development post GDM; and although results from randomized interventional studies more strongly suggested no associations, the conclusion holds a high degree of uncertainty.

scholarly journals Hypovitaminosis D in pregnancy and its correlation with preeclampsia and gestational diabetes mellitus

2017 ◽  
Vol 6 (3) ◽  
pp. 890 ◽  
Author(s):  
Ankita Kumari ◽  
Shaila Mitra ◽  
Harish C Tiwari ◽  
Reena Srivastav
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Health Concern ◽  
Control Group ◽  
The Impact

Background: Hypovitaminosis D has been associated with a number of adverse pregnancy outcomes, and has been recognised as a public health concern. The objective of this study was to determine the impact of Vitamin D deficiency on maternal complications like gestational diabetes mellitus (GDM) and preeclampsia (PE) among pregnant women.Methods: This was a case control study undertaken at antenatal clinics and indoor of BRD Medical College, Gorakhpur, Uttar Pradesh, India. Two maternal blood samples, one at <20 weeks and other at term along with cord blood at delivery were taken. Patients were classified into preeclampsia (n=60), gestational diabetes mellitus (n=35) and control group (n=180) after abstracting past medical records at delivery. Vitamin D was estimated by 25- Hydroxyvitamin D125 RIA kit and categorized according to ACOG criteria. Statistical analysis was done by using chi square test, binary logistic regression and Pearson’s correlation coefficient to compare between two variables. P<0.05 was considered statistically significant.Results: Out of 275 women included in the study, 78% of women were Vitamin D deficient. Mean serum vitamin D was significantly lower among preeclamptic women 11.53±6.22 ng/ml and GDM women 12.62±6.69 ng/ml as compared to controls 24.25±14.44 ng/ml (median=18.2 ng/ml) (P<0.05). Vitamin D deficiency was significantly higher in pregnant women GDM (94.28% vs 68.3%) and preeclampsia (96.67% vs 68.3%) when compared to uncomplicated group.Conclusions: Maternal vitamin D deficiency is highly prevalent in early pregnancy and is significantly associated with elevated risk for GDM and preeclampsia.

Study of vitamin D receptor gene methylation and the risk of gestational diabetes mellitus in Iranian pregnant women

Gene Reports ◽  
2021 ◽  
Vol 22 ◽  
pp. 100978
Author(s):  
Pooneh Mokarram ◽  
Golzar Rahmannezhad ◽  
Mehran Erfani ◽  
Mohammad Reza Rezvanfar ◽  
Farideh Jalali Mashayekhi
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Gene Methylation

scholarly journals Vitamin D and Insulin resistance in gestational diabetes mellitus

2017 ◽  
Vol 8 (3) ◽  
pp. 17-25
Author(s):  
M. Gashlan Hana ◽  
F. H. Noureldeen Amani ◽  
A. Elsherif Hanaa ◽  
Tareq Ohood
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus

scholarly journals Relationship of Early Vitamin D Concentrations and Gestational Diabetes Mellitus in Indian Pregnant Women

2019 ◽  
Vol 6 ◽  
Author(s):  
Pratibha Dwarkanath ◽  
Ponnusamy Vinotha ◽  
Tinku Thomas ◽  
Siji Joseph ◽  
Annamma Thomas ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Relationship Of

scholarly journals Assessment of Polymorphism of the VDR Gene and Serum Vitamin D Values in Gestational Diabetes Mellitus

2019 ◽  
Vol 41 (07) ◽  
pp. 425-431
Author(s):  
Thais Walverde Siqueira ◽  
Edward Araujo Júnior ◽  
Rosiane Mattar ◽  
Silvia Daher
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Vitamin ◽  
Vdr Gene ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference

Objective To evaluate the relationship between vitamin D receptor (VDR) gene polymorphism (FokI [rs10735810]) and serum vitamin D concentration in gestational diabetes mellitus (GDM). Methods A prospective case-control study that recruited healthy pregnant women (control group) (n = 78) and women with GDM (GDM group) (n = 79), with no other comorbidities. Peripheral blood samples were collected in the 3rd trimester of gestation, and all of the pregnant women were followed-up until the end of the pregnancy and the postpartum period. Serum vitamin D concentrations were measured by high-performance liquid chromatography (HPLC). For genomic polymorphism analysis, the genomic DNA was extracted by the dodecyltrimethylammonium bromide/cetyltrimethylammonium bromide (DTAB/CTAB) method, and genotyping was performed by the polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) technique, using the restriction enzyme FokI. The Student-t, Mann-Whitney, chi-squared, and Fischer exact tests were used for the analysis of the results. Results There was no significant difference between the pregnant women in the control and GDM groups regarding serum vitamin D levels (17.60 ± 8.89 ng/mL versus 23.60 ± 10.68 ng/mL; p = 0.1). Also, no significant difference was detected between the FokI genotypic frequency when the 2 groups were compared with each other (p = 0.41). Conclusion There was no association between the FokI polymorphism and the development of GDM, nor was there any change in serum vitamin D levels in patients with GDM.

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