scholarly journals The relationship between serum triglyceride levels and acute pancreatitis in an animal model and a 14-year retrospective clinical study

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Qiyue Zhang ◽  
Mengbin Qin ◽  
Zhihai Liang ◽  
Huali Huang ◽  
Yongfeng Tang ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Clinical Study ◽  
Operating Characteristic ◽  
Serum Amylase ◽  
Animal Experiments ◽  
Serum Triglyceride ◽  
Pancreatic Injury ◽  
Roc Curve Analysis ◽  
Retrospective Clinical Study ◽  
The Relationship

Abstract Objectives The aim of the current study was to evaluate influence of serum triglyceride levels on the course of acute pancreatitis (AP). Methods Rats models of hypertriglyceridemic were used in animal experiments. Following induction of acute pancreatitis, amylase, and pancreas histological scores were all compared. In addition, in a clinical study, clinical data were collected from 1681 AP patients admitted from 2003 to 2016 who were divided into 4 groups based on their serum triglyceride (TG) levels. The clinical features among these 4 groups were compared, and a receiver operating characteristic (ROC) curve analysis was also performed on TG values to estimate their relationship with severity. Results In animal experiments, the hypertriglyceridemic pancreatitis (HTGP) group had markedly higher serum amylase, and histological scores relative to the other animal groups. In the clinical study, we identified significant differences in gender, age, body mass index (BMI), cost, and incidence of partial complications among the 4 TG-based groups. Importantly, the TG levels on day 3–4 after admission could be used to accurately predict disease severity. Conclusions Hypertriglyceridemia (HTG) can aggravate pancreatic injury, and hypertriglyceridemia patients are more likely to suffer from severe pancreatic injury with a higher possibility of complications. In addition, triglyceride levels are correlated with the severity of AP positively.

scholarly journals Sa1378 – Rifaximin in Selective Digestive Decontamination in Acute Pancreatitis – 9 Years of Retrospective Clinical Study

2019 ◽  
Vol 156 (6) ◽  
pp. S-332-S-333
Author(s):  
Jacek Tatur ◽  
Jacek Tatur ◽  
Marta Sznurkowska ◽  
Ewa Jozefik ◽  
Grazyna Rydzewska
Keyword(s):  
Acute Pancreatitis ◽  
Clinical Study ◽  
Selective Digestive Decontamination ◽  
Retrospective Clinical Study

Amylase, lipase, pancreatic isoamylase, and phospholipase A in diagnosis of acute pancreatitis

1995 ◽  
Vol 41 (8) ◽  
pp. 1129-1134 ◽  
Author(s):  
P Clavé ◽  
S Guillaumes ◽  
I Blanco ◽  
N Nabau ◽  
J Mercé ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Operating Characteristic ◽  
Serum Amylase ◽  
Acute Abdominal Pain ◽  
Characteristic Curve ◽  
Threshold Value ◽  
Phospholipase A ◽  
Diagnostic Efficiency ◽  
Pancreatic Isoamylase ◽  
Parallel Fashion

Abstract To determine the utility of serum amylase (AMY), lipase (Lp), pancreatic isoamylase (isoA), phospholipase A (PLA), and urine AMY in the diagnosis of acute pancreatitis, samples of serum and urine were obtained on admission and every day thereafter for 5 days from 384 patients with acute abdominal pain. Diagnostic accuracy, determined as the area under the receiver operating characteristic curve, was > 0.975 for serum AMY, Lp, isoA, and urine AMY. For each of these enzymes, a threshold value (twice to sixfold the upper limit of the reference values) offering diagnostic efficiency > 95% could be determined. In contrast, accuracy and efficiency of serum PLA were low. The profiles of these enzymes in acute pancreatitis decreased in a parallel fashion over 5 days except for PLA. We conclude that diagnostic utilities are similar for serum AMY, Lp, isoA, and urine AMY for acute pancreatitis, provided that an appropriate threshold is established.

Prospective investigation of the relationship between dorsal tilt, carpal malalignment, and capitate shift in distal radial fractures

2020 ◽  
Vol 102-B (1) ◽  
pp. 137-143
Author(s):  
Rachel Dias ◽  
Nick A. Johnson ◽  
Joseph J. Dias
Keyword(s):  
Operating Characteristic ◽  
Distal Radial Fracture ◽  
Radial Fracture ◽  
Roc Curve Analysis ◽  
Distal Radial Fractures ◽  
Initial Radiograph ◽  
Interval Linear ◽  
Adverse Influence ◽  
The Relationship ◽  
Prospective Investigation

Aims Carpal malalignment after a distal radial fracture occurs due to loss of volar tilt. Several studies have shown that this has an adverse influence on function. We aimed to investigate the magnitude of dorsal tilt that leads to carpal malalignment, whether reduction of dorsal tilt will correct carpal malalignment, and which measure of carpal malalignment is the most useful. Methods Radiographs of patients with a distal radial fracture were prospectively collected and reviewed. Measurements of carpal malalignment were recorded on the initial radiograph, the radiograph following reduction of the fracture, and after a further interval. Linear regression modelling was used to assess the relationship between dorsal tilt and carpal malalignment. Receiver operating characteristic (ROC) analysis was used to identify which values of dorsal tilt led to carpal malalignment. Results A total of 250 consecutive patients with 252 distal radial fractures were identified. All measures of carpal alignment were significantly associated with dorsal tilt at each timepoint. This relationship persisted after adjustment for age, sex, and the position of the wrist. Capitate shift consistently had the strongest relationship with dorsal tilt and was the only parameter that was not influenced by age or the position of the wrist. ROC curve analysis identified that abnormal capitate shift was seen with > 9° of dorsal tilt. Conclusion Carpal malalignment is related to dorsal tilt following a distal radial fracture. Reducing the fracture and improving dorsal tilt will reduce carpal malalignment. Capitate shift is easy to assess visually, unrelated to age and sex, and appears to be the most useful measure of carpal malalignment. The aim during reduction of a distal radial fracture should be to realign the capitate with the axis of the radius and prevent carpal malalignment. Cite this article: Bone Joint J 2020;102-B(1):137–143

scholarly journals Diagnosis of inflammatory peri-implant diseases using an immunochromatographic assay for calprotectin in peri-implant crevicular fluid

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Rie Kido ◽  
Jun-ichi Kido ◽  
Yasufumi Nishikawa ◽  
Eijiro Sakamoto ◽  
Yoritoki Tomotake ◽  
...  
Keyword(s):  
Operating Characteristic ◽  
Inflammatory Marker ◽  
Diagnostic System ◽  
Diagnostic Methods ◽  
Enzyme Linked Immunosorbent Assay ◽  
Roc Curve Analysis ◽  
Implant Placement ◽  
Probing Depth ◽  
Crevicular Fluid ◽  
The Relationship

Abstract Background The incidence rate of peri-implant diseases is increasing with implant placement. Early detection of peri-implant diseases is important to prevent and treat these diseases, and a simple and objective diagnostic method is expected. Immunochromatographic (IC) assays are used for rapid diagnostic methods for some diseases. The aim of this clinical study was to determine the amount of calprotectin, an inflammatory marker, in peri-implant crevicular fluid (PICF) using an IC chip, and estimate the possibility of this diagnostic system. Methods Forty-six individuals with dental implants participated in a pilot study. PICF samples were collected from the peri-implant sites with or without inflammation after clinical examinations including probing depth (PD), bleeding on probing (BOP) and gingival index (GI). Calprotectin in PICF was determined by an IC chip and enzyme-linked immunosorbent assay (ELISA) for calprotectin. The density of calprotectin line on the IC chip was measured using an IC reader (IC reader value). The relationship between IC reader value and ELISA value or clinical parameters was investigated. A receiver operating characteristic (ROC) curve analysis of IC reader value of calprotectin was performed to predict inflammation in peri-implant diseases. Results IC reader value of calprotectin was significantly correlated with its ELISA value and PD. IC reader values of calprotectin in PICF samples from periodontal sites with GI-1 and GI-2, and with BOP-positive sites were significantly higher than those of PICF samples from GI-0 sites, and BOP-negative sites, respectively. The IC reader value for calprotectin in PICF samples from inflammatory diseased sites was significantly higher than that of non-diseased sites. ROC analysis suggested that the IC reader value of PICF calprotectin was useful for predicting inflammatory peri-implant diseases. Conclusion IC assay for PICF calprotectin may be a possible system for diagnosing the inflammatory peri-implant diseases.

scholarly journals Triglyceride to HDL-C Ratio Is Associated with Plasma D-Dimer Levels in Different Types of Pancreatitis: A Retrospective Single-Centered Study in China

2022 ◽  
Author(s):  
Xiaoqing Jia ◽  
Xiaoting Zhang ◽  
Dalong Sun ◽  
Rong Li ◽  
Na Yang ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Control Group ◽  
Recurrent Acute Pancreatitis ◽  
Significant Difference ◽  
Different Types ◽  
Coefficient Corrélation ◽  
The Relationship ◽  
D Dimer

Abstract BackgroundThis study aims to evaluate the relationship between D-dimer and dyslipidemia, especially triglyceride to HDL-C ratio (TG/HDL-C) in different types of pancreatitis. We analyzed the D-dimer and dyslipidemia levels in acute pancreatitis (AP), recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP). Material and MethodsA single-centered retrospective study was conducted on 1013 patients diagnosed with AP, RAP or CP. Only patients hospitalized within 24 h of onset were included, and 204 patients were enrolled in pancreatitis groups. 68 normal persons without pancreatitis, malignant diseases, pregnancy, or organ failure, who had health check-ups, were enrolled in the control group. Blood samples were taken within 24h of admission. The epidemiology and etiology were analyzed. D-dimer and dyslipidemia levels were compared between different types of pancreatitis. Furthermore, the area under the receiver-operating characteristic curve (AUC) was used to estimate the validity of the predictor and to define optimal cut-off points for prediction.ResultsWe found that D-dimer and TG/HDL-C ratio could distinguish mild AP (MAP) and non-MAP in AP and RAP patients. The D-dimer level was related to TG/HDL-C ratio and severity of pancreatitis, with the coefficient correlation of 0.379 and 0.427(p<0.01), respectively. TG/HDL-C was related to D-dimer in different types of pancreatitis. Multivariate analysis was conducted in the parameters at admission like alcohol abuse, dyslipidemia and coagulation disturbance in distinguishing AP and RAP groups from the control group, and the parameter like diabetes in RAP and CP groups significantly increased compared with that of the control group. ConclusionsThe value of D-dimer level and TG/HDL-C ratio in predicting the severity of AP and RAP was confirmed but there was no significant difference between CP group and the control group. The D-dimer level was related to dyslipidemia and TG/HDL-C ratio.

scholarly journals Urine trypsinogen-2 as marker of acute pancreatitis

1996 ◽  
Vol 42 (5) ◽  
pp. 685-690 ◽  
Author(s):  
J Hedström ◽  
V Sainio ◽  
E Kemppainen ◽  
P Puolakkainen ◽  
R Haapiainen ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Roc Analysis ◽  
Operating Characteristic ◽  
Serum Amylase ◽  
Time Resolved ◽  
Abdominal Disease ◽  
Serum Trypsinogen ◽  
Urine Amylase ◽  
Better Than

Abstract We examined the clinical utility of urine trypsinogen-2 as a marker of acute pancreatitis (AP). Fifty-nine patients with AP, 42 with acute abdominal diseases of extrapancreatic origin, and 63 without evidence of acute abdominal disease were studied. Urine trypsinogen-2 was determined by a time-resolved immunofluorometric assay. As reference methods we used serum trypsinogen-2, urine amylase, and serum amylase. The diagnostic accuracy of the markers was evaluated by receiver-operating characteristic (ROC) analysis. At admission, urine trypsinogen-2 differentiated patients with AP from controls with high accuracy. The area under the ROC curve (AUC) was 0.978, which was equal to that of serum trypsinogen-2 (0.998) and serum amylase (0.969) and significantly larger than that of urine amylase. For differentiation between severe and mild AP, urine trypsinogen-2 (0.730) was equal to serum trypsinogen-2 (0.721), and clearly better than amylase in serum and urine. These results suggest that determination of urine trypsinogen-2 is a useful test to detect AP and to evaluate disease severity.

scholarly journals Complement C1q as a Potential Biomarker for Obesity and Metabolic Syndrome in Chinese Adolescents

2020 ◽  
Vol 11 ◽  
Author(s):  
Xuelian Yang ◽  
Yanan Ma ◽  
Zhongyi Zhao ◽  
Shihan Zhen ◽  
Deliang Wen
Keyword(s):  
Metabolic Syndrome ◽  
Operating Characteristic ◽  
Area Under The Curve ◽  
Chinese Adolescents ◽  
Trend Test ◽  
Roc Curve Analysis ◽  
Potential Biomarker ◽  
Prevalence Of Obesity ◽  
Complement C1q ◽  
The Relationship

BackgroundComplement C1q (C1q) has been confirmed to be related to obesity, metabolic syndrome (MetS), and its components. However, human data regarding the associations are relatively scarce. This study aimed to investigate associations of C1q with obesity as well as MetS in Chinese adolescents.MethodsA total of 1,191 Chinese adolescents aged 13–18 years were enrolled in this study. The biochemical and anthropometric variables of all the subjects were evaluated using standardized procedures. C1q was measured using the immunoturbidometric assay. The relationship between C1q and obesity or MetS was analyzed using multiple regression analyses.ResultsObesity was more prevalent among participants in the highest tertile than in the lowest tertile of C1q levels. The highest tertile of C1q was related to a greater effect on the risk of MetS, and its trend test was statistically significant. Except for hyperglycemia, the prevalence of other components of MetS significantly increased relative to an increase in C1q tertile. Receiver operating characteristic (ROC) curve analysis of C1q for predicting adolescents with MetS illustrated that the area under the curve (AUC) was 0.82 [95% confidence interval (CI): 0.76, 0.88; P&lt;0.001] in the total population after adjusting for confounders.ConclusionsThis study observed a significantly higher prevalence of obesity and MetS features in adolescents with high C1q. The findings of the current study also reported a significant relationship between C1q levels and MetS components [except for fasting plasma glucose (FPG)] in Chinese adolescents. C1q may represent a biomarker for predicting obesity or MetS in adolescents.

scholarly journals Impact of Acute Pancreatic Injury on Sphingolipid Metabolism in the Salivary Glands

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Małgorzata Żendzian-Piotrowska ◽  
Dominika M. Ziembicka ◽  
Bartłomiej Łukaszuk ◽  
Krzysztof Kurek
Keyword(s):  
Diabetes Mellitus ◽  
Acute Pancreatitis ◽  
Type 1 Diabetes ◽  
Salivary Glands ◽  
Pancreatic Injury ◽  
Biologically Active ◽  
Sphingolipid Metabolism ◽  
Submandibular Salivary Glands ◽  
The Relationship

Acute pancreatic injury can be related to both parenchymal (responsible for exocrine functions) and islet (mainly β-cells, responsible for endocrine functions) damage. During embryonic development, both the salivary glands and the pancreas originate from the foregut, which explains many of the observed histological and functional similarities between these two organs. The relationship between several diseases of the pancreas and salivary glands, resulting from morphological and functional similarities, is well established. Sphingolipids constitute a class of biologically active molecules involved in numerous physiological and pathological processes, including acute pancreatitis (AP) and diabetes mellitus. However, the effect of AP on sphingolipid metabolism in the salivary glands remains uncertain. In the presented study, we examined the effect of AP and type 1 diabetes mellitus on sphingolipid metabolism in the salivary glands of rats. We demonstrated that acute pancreatic injury, related to both exocrine and endocrine functions, affects the metabolism of sphingolipids in the parotid, but not submandibular, salivary glands.

scholarly journals A case of acute pancreatitis with normal serum amylase and lipase value

2021 ◽  
Vol 1 (2) ◽  
Author(s):  
Jayanta Paul ◽  
Keyword(s):  
Acute Pancreatitis ◽  
Ct Scan ◽  
Acute Pain ◽  
Serum Amylase ◽  
Elevated Serum ◽  
Serum Triglyceride ◽  
Normal Serum ◽  
Upper Limit ◽  
Pain Abdomen ◽  
Rule Out

There are several causes of acute pancreatitis (AP). In clinical practice, AP is diagnosed by presence of acute pain abdomen, elevated serum amylase and lipase value (>3 times of upper limit of normal) and ultrasonographic (USG) findings of acute pancreatitis but in only 25-50% of patients with acute pancreatitis, pancreas is visualised. In this case, 44 years gentleman was presented with acute pain abdomen, normal serum amylase and lipase value and no pancreatic abnormality in abdominal USG. After diagnosis of elevated serum triglyceride, computed tomography (CT scan) of abdomen was done to exclude hypertriglyceridemia induced AP. CT scan abdomen showed features of acute pancreatitis. Therefore, in every patient with acute pain abdomen if serum amylase and lipase value and USG abdomen are normal, serum triglyceride should be advised to rule out hypertriglyceridemia induced AP. In this case report we are going to present a case of acute pancreatitis with normal serum amylase and lipase value.

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